Detailed information for compound 1180578

Basic information

Technical information
  • TDR Targets ID: 1180578
  • Name: 5-[1-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5 -yl)ethyl]-2-sulfanylidene-1,3-thiazolidin-4- one
  • MW: 292.421 | Formula: C8H8N2O2S4
  • H donors: 2 H acceptors: 2 LogP: 1.98 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C1SC(=S)NC1=O)C1SC(=S)NC1=O
  • InChi: 1S/C8H8N2O2S4/c1-2(3-5(11)9-7(13)15-3)4-6(12)10-8(14)16-4/h2-4H,1H3,(H,9,11,13)(H,10,12,14)
  • InChiKey: CAXCSMMWQXAWSL-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-[1-(4-oxo-2-thioxo-thiazolidin-5-yl)ethyl]-2-thioxo-thiazolidin-4-one
  • 5-[1-(4-oxo-2-thioxo-5-thiazolidinyl)ethyl]-2-thioxo-4-thiazolidinone
  • 5-[1-(4-keto-2-thioxo-thiazolidin-5-yl)ethyl]-2-thioxo-thiazolidin-4-one
  • NSC340024
  • Rhodanine, 5,5'-ethylidenedi-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0038 0.0922 0.1276
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0922 0.4501
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.039 0.1649
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0013 0.0193 0.0196
Loa Loa (eye worm) mbt repeat family protein 0.0057 0.1484 0.1632
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.113 0.1545
Echinococcus granulosus polycomb protein SCMH1 0.0057 0.1484 0.157
Entamoeba histolytica recQ family helicase, putative 0.0015 0.028 0.0889
Mycobacterium tuberculosis Conserved protein 0.0038 0.0922 0.1276
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0013 0.0193 0.0597
Schistosoma mansoni ferritin light chain 0.0009 0.0082 0.0075
Brugia malayi MH2 domain containing protein 0.0124 0.3434 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0013 0.0193 0.0196
Echinococcus multilocularis dna polymerase kappa 0.0073 0.1948 0.2086
Brugia malayi CXXC zinc finger family protein 0.0034 0.0814 0.2199
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.7295 1
Schistosoma mansoni importin beta-1 0.003 0.0694 0.0688
Echinococcus multilocularis dna polymerase eta 0.0072 0.1909 0.2042
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0878 0.12
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.1015 0.2797
Echinococcus granulosus expressed protein 0.0009 0.0082 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3144 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0922 0.2812
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0672 0.2003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0053 0.00000000046378
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.3144 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0228 0.6462 0.7112
Mycobacterium ulcerans lipase LipD 0.0038 0.0922 0.4501
Echinococcus granulosus cpg binding protein 0.0036 0.087 0.0886
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0065 0.1713 0.1825
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.1484 0.1478
Schistosoma mansoni ferritin light chain 0.0009 0.0082 0.0075
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0013 0.0193 0.0597
Echinococcus granulosus snurportin 1 0.0318 0.9056 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0922 0.1011
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.1091 0.6426
Trichomonas vaginalis esterase, putative 0.0038 0.0922 0.2812
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.1917 0.1912
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0922 0.1276
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0177 0.0304
Brugia malayi beta-lactamase family protein 0.0038 0.0922 0.2521
Leishmania major hypothetical protein, conserved 0.0038 0.0922 0.1026
Schistosoma mansoni ferritin 0.0009 0.0082 0.0075
Mycobacterium tuberculosis Conserved protein 0.0038 0.0922 0.1276
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0922 0.1276
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0013 0.0193 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1948 0.2666
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.039 0.0423
Echinococcus granulosus histone acetyltransferase MYST2 0.0065 0.1713 0.1825
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.1716 0.2349
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.1111 0.1518
Schistosoma mansoni ap endonuclease 0.0019 0.039 0.0383
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0044 0.1111 0.3532
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0044 0.1111 0.654
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0193 0.026
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3144 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0013 0.0193 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.113 0.1545
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.003 0.0689 0.0931
Schistosoma mansoni smad 0.0008 0.0075 0.0068
Trichomonas vaginalis importin beta-1, putative 0.0024 0.053 0.1545
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.2676 0.295
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.1111 0.1515
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.3144 0.3418
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.039 0.0487
Mycobacterium leprae Conserved hypothetical protein 0.0013 0.0193 0.1245
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0065 0.1713 0.1825
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0013 0.0193 0.0256
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.1015 0.1047
Schistosoma mansoni ferritin 0.0009 0.0082 0.0075
Trypanosoma brucei DNA polymerase eta, putative 0.0072 0.1909 0.2613
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0013 0.0193 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1948 0.2666
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0177 0.101
Schistosoma mansoni ran 0.0022 0.0466 0.0459
Loa Loa (eye worm) hypothetical protein 0.0045 0.113 0.1242
Loa Loa (eye worm) hypothetical protein 0.0038 0.0922 0.1011
