Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0141 | 0.697 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0044 | 0.1979 | 1 |
Schistosoma mansoni | ferritin | 0.001 | 0.0257 | 0.0257 |
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 0.0961 | 0.0742 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0016 | 0.0567 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0044 | 0.1979 | 1 |
Schistosoma mansoni | smad | 0.001 | 0.0236 | 0.0236 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0236 | 0.0316 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.001 | 0.0246 | 0.001 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0394 | 0.1991 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.001 | 0.0246 | 0.0331 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.1979 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.001 | 0.0246 | 0.001 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.001 | 0.0236 | 0.0236 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.001 | 0.0246 | 0.5 |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.0961 | 0.1359 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.587 | 0.8419 |
Loa Loa (eye worm) | Smad1 | 0.001 | 0.0236 | 0.0316 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.0813 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.1979 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0044 | 0.1979 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0019 | 0.0705 | 0.0705 |
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0257 | 0.0257 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0236 | 0.0316 |
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0257 | 0.0257 |
Schistosoma mansoni | inositol monophosphatase | 0.0044 | 0.1979 | 0.1979 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.0961 | 0.4087 |
Echinococcus granulosus | expressed protein | 0.001 | 0.0257 | 0.0021 |
Schistosoma mansoni | ferritin | 0.001 | 0.0257 | 0.0257 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.1979 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0044 | 0.1979 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0141 | 0.697 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0039 | 0.1745 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.0961 | 0.4087 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0236 | 0.0316 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0257 | 0.0257 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0236 | 0.0316 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0246 | 0.1244 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0044 | 0.1979 | 0.1785 |
Echinococcus multilocularis | expressed protein | 0.001 | 0.0257 | 0.0021 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0044 | 0.1979 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.001 | 0.0246 | 0.001 |
Brugia malayi | Smad1 | 0.001 | 0.0236 | 0.0316 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0044 | 0.1979 | 0.1785 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 0.0961 | 0.0742 |
Schistosoma mansoni | DNA helicase recq1 | 0.001 | 0.0246 | 0.0246 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0016 | 0.0557 | 0.2815 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.001 | 0.0246 | 0.001 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0044 | 0.1979 | 1 |
Schistosoma mansoni | Smad4 | 0.001 | 0.0236 | 0.0236 |
Loa Loa (eye worm) | inositol-1 | 0.0044 | 0.1979 | 0.2823 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0246 | 0.1244 |
Echinococcus granulosus | ferritin | 0.001 | 0.0257 | 0.0021 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.1979 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0236 | 0.0236 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0236 | 0.0236 |
Schistosoma mansoni | inositol monophosphatase | 0.0044 | 0.1979 | 0.1979 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.001 | 0.0236 | 0.0316 |
Brugia malayi | MH2 domain containing protein | 0.0141 | 0.697 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0039 | 0.1745 | 1 |
Schistosoma mansoni | ferritin | 0.001 | 0.0257 | 0.0257 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0246 | 0.0331 |
Schistosoma mansoni | ferritin | 0.001 | 0.0257 | 0.0257 |
Brugia malayi | Inositol-1 | 0.0044 | 0.1979 | 0.2823 |
Echinococcus multilocularis | ferritin | 0.001 | 0.0257 | 0.0021 |
Schistosoma mansoni | DNA helicase recq5 | 0.001 | 0.0246 | 0.0246 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0236 | 0.0236 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 0.0961 | 0.1359 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0044 | 0.1979 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0246 | 0.0331 |
Treponema pallidum | bacterioferrin (TpF1) | 0.001 | 0.0257 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0246 | 0.0331 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0257 | 0.0257 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.001 | 0.0236 | 0.0316 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0013 | 0.0394 | 0.0796 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.