TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 625.77 | Formula: C32H43N13O
H donors: 3 H acceptors: 6 LogP: 5.34 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: CN1CCN(CC1)c1nc(NCCCCOc2nc(Nc3ccccc3)nc(n2)N2CCN(CC2)C)nc(n1)Nc1ccccc1
InChi: 1S/C32H43N13O/c1-42-16-20-44(21-17-42)30-37-27(36-28(38-30)34-25-11-5-3-6-12-25)33-15-9-10-24-46-32-40-29(35-26-13-7-4-8-14-26)39-31(41-32)45-22-18-43(2)19-23-45/h3-8,11-14H,9-10,15-24H2,1-2H3,(H,35,39,40,41)(H2,33,34,36,37,38)
InChiKey: ADCXFCDFZXRDCX-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	heat shock protein 83-1	0.0033	0.01	0.0237
Onchocerca volvulus		0.003	0.0082	0.0682
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0018	0.0023	0.0035
Schistosoma mansoni	hypothetical protein	0.0452	0.2254	0.5842
Echinococcus multilocularis	neuropeptides capa receptor	0.0018	0.0023	0.0023
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0018	0.002	0.0281
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0287	0.1404	0.1403
Schistosoma mansoni	opsin-like receptor	0.0018	0.0023	0.0035
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0023	0.0023
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0018	0.0023	0.0023
Schistosoma mansoni	amine GPCR	0.0018	0.0023	0.0035
Schistosoma mansoni	hypothetical protein	0.0018	0.0023	0.0035
Trichomonas vaginalis	heat shock protein, putative	0.0027	0.0065	0.0258
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0077	0.0324	0.0821
Brugia malayi	hypothetical protein	0.0018	0.0023	0.0022
Echinococcus granulosus	7tm_1 domain containing protein	0.0018	0.0023	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Schistosoma mansoni	ferritin light chain	0.0018	0.002	0.0029
Toxoplasma gondii	exonuclease III APE	0.0018	0.0022	0.0287
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0077	0.0324	0.1729
Loa Loa (eye worm)	doublecortin family protein	0.0043	0.015	0.015
Echinococcus multilocularis	lamin dm0	0.003	0.0082	0.0092
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0084	0.0358	0.8793
Trypanosoma brucei	cytochrome P450, putative	0.0016	0.0012	0.0008
Brugia malayi	neuropeptide F receptor	0.0018	0.0023	0.0022
Brugia malayi	Endoplasmin precursor	0.0033	0.01	0.0099
Schistosoma mansoni	endoplasmin	0.0033	0.01	0.0237
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0023	0.0035
Trichomonas vaginalis	glucosylceramidase, putative	0.0287	0.1404	0.7921
Schistosoma mansoni	ferritin light chain	0.0018	0.002	0.0029
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0039	0.0128	0.0309
Schistosoma mansoni	heat shock protein	0.0033	0.01	0.0237
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0018	0.0023	0.0035
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0018	0.0023	0.0022
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0077	0.0324	0.0819
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.0762	0.3847	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0018	0.0023	0.0041
Toxoplasma gondii	hypothetical protein	0.0026	0.0063	0.1164
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0254	0.1232	0.1231
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0023	0.0023
Treponema pallidum	heat shock protein 90	0.0027	0.0065	0.1511
Echinococcus granulosus	lipoxygenase domain containing protein	0.0043	0.015	0.0304
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0009	0.0008
Schistosoma mansoni	neuropeptide f receptor 76f	0.0018	0.0023	0.0035
Echinococcus granulosus	lamin dm0	0.003	0.0082	0.0163
Echinococcus multilocularis	neuropeptide receptor A26	0.096	0.4865	0.5657
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0022	0.0035
Trypanosoma cruzi	cytochrome P450, putative	0.0016	0.0012	0.0008
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0018	0.0023	0.0035
Echinococcus multilocularis	serotonin receptor	0.0018	0.0023	0.0023
Brugia malayi	G-protein coupled receptor	0.0018	0.0023	0.0022
Echinococcus granulosus	neuropeptide Y receptor	0.0018	0.0023	0.0041
Echinococcus granulosus	neuropeptide receptor	0.0018	0.0023	0.0041
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0018	0.0023	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0314	0.1542	0.1542
Loa Loa (eye worm)	glutathione reductase	0.0037	0.0117	0.0117
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0011	0.001
Giardia lamblia	Grp94/Hsp90	0.0027	0.0065	0.0246
Echinococcus multilocularis	geminin	0.0361	0.1782	0.207
Echinococcus multilocularis	fmrfamide receptor	0.0018	0.0023	0.0023
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0023	0.0023
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0012	0.0011
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0077	0.0324	0.1739
Echinococcus granulosus	lipoxygenase domain containing protein	0.0043	0.015	0.0304
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0022	0.0035
Echinococcus multilocularis	lamin	0.003	0.0082	0.0092
Schistosoma mansoni	ap endonuclease	0.0018	0.0022	0.0034
Echinococcus multilocularis	serotonin receptor	0.0018	0.0023	0.0023
Loa Loa (eye worm)	latrophilin receptor protein 2	0.008	0.0341	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0018	0.0023	0.0023
Mycobacterium tuberculosis	Probable reductase	0.0084	0.0358	0.8793
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.0324	0.1739
Echinococcus multilocularis	expressed protein	0.0018	0.002	0.002
Loa Loa (eye worm)	G-protein coupled receptor	0.0018	0.0023	0.0023
Echinococcus granulosus	RUN	0.0043	0.015	0.0304
Leishmania major	heat shock protein 83-1	0.0033	0.01	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0116	0.0523	0.1069
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0023	0.0041
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0063	0.143