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0013 0.0193 0.0196
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.1111 0.3422
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.3144 0.3418
Loa Loa (eye worm) beta-lactamase 0.0038 0.0922 0.1011
Brugia malayi Importin beta-1 subunit 0.003 0.0694 0.1842
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.039 0.1091
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0013 0.0193 0.0597
Trichomonas vaginalis ferritin, putative 0.0009 0.0082 0.0095
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0021 0.0429 0.2501
Giardia lamblia Kinase, PLK 0.0114 0.3144 1
Toxoplasma gondii ABC1 family protein 0.0038 0.0922 0.5422
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0922 0.9391
Schistosoma mansoni DNA helicase recq5 0.0012 0.0177 0.0171
Schistosoma mansoni Smad4 0.0008 0.0075 0.0068
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0013 0.0193 0.0196
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0466 0.5582
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0044 0.1111 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0466 0.5051
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0689 0.0936
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0318 0.9056 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0013 0.0193 0.0597
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0466 0.063
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.3144 0.9136
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0013 0.0193 0.0196
Leishmania major DNA polymerase eta, putative 0.0043 0.1091 0.1264
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0013 0.0193 0.0196
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0049 0.1246 0.1756
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0922 0.0916
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0013 0.0193 0.0597
Leishmania major GTP-binding protein, putative 0.0022 0.0466 0.0383
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.1015 0.1009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.053 0.1545
Mycobacterium ulcerans hypothetical protein 0.003 0.0689 0.3254
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.028 0.0378
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0197 0.0262
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.1091 0.1488
Trypanosoma brucei polo-like protein kinase 0.0114 0.3144 0.4307
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0044 0.1111 0.5513
Giardia lamblia DINP protein human, muc B family 0.0049 0.1246 0.3603
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.3144 0.4155
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0878 0.12
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0053 0.00000000046378
Schistosoma mansoni ferritin 0.0009 0.0082 0.0075
Mycobacterium ulcerans hypothetical protein 0.0013 0.0197 0.0618
Schistosoma mansoni apoferritin-2 0.0009 0.0082 0.0075
Loa Loa (eye worm) hypothetical protein 0.0038 0.0922 0.1011
Plasmodium vivax importin-beta 2, putative 0.003 0.0694 0.7526
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0053 0.00000000046378
Brugia malayi mbt repeat family protein 0.0057 0.1484 0.4194
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.039 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0177 0.0115
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0495 0.0488
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0922 0.2812
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0177 0.0115
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.1015 0.1114
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.3434 0.3788
Brugia malayi mbt repeat family protein 0.0057 0.1484 0.4194
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0922 0.1276
Plasmodium falciparum importin beta, putative 0.003 0.0694 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0197 0.0262
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0922 0.1276
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.028 0.0734
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1948 0.2666
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0922 0.2812
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.1948 0.2663
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.039 0.2991
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0082 0.0031
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.3144 1
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.7295 1
Echinococcus granulosus smad 0.0008 0.0075 0.0001
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0694 0.0946
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0082 0.0031
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0073 0.1948 0.613
Leishmania major DNA polymerase eta, putative 0.0072 0.1909 0.2415
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.6809 1
Mycobacterium leprae Probable lipase LipE 0.0038 0.0922 0.9391
Echinococcus granulosus cytochrome P450 2K1 0.0013 0.0193 0.0133
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0466 0.2719
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0065 0.1713 0.4875
Brugia malayi beta-lactamase family protein 0.0038 0.0922 0.2521
Echinococcus multilocularis ferritin 0.0009 0.0082 0.0009
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0197 0.0266
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.1948 1
Echinococcus granulosus importin subunit beta 1 0.003 0.0694 0.069
Mycobacterium tuberculosis Conserved protein 0.003 0.0689 0.0931
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.039 0.4113
Brugia malayi Cytochrome P450 family protein 0.0013 0.0193 0.0352
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.1948 0.2663
Trichomonas vaginalis inositol monophosphatase, putative 0.0044 0.1111 0.3422
Loa Loa (eye worm) hypothetical protein 0.0038 0.0922 0.1011
