Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.3387 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.3387 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.3387 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.3387 | 0.5 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.3387 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.3387 | 0.3387 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.3387 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.3387 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.3387 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.3387 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.3387 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.3387 | 0.3387 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.3387 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.3387 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.3387 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.3387 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.3387 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.3387 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.3387 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 23.9 uM | Binding affinity to Shc Src homology 2 domain by fluorescence anisotropy | ChEMBL. | 19226165 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.