TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 211.223 | Formula: C11H9N5
H donors: 1 H acceptors: 3 LogP: 1.61 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: c1ccn(c1)c1cccc(c1)c1[nH]nnn1
InChi: 1S/C11H9N5/c1-2-7-16(6-1)10-5-3-4-9(8-10)11-12-14-15-13-11/h1-8H,(H,12,13,14,15)
InChiKey: LEXDTPFPHRIPNN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0032	0.0318	0.0318
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.1969	0.4067
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0104	0.1673	0.1657
Schistosoma mansoni	hypothetical protein	0.0016	0.0019	0.0019
Plasmodium vivax	SET domain protein, putative	0.0035	0.0369	0.1802
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.1055	0.1055
Trypanosoma brucei	unspecified product	0.0019	0.0076	0.0719
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0043	0.005
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0076	0.0076
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0076	0.0076
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0598	0.0598
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.1055	0.2049
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0051	0.0679	0.0679
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.1969	0.4067
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0598	0.058
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0824	0.7644
Echinococcus multilocularis	peregrin	0.0034	0.0361	0.0342
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0076	0.0719
Schistosoma mansoni	tar DNA-binding protein	0.0272	0.4814	0.4814
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0496	0.0995
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0071	0.1055	0.1038
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0076	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0071	0.1055	1
Trypanosoma brucei	hypothetical protein, conserved	0.0071	0.1055	1
Mycobacterium tuberculosis	Conserved protein	0.0071	0.1055	0.12
Schistosoma mansoni	tar DNA-binding protein	0.0272	0.4814	0.4814
Schistosoma mansoni	hypothetical protein	0.002	0.0097	0.0097
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0071	0.1055	0.2161
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0185	0.3174	0.3161
Echinococcus multilocularis	tar DNA binding protein	0.0272	0.4814	0.4804
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0076	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1055	0.2161
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0076	0.0118
Schistosoma mansoni	hypothetical protein	0.0285	0.5047	0.5047
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0032	0.0318	0.0299
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0824	0.7644
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0076	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1055	0.2161
Brugia malayi	Pre-SET motif family protein	0.0035	0.0369	0.073
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0076	0.0719
Echinococcus multilocularis	lysine specific demethylase 5A	0.0039	0.0443	0.0425
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0076	0.0719
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.1055	0.2049
Mycobacterium tuberculosis	Conserved protein	0.0071	0.1055	0.12
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0369	0.0369
Echinococcus granulosus	lysine specific demethylase 5A	0.004	0.0478	0.046
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0131	0.0113
Loa Loa (eye worm)	MBCTL1	0.0053	0.0719	0.146
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0272	0.4814	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0076	0.0057
Plasmodium falciparum	phd finger protein, putative	0.0032	0.0318	1
Loa Loa (eye worm)	TAR-binding protein	0.0272	0.4814	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0066	0.0952	0.1946
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0058	0.0806	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0076	0.0118
Echinococcus granulosus	histone lysine methyltransferase setb	0.0051	0.0679	0.0661
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0218	0.0416
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0598	0.058
Brugia malayi	beta-lactamase	0.0071	0.1055	0.2161
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0076	0.0719
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.0719	0.0702
Schistosoma mansoni	jumonji/arid domain-containing protein	0.004	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0419	0.0833
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0598	0.1208
Echinococcus granulosus	PHD finger protein rhinoceros	0.0032	0.0318	0.0299
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0824	0.0824
Loa Loa (eye worm)	PHD-finger family protein	0.0032	0.0318	0.0623
Mycobacterium tuberculosis	Probable lipase LipD	0.0071	0.1055	0.12
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1006	0.2058
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1055	0.2161
Brugia malayi	jmjC domain containing protein	0.004	0.0478	0.0957
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0583	0.0583
Toxoplasma gondii	ABC1 family protein	0.0071	0.1055	1
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0076	0.0057
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.0719	0.146
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0824	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0679	0.1376
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.0369	0.0369
Mycobacterium ulcerans	esterase/lipase LipP	0.0071	0.1055	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0218	0.207
Leishmania major	DNA polymerase eta, putative	0.0019	0.0076	0.0719
Echinococcus granulosus	beta LACTamase domain containing family member	0.0071	0.1055	0.1038
Echinococcus granulosus	zinc finger protein	0.0019	0.0078	0.0059
Brugia malayi	beta-lactamase family protein	0.0071	0.1055	0.2161
Trichomonas vaginalis	esterase, putative	0.0071	0.1055	0.2049
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.0719	0.0719
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0824	0.7814
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0071	0.1055	0.12
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1055	0.2161
Mycobacterium tuberculosis	Probable hydrolase	0.0071	0.1055	0.12
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.0719	0.0702
Schistosoma mansoni	hypothetical protein	0.0016	0.0019	0.0019
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0824	0.7644
Schistosoma mansoni	zinc finger protein	0.0019	0.0078	0.0078
Brugia malayi	RNA recognition motif domain containing protein	0.0272	0.4814	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.1055	0.2049
Trichomonas vaginalis	set domain proteins, putative	0.0274	0.4856	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0364	0.0364
Onchocerca volvulus		0.0035	0.0369	0.0113
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0583	0.0565
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0071	0.1055	0.2161
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0744	0.1511
Schistosoma mansoni	tar DNA-binding protein	0.0272	0.4814	0.4814
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1055	0.2161
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0076	0.0719
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0131	0.0131
Brugia malayi	Bromodomain containing protein	0.0037	0.0417	0.0831
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0076	0.0719
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.066	0.1338
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0076	0.0057
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0076	0.0719
Mycobacterium ulcerans	hypothetical protein	0.0071	0.1055	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0241	0.4232	0.8788
Schistosoma mansoni	tar DNA-binding protein	0.0272	0.4814	0.4814