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0197 0.0262
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0392 0.2285
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3144 1
Brugia malayi cytochrome P450 0.0013 0.0193 0.0352
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0399 0.4329
Schistosoma mansoni ferritin 0.0009 0.0082 0.0075
Schistosoma mansoni inositol monophosphatase 0.0044 0.1111 0.1105
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3144 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0013 0.0193 0.0196
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0193 0.0206
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0013 0.0193 0.0597
Echinococcus granulosus dna polymerase kappa 0.0073 0.1948 0.2086
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.028 0.0121
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0074 0.0067
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0075 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0053 0.00000000046378
Entamoeba histolytica hypothetical protein 0.0024 0.053 0.1687
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0177 0.0115
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.1484 0.1478
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0013 0.0193 0.0597
Mycobacterium ulcerans hypothetical protein 0.003 0.0689 0.3254
Echinococcus multilocularis snurportin 1 0.0318 0.9056 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.039 0.0525
Trypanosoma brucei unspecified product 0.0065 0.1716 0.2349
Schistosoma mansoni DNA helicase recq1 0.0012 0.0177 0.0171
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.2676 0.2897
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1948 0.2666
Loa Loa (eye worm) hypothetical protein 0.0057 0.1484 0.1632
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.039 0.0351
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0013 0.0193 0.0597
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.147 0.4586
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.1694 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0922 0.1011
Echinococcus multilocularis smad 0.0008 0.0075 0.0001
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0814 0.0892
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0466 0.0436
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0177 0.0188
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.2676 0.2897
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0466 0.0436
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0976 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.2676 0.2671
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0075 0.0076
Echinococcus multilocularis importin subunit beta 1 0.003 0.0694 0.069
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0013 0.0193 0.0597
Onchocerca volvulus 0.0057 0.1484 0.2875
Entamoeba histolytica Ran family GTPase 0.0022 0.0466 0.1481
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.039 0.0716
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0134 0.0067
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0922 0.1276
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0922 0.1011
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0193 0.0597
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1948 0.2666
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0922 0.4501
Schistosoma mansoni myelin transcription factor 1 myt1 0.0065 0.1713 0.1707
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0922 0.2812
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0134 0.0067
Onchocerca volvulus 0.0038 0.0922 0.0463
Schistosoma mansoni cpg binding protein 0.0036 0.087 0.0864
Leishmania major DNA polymerase kappa, putative 0.0013 0.0197 0.0006
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3144 0.4305
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0193 0.0256
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0466 0.1162
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.039 0.4227
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.039 0.0529
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0922 0.1259
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0013 0.0193 0.0196
Mycobacterium ulcerans beta-lactamase 0.0038 0.0922 0.4501
Mycobacterium leprae putative cytochrome p450 0.0013 0.0193 0.1245
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0689 0.3254
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.1948 0.2663
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0193 0.0256
Brugia malayi Cytochrome P450 family protein 0.0058 0.1501 0.4246
Echinococcus granulosus Smad4 0.0008 0.0075 0.0001
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0466 0.0633
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3144 1
Echinococcus multilocularis cpg binding protein 0.0036 0.087 0.0886
Schistosoma mansoni cytochrome P450 0.0013 0.0193 0.0187
Leishmania major importin beta-1 subunit, putative 0.0024 0.053 0.0474
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0049 0.1246 0.1482
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0013 0.0193 0.0597
Leishmania major DNA polymerase kappa, putative 0.0049 0.1246 0.1482
Loa Loa (eye worm) cytochrome P450 0.0013 0.0193 0.0206
Trypanosoma cruzi DNA polymerase kappa, putative 0.0073 0.1948 0.2663
Echinococcus multilocularis Smad4 0.0008 0.0075 0.0001
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.1909 0.5458
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0922 0.0944
Schistosoma mansoni ran 0.0022 0.0466 0.0459
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0013 0.0193 0.0196
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.2676 0.2897
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0075 0.0001
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.3144 0.3467
