TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 372.46 | Formula: C24H24N2O2
H donors: 1 H acceptors: 1 LogP: 6.58 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=c1onc([nH]1)c1ccc(cc1)C#Cc1ccc2c(c1)C(C)(C)CCC2(C)C
InChi: 1S/C24H24N2O2/c1-23(2)13-14-24(3,4)20-15-17(9-12-19(20)23)6-5-16-7-10-18(11-8-16)21-25-22(27)28-26-21/h7-12,15H,13-14H2,1-4H3,(H,25,26,27)
InChiKey: XLEZJKPLVACZAN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	retinoic acid receptor, beta	Starlite/ChEMBL	References
Homo sapiens	retinoic acid receptor, gamma	Starlite/ChEMBL	References
Homo sapiens	retinoic acid receptor, alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	Get druggable targets OG5_131607	All targets in OG5_131607
Loa Loa (eye worm)	nuclear receptor nhr-7B	Get druggable targets OG5_131607	All targets in OG5_131607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131607	All targets in OG5_131607
Brugia malayi	nuclear hormone receptor	Get druggable targets OG5_131607	All targets in OG5_131607

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0017	0.0032	0.0033
Echinococcus granulosus	dna polymerase eta	0.002	0.0062	0.0111
Brugia malayi	intermediate filament protein	0.0028	0.0158	0.0166
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0017	0.0026	0.001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0037	0.0269	0.0283
Trichomonas vaginalis	penicillin-binding protein, putative	0.0113	0.1208	1
Echinococcus multilocularis	FTZ F1 alpha	0.0037	0.0269	0.0253
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0085	0.0169
Brugia malayi	nuclear receptor NHR-67	0.0017	0.0032	0.0033
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0017	0.0026	0.0024
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0113	0.1208	0.1275
Trypanosoma cruzi	trypanothione reductase, putative	0.0039	0.0295	0.244
Echinococcus multilocularis	smad	0.0017	0.0026	0.001
Brugia malayi	nuclear receptor NHR-88	0.0017	0.0032	0.0033
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0016	0.0021	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0322	0.0339
Mycobacterium tuberculosis	Probable lipase LipD	0.0113	0.1208	0.1329
Brugia malayi	PHD-finger family protein	0.0024	0.0113	0.0119
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0039	0.0301	0.0285
Echinococcus multilocularis	Smad4	0.0017	0.0026	0.001
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0419	0.0441
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0062	0.051
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0057	0.006
Brugia malayi	Nuclear hormone receptor E75	0.0017	0.0032	0.0033
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0098	0.1024	0.1116
Brugia malayi	MH2 domain containing protein	0.0017	0.0026	0.0027
Brugia malayi	jmjC domain containing protein	0.006	0.0558	0.0589
Schistosoma mansoni	hypothetical protein	0.0035	0.0244	0.0598
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0113	0.1208	0.1275
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0272	0.0286
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0062	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0269	0.0283
Leishmania major	hypothetical protein, conserved	0.0016	0.0017	0.0139
Brugia malayi	Steroid receptor seven-up type 2	0.0037	0.0269	0.0283
Echinococcus granulosus	thioredoxin glutathione reductase	0.0039	0.0301	0.0702
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0037	0.0269	0.0661
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0017	0.0026	0.001
Echinococcus granulosus	nuclear receptor nhr 48	0.0017	0.0032	0.0037
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0085	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0037	0.0269	0.0622
Plasmodium falciparum	glutathione reductase	0.0039	0.0295	1
Leishmania major	hypothetical protein, conserved	0.0113	0.1208	1
Trypanosoma brucei	unspecified product	0.002	0.0062	0.051
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0017	0.0026	0.0065
Brugia malayi	MH1 domain containing protein	0.0017	0.0026	0.0027
Schistosoma mansoni	phd/f-box containing protein	0.0016	0.0017	0.0041
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0158	0.0166
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0154	0.1712	0.1808
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0723	0.8687	1
Brugia malayi	MH2 domain containing protein	0.0247	0.285	0.3009
Brugia malayi	beta-lactamase family protein	0.0113	0.1208	0.1275
Brugia malayi	nuclear receptor NHR-88	0.0037	0.0269	0.0283
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0037	0.0269	0.0622
Entamoeba histolytica	hypothetical protein	0.0035	0.0244	1
Loa Loa (eye worm)	steroid hormone receptor	0.0037	0.0269	0.0283
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0062	0.051
Schistosoma mansoni	smad	0.0017	0.0026	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0105	0.1114	0.1175
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0049	0.0419	0.0403
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0113	0.1208	0.1329
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0033
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0057	0.006
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0154	0.1712	0.1808
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0037	0.0269	0.0283
Brugia malayi	nuclear receptor RXR	0.0019	0.0057	0.006
Trichomonas vaginalis	esterase, putative	0.0113	0.1208	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0062	0.0581	0.1427
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0017	0.0032	0.0033
