Detailed information for compound 1179938

Basic information

Technical information
  • TDR Targets ID: 1179938
  • Name: (7-methoxythieno[5,4-b]quinolin-2-yl)-[4-[3-( trifluoromethyl)phenyl]piperazin-1-yl]methano ne
  • MW: 471.495 | Formula: C24H20F3N3O2S
  • H donors: 0 H acceptors: 2 LogP: 5.78 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)nc1c(c2)cc(s1)C(=O)N1CCN(CC1)c1cccc(c1)C(F)(F)F
  • InChi: 1S/C24H20F3N3O2S/c1-32-19-6-5-15-11-16-12-21(33-22(16)28-20(15)14-19)23(31)30-9-7-29(8-10-30)18-4-2-3-17(13-18)24(25,26)27/h2-6,11-14H,7-10H2,1H3
  • InChiKey: WIKZWGFZAMEDGH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (7-methoxy-2-thieno[5,4-b]quinolinyl)-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]methanone
  • C303-0404
  • NCGC00107809-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0178 0.4065
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0119 0.0155
Mycobacterium tuberculosis Conserved protein 0.0035 0.0306 0.0998
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0306 0.0397
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2673 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0119 0.0155
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0102 0.0102
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0488 0.1085
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0096 0.0001
Brugia malayi Muscleblind-like protein 0.0148 0.1733 0.2248
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0174 0.0225
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0427 0.3187
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0168 0.0474
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.0105 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Loa Loa (eye worm) hypothetical protein 0.0267 0.3233 0.4192
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0408 0.1073
Brugia malayi nuclear hormone receptor 0.002 0.0119 0.0155
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0488 0.0581
Loa Loa (eye worm) hypothetical protein 0.0023 0.0162 0.021
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0119 0.0289
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0102 0.0132
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.011 0.1251 0.3039
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0084 0.0932 0.0932
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0117 0.172
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0102 0.5
Schistosoma mansoni Smad4 0.0019 0.0105 0.0256
Mycobacterium ulcerans hypothetical protein 0.0035 0.0306 0.1281
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0488 0.0633
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.0332 0.1096
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0119 0.0119
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.009 0.0177
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0095 0.0113
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0157 0.0204
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0197 0.0584
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.1412 0.1412
Brugia malayi MH1 domain containing protein 0.0042 0.0401 0.052
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0401 0.0401
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0095 0.0606
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0126 0.0313
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0119 0.0136
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0102 0.0018
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0095 0.0229
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0178 0.0578
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.3718 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0622 0.7711 1
Echinococcus multilocularis neuropeptide receptor A26 0.0458 0.5645 0.5645
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0306 0.6184
Loa Loa (eye worm) hypothetical protein 0.0182 0.2168 0.2811
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0306 0.0797
Mycobacterium ulcerans polyketide synthase 0.0026 0.0197 0.0684
Brugia malayi MH1 domain containing protein 0.0042 0.0401 0.052
Loa Loa (eye worm) Smad1 0.0042 0.0401 0.052
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.1412 0.5205
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0119 0.0119
Echinococcus granulosus FTZ F1 alpha 0.002 0.0119 0.0142
Echinococcus granulosus geminin 0.0337 0.4116 0.4902
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0119 0.0155
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0306 0.6184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Schistosoma mansoni hypothetical protein 0.0182 0.2168 0.5266
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0397
Brugia malayi ecdysteroid receptor 0.002 0.0119 0.0155
Loa Loa (eye worm) hypothetical protein 0.0021 0.0137 0.0177
Entamoeba histolytica hypothetical protein 0.011 0.1251 1
Toxoplasma gondii hypothetical protein 0.0049 0.0488 0.3406
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1412 0.735
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0157 0.0433
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0488 0.1085
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0105 0.0105
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0102 0.0164
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0306 0.0998
Schistosoma mansoni tar DNA-binding protein 0.0271 0.3282 0.7973
Brugia malayi Latrophilin receptor protein 2 0.0084 0.0932 0.1208
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0119 0.0289
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0102 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0181 0.0236
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.1412 0.3431
Schistosoma mansoni ap endonuclease 0.0019 0.0102 0.0247
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.0332 0.1422
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0119 0.0119
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0306 0.0364
Brugia malayi steroid hormone receptor 0.002 0.0119 0.0155
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0155
Brugia malayi MH2 domain containing protein 0.0019 0.0105 0.0137
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0119 0.0142