Echinococcus multilocularis	snurportin 1	0.0352	0.1737	0.2018
Onchocerca volvulus		0.0032	0.0092	0.0795
Plasmodium vivax	multidomain scavenger receptor, putative	0.0043	0.015	0.306
Trichomonas vaginalis	conserved hypothetical protein	0.0314	0.1542	0.8711
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0377	0.0377
Brugia malayi	hypothetical protein	0.0068	0.0279	0.0278
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.0184	0.4402
Brugia malayi	Bromodomain containing protein	0.0087	0.0376	0.0375
Leishmania major	heat shock protein 83-1	0.0033	0.01	0.0237
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0066	0.0262
Trypanosoma brucei	Heat shock protein 83, putative	0.0033	0.01	0.0237
Schistosoma mansoni	ferritin	0.0018	0.002	0.0029
Echinococcus granulosus	geminin	0.0361	0.1782	0.366
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0023	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0076	0.0318	0.6691
Entamoeba histolytica	hypothetical protein	0.0027	0.0066	0.145
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0047	0.0172	0.0348
Plasmodium falciparum	endoplasmin, putative	0.002	0.0034	0.0537
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0082	0.0348	0.0711
Entamoeba histolytica	hypothetical protein	0.004	0.0133	0.3677
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Toxoplasma gondii	thioredoxin reductase	0.0037	0.0117	0.2338
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0023	0.0035
Leishmania major	heat shock protein 83-1	0.0033	0.01	0.0237
Brugia malayi	MH2 domain containing protein	0.0132	0.0608	0.0607
Leishmania major	hypothetical protein, conserved	0.0105	0.0471	0.1203
Echinococcus multilocularis	polycomb protein SCMH1	0.0102	0.0451	0.0521
Schistosoma mansoni	sex comb on midleg homolog	0.0102	0.0451	0.1148
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0023	0.0035
Brugia malayi	hypothetical protein	0.0018	0.0023	0.0022
Echinococcus multilocularis	heat shock protein 90	0.0033	0.01	0.0113
Schistosoma mansoni	hypothetical protein	0.0361	0.1782	0.4614
Trypanosoma cruzi	ISWI complex protein	0.0035	0.0107	0.0256
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0039	0.0128	0.0309
Echinococcus granulosus	histone lysine methyltransferase setb	0.0039	0.0132	0.0265
Trypanosoma brucei	heat shock protein 90, putative	0.0033	0.01	0.0237
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0183	0.0871	0.0871
Leishmania major	heat shock protein 83-1	0.0033	0.01	0.0237
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0116	0.0523	0.1336
Brugia malayi	hypothetical protein	0.0043	0.015	0.0149
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0352	0.1737	0.1737
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.0358	0.1767	1
Loa Loa (eye worm)	mbt repeat family protein	0.0102	0.0451	0.0451
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0102	0.0451	0.4896
Trichomonas vaginalis	glucosylceramidase, putative	0.0188	0.0897	0.5017
Echinococcus granulosus	ubiquitin specific protease 41	0.0077	0.0324	0.0661
Schistosoma mansoni	cpg binding protein	0.0032	0.0092	0.0216
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0018	0.0023	0.0023
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0023	0.0041
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0022	0.0035
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0077	0.0324	0.0819
Brugia malayi	Latrophilin receptor protein 2	0.008	0.0341	0.034
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.0318	0.0649
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0318	0.6691
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0023	0.0023
Leishmania major	heat shock protein 83-1	0.0033	0.01	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0018	0.0023	0.0041
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0037	0.012	0.0136
Trichomonas vaginalis	glucosylceramidase, putative	0.0198	0.0949	0.5315
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0023	0.0023
Echinococcus granulosus	neuropeptides capa receptor	0.0018	0.0023	0.0041
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0023	0.0035
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0023	0.0035
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0077	0.0324	0.0323
Schistosoma mansoni	zinc finger protein	0.0035	0.0107	0.0256
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0023	0.0023
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0043	0.015	0.0172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0023	0.0023
Plasmodium falciparum	thioredoxin reductase	0.0037	0.0117	0.2338
Brugia malayi	PHD-finger family protein	0.0058	0.0229	0.0228
Echinococcus granulosus	G protein coupled receptor 139	0.0018	0.0023	0.0041
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0022	0.004
Echinococcus granulosus	dnaJ subfamily B	0.0452	0.2254	0.4631
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0318	0.5
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0027	0.0065	0.1511
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0018	0.0023	0.0035
Echinococcus multilocularis	heat shock protein 90	0.0027	0.0065	0.0073
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0023	0.0023
Schistosoma mansoni	sex comb on midleg homolog	0.0102	0.0451	0.1148
Schistosoma mansoni	hypothetical protein	0.0018	0.0023	0.0035
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0023	0.0035
Loa Loa (eye worm)	CYP4Cod1	0.0016	0.0012	0.0012
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0023	0.0023
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0023	0.0041
Schistosoma mansoni	hypothetical protein	0.0621	0.3119	0.8093
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0023	0.0041