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0062	0.051
Schistosoma mansoni	lamin	0.0028	0.0158	0.0387
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0113	0.1208	0.1329
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0269	0.0283
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0017	0.0032	0.0015
Leishmania major	DNA polymerase kappa, putative	0.002	0.0062	0.051
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0049	0.0419	0.0992
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0017	0.0032	0.0015
Brugia malayi	nuclear receptor RXR	0.0017	0.0032	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1208	0.1275
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0037	0.0269	0.0253
Mycobacterium leprae	Probable lipase LipE	0.0113	0.1208	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0017	0.0032	0.0037
Onchocerca volvulus		0.0037	0.0269	0.0245
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0037	0.0269	0.0661
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0037	0.0269	0.0283
Schistosoma mansoni	hypothetical protein	0.002	0.0063	0.0154
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0062	0.051
Brugia malayi	ecdysone receptor	0.0017	0.0032	0.0033
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0062	0.051
Brugia malayi	hypothetical protein	0.0019	0.0057	0.006
Schistosoma mansoni	bromodomain containing protein	0.0061	0.0565	0.1388
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0017	0.0032	0.0037
Loa Loa (eye worm)	thioredoxin reductase	0.0039	0.0295	0.0311
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0062	0.051
Brugia malayi	steroid hormone receptor	0.0037	0.0269	0.0283
Brugia malayi	orphan nuclear receptor NR2E1	0.0017	0.0032	0.0033
Onchocerca volvulus		0.0028	0.0158	0.013
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0049	0.0419	0.0441
Brugia malayi	glutathione reductase	0.0039	0.0295	0.0311
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0158	0.0166
Echinococcus granulosus	histone lysine methyltransferase setb	0.0016	0.0021	0.001
Echinococcus granulosus	GPCR family 2	0.0049	0.0419	0.0992
Trypanosoma brucei	hypothetical protein, conserved	0.0113	0.1208	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0113	0.1208	0.1329
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0037	0.0269	0.0283
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0039	0.0295	0.027
Echinococcus multilocularis	zinc finger protein	0.0019	0.005	0.0034
Mycobacterium tuberculosis	Probable dehydrogenase	0.0088	0.0903	0.0976
Echinococcus multilocularis	tumor protein p63	0.0324	0.3799	0.3788
Onchocerca volvulus		0.0113	0.1208	0.1216
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0062	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0057	0.006
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0062	0.051
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0151	0.0159
Brugia malayi	jmjC domain containing protein	0.0016	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0049	0.0419	0.1029
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0088	0.0903	0.0976
Brugia malayi	latrophilin 2 splice variant baaae	0.0105	0.1114	0.1175
Trypanosoma cruzi	hypothetical protein, conserved	0.0113	0.1208	1
Echinococcus multilocularis	musashi	0.0028	0.0158	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0033
Echinococcus granulosus	mothers against decapentaplegic 5	0.0017	0.0026	0.0024
Schistosoma mansoni	coup transcription factor	0.0037	0.0269	0.0661
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0037	0.0269	0.0253
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0019	0.0057	0.014
Brugia malayi	Nuclear hormone receptor-like 1	0.0037	0.0269	0.0283
Schistosoma mansoni	nuclear receptor	0.0017	0.0032	0.0078
Echinococcus granulosus	zinc finger protein	0.0019	0.005	0.0083
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0244	0.0227
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0026	0.0065
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0057	0.0523	0.1249
Loa Loa (eye worm)	MH1 domain-containing protein	0.0017	0.0026	0.0027
Echinococcus multilocularis	geminin	0.0346	0.4069	0.4059
Brugia malayi	nuclear hormone receptor	0.0037	0.0269	0.0283
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0037	0.0269	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0033
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0034	0.0243	0.0227
Brugia malayi	MH1 domain containing protein	0.0017	0.0026	0.0027
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0062	0.0151
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0062	0.051
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0037	0.0269	0.0283
Echinococcus multilocularis	lamin	0.0028	0.0158	0.0141
Brugia malayi	conserved hypotetical protein	0.0017	0.0032	0.0033
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0028	0.0029
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0085	0.021
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1208	0.1275
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0016	0.0021	0.0051
Brugia malayi	Smad1	0.0017	0.0026	0.0027
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0016	0.0021	0.0004
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0017	0.0032	0.0078
Brugia malayi	MH2 domain containing protein	0.0017	0.0026	0.0027
Brugia malayi	beta-lactamase family protein	0.0113	0.1208	0.1275
Mycobacterium tuberculosis	Probable oxidoreductase	0.0098	0.1024	0.1116
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0017	0.0032	0.0078