Brugia malayi TAR-binding protein 0.0271 0.3282 0.4256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Onchocerca volvulus 0.0035 0.0306 0.1984
Mycobacterium ulcerans beta-lactamase 0.0035 0.0306 0.1281
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0401 0.052
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0119 0.0289
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0178 0.051
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0488 0.0488
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0408 0.0864
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0178 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0488 0.341
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0117 0.0245
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0084 0.0932 0.0932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0488 0.1085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0119 0.0155
Schistosoma mansoni Smad4 0.0042 0.0401 0.0974
Schistosoma mansoni hypothetical protein 0.0097 0.1094 0.2659
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0119 0.0119
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.1689 0.4529
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1412 0.735
Mycobacterium ulcerans lipase LipD 0.0035 0.0306 0.1281
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0126 0.2064
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0181 0.0234
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0095 0.0113
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0488 0.1289
Onchocerca volvulus 0.0097 0.1094 0.9792
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.1251 0.1489
Mycobacterium ulcerans hypothetical protein 0.0161 0.1895 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0181 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Echinococcus granulosus neuropeptide receptor A26 0.0458 0.5645 0.6722
Echinococcus multilocularis muscleblind protein 0.0148 0.1733 0.1733
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0012 0.0024 0.0097
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0119 0.0289
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0119 0.0142
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0197 0.0684
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0155
Echinococcus granulosus GPCR family 2 0.0084 0.0932 0.1109
Echinococcus multilocularis survival motor neuron protein 1 0.0477 0.5886 0.5886
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0102 0.1911
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0397
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0306 0.0397
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0102 0.0246
Schistosoma mansoni smad1 5 8 and 0.0042 0.0401 0.0974
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0306 0.0998
Brugia malayi nuclear receptor NHR-88 0.002 0.0119 0.0155
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0306 0.0306
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0119 0.0119
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0119 0.0142
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0102 0.0161
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0168 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Schistosoma mansoni tar DNA-binding protein 0.0271 0.3282 0.7973
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0102 0.0018
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0095 0.0229
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0178 0.0578
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0119 0.0155
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0119 0.0155
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0068 0.0415
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0119 0.0155
Leishmania major hypothetical protein, conserved 0.0035 0.0306 0.0582
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0102 0.0221
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0178 0.4065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Echinococcus granulosus neuropeptide s receptor 0.0458 0.5645 0.6722
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0197 0.481
Echinococcus multilocularis Smad4 0.0042 0.0401 0.0401
Schistosoma mansoni tar DNA-binding protein 0.0271 0.3282 0.7973
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0119 0.0289
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0408 0.0864
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0488 0.1085
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0155
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0119 0.0136
Brugia malayi Calcitonin receptor-like protein seb-1 0.0267 0.3233 0.4192
Entamoeba histolytica hypothetical protein 0.011 0.1251 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0102 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Loa Loa (eye worm) latrophilin receptor protein 2 0.0084 0.0932 0.1208
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0197 0.0584
Echinococcus multilocularis tumor protein p63 0.0677 0.8398 0.8398
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.1412 1
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0181 0.0181
Echinococcus multilocularis muscleblind protein 1 0.0148 0.1733 0.1733
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.1251 0.1251
Brugia malayi beta-lactamase family protein 0.0035 0.0306 0.0397
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0401 0.0478
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0197 0.0684
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0119 0.0155
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0105 0.0137
Schistosoma mansoni survival motor neuron protein 0.0097 0.1094 0.2659
Loa Loa (eye worm) nuclear factor I 0.0023 0.0162 0.021
Schistosoma mansoni hypothetical protein 0.0337 0.4116 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0095 0.0123
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0013
Schistosoma mansoni nuclear hormone receptor 0.002 0.0119 0.0289
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0306 0.0998
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.3718 1
Onchocerca volvulus 0.0043 0.0408 0.2996
