Detailed information for compound 1180402

Basic information

Technical information
  • TDR Targets ID: 1180402
  • Name: 2,5-dimethoxy-N-[2-(2-phenyl-[1,3]thiazolo[2, 3-e][1,2,4]triazol-6-yl)ethyl]benzenesulfonam ide
  • MW: 444.527 | Formula: C20H20N4O4S2
  • H donors: 1 H acceptors: 4 LogP: 3.41 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)S(=O)(=O)NCCc1csc2n1nc(n2)c1ccccc1)OC
  • InChi: 1S/C20H20N4O4S2/c1-27-16-8-9-17(28-2)18(12-16)30(25,26)21-11-10-15-13-29-20-22-19(23-24(15)20)14-6-4-3-5-7-14/h3-9,12-13,21H,10-11H2,1-2H3
  • InChiKey: LZKMNIBERZRTAI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,5-dimethoxy-N-[2-(2-phenylthiazolo[2,3-e][1,2,4]triazol-6-yl)ethyl]benzenesulfonamide
  • 2,5-dimethoxy-N-[2-(2-phenyl-6-thiazolo[2,3-e][1,2,4]triazolyl)ethyl]benzenesulfonamide
  • G856-5011
  • NCGC00136207-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.1059
Schistosoma mansoni hypothetical protein 0.0129 0.2387 0.7072
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0715 0.5206
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.1059
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0153 0.288 1
Giardia lamblia DINP protein human, muc B family 0.0021 0.0155 1
Mycobacterium leprae conserved hypothetical protein 0.0078 0.132 0.2495
Mycobacterium ulcerans lipase LipD 0.0078 0.132 0.4473
Mycobacterium tuberculosis Conserved protein 0.0078 0.132 0.127
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0072 0.0049
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.132 0.127
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.132 1
Plasmodium vivax hypothetical protein, conserved 0.0078 0.132 0.4473
Treponema pallidum exodeoxyribonuclease (exoA) 0.0017 0.0072 0.0049
Entamoeba histolytica hypothetical protein 0.004 0.0539 1
Schistosoma mansoni hypothetical protein 0.004 0.0539 0.1461
Brugia malayi hypothetical protein 0.004 0.0539 0.0727
Brugia malayi MH2 domain containing protein 0.0025 0.0235 0.0316
Plasmodium vivax glutathione reductase, putative 0.0049 0.0715 0.2329
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0155 0.0097
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0155 0.0765
Toxoplasma gondii hypothetical protein 0.0053 0.0802 0.2636
Schistosoma mansoni ap endonuclease 0.0017 0.0072 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.1059
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0153 0.288 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0155 0.0097
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.226 0.7015
Echinococcus multilocularis thyroid hormone receptor alpha 0.014 0.2602 0.7724
Entamoeba histolytica hypothetical protein 0.004 0.0539 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0235 0.0536
Mycobacterium leprae Probable lipase LipE 0.0078 0.132 0.2495
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0072 0.0111
Trypanosoma brucei trypanothione reductase 0.0049 0.0715 0.5359
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.226 0.2214
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0153 0.288 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0715 0.0661
Loa Loa (eye worm) MH2 domain-containing protein 0.0372 0.7415 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0155 0.1768
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0715 0.2329
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0053 0.0802 0.2636
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0235 0.0536
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0539 0.1461
Toxoplasma gondii thioredoxin reductase 0.0049 0.0715 0.2329
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0155 0.0765
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.132 0.127
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.01 0.1788 0.174
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.1631 0.2199
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0155 0.0209
Echinococcus multilocularis peptidase Clp (S14 family) 0.01 0.1788 0.5252
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0017 0.0072 0.0049
Schistosoma mansoni smad1 5 8 and 0.0025 0.0235 0.0536
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0155 0.1059
Schistosoma mansoni hypothetical protein 0.0176 0.3351 1
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.132 1
Onchocerca volvulus 0.0078 0.132 0.5
Schistosoma mansoni ap endonuclease 0.0017 0.0072 0.0042
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0155 0.0293
Brugia malayi MH1 domain containing protein 0.0025 0.0235 0.0316
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0153 0.288 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.292 0.3938
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0153 0.288 1
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.132 0.127
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0155 0.0293
Echinococcus multilocularis dna polymerase eta 0.0021 0.0155 0.0293
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.132 0.1781
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0153 0.288 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0155 0.0293
