Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | galactokinase, putative | 0.0322 | 0.3643 | 0.3643 |
Trypanosoma brucei | homoserine kinase | 0.0322 | 0.3643 | 0.3643 |
Brugia malayi | mevalonate kinase family protein | 0.0322 | 0.3643 | 0.3643 |
Leishmania major | mevalonate kinase, putative | 0.0322 | 0.3643 | 0.3643 |
Leishmania major | homoserine kinase, putative | 0.0322 | 0.3643 | 0.3643 |
Trypanosoma cruzi | galactokinase, putative | 0.0322 | 0.3643 | 0.3643 |
Trypanosoma cruzi | phosphomevalonate kinase protein, putative | 0.0137 | 0.0551 | 0.0551 |
Echinococcus multilocularis | galactokinase | 0.0322 | 0.3643 | 0.3643 |
Trypanosoma cruzi | phosphomevalonate kinase protein, putative | 0.0137 | 0.0551 | 0.0551 |
Trichomonas vaginalis | galactokinase, putative | 0.0322 | 0.3643 | 0.3643 |
Mycobacterium ulcerans | homoserine kinase | 0.0322 | 0.3643 | 0.3643 |
Trypanosoma cruzi | galactokinase, putative | 0.0186 | 0.1368 | 0.1368 |
Trypanosoma brucei | phosphomevalonate kinase protein, putative | 0.0322 | 0.3643 | 0.3643 |
Mycobacterium ulcerans | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 0.0322 | 0.3643 | 0.3643 |
Chlamydia trachomatis | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 0.0137 | 0.0551 | 0.5 |
Leishmania major | fucose kinase, putative | 0.0137 | 0.0551 | 0.0551 |
Mycobacterium ulcerans | phosphomevalonate kinase | 0.0322 | 0.3643 | 0.3643 |
Loa Loa (eye worm) | galactokinase | 0.0322 | 0.3643 | 0.4717 |
Leishmania major | phosphomevalonate kinase protein, putative | 0.0322 | 0.3643 | 0.3643 |
Leishmania major | fucose kinase, putative | 0.0137 | 0.0551 | 0.0551 |
Trypanosoma cruzi | homoserine kinase | 0.0322 | 0.3643 | 0.3643 |
Wolbachia endosymbiont of Brugia malayi | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 0.0322 | 0.3643 | 0.5 |
Trypanosoma brucei | mevalonate kinase, putative | 0.0322 | 0.3643 | 0.3643 |
Trypanosoma brucei | Putative Phosphatase/Protein of unknown function DUF89, putative | 0.0115 | 0.0196 | 0.0196 |
Trypanosoma cruzi | mevalonate kinase, putative | 0.0322 | 0.3643 | 0.3643 |
Trypanosoma cruzi | fucose kinase, putative | 0.0186 | 0.1368 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.3643 | 0.4717 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 0.7724 | 1 |
Trichomonas vaginalis | galactokinase, putative | 0.0322 | 0.3643 | 0.3643 |
Brugia malayi | galactokinase family protein | 0.0322 | 0.3643 | 0.3643 |
Trichomonas vaginalis | galactokinase, putative | 0.0322 | 0.3643 | 0.3643 |
Mycobacterium leprae | Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) | 0.0322 | 0.3643 | 1 |
Mycobacterium ulcerans | galactokinase | 0.0322 | 0.3643 | 0.3643 |
Echinococcus multilocularis | Mevalonate galactokinase | 0.0322 | 0.3643 | 0.3643 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0137 | 0.0551 | 0.0551 |
Leishmania major | galactokinase-like protein | 0.0322 | 0.3643 | 0.3643 |
Leishmania major | hypothetical protein, conserved | 0.0115 | 0.0196 | 0.0196 |
Trypanosoma cruzi | galactokinase-like protein, putative | 0.0186 | 0.1368 | 0.1368 |
Trypanosoma cruzi | Putative Phosphatase/Protein of unknown function DUF89, putative | 0.0115 | 0.0196 | 0.0196 |
Trichomonas vaginalis | galactokinase, putative | 0.0186 | 0.1368 | 0.1368 |
Trypanosoma cruzi | galactokinase, putative | 0.0322 | 0.3643 | 0.3643 |
Toxoplasma gondii | GHMP kinase, putative | 0.0322 | 0.3643 | 1 |
Echinococcus multilocularis | N acetylgalactosamine kinase | 0.0322 | 0.3643 | 0.3643 |
Trypanosoma cruzi | homoserine kinase | 0.0322 | 0.3643 | 0.3643 |
Toxoplasma gondii | GHMP kinase, N-terminal domain-containing protein | 0.0322 | 0.3643 | 1 |
Entamoeba histolytica | galactokinase, putative | 0.0322 | 0.3643 | 1 |
Mycobacterium tuberculosis | Possible D-alpha-D-heptose-7-phosphate kinase HddA | 0.0322 | 0.3643 | 1 |
Trichomonas vaginalis | galactokinase, putative | 0.0137 | 0.0551 | 0.0551 |
Mycobacterium ulcerans | mevalonate kinase, Erg12 | 0.0322 | 0.3643 | 0.3643 |
Echinococcus granulosus | N acetylgalactosamine kinase | 0.0322 | 0.3643 | 0.3643 |
Trypanosoma brucei | galactokinase-like protein, putative | 0.0137 | 0.0551 | 0.0551 |
Trypanosoma cruzi | Putative Phosphatase/Protein of unknown function DUF89, putative | 0.0115 | 0.0196 | 0.0196 |
Trypanosoma cruzi | fucose kinase, putative | 0.0186 | 0.1368 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0551 | 0.0713 |
Loa Loa (eye worm) | diphosphomevalonate decarboxylase | 0.0567 | 0.7724 | 1 |
Schistosoma mansoni | mevalonate kinase | 0.0322 | 0.3643 | 0.3643 |
Trichomonas vaginalis | mevalonate kinase, putative | 0.0137 | 0.0551 | 0.0551 |
Treponema pallidum | hypothetical protein | 0.0322 | 0.3643 | 1 |
Mycobacterium tuberculosis | Probable galactokinase GalK (galactose kinase) | 0.0322 | 0.3643 | 1 |
Schistosoma mansoni | galactokinase | 0.0322 | 0.3643 | 0.3643 |
Echinococcus granulosus | galactokinase | 0.0322 | 0.3643 | 0.3643 |
Echinococcus granulosus | Mevalonate galactokinase | 0.0322 | 0.3643 | 0.3643 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 12.72 ug ml-1 | Cytotoxicity against human MCF7 cells after 3 days by MTT assay | ChEMBL. | 15974612 |
IC50 (functional) | > 20 ug ml-1 | Cytotoxicity against human HepG2 cells after 3 days by MTT assay | ChEMBL. | 15974612 |
IC50 (functional) | > 20 ug ml-1 | Cytotoxicity against human MDA-MB-231 cells after 3 days by MTT assay | ChEMBL. | 15974612 |
IC50 (binding) | = 91 uM | Inhibition of eIF4A-mediated cap-dependent protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract by [35S]methionine metabolic labeling study | ChEMBL. | 16532013 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15974612 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.