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0488 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0271 0.3282 0.4256
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0401 0.0974
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0155
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0105 0.0126
Brugia malayi MH1 domain containing protein 0.0023 0.0162 0.021
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0178 0.0578
Echinococcus granulosus Smad4 0.0042 0.0401 0.0478
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0119 0.0289
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0137 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0119 0.0155
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0488 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0306 0.0998
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0119 0.0119
Brugia malayi MH2 domain containing protein 0.0042 0.0401 0.052
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.3718 1
Mycobacterium ulcerans thioesterase 0.0021 0.0126 0.0294
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0119 0.0119
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0126 0.0294
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0105 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0119 0.0155
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0488 0.0581
Echinococcus granulosus tumor protein p63 0.0677 0.8398 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0197 0.481
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Mycobacterium tuberculosis Conserved protein 0.0035 0.0306 0.0998
Schistosoma mansoni tar DNA-binding protein 0.0271 0.3282 0.7973
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0119 0.0155
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0095 0.0123
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0306 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0119 0.0155
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0181 0.1215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0119 0.0155
Echinococcus multilocularis tar DNA binding protein 0.0271 0.3282 0.3282
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0306 0.1281
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0488 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0306 0.0582
Onchocerca volvulus 0.002 0.0119 0.0136
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0488 1
Schistosoma mansoni coup transcription factor 0.002 0.0119 0.0289
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0119 0.0155
Entamoeba histolytica hypothetical protein 0.011 0.1251 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0088 0.0555
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0095 0.0229
Brugia malayi hypothetical protein 0.011 0.1251 0.1622
Echinococcus multilocularis smad 0.0042 0.0401 0.0401
Schistosoma mansoni hypothetical protein 0.0084 0.0932 0.2263
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0105 0.0126
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0119 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0105 0.0137
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0267 0.3233 0.4192
Schistosoma mansoni tar DNA-binding protein 0.0271 0.3282 0.7973
Schistosoma mansoni smad1 5 8 and 0.0042 0.0401 0.0974
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0178 0.051
Brugia malayi MAP kinase sur-1 0.0049 0.0488 0.0633
Brugia malayi MH1 domain containing protein 0.0023 0.0162 0.021
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0102 0.1911
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0119 0.0136
Loa Loa (eye worm) RNA binding protein 0.0271 0.3282 0.4256
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0401 0.0401
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0408 0.0864
Brugia malayi Smad1 0.0042 0.0401 0.052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0119 0.0142
Schistosoma mansoni hypothetical protein 0.0084 0.0932 0.2263
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0119 0.0289
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.1412 0.3635
Schistosoma mansoni hypothetical protein 0.0084 0.0932 0.2263
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0397
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0119 0.0155
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0306 0.0998
Onchocerca volvulus 0.0035 0.0306 0.1984
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0095 0.0231
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0306 0.0998
Entamoeba histolytica hypothetical protein 0.011 0.1251 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0306 0.0998
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0102 0.0132
Schistosoma mansoni smad1 5 8 and 0.0042 0.0401 0.0974
Loa Loa (eye worm) transcription factor SMAD2 0.0622 0.7711 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0527 0.1191
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0306 0.6184
Onchocerca volvulus 0.0035 0.0306 0.1984
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.1115 0.2709
Brugia malayi RNA recognition motif domain containing protein 0.0271 0.3282 0.4256
Echinococcus multilocularis neuropeptide s receptor 0.0458 0.5645 0.5645
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0181 0.0215
Echinococcus granulosus tar DNA binding protein 0.0271 0.3282 0.3908
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0306 0.6184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Brugia malayi hypothetical protein 0.0477 0.5886 0.7633
Loa Loa (eye worm) hypothetical protein 0.0099 0.1115 0.1446
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0178 0.023
Echinococcus granulosus smad 0.0042 0.0401 0.0478
Mycobacterium leprae Probable lipase LipE 0.0035 0.0306 0.901
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1689 0.44
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0197 0.1332
Schistosoma mansoni hypothetical protein 0.0337 0.4116 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0121 0.0295
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0306 0.0743
Schistosoma mansoni thyroid hormone receptor 0.002 0.0119 0.0289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0119 0.0155
