Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0567 | 0.1528 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.5223 | 0.5223 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0035 | 0.1615 | 0.5813 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0567 | 0.2571 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0013 | 0.0207 | 0.0014 |
Schistosoma mansoni | alpha-glucosidase | 0.0137 | 0.809 | 0.809 |
Loa Loa (eye worm) | histone methyltransferase | 0.0018 | 0.0515 | 0.0542 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0035 | 0.1615 | 0.17 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0051 | 0.2632 | 0.2126 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.2511 | 0.2643 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0035 | 0.1615 | 0.6117 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.8658 | 0.9113 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.5223 | 0.5223 |
Schistosoma mansoni | cpg binding protein | 0.0062 | 0.3289 | 0.3289 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0207 | 0.0014 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.2511 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0567 | 0.1495 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.2511 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0207 | 0.0014 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.2511 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0013 | 0.0207 | 0.0014 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.1615 | 0.6117 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0015 | 0.0288 | 0.0288 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0111 | 0.6398 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0567 | 0.1528 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0092 | 0.5223 | 0.5498 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.1615 | 0.6117 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0567 | 0.1528 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.2511 | 0.9503 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.5223 | 0.5223 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 0.8658 | 0.8658 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.016 | 0.9501 | 0.9501 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.2511 | 0.9503 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0207 | 0.0014 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.2511 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0567 | 0.0597 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0207 | 0.0014 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0035 | 0.1615 | 0.1615 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0013 | 0.0204 | 0.039 |
Brugia malayi | hypothetical protein | 0.0051 | 0.2632 | 0.277 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0567 | 0.0567 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0051 | 0.2632 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0567 | 0.1528 |
Brugia malayi | hypothetical protein | 0.0033 | 0.1475 | 0.1552 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0567 | 0.0567 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0207 | 0.0014 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 0.2511 | 0.2511 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.005 | 0.2511 | 0.9503 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0567 | 0.0597 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0567 | 0.0567 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.1615 | 0.6117 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0567 | 0.1528 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0013 | 0.0204 | 0.004 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0015 | 0.0288 | 0.0288 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0567 | 0.1495 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0023 | 0.0831 | 0.0831 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 0.2511 | 0.2643 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0207 | 0.0014 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.0567 | 0.1495 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0207 | 0.0014 |
Schistosoma mansoni | cpg binding protein | 0.0058 | 0.3078 | 0.3078 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0567 | 0.1528 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 0.8658 | 0.8658 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 0.2511 | 0.2511 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0207 | 0.0014 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.1615 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.005 | 0.2511 | 0.9505 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0567 | 0.1528 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.1615 | 0.6117 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1615 | 0.5813 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0051 | 0.2632 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0035 | 0.1615 | 0.17 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0567 | 0.1528 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0567 | 0.1495 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.8658 | 0.9113 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0.2511 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 0.9501 | 0.9501 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.2632 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.5223 | 0.5223 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0567 | 0.1495 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0567 | 0.0597 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 0.2511 | 0.2511 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0035 | 0.1615 | 0.6117 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 0.9501 | 0.9501 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0567 | 0.0567 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.1615 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0204 | 0.0215 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0567 | 0.1528 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.2632 | 0.277 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0092 | 0.5223 | 0.5498 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.016 | 0.9501 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0137 | 0.809 | 0.809 |
Brugia malayi | CXXC zinc finger family protein | 0.0058 | 0.3078 | 0.3239 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.2632 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0567 | 0.0567 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0207 | 0.0014 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0035 | 0.1615 | 0.1615 |
Schistosoma mansoni | alpha glucosidase | 0.0035 | 0.1615 | 0.1615 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.005 | 0.2511 | 0.9503 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1615 | 0.5813 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0567 | 0.1528 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.005 | 0.2511 | 0.9503 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0567 | 0.1495 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0567 | 0.1528 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0013 | 0.0207 | 0.0014 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0567 | 0.1528 |
Echinococcus granulosus | cpg binding protein | 0.0062 | 0.3289 | 0.3289 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0567 | 0.1528 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0567 | 0.0567 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0567 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0207 | 0.0014 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0207 | 0.0014 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0058 | 0.3078 | 0.3239 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.5223 | 0.5223 |
Onchocerca volvulus | 0.0092 | 0.5228 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0207 | 0.0014 |
Echinococcus multilocularis | cpg binding protein | 0.0062 | 0.3289 | 0.3289 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 0.8658 | 0.8658 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.0567 | 0.1495 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0207 | 0.0014 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.1615 | 0.6117 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0207 | 0.0014 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0124 | 0.7238 | 0.7238 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 0.2511 | 0.2511 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.005 | 0.2511 | 0.1874 |
Brugia malayi | Muscleblind-like protein | 0.0146 | 0.8658 | 0.9113 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0023 | 0.0831 | 0.0831 |
Trypanosoma brucei | glucosidase, putative | 0.0035 | 0.1615 | 0.5829 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0015 | 0.0288 | 0.0288 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0567 | 0.1528 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0018 | 0.05 | 0.0526 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.2511 | 0.2511 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0567 | 0.0567 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0567 | 0.0597 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0015 | 0.0288 | 0.0288 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.016 | 0.9501 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0567 | 0.0567 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0567 | 0.1573 |
Leishmania major | hypothetical protein, conserved | 0.0051 | 0.2632 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.5223 | 0.5223 |
Onchocerca volvulus | 0.0058 | 0.3078 | 0.5887 | |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0013 | 0.0204 | 0.0215 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0567 | 0.1573 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.2632 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0567 | 0.0567 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0567 | 0.1528 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.5223 | 0.5223 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0567 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0567 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0207 | 0.0014 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0018 | 0.0515 | 0.0515 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0015 | 0.0288 | 0.0288 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0018 | 0.0515 | 0.0515 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.005 | 0.2511 | 0.9505 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.1615 | 0.6117 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.005 | 0.2511 | 0.9503 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.1615 | 0.6117 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0831 | 0.0831 |
Schistosoma mansoni | cpg binding protein | 0.0062 | 0.3289 | 0.3289 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0567 | 0.1495 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0567 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.2632 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Binding affinity to mouse recombinant HSP47 expressed in Escherichia coli JM109 after 10 mins by surface plasmon resonance assay | ChEMBL. | 20471275 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.