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0092	0.0092
Brugia malayi	RE15519p	0.0018	0.0023	0.0022
Schistosoma mansoni	loxhd1	0.0043	0.015	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0018	0.0023	0.0023
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0102	0.0451	0.1148
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0018	0.0023	0.0023
Loa Loa (eye worm)	MBCTL1	0.0116	0.0523	0.0523
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0018	0.0023	0.0022
Trichomonas vaginalis	glucosylceramidase, putative	0.0287	0.1404	0.7921
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.0184	0.424
Plasmodium falciparum	importin beta, putative	0.0033	0.0098	0.1928
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0018	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0098	0.0098
Plasmodium falciparum	LCCL domain-containing protein	0.0043	0.015	0.306
Echinococcus granulosus	biogenic amine 5HT receptor	0.0018	0.0023	0.0041
Schistosoma mansoni	peptidase Clp (S14 family)	0.0076	0.0318	0.0804
Schistosoma mansoni	hypothetical protein	0.0018	0.0023	0.0035
Toxoplasma gondii	aldehyde dehydrogenase	0.0067	0.0274	0.5736
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0084	0.0358	0.8758
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Echinococcus multilocularis	endoplasmin	0.0027	0.0065	0.0073
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.0274	0.0682
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0039	0.0128	0.0257
Onchocerca volvulus		0.0043	0.015	0.1463
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.008	0.0341	0.0394
Trypanosoma brucei	heat shock protein 90, putative	0.0033	0.01	0.0237
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0404	0.2004	0.2328
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0018	0.0023	0.0023
Schistosoma mansoni	zinc finger protein	0.0046	0.0167	0.041
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.01	0.0237
Schistosoma mansoni	lamin	0.003	0.0082	0.019
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0018	0.0023	0.0022
Schistosoma mansoni	hypothetical protein	0.0035	0.0107	0.0256
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0023	0.0041
Loa Loa (eye worm)	heat shock protein 90	0.0033	0.01	0.01
Echinococcus granulosus	expressed protein	0.0018	0.002	0.0036
Schistosoma mansoni	hypothetical protein	0.0352	0.1737	0.4497
Echinococcus multilocularis	dro:myosuppressin receptor	0.0018	0.0023	0.0023
Echinococcus granulosus	fmrfamide receptor	0.0018	0.0023	0.0041
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.0762	0.3847	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0404	0.0404
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0026	0.0063	0.1103
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0116	0.0523	0.0605
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0022	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0022	0.0287
Trypanosoma cruzi	trypanothione reductase, putative	0.0037	0.0117	0.0281
Brugia malayi	Dopamine receptor protein 1	0.0018	0.0023	0.0022
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0018	0.0023	0.0041
Echinococcus granulosus	sterol regulatory element binding protein	0.0314	0.1542	0.3165
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0039	0.0132	0.0318
Entamoeba histolytica	hypothetical protein	0.004	0.0133	0.3677
Loa Loa (eye worm)	PHD-finger family protein	0.0047	0.017	0.017
Schistosoma mansoni	hypothetical protein	0.0043	0.015	0.0368
Echinococcus multilocularis	protein patched	0.0314	0.1542	0.1791
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.0184	0.4402
Brugia malayi	Importin beta-1 subunit	0.0033	0.0098	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0552	0.0552
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0183	0.0871	0.2243
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0084	0.0358	0.8793
Leishmania major	heat shock protein 83-1	0.0033	0.01	0.0237
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0077	0.0324	0.0661
Trichomonas vaginalis	endoplasmin, putative	0.002	0.0034	0.0078
Leishmania major	heat shock protein 83-1	0.0033	0.01	0.0237
Echinococcus multilocularis	ferritin	0.0018	0.002	0.002
Schistosoma mansoni	neuropeptide F-like receptor	0.0018	0.0023	0.0035
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.008	0.0341	0.0696
Schistosoma mansoni	hypothetical protein	0.008	0.0341	0.0864
Echinococcus granulosus	heat shock protein 90	0.0033	0.01	0.02
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Loa Loa (eye worm)	MH2 domain-containing protein	0.0132	0.0608	0.0608
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0023	0.0035
Echinococcus multilocularis	microtubule associated protein 2	0.0763	0.3852	0.4479
Trypanosoma brucei	heat shock protein, putative	0.0033	0.01	0.0237
Schistosoma mansoni	neuropeptide F-like receptor	0.0018	0.0023	0.0035
Plasmodium vivax	importin-beta 2, putative	0.0033	0.0098	0.1928
Brugia malayi	Doublecortin family protein	0.0043	0.015	0.0149
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0018	0.0023	0.0023
Leishmania major	heat shock protein 83-1	0.0033	0.01	0.0237
Onchocerca volvulus	Huntingtin homolog	0.0121	0.0552	0.6058
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Mycobacterium tuberculosis	Probable oxidoreductase	0.0093	0.0406	1
Brugia malayi	Dopamine receptor	0.0018	0.0023	0.0022
Loa Loa (eye worm)	hypothetical protein	0.003	0.0082	0.0082
Trichomonas vaginalis	glucosylceramidase, putative	0.0287	0.1404	0.7921
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0023	0.0023
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0023	0.0035
Mycobacterium ulcerans	bacterioferritin BfrA	0.0018	0.002	0.0021
