Detailed information for compound 1177957

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 294.366 | Formula: C15H18O4S
  • H donors: 1 H acceptors: 3 LogP: 3.23 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC[C@H]1OC(=O)[C@H]([C@@H]1CC(=O)O)Sc1ccccc1
  • InChi: 1S/C15H18O4S/c1-2-6-12-11(9-13(16)17)14(15(18)19-12)20-10-7-4-3-5-8-10/h3-5,7-8,11-12,14H,2,6,9H2,1H3,(H,16,17)/t11-,12-,14+/m1/s1
  • InChiKey: YEEDVGAXWQCIRV-BZPMIXESSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.4754 0.4754
Giardia lamblia DINP protein human, muc B family 0.006 0.0709 0.315
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0936 0.1001
Mycobacterium leprae Probable lipase LipE 0.0071 0.0936 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0133 0.225 0.4005
Trypanosoma brucei unspecified product 0.006 0.0709 0.1261
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.4754 1
Schistosoma mansoni hypothetical protein 0.0331 0.6457 0.691
Loa Loa (eye worm) acetyltransferase 0.0293 0.5652 0.5652
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0777 0.0832
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0133 0.225 0.7798
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0693 0.0693
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0468 0.9344 0.9344
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0709 0.1261
Loa Loa (eye worm) hypothetical protein 0.0071 0.0936 0.0936
Schistosoma mansoni cpg binding protein 0.0152 0.2657 0.2843
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0709 0.1261
Loa Loa (eye worm) hypothetical protein 0.0086 0.1252 0.1252
Trypanosoma brucei PAB1-binding protein , putative 0.0079 0.1108 0.1972
Schistosoma mansoni DNA polymerase eta 0.0086 0.1252 0.1339
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0122 0.0257
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0936 0.1665
Loa Loa (eye worm) hypothetical protein 0.0071 0.0936 0.0936
Brugia malayi F/Y-rich N-terminus family protein 0.0044 0.0363 0.0363
Schistosoma mansoni hypothetical protein 0.0168 0.299 0.32
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3112 0.6545
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.1004 0.187
Toxoplasma gondii LsmAD domain-containing protein 0.0079 0.1108 0.2065
Echinococcus granulosus dna polymerase kappa 0.006 0.0709 0.0709
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.064 0.0685
Trichomonas vaginalis ap endonuclease, putative 0.0133 0.225 0.4732
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0189 0.0189
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.1004 0.2111
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0036 0.0189 0.0189
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0301 0.0535
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.1587 0.1587
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0133 0.225 1
Onchocerca volvulus 0.0102 0.1587 0.5427
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.4754 0.4754
Loa Loa (eye worm) beta-lactamase 0.0071 0.0936 0.0936
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.1004 0.2111
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0777 0.0832
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0122 0.0257
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0777 0.0777
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0936 0.4158
Echinococcus granulosus tar DNA binding protein 0.0064 0.0777 0.0777
Trypanosoma cruzi DNA polymerase eta, putative 0.0086 0.1252 0.2228
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0839 0.0927
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0133 0.225 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0936 0.1034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0468 0.9344 0.9344
Mycobacterium ulcerans beta-lactamase 0.0071 0.0936 0.1215
Brugia malayi beta-lactamase family protein 0.0071 0.0936 0.0936
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.0709 0.1491
Trypanosoma brucei unspecified product 0.0042 0.0312 0.0556
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0777 0.0777
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0777 0.0832
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.4754 1
Toxoplasma gondii hypothetical protein 0.0047 0.0429 0.0799
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.1004 0.1786
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3112 0.6545
Mycobacterium tuberculosis Conserved protein 0.0071 0.0936 0.1034
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.1108 0.4923
Brugia malayi mbt repeat family protein 0.005 0.0493 0.0493
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0936 0.1034
Trichomonas vaginalis esterase, putative 0.0071 0.0936 0.1968
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0122 0.0257
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0133 0.225 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0133 0.225 0.225
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.1004 0.1786
Entamoeba histolytica acetyltransferase, GNAT family 0.0079 0.1108 0.4923
Loa Loa (eye worm) hypothetical protein 0.0071 0.0936 0.0936
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0224 0.4185 0.4185
Trichomonas vaginalis helicase, putative 0.0033 0.0122 0.0257
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.5618 1
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0709 0.1261
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.064 0.064
Leishmania major DNA polymerase kappa, putative 0.006 0.0709 0.1261
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0122 0.0257
Plasmodium vivax ataxin-2 like protein, putative 0.0079 0.1108 0.4923
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0777 0.0777
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0122 0.0257
Loa Loa (eye worm) hypothetical protein 0.0071 0.0936 0.0936
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0936 0.1968
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0122 0.0257
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0493 0.0528
Loa Loa (eye worm) hypothetical protein 0.0057 0.064 0.064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0468 0.9344 0.9344
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0493 0.0528
Mycobacterium tuberculosis Conserved hypothetical protein 0.006 0.0709 0.0784
Schistosoma mansoni inositol monophosphatase 0.0074 0.1004 0.1074
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.5618 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0493 0.0493
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0312 0.0556
Onchocerca volvulus 0.0144 0.2483 0.8492
Echinococcus granulosus histone acetyltransferase KAT2B 0.0285 0.5477 0.5477
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0468 0.9344 0.9344