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0072 0.0042
Echinococcus granulosus Smad4 0.0025 0.0235 0.0536
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0153 0.288 0.8568
Schistosoma mansoni thyroid hormone receptor 0.014 0.2602 0.7724
Schistosoma mansoni DNA polymerase eta 0.0021 0.0155 0.0293
Trypanosoma brucei unspecified product 0.0021 0.0155 0.1059
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.1059
Brugia malayi MH2 domain containing protein 0.0025 0.0235 0.0316
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0155 0.0765
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0053 0.0802 0.2636
Brugia malayi beta-lactamase 0.0078 0.132 0.1781
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.132 1
Echinococcus multilocularis Smad4 0.0025 0.0235 0.0536
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0539 0.1461
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0715 0.0965
Entamoeba histolytica hypothetical protein 0.004 0.0539 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0153 0.288 1
Trichomonas vaginalis esterase, putative 0.0078 0.132 1
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.132 1
Mycobacterium tuberculosis Conserved protein 0.0078 0.132 0.127
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1631 0.4775
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0715 0.1995
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0017 0.0072 0.0049
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.132 1
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0072 0.0111
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0072 0.0097
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0053 0.0802 0.2636
Loa Loa (eye worm) hypothetical protein 0.0155 0.292 0.3938
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.2387 0.7072
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.1059
Plasmodium falciparum glutathione reductase 0.0049 0.0715 0.2329
Echinococcus granulosus dna polymerase eta 0.0021 0.0155 0.0293
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.2004 0.5783
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.226 0.2214
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0153 0.288 0.8568
Schistosoma mansoni hypothetical protein 0.0176 0.3351 1
Brugia malayi MH2 domain containing protein 0.0372 0.7415 1
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0155 0.1059
Entamoeba histolytica hypothetical protein 0.004 0.0539 1
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.132 0.127
Leishmania major DNA polymerase kappa, putative 0.0021 0.0155 0.0765
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0235 0.0536
Loa Loa (eye worm) hypothetical protein 0.0078 0.132 0.1781
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0155 0.0765
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1631 0.4775
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.132 0.4473
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.132 0.3833
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.1059
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0155 0.0765
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0153 0.288 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.1059
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0155 0.0765
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.2004 0.1957
Echinococcus granulosus dna polymerase kappa 0.0021 0.0155 0.0293
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.132 0.3833
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.2004 0.1957
Echinococcus multilocularis geminin 0.0176 0.3351 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0058 0.0319
Echinococcus multilocularis muscleblind protein 1 0.0155 0.292 0.869
Loa Loa (eye worm) beta-lactamase 0.0078 0.132 0.1781
Mycobacterium tuberculosis Probable reductase 0.0111 0.2004 0.1957
Mycobacterium ulcerans beta-lactamase 0.0078 0.132 0.4473
Loa Loa (eye worm) hypothetical protein 0.0078 0.132 0.1781
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.2004 0.1957
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.0072 0.0111
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.132 0.3833
Mycobacterium tuberculosis Conserved protein 0.0078 0.132 0.127
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.132 0.4473
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0155 0.0209
Schistosoma mansoni Smad4 0.0025 0.0235 0.0536
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0155 0.1059
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.01 0.1788 0.174
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0155 0.0765
Schistosoma mansoni thyroid hormone receptor 0.014 0.2602 0.7724
Leishmania major trypanothione reductase 0.0049 0.0715 0.5206
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0235 0.0536
Echinococcus granulosus smad 0.0025 0.0235 0.0536
Echinococcus granulosus muscleblind protein 0.0155 0.292 0.869
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.132 0.1781
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.1059