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0018	0.0023	0.0035
Echinococcus granulosus	neuropeptide FF receptor 2	0.0018	0.0023	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Schistosoma mansoni	cellular tumor antigen P53	0.0055	0.021	0.0523
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0018	0.0023	0.0035
Schistosoma mansoni	apoferritin-2	0.0018	0.002	0.0029
Echinococcus granulosus	neuropeptide Y receptor	0.0018	0.0023	0.0041
Trichomonas vaginalis	glucosylceramidase, putative	0.0287	0.1404	0.7921
Toxoplasma gondii	heat shock protein 90, putative	0.0033	0.01	0.1973
Loa Loa (eye worm)	melatonin receptor type 1A	0.0018	0.0023	0.0023
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0082	0.0348	0.0402
Toxoplasma gondii	heat shock protein HSP90	0.0033	0.01	0.1973
Schistosoma mansoni	amine GPCR	0.0018	0.0023	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0523	0.0523
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0318	0.6691
Echinococcus granulosus	tumor protein p63	0.0374	0.185	0.3799
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0023	0.0023
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0358	0.1767	1
Brugia malayi	Serotonin receptor	0.0018	0.0023	0.0022
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0318	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0318	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Brugia malayi	hypothetical protein	0.004	0.0133	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0077	0.0324	0.1739
Schistosoma mansoni	importin beta-1	0.0033	0.0098	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0451	0.0451
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0018	0.0023	0.0023
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0023	0.0035
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0012	0.0011
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0133	0.0152
Trichomonas vaginalis	glucosylceramidase, putative	0.0287	0.1404	0.7921
Echinococcus granulosus	intermediate filament protein	0.003	0.0082	0.0163
Onchocerca volvulus		0.0055	0.021	0.2144
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0098	0.0232
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0023	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Echinococcus granulosus	neuropeptide receptor A26	0.096	0.4865	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0023	0.0041
Echinococcus multilocularis	protein dispatched 1	0.0314	0.1542	0.1791
Echinococcus multilocularis	GPCR, family 2	0.008	0.0341	0.0394
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0318	0.5
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0022	0.0022
Trypanosoma cruzi	ISWI complex protein	0.0035	0.0107	0.0256
Schistosoma mansoni	heat shock protein	0.0033	0.01	0.0237
Trichomonas vaginalis	glucosylceramidase, putative	0.0287	0.1404	0.7921
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0009	0.0007
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0012	0.0012
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0023	0.0035
Echinococcus multilocularis	cpg binding protein	0.0038	0.0124	0.0141
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0023	0.0035
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0018	0.0023	0.0022
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0023	0.0035
Schistosoma mansoni	cpg binding protein	0.0038	0.0124	0.0298
Echinococcus granulosus	somatostatin receptor	0.0018	0.0023	0.0041
Brugia malayi	G protein-coupled receptor	0.0018	0.0023	0.0022
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0033	0.01	0.0446
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.0117	0.0117
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0009	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Onchocerca volvulus	Huntingtin homolog	0.0121	0.0552	0.6058
Schistosoma mansoni	polycystin 1-related	0.0043	0.015	0.0368
Entamoeba histolytica	heat shock protein 90, putative	0.0033	0.01	0.2581
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0022	0.0012
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0093	0.0406	1
Echinococcus multilocularis	sex peptide receptor	0.0018	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0436	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Plasmodium vivax	endoplasmin, putative	0.0033	0.01	0.1973
Schistosoma mansoni	intermediate filament proteins	0.003	0.0082	0.019
Echinococcus granulosus	zinc finger protein	0.0046	0.0167	0.0337
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.01	0.0237
Brugia malayi	hypothetical protein	0.0018	0.0023	0.0022
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0039	0.0132	0.015
Schistosoma mansoni	adenoreceptor	0.0018	0.0023	0.0035
Brugia malayi	hypothetical protein	0.0018	0.0023	0.0022
Brugia malayi	larval opioid receptor	0.0018	0.0023	0.0022
Schistosoma mansoni	hypothetical protein	0.008	0.0341	0.0864
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0022	0.0021
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0009	0.0007
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0009	0.0007
Echinococcus granulosus	heat shock protein	0.0033	0.01	0.02
Echinococcus multilocularis	zinc finger protein	0.0046	0.0167	0.0191
Echinococcus granulosus	SAM and MBT domain containing protein	0.0102	0.0451	0.0921
Plasmodium falciparum	ataxin-2 like protein, putative	0.0105	0.0471	1
Mycobacterium ulcerans	heat shock protein 90	0.0027	0.0065	0.0138
Brugia malayi	Serotonin receptor	0.0018	0.0023	0.0022
Schistosoma mansoni	patched 1	0.0314	0.1542	0.3988
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0047	0.0172	0.0197
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.008	0.0341	0.034