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.006 0.0709 0.0709
Schistosoma mansoni cpg binding protein 0.0152 0.2657 0.2843
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0936 0.1968
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0936 0.1665
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0122 0.0257
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0936 0.1215
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.064 0.064
Loa Loa (eye worm) RNA binding protein 0.0064 0.0777 0.0777
Brugia malayi acetyltransferase, GNAT family protein 0.0293 0.5652 0.5652
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.1108 0.4923
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0936 0.1968
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0693 0.0693
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0936 0.1001
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0086 0.126 0.2349
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0189 0.0189
Leishmania major hypothetical protein, conserved 0.0071 0.0936 0.1665
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0301 0.0535
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.4754 1
Echinococcus granulosus cpg binding protein 0.0152 0.2657 0.2657
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0709 0.1261
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0045 0.0375 0.0375
Schistosoma mansoni inositol monophosphatase 0.0074 0.1004 0.1074
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2924 0.615
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0709 0.1261
Schistosoma mansoni survival motor neuron protein 0.0102 0.1587 0.1698
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0493 0.0493
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0936 0.1665
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0133 0.225 0.225
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0709 0.0078
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0777 0.0777
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0133 0.225 0.2488
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0468 0.9344 0.9344
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0045 0.0375 0.0375
Schistosoma mansoni hypothetical protein 0.0102 0.1587 0.1698
Echinococcus multilocularis dna polymerase eta 0.0086 0.1252 0.1252
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.037 0.069
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2924 0.615
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0133 0.225 0.4005
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0709 0.1261
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0468 0.9344 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.064 0.064
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0086 0.126 0.2651
Brugia malayi Inositol-1 0.0074 0.1004 0.1004
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.4754 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0122 0.0257
Echinococcus multilocularis cpg binding protein 0.0152 0.2657 0.2657
Loa Loa (eye worm) histone methyltransferase 0.0045 0.0375 0.0375
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0936 0.1034
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0936 0.1034
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0133 0.225 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0183 0.0183
Toxoplasma gondii ABC1 family protein 0.0071 0.0936 0.1744
Onchocerca volvulus 0.005 0.0493 0.1686
Schistosoma mansoni ap endonuclease 0.0133 0.225 0.2408
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0936 0.1034
Onchocerca volvulus 0.0071 0.0936 0.32
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2924 0.615
Loa Loa (eye worm) hypothetical protein 0.005 0.0493 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0122 0.0257
Leishmania major DNA polymerase eta, putative 0.0086 0.1252 0.2228
Echinococcus granulosus geminin 0.0168 0.299 0.299
Brugia malayi ImpB/MucB/SamB family protein 0.006 0.0709 0.0709
Mycobacterium ulcerans lipase LipD 0.0071 0.0936 0.1215
Leishmania major hypothetical protein, conserved 0.0079 0.1108 0.1972
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0086 0.126 0.5601
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0709 0.1261
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0493 0.0493
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.4754 1
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0709 0.1261
Brugia malayi hypothetical protein 0.0079 0.1108 0.1108
Loa Loa (eye worm) MBCTL1 0.0057 0.064 0.064
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0936 0.1034
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0493 0.1686
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0086 0.126 0.2349
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0709 0.1261
Loa Loa (eye worm) CXXC zinc finger family protein 0.0144 0.2483 0.2483
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0493 0.0493
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0936 0.0936
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0312 0.0556
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.037 0.0659
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0709 0.1261
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.006 0.0709 0.0709
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0224 0.4185 0.4185
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.5618 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0468 0.9344 1
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2924 0.615
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0305 0.5905 0.6319
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.0709 0.0784
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0936 1
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0709 0.1261
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0709 0.1261
Leishmania major DNA polymerase eta, putative 0.0044 0.037 0.0659
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.2359 0.4199
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0936 0.0936
Mycobacterium ulcerans hypothetical protein 0.0071 0.0936 0.1215
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2924 0.615
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0183 0.0183
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0293 0.5652 0.6048
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0036 0.0189 0.0202
Mycobacterium tuberculosis Conserved protein 0.0071 0.0936 0.1034
Giardia lamblia Histone acetyltransferase GCN5 0.0079 0.1108 0.4923
Schistosoma mansoni cpg binding protein 0.0144 0.2483 0.2657
Brugia malayi beta-lactamase family protein 0.0071 0.0936 0.0936
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0122 0.0257