Schistosoma mansoni	nuclear hormone receptor	0.0037	0.0269	0.0661
Loa Loa (eye worm)	MH2 domain-containing protein	0.0247	0.285	0.3009
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0037	0.0269	0.0283
Mycobacterium tuberculosis	Conserved protein	0.0113	0.1208	0.1329
Toxoplasma gondii	thioredoxin reductase	0.0039	0.0295	0.2334
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0018	0.0039	0.0023
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0049	0.0419	0.0992
Entamoeba histolytica	hypothetical protein	0.0035	0.0244	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.006	0.0558	0.1336
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0787	0.9468	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0113	0.1208	0.1329
Schistosoma mansoni	lamin	0.0028	0.0158	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0033
Echinococcus multilocularis	nuclear receptor nhr 48	0.0017	0.0032	0.0015
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0026	0.0065
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0088	0.0903	0.0976
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0062	0.0064
Brugia malayi	Nuclear hormone receptor E75	0.0017	0.0032	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1712	0.1808
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0113	0.1208	0.1193
Mycobacterium ulcerans	lipase LipD	0.0113	0.1208	1
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0016	0.0021	0.0051
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0037	0.0269	0.0661
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0037	0.0269	0.0283
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0244	0.0598
Schistosoma mansoni	zinc finger protein	0.0019	0.005	0.0124
Loa Loa (eye worm)	Smad1	0.0017	0.0026	0.0027
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0062	0.051
Echinococcus granulosus	intermediate filament protein	0.0028	0.0158	0.0348
Brugia malayi	jmjC domain containing protein	0.0016	0.0017	0.0017
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0017	0.0032	0.0015
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0113	0.1208	0.2968
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0037	0.0269	0.0253
Loa Loa (eye worm)	glutathione reductase	0.0039	0.0295	0.0311
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0049	0.0419	0.0441
Echinococcus granulosus	ecdysone induced protein 78C	0.0037	0.0269	0.0622
Echinococcus granulosus	beta LACTamase domain containing family member	0.0113	0.1208	0.2939
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1208	0.1275
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0032	0.0078
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0062	0.051
Echinococcus multilocularis	dna polymerase eta	0.002	0.0062	0.0045
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0017	0.0032	0.0033
Loa Loa (eye worm)	hypothetical protein	0.002	0.0062	0.0064
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0806	0.9705	1
Plasmodium vivax	thioredoxin reductase, putative	0.0039	0.0295	0.2334
Entamoeba histolytica	hypothetical protein	0.0035	0.0244	1
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0016	0.0017	0.0139
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0037	0.0269	0.0622
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0018	0.0039	0.0056
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0063	0.0066
Schistosoma mansoni	hypothetical protein	0.0049	0.0419	0.1029
Schistosoma mansoni	nuclear receptor nhr-48	0.0017	0.0032	0.0078
Schistosoma mansoni	thyroid hormone receptor	0.0037	0.0269	0.0661
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0037	0.0269	0.0622
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0019	0.0057	0.006
Plasmodium vivax	hypothetical protein, conserved	0.0113	0.1208	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0037	0.0269	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0039	0.03	0.0316
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0037	0.0269	0.0253
Toxoplasma gondii	ABC1 family protein	0.0113	0.1208	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0037	0.0269	0.0283
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0062	0.0045
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0016	0.0021	0.0051
Schistosoma mansoni	nuclear receptor	0.0017	0.0032	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0158	0.0166
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0062	0.0064
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0017	0.0032	0.0033
Mycobacterium ulcerans	hypothetical protein	0.0113	0.1208	1
Schistosoma mansoni	phosphatidylserine receptor	0.0016	0.0017	0.0041
Brugia malayi	jmjC domain containing protein	0.0016	0.0017	0.0017
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0098	0.1024	0.3968
Echinococcus multilocularis	ecdysone induced protein 78C	0.0037	0.0269	0.0253
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0037	0.0269	0.0622
Schistosoma mansoni	zinc finger protein	0.0017	0.0032	0.0078
Schistosoma mansoni	cellular tumor antigen P53	0.0047	0.0402	0.0988
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0062	0.051
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1208	0.1275
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0017	0.0032	0.0015
Schistosoma mansoni	thyroid hormone receptor	0.0037	0.0269	0.0661
Plasmodium falciparum	thioredoxin reductase	0.0039	0.0295	1
Leishmania major	trypanothione reductase	0.0039	0.0295	0.244
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0019	0.0057	0.004
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0062	0.0111
