Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase | 0.0051 | 0.1694 | 0.1731 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.211 | 0.6348 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0017 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | cytochrome P450 | 0.0044 | 0.1382 | 0.1382 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Trypanosoma cruzi | cytochrome P450, putative | 0.007 | 0.2529 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.1694 | 0.6365 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.2221 | 0.7314 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.211 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0017 | 0.0234 | 1 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0044 | 0.1382 | 0.5004 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.1694 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0063 | 0.2221 | 0.8658 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.2221 | 0.7314 |
Schistosoma mansoni | cytochrome P450 | 0.0044 | 0.1382 | 0.6551 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.162 | 0.7678 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.162 | 0.7678 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0051 | 0.1694 | 0.8031 |
Brugia malayi | hypothetical protein | 0.0241 | 0.9789 | 0.9789 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0044 | 0.1382 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.2221 | 0.7314 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.007 | 0.2529 | 0.2529 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.2221 | 0.7314 |
Trypanosoma brucei | protein kinase, putative | 0.0051 | 0.1694 | 0.2724 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0044 | 0.1382 | 0.6121 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Leishmania major | cytochrome p450-like protein | 0.007 | 0.2529 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0234 | 0.0234 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.005 | 0.1644 | 0.6146 |
Trypanosoma cruzi | cytochrome P450, putative | 0.007 | 0.2529 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0017 | 0.0234 | 0.0239 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0234 | 0.1108 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.007 | 0.2529 | 0.2529 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.1694 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.211 | 0.2155 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.1694 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0161 | 0.6388 | 0.6388 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.211 | 0.1963 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0234 | 0.0234 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0051 | 0.1694 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.1382 | 0.6551 |
Onchocerca volvulus | Cathepsin L homolog | 0.0017 | 0.0234 | 0.1443 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.162 | 0.162 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.2221 | 0.7314 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.2221 | 0.7314 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0234 | 0.0234 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.211 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0234 | 0.1108 |
Leishmania major | cathepsin L-like protease | 0.0063 | 0.2221 | 0.8658 |
Leishmania major | cathepsin L-like protease | 0.0063 | 0.2221 | 0.8658 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0051 | 0.1694 | 0.6365 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Echinococcus multilocularis | 0.0044 | 0.1382 | 0.1202 | |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0044 | 0.1382 | 0.5004 |
Onchocerca volvulus | 0.0017 | 0.0234 | 0.1443 | |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0051 | 0.1694 | 0.6365 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0017 | 0.0234 | 0.0234 |
Brugia malayi | Cytochrome P450 family protein | 0.007 | 0.2529 | 0.2529 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0017 | 0.0234 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0044 | 0.1382 | 0.5004 |
Trypanosoma brucei | cytochrome P450, putative | 0.007 | 0.2529 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.9789 | 0.9789 |
Loa Loa (eye worm) | CYP4Cod1 | 0.007 | 0.2529 | 0.2529 |
Brugia malayi | Cytochrome P450 family protein | 0.0161 | 0.6388 | 0.6388 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Brugia malayi | Cytochrome P450 family protein | 0.0044 | 0.1382 | 0.1382 |
Onchocerca volvulus | 0.0017 | 0.0234 | 0.1443 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0234 | 0.0234 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.2221 | 0.8658 |
Onchocerca volvulus | 0.0017 | 0.0234 | 0.1443 | |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0234 | 0.0234 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.2221 | 0.8658 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0051 | 0.1694 | 0.1731 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.2221 | 0.7314 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.2221 | 0.7314 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Brugia malayi | Cytochrome P450 family protein | 0.007 | 0.2529 | 0.2529 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0051 | 0.1694 | 0.6365 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0017 | 0.0234 | 0.0239 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Loa Loa (eye worm) | cysteine protease | 0.0017 | 0.0234 | 0.0234 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0051 | 0.1694 | 0.1529 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.211 | 0.6348 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0051 | 0.1694 | 0.2724 |
Echinococcus granulosus | cathepsin l1 | 0.0017 | 0.0234 | 0.0239 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.2221 | 0.7314 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Onchocerca volvulus | 0.0017 | 0.0234 | 0.1443 | |
Onchocerca volvulus | 0.0017 | 0.0234 | 0.1443 | |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.211 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.211 | 0.6348 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0044 | 0.1382 | 0.5004 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.2221 | 0.7314 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Leishmania major | cytochrome p450-like protein | 0.0044 | 0.1382 | 0.5004 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0058 | 0.1987 | 0.764 |
Brugia malayi | MAP kinase sur-1 | 0.0051 | 0.1694 | 0.1694 |
Plasmodium vivax | vivapain-2 | 0.0017 | 0.0234 | 0.5 |
Loa Loa (eye worm) | ctsf protein | 0.0017 | 0.0234 | 0.0234 |
Onchocerca volvulus | Cathepsin L homolog | 0.0017 | 0.0234 | 0.1443 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0241 | 0.9789 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0051 | 0.1694 | 0.6365 |
Mycobacterium leprae | putative cytochrome p450 | 0.0044 | 0.1382 | 0.5 |
Onchocerca volvulus | 0.0017 | 0.0234 | 0.1443 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Onchocerca volvulus | 0.0017 | 0.0234 | 0.1443 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0017 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0673 | 0.0673 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0017 | 0.0234 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0017 | 0.0234 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0241 | 0.9789 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0044 | 0.1382 | 0.1412 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0234 | 0.0234 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0044 | 0.1382 | 0.5004 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.211 | 0.8175 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0017 | 0.0234 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0051 | 0.1694 | 0.7786 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.2221 | 0.8658 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.1694 | 0.6365 |
Leishmania major | cathepsin L-like protease | 0.0063 | 0.2221 | 0.8658 |
Onchocerca volvulus | 0.0049 | 0.162 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0234 | 0.0234 |
Brugia malayi | cytochrome P450 | 0.0044 | 0.1382 | 0.1382 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.1694 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0051 | 0.1694 | 0.1529 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.2221 | 0.7314 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Onchocerca volvulus | Cathepsin F homolog | 0.0017 | 0.0234 | 0.1443 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0234 | 0.138 |
Loa Loa (eye worm) | fibroinase | 0.0017 | 0.0234 | 0.0234 |
Plasmodium vivax | vivapain-2 | 0.0017 | 0.0234 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0017 | 0.0234 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.007 | 0.2529 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0051 | 0.1694 | 0.1694 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.211 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.