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0493 0.0493
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0133 0.225 0.225
Treponema pallidum exodeoxyribonuclease (exoA) 0.0133 0.225 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0086 0.126 0.126
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.1108 0.1972
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.064 0.064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0122 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0122 0.0257
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0709 0.1261
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0709 0.1261
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.1004 0.1004
Loa Loa (eye worm) hypothetical protein 0.0071 0.0936 0.0936
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0936 0.0936
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0936 0.1034
Brugia malayi hypothetical protein 0.0051 0.0513 0.0513
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0709 0.1261
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0133 0.225 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.006 0.0709 0.315
Brugia malayi beta-lactamase 0.0071 0.0936 0.0936
Brugia malayi RNA binding protein 0.0064 0.0777 0.0777
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2924 0.615
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0312 0.0556
Mycobacterium ulcerans hypothetical protein 0.0154 0.269 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0693 0.0742
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.1004 0.1004
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.1004 0.1786
Loa Loa (eye worm) inositol-1 0.0074 0.1004 0.1004
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.006 0.0709 0.0709
Schistosoma mansoni hypothetical protein 0.0168 0.299 0.32
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.2359 0.4199
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0693 0.0742
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0468 0.9344 0.9344
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0709 0.1261
Echinococcus granulosus dna polymerase eta 0.0086 0.1252 0.1252
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.269 0.2974
Toxoplasma gondii exonuclease III APE 0.0133 0.225 0.4193
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0777 0.0832
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0936 0.1968
Echinococcus multilocularis dna polymerase kappa 0.006 0.0709 0.0709
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.064 0.064
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.5618 1
Schistosoma mansoni ap endonuclease 0.0133 0.225 0.2408
Schistosoma mansoni terminal deoxycytidyl transferase 0.006 0.0709 0.0758
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.4754 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0936 0.1215
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0301 0.0535
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0491 0.0874
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0693 0.1292
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0709 0.0078
Toxoplasma gondii histone lysine methyltransferase SET1 0.028 0.5366 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0122 0.0257
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.1004 0.446
Loa Loa (eye worm) hypothetical protein 0.0079 0.1108 0.1108
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0293 0.5652 0.5652
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0693 0.1234
Mycobacterium tuberculosis Conserved protein 0.0071 0.0936 0.1034
Echinococcus multilocularis geminin 0.0168 0.299 0.299
Brugia malayi exodeoxyribonuclease III family protein 0.0133 0.225 0.225
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0122 0.0257
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0122 0.0257
Trypanosoma brucei DNA polymerase eta, putative 0.0086 0.1252 0.2228
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0133 0.225 0.4005
Trichomonas vaginalis ap endonuclease, putative 0.0133 0.225 0.4732
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.006 0.0709 0.0758
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2924 0.615
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0493 0.0528
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.0709 0.1491
Trypanosoma brucei unspecified product 0.0042 0.0312 0.0556
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0301 0.0535
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0453 0.9044 1
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.2924 1
Brugia malayi ImpB/MucB/SamB family protein 0.0086 0.1252 0.1252
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0468 0.9344 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0936 0.0936
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0936 0.1968
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0693 0.0766
Brugia malayi TAR-binding protein 0.0064 0.0777 0.0777
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0122 0.0257
Onchocerca volvulus 0.0071 0.0936 0.32
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0777 0.0832
Schistosoma mansoni hypothetical protein 0.0035 0.0183 0.0196
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.1004 0.2111
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.0709 0.1261
Plasmodium falciparum histone acetyltransferase GCN5 0.0079 0.1108 0.4923
Loa Loa (eye worm) hypothetical protein 0.0071 0.0936 0.0936
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.1108 0.1972
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0709 0.1261
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.1004 0.1786
Brugia malayi mbt repeat family protein 0.005 0.0493 0.0493
Echinococcus granulosus mixed lineage leukemia protein mll 0.0036 0.0189 0.0189
Trichomonas vaginalis bromodomain-containing protein, putative 0.0086 0.126 0.2651
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.1004 0.1555
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0122 0.0257
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0133 0.225 0.4005
Brugia malayi CXXC zinc finger family protein 0.0144 0.2483 0.2483
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.2359 0.4199
Onchocerca volvulus 0.0071 0.0936 0.32

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) > 100 uM Antiproliferative activity against human SW1573 cells after 48 hrs by SRB assay ChEMBL. 18789684
GI50 (functional) > 100 uM Antiproliferative activity against human T47D cells after 48 hrs by SRB assay ChEMBL. 18789684
GI50 (functional) > 100 uM Antiproliferative activity against human WiDr cells after 48 hrs by SRB assay ChEMBL. 18789684

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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