Trypanosoma cruzi	hypothetical protein, conserved	0.0113	0.1208	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0653	0.0689
Brugia malayi	jmjC domain containing protein	0.0062	0.0581	0.0613
Brugia malayi	Bromodomain containing protein	0.0072	0.0703	0.0742
Brugia malayi	nuclear hormone receptor family member odr-7	0.0017	0.0032	0.0033
Brugia malayi	hypothetical protein	0.0019	0.0057	0.006
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0033
Trichomonas vaginalis	D-aminoacylase, putative	0.0113	0.1208	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0113	0.1208	0.2968
Brugia malayi	Thioredoxin reductase	0.0039	0.0295	0.0311
Echinococcus granulosus	lamin dm0	0.0028	0.0158	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0402	0.0424
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0062	0.051
Schistosoma mansoni	retinoic acid receptor RXR	0.0037	0.0269	0.0661
Schistosoma mansoni	hypothetical protein	0.0105	0.1114	0.2736
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0016	0.0017	0.0139
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0037	0.0269	0.0283
Loa Loa (eye worm)	MH2 domain-containing protein	0.0017	0.0026	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0269	0.0283
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0037	0.0269	0.0283
Brugia malayi	nuclear hormone receptor	0.0787	0.9468	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0057	0.0523	0.0507
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0019	0.0057	0.01
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0037	0.0269	0.0283
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0037	0.0269	0.0661
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0037	0.0269	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0021	0.0021
Schistosoma mansoni	RAR-like nuclear receptor	0.0037	0.0269	0.0661
Schistosoma mansoni	hypothetical protein	0.0346	0.4069	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0098	0.1024	0.1116
Echinococcus granulosus	lamin	0.0028	0.0158	0.0348
Echinococcus granulosus	FTZ F1 alpha	0.0037	0.0269	0.0622
Onchocerca volvulus	Protein ultraspiracle homolog	0.0037	0.0269	0.0245
Onchocerca volvulus		0.0113	0.1208	0.1216
Onchocerca volvulus	Bile acid receptor homolog	0.0037	0.0269	0.0245
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0032	0.0078
Loa Loa (eye worm)	transcription factor SMAD2	0.0247	0.285	0.3009
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0037	0.0269	0.0661
Brugia malayi	jmjC domain containing protein	0.0016	0.0017	0.0017
Brugia malayi	tailless protein	0.0017	0.0032	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0269	0.0283
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0037	0.0269	0.0253
Mycobacterium tuberculosis	Probable reductase	0.0088	0.0903	0.0976
Mycobacterium leprae	conserved hypothetical protein	0.0113	0.1208	1
Echinococcus granulosus	tumor protein p63	0.0324	0.3799	0.9332
Echinococcus multilocularis	lamin dm0	0.0028	0.0158	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0269	0.0283
Brugia malayi	beta-lactamase	0.0113	0.1208	0.1275
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0269	0.0283
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0037	0.0269	0.0622
Giardia lamblia	DINP protein human, muc B family	0.002	0.0062	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0057	0.006
Schistosoma mansoni	hypothetical protein	0.0049	0.0419	0.1029
Echinococcus multilocularis	lysine specific demethylase 5A	0.006	0.0558	0.0542
Onchocerca volvulus		0.0047	0.0402	0.0383
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0026	0.0065
Schistosoma mansoni	Smad4	0.0017	0.0026	0.0065
Mycobacterium ulcerans	esterase/lipase LipP	0.0113	0.1208	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0269	0.0283
Brugia malayi	photoreceptor-specific nuclear receptor	0.0037	0.0269	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0057	0.006
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0062	0.051
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0016	0.0021	0.0004
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0037	0.0269	0.0283
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0088	0.0903	0.0976
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0037	0.0269	0.0283
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0037	0.0269	0.0661
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0062	0.051
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0037	0.0269	0.0283
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0017	0.0032	0.0037
Loa Loa (eye worm)	jmjC domain-containing protein	0.0062	0.0581	0.0613
Brugia malayi	Latrophilin receptor protein 2	0.0049	0.0419	0.0441
Echinococcus multilocularis	GPCR, family 2	0.0049	0.0419	0.0403
Loa Loa (eye worm)	DR-78	0.0017	0.0032	0.0033
Trichomonas vaginalis	penicillin-binding protein, putative	0.0113	0.1208	1
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0158	0.0166
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0062	0.051
Trichomonas vaginalis	D-aminoacylase, putative	0.0113	0.1208	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0037	0.0269	0.0661
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0017	0.0017
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0158	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0769	0.9256	0.9776
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0062	0.051
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0016	0.0021	0.001
Schistosoma mansoni	jumonji domain containing protein	0.006	0.0558	0.1372