Plasmodium falciparum	glutathione reductase	0.0037	0.0117	0.2338
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0314	0.1542	0.3988
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0084	0.0358	0.8793
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.0274	0.0689
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Echinococcus granulosus	microtubule associated protein 2	0.0763	0.3852	0.7917
Echinococcus multilocularis	neuropeptide receptor	0.0018	0.0023	0.0023
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0023	0.0041
Echinococcus granulosus	hypothetical protein	0.0018	0.0023	0.0041
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0039	0.0132	0.0318
Loa Loa (eye worm)	transcription factor SMAD2	0.0132	0.0608	0.0608
Echinococcus granulosus	endoplasmin	0.0027	0.0065	0.0129
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0132	0.0132
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.0275	0.0692
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0018	0.0023	0.0041
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0093	0.0406	1
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.0762	0.3847	0.4473
Brugia malayi	hypothetical protein	0.0121	0.0552	0.0551
Echinococcus multilocularis	somatostatin receptor	0.0018	0.0023	0.0023
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0023	0.0023
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0082	0.0081
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0067	0.0274	0.0558
Echinococcus multilocularis	neuropeptide Y receptor	0.0018	0.0023	0.0023
Entamoeba histolytica	hypothetical protein	0.004	0.0133	0.3677
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0314	0.1542	0.1542
Trypanosoma brucei	PAB1-binding protein , putative	0.0105	0.0471	0.1203
Echinococcus granulosus	fetal alzheimer antigen falz	0.0053	0.0201	0.0408
Brugia malayi	G protein-coupled receptor F59B2.13	0.0018	0.0023	0.0022
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0023	0.0041
Echinococcus granulosus	biogenic amine 5HT receptor	0.0018	0.0023	0.0041
Echinococcus multilocularis	tumor protein p63	0.0374	0.185	0.2149
Echinococcus granulosus	allatostatin A receptor	0.0018	0.0023	0.0041
Toxoplasma gondii	HEAT repeat-containing protein	0.0033	0.0098	0.1928
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0183	0.0871	0.2243
Schistosoma mansoni	myosin xvIII	0.0018	0.0023	0.0035
Schistosoma mansoni	histamine h1 receptor	0.0018	0.0023	0.0035
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0077	0.0324	0.0374
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0067	0.0274	0.6669
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0018	0.0023	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0079	0.0079
Brugia malayi	Dopamine receptor protein 2	0.0018	0.0023	0.0022
Schistosoma mansoni	hypothetical protein	0.008	0.0341	0.0864
Leishmania major	heat shock protein 83-1	0.0033	0.01	0.0237
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0023	0.0041
Schistosoma mansoni	hypothetical protein	0.0173	0.0819	0.2109
Schistosoma mansoni	rab6-interacting	0.0043	0.015	0.0368
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0018	0.0023	0.0023
Leishmania major	heat shock protein 83-1	0.0033	0.01	0.0237
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0137	0.0635	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0055	0.021	0.021
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0026	0.0063	0.1164
Trichomonas vaginalis	heat shock protein, putative	0.002	0.0034	0.0078
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0082	0.0082
Echinococcus granulosus	Protein patched homolog 1	0.0314	0.1542	0.3165
Trichomonas vaginalis	glucosylceramidase, putative	0.0198	0.0949	0.5315
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0552	0.0552
Loa Loa (eye worm)	bromodomain containing protein	0.004	0.0135	0.0135
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0023	0.0041
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0133	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0819	0.0819
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Brugia malayi	hypothetical protein	0.0018	0.0023	0.0022
Schistosoma mansoni	hypothetical protein	0.004	0.0133	0.0323
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0018	0.0023	0.0035
Leishmania major	heat shock protein 83-1	0.0033	0.01	0.0237
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0027	0.0066	0.0148
Schistosoma mansoni	ap endonuclease	0.0018	0.0022	0.0034
Brugia malayi	mbt repeat family protein	0.0102	0.0451	0.045
Echinococcus granulosus	7TM GPCR rhodopsin	0.0018	0.0023	0.0041
Trypanosoma brucei	heat shock protein, putative	0.0033	0.01	0.0237
Leishmania major	heat shock protein 83-1	0.0033	0.01	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Trypanosoma cruzi	heat shock protein 90, putative	0.0033	0.01	0.0237
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0254	0.1232	0.1232
Schistosoma mansoni	cpg binding protein	0.0038	0.0124	0.0298
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0183	0.0871	0.1786
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0022	0.0069
Echinococcus multilocularis	musashi	0.003	0.0082	0.0092
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0023	0.0041
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.0318	0.7715
Brugia malayi	latrophilin 2 splice variant baaae	0.0173	0.0819	0.0819
Loa Loa (eye worm)	hypothetical protein	0.008	0.0341	0.0341
Loa Loa (eye worm)	TYRA-2 protein	0.0018	0.0023	0.0023
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.0184	0.0373
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0027	0.0065	0.1166
