Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0339 | 0.0461 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.2731 | 0.2948 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0339 | 0.0461 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0032 | 0.2731 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0032 | 0.2731 | 0.5519 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0031 | 0.2408 | 0.4775 |
Mycobacterium ulcerans | pyruvate kinase | 0.0032 | 0.2731 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0947 | 0.1188 |
Chlamydia trachomatis | pyruvate kinase | 0.0032 | 0.2731 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0947 | 0.1287 |
Plasmodium vivax | pyruvate kinase, putative | 0.0032 | 0.2731 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0032 | 0.2731 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0947 | 0.1287 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0435 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3679 | 0.3972 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0032 | 0.2731 | 0.5519 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4417 | 0.4769 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0032 | 0.2731 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0032 | 0.2731 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.2408 | 0.4775 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0032 | 0.2731 | 0.5519 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0032 | 0.2731 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0032 | 0.2731 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.1535 | 0.2086 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0339 | 0.0461 |
Echinococcus multilocularis | dna polymerase eta | 0.0044 | 0.4672 | 0.6348 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0032 | 0.2731 | 0.5519 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0618 | 0.0774 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.1356 | 0.1052 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.7978 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1014 | 0.1095 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0032 | 0.2731 | 0.2475 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4087 | 0.4413 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.2731 | 0.2948 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0044 | 0.4672 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.3667 | 0.3444 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0435 | 0.0592 |
Leishmania major | pyruvate kinase | 0.0032 | 0.2731 | 0.5519 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0618 | 0.0667 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.2731 | 0.371 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.2731 | 0.371 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.736 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0032 | 0.2731 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0044 | 0.4672 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0339 | 0.0425 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3258 | 0.4427 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0339 | 0.0461 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2731 | 0.2948 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3258 | 0.4427 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0339 | 0.0425 |
Plasmodium falciparum | pyruvate kinase | 0.0032 | 0.2731 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0032 | 0.2731 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0032 | 0.2731 | 0.3423 |
Leishmania major | pyruvate kinase | 0.0032 | 0.2731 | 0.5519 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.9262 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0032 | 0.2731 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.2731 | 0.2948 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0339 | 0.0366 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0032 | 0.2731 | 0.2475 |
Echinococcus granulosus | pyruvate kinase | 0.0032 | 0.2731 | 0.371 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0023 | 0.1014 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4672 | 0.5044 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.736 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0044 | 0.4672 | 0.6348 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0044 | 0.4672 | 0.4485 |
Schistosoma mansoni | DNA polymerase eta | 0.0044 | 0.4672 | 0.5856 |
Echinococcus granulosus | pyruvate kinase | 0.0032 | 0.2731 | 0.371 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0023 | 0.1014 | 0.1095 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0435 | 0.0546 |
Leishmania major | DNA polymerase eta, putative | 0.0044 | 0.4672 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0032 | 0.2731 | 0.3423 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0106 | 0.0114 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 5.1 | Antimycobacterial activity against rifampicin/isoniazid-susceptible Mycobacterium tuberculosis H37Rv ATCC 27294 by BACTEC 460 radiometric method | ChEMBL. | 19022537 |
Inhibition (functional) | = 58 % | Antimycobacterial activity against rifampicin/isoniazid-susceptible Mycobacterium tuberculosis H37Rv ATCC 27294 at 6.25 ug/ml after 5 days by microplate alamar blue assay | ChEMBL. | 19022537 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mycobacterium tuberculosis | ChEMBL23 | 19022537 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.