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0017	0.0032	0.0015
Schistosoma mansoni	hypothetical protein	0.0049	0.0419	0.1029
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0062	0.051
Trichomonas vaginalis	D-aminoacylase, putative	0.0113	0.1208	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Mycobacterium ulcerans	beta-lactamase	0.0113	0.1208	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0062	0.051
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0062	0.0581	0.1427
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0062	0.051
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0019	0.0057	0.014
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0033
Mycobacterium tuberculosis	Conserved protein	0.0113	0.1208	0.1329
Echinococcus granulosus	Smad4	0.0017	0.0026	0.0024
Brugia malayi	hypothetical protein	0.0017	0.0032	0.0033
Trypanosoma brucei	trypanothione reductase	0.0039	0.0295	0.244
Schistosoma mansoni	jumonji domain containing protein	0.0016	0.0017	0.0041
Loa Loa (eye worm)	beta-lactamase	0.0113	0.1208	0.1275
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0062	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0033
Onchocerca volvulus		0.0113	0.1208	0.1216
Plasmodium vivax	glutathione reductase, putative	0.0039	0.0295	0.2334
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0244	0.056
Mycobacterium tuberculosis	Probable esterase LipL	0.0113	0.1208	0.1329
Onchocerca volvulus		0.0028	0.0158	0.013
Echinococcus granulosus	smad	0.0017	0.0026	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1208	0.1275
Schistosoma mansoni	DNA polymerase eta	0.002	0.0062	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0033
Loa Loa (eye worm)	nuclear hormone receptor	0.0017	0.0032	0.0033
Brugia malayi	Bromodomain containing protein	0.0037	0.0271	0.0285
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0037	0.0269	0.0283
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0088	0.0903	0.0976
Schistosoma mansoni	hypothetical protein	0.0346	0.4069	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0113	0.1208	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0017	0.0017
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0034	0.0243	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0269	0.0283
Echinococcus granulosus	lysine specific demethylase 5A	0.0062	0.0581	0.1392
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0017	0.0032	0.0037
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0062	0.051
Mycobacterium tuberculosis	Probable hydrolase	0.0113	0.1208	0.1329
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0037	0.0269	0.0622
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0037	0.0269	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0057	0.006
Echinococcus granulosus	thyroid hormone receptor alpha	0.0017	0.0032	0.0037
Entamoeba histolytica	hypothetical protein	0.0035	0.0244	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1208	0.1275
Echinococcus granulosus	geminin	0.0346	0.4069	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0017	0.0017
Echinococcus granulosus	dna polymerase kappa	0.002	0.0062	0.0111
Mycobacterium tuberculosis	Conserved protein	0.0113	0.1208	0.1329
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.006	0.0558	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0057	0.006
Schistosoma mansoni	protein phosphatase 2C	0.0016	0.0017	0.0041
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0037	0.0269	0.0283
Brugia malayi	hypothetical protein	0.0035	0.0244	0.0256
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0154	0.1712	0.1808
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0049	0.0419	0.0403
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0037	0.0269	0.0253
Brugia malayi	ecdysteroid receptor	0.0037	0.0269	0.0283
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0037	0.0269	0.0253
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0016	0.0017	0.0139
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0016	0.0017	0.0041
Leishmania major	DNA polymerase eta, putative	0.002	0.0062	0.051

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Activity at RXRalpha ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay	ChEMBL.	19058965
Activity (binding)		Activity at RXRgamma ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay	ChEMBL.	19058965
Activity (binding)		Activity at RXRbeta ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay	ChEMBL.	19058965
EC50 (binding)	= 26 nM	Activity at human RARbeta ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay	ChEMBL.	19058965
EC50 (binding)	= 91 nM	Activity at human RARgamma ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay	ChEMBL.	19058965
EC50 (binding)	> 1000 nM	Activity at human RARalpha ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay	ChEMBL.	19058965
Efficacy (binding)	< 10 %	Activity at human RARalpha ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation at 10 uM after 16 hrs by Gal4 response element-driven luciferase reporter gene assay relative to all-trans retinoic acid	ChEMBL.	19058965
Efficacy (binding)	= 48 %	Activity at human RARgamma ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay relative to all-trans retinoic acid	ChEMBL.	19058965
Efficacy (binding)	= 50 %	Activity at human RARbeta ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay relative to all-trans retinoic acid	ChEMBL.	19058965

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL468608

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1180443