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0121	0.0549	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Echinococcus granulosus	thioredoxin glutathione reductase	0.0037	0.012	0.024
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Echinococcus multilocularis	Niemann Pick C1 protein	0.0314	0.1542	0.1791
Schistosoma mansoni	microtubule-associated protein tau	0.0763	0.3852	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0188	0.0897	0.5017
Brugia malayi	Probable ClpP-like protease	0.0076	0.0318	0.0317
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0318	0.0797
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0762	0.3847	1
Echinococcus granulosus	orexin receptor type 2	0.0018	0.0023	0.0041
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0022	0.0287
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.0762	0.3847	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.008	0.0341	0.0394
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0183	0.0871	0.2243
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0022	0.0333
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0022	0.0023
Schistosoma mansoni	hypothetical protein	0.008	0.0341	0.0864
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0404	0.2004	0.4115
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Loa Loa (eye worm)	neuropeptide F receptor	0.0018	0.0023	0.0023
Echinococcus granulosus	GPCR family 2	0.008	0.0341	0.0696
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0009	0.0007
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0018	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0121	0.0549	0.1124
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0183	0.0871	0.101
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0039	0.0128	0.0146
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0254	0.1232	0.1231
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0183	0.0871	0.1786
Echinococcus granulosus	polycomb protein SCMH1	0.0102	0.0451	0.0921
Echinococcus granulosus	serotonin receptor	0.0018	0.0023	0.0041
Schistosoma mansoni	opsin-like receptor	0.0018	0.0023	0.0035
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0053	0.0201	0.0231
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0063	0.1164
Brugia malayi	hypothetical protein	0.0018	0.0023	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Leishmania major	heat shock protein 83-1	0.0033	0.01	0.0237
Echinococcus granulosus	neuropeptide s receptor	0.096	0.4865	1
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0077	0.0324	0.0821
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0018	0.002	0.0281
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0077	0.0324	0.0661
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0018	0.0023	0.0023
Schistosoma mansoni	lipoxygenase	0.0121	0.0549	0.1406
Schistosoma mansoni	ferritin	0.0018	0.002	0.0029
Trichomonas vaginalis	heat shock protein, putative	0.0027	0.0065	0.0258
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0027	0.0065	0.1415
Brugia malayi	Thioredoxin reductase	0.0037	0.0117	0.0116
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0077	0.0324	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0023	0.0035
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0358	0.1767	1
Echinococcus multilocularis	fmrfamide receptor	0.0018	0.0023	0.0023
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0077	0.0324	0.0821
Plasmodium falciparum	ataxin-2 like protein, putative	0.0105	0.0471	1
Schistosoma mansoni	amine GPCR	0.0018	0.0023	0.0035
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0018	0.0023	0.0041
Mycobacterium ulcerans	bacterioferritin BfrB	0.0018	0.002	0.0021
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0023	0.0023
Echinococcus granulosus	lamin	0.003	0.0082	0.0163
Schistosoma mansoni	hypothetical protein	0.0361	0.1782	0.4614
Onchocerca volvulus		0.0043	0.015	0.1463
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0077	0.0324	0.0374
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.0184	0.0211
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0133	0.0323
Leishmania major	importin beta-1 subunit, putative	0.0027	0.0066	0.0148
Trichomonas vaginalis	glucosylceramidase, putative	0.0188	0.0897	0.5017
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0092	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Brugia malayi	RNA, U transporter 1	0.0094	0.0411	0.041
Echinococcus multilocularis	orexin receptor type 2	0.0018	0.0023	0.0023
Schistosoma mansoni	growth hormone secretagogue receptor	0.0018	0.0023	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0471	0.0471
Schistosoma mansoni	endoplasmin	0.0033	0.01	0.0237
Echinococcus multilocularis	Polycystic kidney disease protein	0.0043	0.015	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.0117	0.2338
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0358	0.1767	1
Echinococcus multilocularis	g-protein coupled receptor	0.0018	0.0023	0.0023
Echinococcus multilocularis	allatostatin A receptor	0.0018	0.0023	0.0023
Trypanosoma cruzi	PAB1-binding protein , putative	0.0105	0.0471	0.1203
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0018	0.0023	0.0041
Echinococcus granulosus	histone acetyltransferase MYST2	0.0116	0.0523	0.1069
Leishmania major	heat shock protein 83-1	0.0033	0.01	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0043	0.015	0.015
Brugia malayi	sulfakinin receptor protein	0.0018	0.0023	0.0022
Trypanosoma cruzi	heat shock protein 85, putative	0.0027	0.0065	0.0146
Trichomonas vaginalis	heat shock protein, putative	0.0033	0.01	0.0458
Echinococcus granulosus	Polycystic kidney disease protein	0.0043	0.015	0.0304
Schistosoma mansoni	ferritin	0.0018	0.002	0.0029
