Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.3705 | 0.3615 |
Entamoeba histolytica | recQ family DNA helicase | 0.0011 | 0.0141 | 0.0141 |
Entamoeba histolytica | recQ family helicase, putative | 0.0021 | 0.3705 | 0.3705 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.3705 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0021 | 0.3705 | 0.3705 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0011 | 0.0141 | 0.5 |
Schistosoma mansoni | DNA helicase recq5 | 0.0021 | 0.3705 | 0.3705 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.3705 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0021 | 0.3705 | 0.3615 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0011 | 0.0141 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.3705 | 0.5 |
Loa Loa (eye worm) | RecQ helicase | 0.0021 | 0.3705 | 0.3615 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.3705 | 0.3615 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0021 | 0.3705 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0141 | 0.0000000030405 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0141 | 0.0381 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0011 | 0.0141 | 0.0141 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.