Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0077 | 0.5736 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0077 | 0.5736 | 1 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0023 | 0.1168 | 0.1956 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0077 | 0.5736 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.238 | 0.238 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1168 | 0.1168 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.4101 | 0.4101 |
Onchocerca volvulus | 0.0077 | 0.5736 | 0.9513 | |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0023 | 0.1168 | 0.0546 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0023 | 0.1168 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0077 | 0.5736 | 1 |
Brugia malayi | intermediate filament protein | 0.008 | 0.5969 | 0.5969 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1168 | 0.1168 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0055 | 0.3837 | 0.6071 |
Brugia malayi | AMP-binding enzyme family protein | 0.0077 | 0.5736 | 0.5736 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0077 | 0.5736 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0043 | 0.2858 | 0.2858 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0023 | 0.1168 | 0.5 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0023 | 0.1168 | 0.5 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0023 | 0.1168 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.4101 | 0.4101 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.1168 | 0.0546 |
Toxoplasma gondii | propionate-CoA ligase | 0.0023 | 0.1168 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0023 | 0.1168 | 0.1168 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0023 | 0.1168 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0058 | 0.4101 | 0.5 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0023 | 0.1168 | 0.0546 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0077 | 0.5736 | 1 |
Onchocerca volvulus | 0.008 | 0.5969 | 1 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.008 | 0.5969 | 0.5969 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.4101 | 0.4101 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0077 | 0.5736 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0023 | 0.1168 | 0.1168 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0023 | 0.1168 | 0.5 |
Echinococcus granulosus | lamin | 0.008 | 0.5969 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0077 | 0.5736 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0058 | 0.4101 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1168 | 0.1168 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0039 | 0.2503 | 0.4192 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0023 | 0.1168 | 0.1956 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0077 | 0.5736 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.008 | 0.5969 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0077 | 0.5736 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.008 | 0.5969 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0077 | 0.5736 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0077 | 0.5736 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0077 | 0.5736 | 0.5736 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.1168 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.5736 | 0.5736 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0058 | 0.4101 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0039 | 0.2503 | 0.4192 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0023 | 0.1168 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.238 | 0.238 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0023 | 0.1168 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0058 | 0.4101 | 0.6421 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0077 | 0.5736 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0077 | 0.5736 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0023 | 0.1168 | 0.1168 |
Brugia malayi | AMP-binding enzyme family protein | 0.0077 | 0.5736 | 0.5736 |
Loa Loa (eye worm) | intermediate filament protein | 0.008 | 0.5969 | 0.5969 |
Echinococcus multilocularis | musashi | 0.008 | 0.5969 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0077 | 0.5736 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2503 | 0.2503 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0023 | 0.1168 | 0.0546 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0023 | 0.1168 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0055 | 0.3837 | 0.6071 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0023 | 0.1168 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1168 | 0.1168 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0023 | 0.1168 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.008 | 0.5969 | 0.5969 |
Echinococcus multilocularis | lamin dm0 | 0.008 | 0.5969 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.5736 | 0.5736 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0055 | 0.3837 | 0.6071 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0077 | 0.5736 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.5736 | 0.5736 |
Schistosoma mansoni | lamin | 0.008 | 0.5969 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1168 | 0.1168 |
Mycobacterium ulcerans | hypothetical protein | 0.0077 | 0.5736 | 1 |
Onchocerca volvulus | 0.008 | 0.5969 | 1 | |
Echinococcus granulosus | lamin dm0 | 0.008 | 0.5969 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0043 | 0.2858 | 0.2858 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5969 | 0.5969 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.4101 | 0.4101 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0023 | 0.1168 | 0.0546 |
Schistosoma mansoni | lamin | 0.008 | 0.5969 | 1 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0023 | 0.1168 | 0.1168 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0023 | 0.1168 | 0.1168 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0058 | 0.4101 | 0.6617 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0055 | 0.3837 | 0.6071 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0023 | 0.1168 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.4101 | 0.4101 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.1168 | 0.0546 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0023 | 0.1168 | 0.0546 |
Echinococcus multilocularis | lamin | 0.008 | 0.5969 | 1 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0023 | 0.1168 | 0.1956 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5847 | 0.5847 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1168 | 0.1168 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.1168 | 0.0546 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0077 | 0.5736 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.