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1687	0.8597	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0105	0.0471	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.0274	0.0689
Plasmodium vivax	glutathione reductase, putative	0.0037	0.0117	0.2338
Schistosoma mansoni	lipoxygenase	0.0043	0.015	0.0368
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0009	0.0008
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0093	0.0406	1
Trypanosoma cruzi	cytochrome P450, putative	0.0016	0.0012	0.0008
Brugia malayi	glutathione reductase	0.0037	0.0117	0.0116
Entamoeba histolytica	heat shock protein 90, putative	0.0033	0.01	0.2581
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0318	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0137	0.0635	0.1301
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.0274	0.0682
Loa Loa (eye worm)	neuropeptide F receptor	0.0018	0.0023	0.0023
Echinococcus multilocularis	neuropeptide s receptor	0.096	0.4865	0.5657
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0003	0.0003
Echinococcus multilocularis	neuropeptides capa receptor	0.0018	0.0023	0.0023
Brugia malayi	hypothetical protein	0.0018	0.0023	0.0022
Brugia malayi	ORL1-like opioid receptor	0.0018	0.0023	0.0022
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0066	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Trypanosoma brucei	heat shock protein, putative	0.0033	0.01	0.0237
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0018	0.0023	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Echinococcus multilocularis	importin subunit beta 1	0.0033	0.0098	0.0111
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0183	0.0871	0.087
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.0762	0.3847	0.9987
Trypanosoma brucei	heat shock protein, putative	0.0033	0.01	0.0237
Brugia malayi	neuropeptide F receptor	0.0018	0.0023	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Brugia malayi	CHE-14 protein	0.0314	0.1542	0.1541
Trichomonas vaginalis	glucosylceramidase, putative	0.0188	0.0897	0.5017
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0082	0.0082
Trypanosoma cruzi	Heat shock protein 83, putative	0.0033	0.01	0.0237
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0023	0.0035
Brugia malayi	G-protein coupled receptor	0.0018	0.0023	0.0022
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0009	0.0013
Trichomonas vaginalis	heat shock protein, putative	0.0027	0.0065	0.0258
Echinococcus granulosus	neuropeptides capa receptor	0.0018	0.0023	0.0041
Trypanosoma cruzi	heat shock protein 90, putative	0.0027	0.0065	0.0146
Schistosoma mansoni	hypothetical protein	0.0047	0.017	0.0418
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0027	0.0065	0.0246
Brugia malayi	hypothetical protein	0.0018	0.0023	0.0022
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0018	0.0023	0.0035
Echinococcus multilocularis	heat shock protein	0.0033	0.01	0.0113
Brugia malayi	putative neuropeptide receptor	0.0018	0.0023	0.0022
Trichomonas vaginalis	importin beta-1, putative	0.0027	0.0066	0.0262
Leishmania major	hypothetical protein, conserved	0.0035	0.0107	0.0256
Trichomonas vaginalis	glucosylceramidase, putative	0.0188	0.0897	0.5017
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.0318	0.0367
Schistosoma mansoni	hypothetical protein	0.0018	0.0023	0.0035
Echinococcus multilocularis	dnaJ subfamily B	0.0452	0.2254	0.262
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0022	0.0035
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0102	0.0451	0.0521
Echinococcus granulosus	dro:myosuppressin receptor	0.0018	0.0023	0.0041
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0018	0.0023	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0762	0.3847	0.3847
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0027	0.0065	0.0129
Brugia malayi	intermediate filament protein	0.003	0.0082	0.0081
Trichomonas vaginalis	glucosylceramidase, putative	0.0188	0.0897	0.5017
Trypanosoma brucei	heat shock protein, putative	0.0033	0.01	0.0237
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0018	0.0023	0.0022
Trypanosoma brucei	trypanothione reductase	0.0037	0.0117	0.0281
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0318	0.0797
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0037	0.0117	0.2718
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0018	0.0023	0.0041
Leishmania major	cytochrome p450-like protein	0.0016	0.0012	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0067	0.0274	0.069
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0755	0.0755
Echinococcus multilocularis	neuropeptide Y receptor	0.0018	0.0023	0.0023
Echinococcus granulosus	cpg binding protein	0.0038	0.0124	0.0249
Echinococcus granulosus	sex peptide receptor	0.0018	0.0023	0.0041
Trypanosoma cruzi	PAB1-binding protein , putative	0.0105	0.0471	0.1203
Echinococcus granulosus	neuropeptide receptor	0.0018	0.0023	0.0041
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0053	0.0201	0.05
Brugia malayi	AKH receptor	0.0018	0.0023	0.0022
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0266	0.5558
Brugia malayi	GnHR receptor homolog	0.0018	0.0023	0.0022
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0116	0.0523	0.0522
Onchocerca volvulus		0.0102	0.0451	0.4896
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0022	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0287	0.1404	0.1404
Schistosoma mansoni	amine GPCR	0.0018	0.0023	0.0035
Leishmania major	trypanothione reductase	0.0037	0.0117	0.0281
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0183	0.0871	0.101
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0018	0.0023	0.0023