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0922 0.1276
Toxoplasma gondii exonuclease III APE 0.0019 0.039 0.2269
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.039 0.1091
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1948 0.2666
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.039 0.0276
Brugia malayi Inositol-1 0.0044 0.1111 0.3082
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0922 0.1256
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.0689 0.0685
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.7295 1
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.3144 0.314
Onchocerca volvulus 0.0038 0.0922 0.0463
Loa Loa (eye worm) hypothetical protein 0.0146 0.407 0.449
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.2676 0.2671
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0878 0.12
Echinococcus multilocularis expressed protein 0.0009 0.0082 0.0009
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0689 0.0936
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0013 0.0193 0.0196
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0197 0.1129
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.1015 0.1009
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0466 0.0507
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.1015 0.1413
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0177 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1948 0.2666
Loa Loa (eye worm) hypothetical protein 0.003 0.0694 0.0759
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0013 0.0193 0.026
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.057 0.7596
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0177 0.0115
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0013 0.0193 0.0597
Loa Loa (eye worm) inositol-1 0.0044 0.1111 0.122
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0922 0.2812
Schistosoma mansoni cpg binding protein 0.0036 0.087 0.0864
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0193 0.0256
Schistosoma mansoni hypothetical protein 0.0013 0.0193 0.0187
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0013 0.0193 0.0597
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0013 0.0193 0.0597
Schistosoma mansoni DNA polymerase eta 0.0072 0.1909 0.1903
Schistosoma mansoni kinase 0.0058 0.1514 0.1508
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0197 0.0262
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0013 0.0193 0.0196
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0057 0.1484 0.2875
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.053 0.1545
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0013 0.0193 0.0597
Schistosoma mansoni inositol monophosphatase 0.0044 0.1111 0.1105
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.2676 0.2897
Trypanosoma brucei unspecified product 0.0028 0.0647 0.0882
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0197 0.0266
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0197 0.2141
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.1111 0.1515
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1948 0.2666
Echinococcus granulosus bloom syndrome protein 0.0029 0.0672 0.0666
Schistosoma mansoni apoferritin-2 0.0009 0.0082 0.0075
Brugia malayi polk-prov protein 0.0045 0.113 0.3142
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0075 0.0001
Toxoplasma gondii cytochrome p450 superfamily protein 0.0013 0.0193 0.1106
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0013 0.0193 0.0196
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.039 0.0936
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0922 0.0916
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0922 0.2521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.2676 0.2671
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0672 0.1777
Brugia malayi Cytochrome P450 family protein 0.0013 0.0193 0.0352
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3144 0.4305
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0193 0.0206
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.053 0.0718
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0197 0.0191
Loa Loa (eye worm) hypothetical protein 0.0065 0.1713 0.1885
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0013 0.0193 0.0196
Onchocerca volvulus 0.0038 0.0922 0.0463
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0689 0.3254
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0976 0.1357
Trichomonas vaginalis DNA polymerase eta, putative 0.0073 0.1948 0.613
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0053 0.00000000046378
Loa Loa (eye worm) hypothetical protein 0.0012 0.0177 0.0188
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.1909 0.2609
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.1948 0.2666
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.003 0.0689 0.3254
Schistosoma mansoni hypothetical protein 0.0318 0.9056 0.9056
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0057 0.1484 0.1478
Trichomonas vaginalis Citrate lyase beta chain, putative 0.003 0.0689 0.2059
Echinococcus granulosus ferritin 0.0009 0.0082 0.0009
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0197 0.0266
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0193 0.0206
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0053 0.00000000046378
Loa Loa (eye worm) hypothetical protein 0.0072 0.1909 0.2102
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0013 0.0193 0.0597
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.2676 0.7743
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0013 0.0193 0.0196
Schistosoma mansoni smad1 5 8 and 0.0008 0.0075 0.0068
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0013 0.0193 0.0597
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.1246 0.1704
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3144 1
