Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.2667 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.2667 | 1 |
Trichomonas vaginalis | type II inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.4678 | 1 |
Trichomonas vaginalis | Phospholipase C precursor, putative | 0.0004 | 0.0053 | 0.0199 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.2667 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.2667 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.2667 | 0.5 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.0525 | 0.1969 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.4393 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.2667 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.1916 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.2667 | 0.6023 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.2667 | 0.2966 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.2667 | 0.6023 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.2667 | 0.2628 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0525 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0634 | 0.1257 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Trichomonas vaginalis | sphingomyelinase C 2 precursor, putative | 0.0004 | 0.0053 | 0.0199 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.2667 | 0.2628 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0634 | 0.0584 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.1969 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.4393 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.2667 | 1 |
Trichomonas vaginalis | type IV inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.4678 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Onchocerca volvulus | 0.0028 | 0.4393 | 1 | |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.8867 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.092 | 0.1996 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.2667 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0634 | 0.1257 |
Trichomonas vaginalis | skeletal muscle/kidney enriched inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.2667 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.2667 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0525 | 0.1969 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4678 | 0.465 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.2667 | 1 |
Trichomonas vaginalis | ocrl type II inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.1969 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.2667 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.1969 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.2667 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0634 | 0.1257 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.2667 | 0.5651 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.1916 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.1969 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.1969 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0634 | 0.1257 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.2667 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0939 | 0.2042 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0109 | 0.0056 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4678 | 0.465 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.2667 | 0.5651 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.4393 | 0.4363 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of human recombinant MAOA expressed in baculovirus infected BTI insect cells assessed as hydrogen peroxide production at 100 uM after 15 mins by Amplex red assay | ChEMBL. | 20702005 | |
Inhibition (binding) | Inhibition of human recombinant MAOB expressed in baculovirus infected BTI insect cells assessed as hydrogen peroxide production at 100 uM after 15 mins by Amplex red assay | ChEMBL. | 20702005 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.