Brugia malayi	mbt repeat family protein	0.0102	0.0451	0.045
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0023	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Brugia malayi	Bromodomain containing protein	0.0172	0.0814	0.0813
Loa Loa (eye worm)	hypothetical protein	0.0043	0.015	0.015
Echinococcus granulosus	heat shock protein 90	0.0027	0.0065	0.0129
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0018	0.0023	0.0023
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0098	0.0232
Plasmodium vivax	heat shock protein 86, putative	0.0033	0.01	0.1973
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0023	0.0041
Echinococcus granulosus	g-protein coupled receptor	0.0018	0.0023	0.0041
Echinococcus multilocularis	RUN	0.0043	0.015	0.0172
Leishmania major	heat shock protein 83-1	0.0033	0.01	0.0237
Schistosoma mansoni	apoferritin-2	0.0018	0.002	0.0029
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0018	0.0023	0.0022
Plasmodium falciparum	heat shock protein 90	0.0033	0.01	0.1973
Entamoeba histolytica	hypothetical protein	0.004	0.0133	0.3677
Schistosoma mansoni	ferritin	0.0018	0.002	0.0029
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0011	0.0011
Schistosoma mansoni	rab6-interacting	0.0043	0.015	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0084	0.0358	0.8793
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0018	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Trypanosoma brucei	heat shock protein, putative	0.0033	0.01	0.0237
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0067	0.0274	0.0316
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.0762	0.3847	0.3846
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0018	0.0023	0.0035
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0762	0.3847	1
Onchocerca volvulus	Glucosylceramidase homolog	0.0188	0.0897	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.008	0.0341	0.0696
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0043	0.015	0.0172
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0022	0.0012
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0116	0.0523	0.0605
Trypanosoma cruzi	heat shock protein 90, putative	0.002	0.003	0.0054
Brugia malayi	putative neuropeptide receptor NPR1	0.0018	0.0023	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0023	0.0041
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.0762	0.3847	0.7906
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0077	0.0324	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0023
Echinococcus multilocularis	sterol regulatory element binding protein	0.0314	0.1542	0.1791
Brugia malayi	hypothetical protein	0.0018	0.0023	0.0022
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0027	0.0065	0.0146
Echinococcus multilocularis	neuropeptide receptor	0.0018	0.0023	0.0023
Brugia malayi	heat shock protein 90	0.0033	0.01	0.0099
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0012	0.0012
Trypanosoma brucei	ISWI complex protein	0.0035	0.0107	0.0256
Schistosoma mansoni	amine GPCR	0.0018	0.0023	0.0035
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0023	0.0035
Trichomonas vaginalis	glucosylceramidase, putative	0.0188	0.0897	0.5017
Schistosoma mansoni	bromodomain containing protein	0.0146	0.0677	0.1738
Leishmania major	heat shock protein 83-1	0.0033	0.01	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0254	0.1232	0.1232
Schistosoma mansoni	opsin-like receptor	0.0018	0.0023	0.0035
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.0274	0.0682
Brugia malayi	hypothetical protein	0.0018	0.0023	0.0022
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0018	0.0023	0.0041
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0018	0.0023	0.0023
Brugia malayi	hypothetical protein	0.0043	0.015	0.0149
Schistosoma mansoni	lamin	0.003	0.0082	0.019
Brugia malayi	hypothetical protein	0.0105	0.0471	0.047
Mycobacterium tuberculosis	Probable dehydrogenase	0.0084	0.0358	0.8793
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0318	0.6691
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0018	0.0023	0.0035
Echinococcus granulosus	ferritin	0.0018	0.002	0.0036
Echinococcus multilocularis	G protein coupled receptor 139	0.0018	0.0023	0.0023
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0018	0.0023	0.0023
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.01	0.0237
Echinococcus granulosus	Niemann Pick C1 protein	0.0314	0.1542	0.3165
Echinococcus multilocularis	ubiquitin specific protease 41	0.0077	0.0324	0.0374
Schistosoma mansoni	hypothetical protein	0.0047	0.0172	0.0424
Brugia malayi	Melatonin receptor type 1A	0.0018	0.0023	0.0022
Echinococcus granulosus	snurportin 1	0.0352	0.1737	0.3567
Trypanosoma brucei	heat shock protein, putative	0.0033	0.01	0.0237
Loa Loa (eye worm)	G-protein coupled receptor	0.0018	0.0023	0.0023
Trypanosoma brucei	heat shock protein, putative	0.0033	0.01	0.0237
Loa Loa (eye worm)	endoplasmin	0.0033	0.01	0.01
Onchocerca volvulus		0.003	0.0082	0.0682
Echinococcus granulosus	importin subunit beta 1	0.0033	0.0098	0.0196
Toxoplasma gondii	LsmAD domain-containing protein	0.0105	0.0471	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0009	0.0009
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0023	0.0035

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 1.33 uM	Antileishmanial activity against amastigote stage of Leishmania donovani MHOM/IN/80/Dd8 infected in mouse J-774A.1 cells after 72 hrs by luciferase reporter gene assay	ChEMBL.	24900613

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Leishmania donovani	ChEMBL23	24900613

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3091473

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1180545