Echinococcus multilocularis inositol monophosphatase 1 0.0044 0.1111 0.1154
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0197 0.0389
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.3434 0.3788
Schistosoma mansoni cpg binding protein 0.0034 0.0814 0.0808
Schistosoma mansoni smad1 5 8 and 0.0008 0.0075 0.0068
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.1015 0.1047
Schistosoma mansoni smad1 5 8 and 0.0008 0.0075 0.0068
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0075 0.0001
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0466 0.0972
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.039 0.0525
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0922 0.0944
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0672 0.2003
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0013 0.0193 0.0597
Echinococcus multilocularis 0.0013 0.0193 0.0133
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0694 0.0946
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0193 0.0256
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.013 0.0164
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3144 1
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0082 0.1966
Brugia malayi Cytochrome P450 family protein 0.0013 0.0193 0.0352
Trypanosoma brucei unspecified product 0.0028 0.0647 0.0882
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0013 0.0193 0.0597
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0922 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0013 0.0193 0.0597
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0075 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0922 0.1256
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0922 0.1276
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.028 0.0374
Mycobacterium ulcerans hypothetical protein 0.0038 0.0922 0.4501
Brugia malayi beta-lactamase 0.0038 0.0922 0.2521
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0013 0.0193 0.0196
Echinococcus granulosus SAM and MBT domain containing protein 0.0057 0.1484 0.157
Leishmania major hypothetical protein, conserved 0.0257 0.7295 1
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0197 0.0266
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0013 0.0193 0.0196
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0694 0.4071
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.039 0.0351
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0053 0.00000000046378
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.039 0.1239
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0228 0.6462 0.7112
Trypanosoma brucei DNA polymerase kappa, putative 0.0073 0.1948 0.2666
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0672 0.0666
Echinococcus granulosus dna polymerase eta 0.0072 0.1909 0.2042
Brugia malayi RNA, U transporter 1 0.0085 0.2287 0.6585
Giardia lamblia DNA damage repair protein 0.0013 0.0197 0.0068
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0197 0.0266
Echinococcus multilocularis polycomb protein SCMH1 0.0057 0.1484 0.157
Echinococcus multilocularis histone acetyltransferase MYST2 0.0065 0.1713 0.1825
Loa Loa (eye worm) RecQ helicase 0.0029 0.0672 0.0735
Loa Loa (eye worm) histone methyltransferase 0.001 0.0134 0.0141
Trichomonas vaginalis ran, putative 0.0022 0.0466 0.1336
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.1948 0.2666
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0075 0.0076
Loa Loa (eye worm) hypothetical protein 0.0038 0.0922 0.1011
Mycobacterium ulcerans DNA polymerase IV 0.0073 0.1948 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0013 0.0193 0.0196
Loa Loa (eye worm) MBCTL1 0.0065 0.1713 0.1885
Loa Loa (eye worm) Smad1 0.0008 0.0075 0.0076
Echinococcus granulosus inositol monophosphatase 1 0.0044 0.1111 0.1154
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0466 0.063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0053 0.00000000046378
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.1111 0.3422
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.1501 0.1652
Leishmania major DNA damage repair protein, putative 0.0013 0.0197 0.0006
Schistosoma mansoni ap endonuclease 0.0019 0.039 0.0383
Entamoeba histolytica recQ family DNA helicase 0.0006 0.0007 0.0021
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0689 0.0698
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0177 0.101
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.147 0.4586
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.1111 0.1292
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0013 0.0193 0.0597
Echinococcus multilocularis SAM and MBT domain containing protein 0.0057 0.1484 0.157
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.0689 0.0685
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.1015 0.3227

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 45.4 uM PUBCHEM_BIOASSAY: Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 52.4 uM PUBCHEM_BIOASSAY: Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 80 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 80 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in an orthogonal absorbance-based assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: Dose Response validation of uHTS RPN11 inhibitor hits using a MMP-2 Fluorescence assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.1192 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3778 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 9.5283 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.8336 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 42.2841 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 42.5615 uM PubChem BioAssay. qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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