Trypanosoma brucei protein kinase, putative 0.0049 0.0488 0.1289
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0084 0.0932 0.1109
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0488 1
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0119 0.0289
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0306 0.6184
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.0332 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0119 0.0142
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0095 0.0123
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0401 0.0478
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.1094 0.1419
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0306 0.0998
Schistosoma mansoni ap endonuclease 0.0019 0.0102 0.0247
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.1412 0.1682
Loa Loa (eye worm) beta-lactamase 0.0035 0.0306 0.0397
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0095 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0119 0.0155
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0119 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0119 0.0155
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0488 0.1085
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0267 0.3233 0.4192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0181 0.3563
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0119 0.0155
Brugia malayi latrophilin 2 splice variant baaae 0.0182 0.2168 0.2811
Schistosoma mansoni smad 0.0042 0.0401 0.0974
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0306 0.901
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0155
Brugia malayi beta-lactamase 0.0035 0.0306 0.0397
Schistosoma mansoni smad 0.0019 0.0105 0.0256
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0488 0.0488
Schistosoma mansoni hypothetical protein 0.0084 0.0932 0.2263
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0488 0.1085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0119 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.1895 0.7042
Schistosoma mansoni transcription factor LCR-F1 0.011 0.1251 0.3039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0119 0.0289
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0084 0.0932 0.1109
Mycobacterium ulcerans polyketide synthase 0.0025 0.0178 0.0578
Brugia malayi MH2 domain containing protein 0.0622 0.7711 1
Onchocerca volvulus 0.0023 0.0157 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0119 0.0142
Loa Loa (eye worm) hypothetical protein 0.0084 0.0932 0.1208
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0095 0.0229
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0119 0.0142
Echinococcus granulosus muscleblind protein 0.0148 0.1733 0.2064
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0119 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Toxoplasma gondii exonuclease III APE 0.0019 0.0102 0.0652
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0095 0.0231
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0401 0.052
Loa Loa (eye worm) TAR-binding protein 0.0271 0.3282 0.4256
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0119 0.0155
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0155
Brugia malayi RNA binding protein 0.0271 0.3282 0.4256
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0102 0.0121
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0102 0.0018
Brugia malayi beta-lactamase family protein 0.0035 0.0306 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0119 0.0155
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0102 0.5
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0047 0.0456 0.0592
Loa Loa (eye worm) hypothetical protein 0.0148 0.1733 0.2248
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0197 0.481
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0178 0.051
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1689 0.44
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0306 0.1281
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0084 0.0932 0.1208
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0105 0.0137
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0155
Toxoplasma gondii ABC1 family protein 0.0035 0.0306 0.2109
Onchocerca volvulus 0.0099 0.1115 1
Loa Loa (eye worm) hypothetical protein 0.0477 0.5886 0.7633
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0095 0.0123
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.1412 0.3431
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0181 0.0459
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.3718 1
Echinococcus granulosus survival motor neuron protein 1 0.0477 0.5886 0.7009
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0096 0.0001
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0117 0.0245
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1412 0.735
Loa Loa (eye worm) hypothetical protein 0.0148 0.1733 0.2248
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.0332 0.1096
Trichomonas vaginalis esterase, putative 0.0035 0.0306 0.6184
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0119 0.0119
Schistosoma mansoni Smad4 0.0019 0.0105 0.0256
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0197 0.0584
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0306 0.0743
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0488 0.1186
Echinococcus multilocularis geminin 0.0337 0.4116 0.4116
Brugia malayi MH2 domain containing protein 0.0042 0.0401 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Loa Loa (eye worm) hypothetical protein 0.0041 0.0389 0.0505
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0157 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0095 0.1777
Echinococcus multilocularis GPCR, family 2 0.0084 0.0932 0.0932
Loa Loa (eye worm) acyl carrier protein 0.0011 0.001 0.0012
Schistosoma mansoni thyroid hormone receptor 0.002 0.0119 0.0289
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0095 0.0095
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0306 0.0582
Entamoeba histolytica hypothetical protein 0.0025 0.0181 0.0739

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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