Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0028 | 0.0992 | 0.0629 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.1066 | 0.1126 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0134 | 0.5594 | 0.8234 |
Echinococcus multilocularis | muscleblind protein | 0.0148 | 0.6224 | 0.8937 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0134 | 0.5594 | 0.7984 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0128 | 0.5322 | 0.5854 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.1018 | 0.1087 |
Echinococcus granulosus | muscleblind protein | 0.0148 | 0.6224 | 0.9217 |
Loa Loa (eye worm) | doublecortin family protein | 0.0022 | 0.075 | 0.0337 |
Loa Loa (eye worm) | acetyltransferase | 0.0165 | 0.6926 | 0.7788 |
Schistosoma mansoni | rab6-interacting | 0.0022 | 0.075 | 0.0648 |
Brugia malayi | TAR-binding protein | 0.0128 | 0.5322 | 0.5854 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0069 | 0.2772 | 0.3826 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0992 | 0.2533 |
Brugia malayi | hypothetical protein | 0.0022 | 0.075 | 0.0337 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.3771 | 0.5222 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0069 | 0.2772 | 0.371 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0044 | 0.1705 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.1066 | 0.0718 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0165 | 0.6926 | 0.7788 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0992 | 0.2533 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.1967 | 0.1806 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0561 | 0.011 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0069 | 0.2772 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.3771 | 0.5222 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0048 | 0.188 | 1 |
Echinococcus multilocularis | RUN | 0.0022 | 0.075 | 0.0648 |
Brugia malayi | Pre-SET motif family protein | 0.0207 | 0.8759 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1274 | 0.097 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.2772 | 0.371 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.1967 | 0.1806 |
Schistosoma mansoni | polycystin 1-related | 0.0022 | 0.075 | 0.0648 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.1066 | 0.1126 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.2772 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1967 | 0.1806 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0022 | 0.075 | 0.0668 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.3771 | 0.5222 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.3771 | 0.5222 |
Brugia malayi | Muscleblind-like protein | 0.0148 | 0.6224 | 0.6942 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.5322 | 0.7571 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.2772 | 0.5 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0044 | 0.1705 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0128 | 0.5322 | 0.7571 |
Loa Loa (eye worm) | RNA binding protein | 0.0128 | 0.5322 | 0.5854 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0048 | 0.188 | 0.2432 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.047 | 0.0231 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.3771 | 0.5385 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0992 | 0.0629 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.1967 | 0.1806 |
Onchocerca volvulus | 0.003 | 0.1066 | 0.0341 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.2772 | 0.371 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0992 | 0.5276 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.1066 | 0.1126 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.5322 | 0.7571 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0022 | 0.075 | 0.0668 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1066 | 0.0718 |
Schistosoma mansoni | lipoxygenase | 0.0134 | 0.5594 | 0.7984 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0022 | 0.075 | 0.0648 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.2772 | 0.5 |
Brugia malayi | RNA binding protein | 0.0128 | 0.5322 | 0.5854 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0044 | 0.1705 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.047 | 0.0231 |
Schistosoma mansoni | rab6-interacting | 0.0022 | 0.075 | 0.0648 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.3771 | 0.5222 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.047 | 0.0224 |
Schistosoma mansoni | loxhd1 | 0.0022 | 0.075 | 0.0648 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0992 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.075 | 0.0337 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0022 | 0.075 | 0.0668 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0022 | 0.075 | 0.0648 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.1066 | 0.567 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0992 | 0.3577 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0069 | 0.2772 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.6224 | 0.6942 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1274 | 0.097 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0048 | 0.188 | 0.678 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0022 | 0.075 | 0.0648 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.047 | 0.0224 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.1066 | 0.1161 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0092 | 0.3771 | 0.3982 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.047 | 0.0231 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.5322 | 0.7571 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0165 | 0.6926 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.016 | 0.6726 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0165 | 0.6926 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0148 | 0.6224 | 0.8937 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.047 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.6224 | 0.6942 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0048 | 0.188 | 0.678 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.075 | 0.0337 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.1066 | 0.1126 |
Schistosoma mansoni | lipoxygenase | 0.0094 | 0.3844 | 0.5333 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.5322 | 0.7571 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0022 | 0.075 | 0.399 |
Brugia malayi | hypothetical protein | 0.0022 | 0.075 | 0.0337 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0992 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.047 | 0.0224 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.047 | 0.0224 |
Echinococcus granulosus | RUN | 0.0022 | 0.075 | 0.0668 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.075 | 0.0648 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.047 | 0.0224 |
Brugia malayi | Doublecortin family protein | 0.0022 | 0.075 | 0.0337 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.1066 | 0.3844 |
Loa Loa (eye worm) | TAR-binding protein | 0.0128 | 0.5322 | 0.5854 |
Echinococcus granulosus | tar DNA binding protein | 0.0128 | 0.5322 | 0.7808 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.1066 | 0.1126 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1274 | 0.1442 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.047 | 0.0224 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0128 | 0.5322 | 0.5854 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0992 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.1066 | 0.1126 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0207 | 0.8759 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0092 | 0.3771 | 0.3982 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0069 | 0.2772 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.5322 | 0.7571 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.3771 | 0.5385 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of purified human recombinant APE1 expressed in Escherichia coli M15 cells | ChEMBL. | 19072053 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.