Loa Loa (eye worm) hypothetical protein 0.0078 0.132 0.1781
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.132 0.127
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0155 0.0293
Plasmodium falciparum thioredoxin reductase 0.0049 0.0715 0.2329
Brugia malayi beta-lactamase family protein 0.0078 0.132 0.1781
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0058 0.0078
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.132 1
Echinococcus multilocularis smad 0.0025 0.0235 0.0536
Schistosoma mansoni smad1 5 8 and 0.0025 0.0235 0.0536
Onchocerca volvulus 0.0078 0.132 0.5
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0058 0.0319
Loa Loa (eye worm) glutathione reductase 0.0049 0.0715 0.0965
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.1059
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.1059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1631 0.4775
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1631 0.4775
Loa Loa (eye worm) hypothetical protein 0.0021 0.0155 0.0209
Toxoplasma gondii ABC1 family protein 0.0078 0.132 0.4473
Loa Loa (eye worm) hypothetical protein 0.0078 0.132 0.1781
Schistosoma mansoni smad1 5 8 and 0.0025 0.0235 0.0536
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.0072 0.0111
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.2387 0.7072
Mycobacterium ulcerans hypothetical protein 0.0078 0.132 0.4473
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.132 0.127
Brugia malayi glutathione reductase 0.0049 0.0715 0.0965
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0235 0.0536
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.2004 0.1957
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0155 0.0293
Brugia malayi MH1 domain containing protein 0.0025 0.0235 0.0316
Leishmania major hypothetical protein, conserved 0.0078 0.132 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.01 0.1788 0.4744
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0072 0.0042
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0058 0.0319
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1631 0.4775
Toxoplasma gondii exonuclease III APE 0.0017 0.0072 0.0049
Loa Loa (eye worm) transcription factor SMAD2 0.0372 0.7415 1
Echinococcus granulosus geminin 0.0176 0.3351 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0153 0.288 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.1631 0.2199
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.132 1
Brugia malayi beta-lactamase family protein 0.0078 0.132 0.1781
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.0072 0.0426
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0155 0.0342
Brugia malayi Probable ClpP-like protease 0.0153 0.288 0.3884
Brugia malayi Smad1 0.0025 0.0235 0.0316
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0153 0.288 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.132 0.1781
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0155 0.1059
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0017 0.0072 0.1446
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0235 0.0316
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0155 0.0765
Loa Loa (eye worm) hypothetical protein 0.0078 0.132 0.1781
Loa Loa (eye worm) Smad1 0.0025 0.0235 0.0316
Echinococcus granulosus peptidase Clp S14 family 0.01 0.1788 0.5252
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0072 0.0049
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0715 0.1995
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.2004 0.1957
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0058 0.0319
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1631 0.4775
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0072 0.0097
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0072 0.0111
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0235 0.0316
Schistosoma mansoni peptidase Clp (S14 family) 0.0153 0.288 0.8568
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0153 0.288 1
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0155 0.0342
Brugia malayi Muscleblind-like protein 0.0155 0.292 0.3938
Onchocerca volvulus 0.0078 0.132 0.5
Leishmania major DNA polymerase eta, putative 0.0021 0.0155 0.0765
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0017 0.0072 0.0014
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.132 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1631 0.4775
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.226 0.2214
Schistosoma mansoni smad 0.0025 0.0235 0.0536
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0539 0.1461
Echinococcus multilocularis muscleblind protein 0.0155 0.292 0.869
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0155 0.0209
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.132 0.127
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.132 0.3833
Brugia malayi Thioredoxin reductase 0.0049 0.0715 0.0965
Loa Loa (eye worm) hypothetical protein 0.0153 0.288 0.3884

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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