Mycobacterium leprae	conserved hypothetical protein	0.0071	0.1055	0.5
Brugia malayi	TAR-binding protein	0.0272	0.4814	1
Loa Loa (eye worm)	beta-lactamase	0.0071	0.1055	0.2161
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0076	0.0719
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0583	0.0565
Brugia malayi	Bromodomain containing protein	0.0034	0.0361	0.0713
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0076	0.0118
Schistosoma mansoni	bromodomain containing protein	0.0061	0.0871	0.0871
Onchocerca volvulus		0.0071	0.1055	0.1624
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0824	0.0807
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0824	0.0824
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0583	0.0583
Mycobacterium tuberculosis	Conserved protein	0.0071	0.1055	0.12
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0583	0.0565
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0583	0.0583
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0369	0.1802
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0598	0.0598
Brugia malayi	Bromodomain containing protein	0.0073	0.1084	0.222
Mycobacterium ulcerans	lipase LipD	0.0071	0.1055	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0076	0.0719
Brugia malayi	RNA binding protein	0.0272	0.4814	1
Leishmania major	hypothetical protein, conserved	0.0027	0.0218	0.207
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.0318	0.119
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0218	0.207
Brugia malayi	PHD-finger family protein	0.0032	0.0318	0.0623
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0051	0.0679	0.0679
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.0719	0.0702
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.1055	0.2049
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0071	0.1055	0.12
Schistosoma mansoni	hypothetical protein	0.0032	0.0318	0.0318
Onchocerca volvulus		0.0274	0.4856	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0583	0.1176
Brugia malayi	hypothetical protein	0.0027	0.0218	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0364	0.0718
Mycobacterium tuberculosis	Probable esterase LipL	0.0071	0.1055	0.12
Giardia lamblia	PHD finger protein 15	0.0032	0.0318	1
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0076	0.0719
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0104	0.1673	0.1657
Brugia malayi	MH2 domain containing protein	0.012	0.1969	0.4067
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0032	0.0013
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0364	0.0718
Schistosoma mansoni	jumonji domain containing protein	0.0083	0.1272	0.1272
Loa Loa (eye worm)	RNA binding protein	0.0272	0.4814	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0051	0.0679	0.0661
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.0345	0.0327
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0076	0.0719
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0071	0.1055	0.12
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0076	0.0719
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0375	0.0356
Schistosoma mansoni	tar DNA-binding protein	0.0272	0.4814	0.4814
Onchocerca volvulus		0.0071	0.1055	0.1624
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0076	0.0057
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.1055	0.1055
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0076	0.0719
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0076	0.0719
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0824	0.7243
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.1055	1
Echinococcus granulosus	tar DNA binding protein	0.0272	0.4814	0.4804
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0076	0.0719
Loa Loa (eye worm)	jmjC domain-containing protein	0.004	0.0478	0.0957
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0719	0.146
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0058	0.0806	0.0788
Onchocerca volvulus		0.0047	0.0598	0.0617
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.0318	0.119
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0076	0.0719
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0375	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0318	0.0623
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0076	0.0719
Brugia malayi	beta-lactamase family protein	0.0071	0.1055	0.2161
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0583	0.1176
Echinococcus granulosus	peregrin	0.0034	0.0361	0.0342
Mycobacterium ulcerans	beta-lactamase	0.0071	0.1055	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0071	0.1055	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0131	0.0113
Brugia malayi	mbt repeat family protein	0.0047	0.0598	0.1208
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.005	0.066	0.1338
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0076	0.0719
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0185	0.3174	0.3161
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0076	0.0076
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0598	0.0617
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0583	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1055	0.2161
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.066	0.1338
Echinococcus multilocularis	zinc finger protein	0.0019	0.0078	0.0059
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0032	0.0013
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0598	0.058
Schistosoma mansoni	jumonji/arid domain-containing protein	0.004	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0598	0.1208
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0598	0.0598
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0455	0.8237	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0076	0.0719
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.1055	0.2049
Brugia malayi	hypothetical protein	0.0017	0.0043	0.0049
Brugia malayi	Pre-SET motif family protein	0.0241	0.4232	0.8788
Mycobacterium tuberculosis	Probable lipase LipE	0.0071	0.1055	0.12
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0076	0.0719
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0824	0.0807
Brugia malayi	jmjC domain containing protein	0.0104	0.1673	0.345
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0097	0.0162
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.0719	0.0702
Schistosoma mansoni	hypothetical protein	0.0016	0.0019	0.0019
Brugia malayi	PHD-finger family protein	0.0024	0.0174	0.0324
Brugia malayi	mbt repeat family protein	0.0047	0.0598	0.1208
Mycobacterium leprae	Probable lipase LipE	0.0071	0.1055	0.5
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0218	0.207
Schistosoma mansoni	hypothetical protein	0.0016	0.0019	0.0019
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.066	0.1338
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.0318	0.119
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0598	0.058
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0369	0.0351
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0076	0.0719
Echinococcus granulosus	jumonji domain containing protein	0.0044	0.0551	0.0533
Loa Loa (eye worm)	hypothetical protein	0.004	0.0462	0.0923
Echinococcus multilocularis	jumonji domain containing protein	0.0044	0.0551	0.0533
Onchocerca volvulus		0.0071	0.1055	0.1624
Leishmania major	hypothetical protein, conserved	0.0071	0.1055	1
Echinococcus granulosus	dna polymerase eta	0.0019	0.0076	0.0057
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.1055	1

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (ADMET)	= 436.11 uM	Cytotoxicity against human MT2 cells after 4 days by XTT assay	ChEMBL.	19053778

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL507813

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1179309