Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0863 | 0.5223 | 0.5223 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.077 | 0.4651 | 0.4532 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0117 | 0.0117 |
Brugia malayi | Bromodomain containing protein | 0.0086 | 0.0409 | 0.0359 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0747 | 0.0747 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.4651 | 0.4651 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0117 | 0.0103 |
Brugia malayi | hypothetical protein | 0.0141 | 0.0747 | 0.0699 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.077 | 0.4651 | 0.4643 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.0218 | 0.0204 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.077 | 0.4651 | 0.4643 |
Loa Loa (eye worm) | hypothetical protein | 0.0863 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.4651 | 0.4651 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.0229 | 0.0179 |
Brugia malayi | hypothetical protein | 0.077 | 0.4651 | 0.4623 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.077 | 0.4651 | 0.4643 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0747 | 0.0747 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.4651 | 0.4651 |
Brugia malayi | conserved hypotetical protein | 0.077 | 0.4651 | 0.4623 |
Schistosoma mansoni | bromodomain containing protein | 0.0073 | 0.0325 | 0.0312 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0035 | 0.0021 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0054 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0055 | 0.0218 | 0.0204 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0054 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0054 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.03 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0378 | 0.0378 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.4651 | 0.4651 |
Brugia malayi | tailless protein | 0.077 | 0.4651 | 0.4623 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.077 | 0.4651 | 0.4643 |
Brugia malayi | hypothetical protein | 0.0863 | 0.5223 | 0.5199 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0863 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.0863 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.077 | 0.4651 | 0.4651 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0272 | 0.1559 | 0.1548 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0863 | 0.5223 | 0.5199 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.4651 | 0.4651 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0054 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0054 | 0.0054 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.077 | 0.4651 | 0.4643 |
Brugia malayi | Nuclear hormone receptor E75 | 0.077 | 0.4651 | 0.4623 |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.0147 | 0.0096 |
Brugia malayi | nuclear receptor NHR-67 | 0.077 | 0.4651 | 0.4623 |
Brugia malayi | Nuclear hormone receptor E75 | 0.077 | 0.4651 | 0.4623 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.4651 | 0.4651 |
Onchocerca volvulus | 0.077 | 0.4651 | 0.4532 | |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0041 | 0.013 | 0.0117 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.077 | 0.4651 | 0.4532 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0054 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0502 | 0.0502 |
Loa Loa (eye worm) | DR-78 | 0.077 | 0.4651 | 0.4651 |
Onchocerca volvulus | Huntingtin homolog | 0.0141 | 0.0747 | 0.0541 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0863 | 0.5223 | 0.5217 |
Brugia malayi | nuclear hormone receptor | 0.077 | 0.4651 | 0.4623 |
Onchocerca volvulus | Huntingtin homolog | 0.0141 | 0.0747 | 0.0541 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.077 | 0.4651 | 0.4623 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.077 | 0.4651 | 0.4643 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.1559 | 0.1559 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.077 | 0.4651 | 0.4643 |
Schistosoma mansoni | eyes absent homolog | 0.0101 | 0.0502 | 0.0489 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0055 | 0.0218 | 0.0167 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.077 | 0.4651 | 0.4643 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0164 | 0.0164 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.077 | 0.4651 | 0.4643 |
Brugia malayi | hypothetical protein | 0.0863 | 0.5223 | 0.5199 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.077 | 0.4651 | 0.4643 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0021 | 0.0021 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0932 | 0.5653 | 0.5647 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0035 | 0.0021 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0054 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.077 | 0.4651 | 0.4651 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.077 | 0.4651 | 0.4623 |
Brugia malayi | hypothetical protein | 0.077 | 0.4651 | 0.4623 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0178 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.4651 | 0.4651 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0054 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0863 | 0.5223 | 0.5223 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.4651 | 0.4651 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0035 | 0.0021 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0054 | 0.5 |
Brugia malayi | hypothetical protein | 0.0272 | 0.1559 | 0.1515 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0148 | 0.0148 |
Brugia malayi | nuclear receptor RXR | 0.077 | 0.4651 | 0.4623 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0863 | 0.5223 | 0.5217 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.077 | 0.4651 | 0.4643 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.03 | 0.0286 |
Brugia malayi | nuclear receptor NHR-88 | 0.077 | 0.4651 | 0.4623 |
Brugia malayi | nuclear receptor RXR | 0.0863 | 0.5223 | 0.5199 |
Brugia malayi | ecdysone receptor | 0.077 | 0.4651 | 0.4623 |
Schistosoma mansoni | nuclear hormone receptor | 0.077 | 0.4651 | 0.4643 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.077 | 0.4651 | 0.4643 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0021 | 0.0008 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0863 | 0.5223 | 0.5217 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.077 | 0.4651 | 0.4643 |
Schistosoma mansoni | zinc finger protein | 0.077 | 0.4651 | 0.4643 |
Schistosoma mansoni | nuclear receptor | 0.077 | 0.4651 | 0.4643 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0863 | 0.5223 | 0.5199 |
Onchocerca volvulus | 0.077 | 0.4651 | 0.4532 | |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0863 | 0.5223 | 0.5217 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.0229 | 0.0229 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.0229 | 0.0179 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.077 | 0.4651 | 0.4623 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.077 | 0.4651 | 0.4643 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.077 | 0.4651 | 0.4643 |
Loa Loa (eye worm) | hypothetical protein | 0.0863 | 0.5223 | 0.5223 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0117 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0502 | 0.0502 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.4651 | 0.4651 |
Schistosoma mansoni | nuclear hormone receptor | 0.077 | 0.4651 | 0.4643 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0272 | 0.1559 | 0.1548 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0054 | 0.0002 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0041 | 0.013 | 0.0117 |
Brugia malayi | hypothetical protein | 0.0101 | 0.0502 | 0.0453 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.077 | 0.4651 | 0.4651 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.077 | 0.4651 | 0.4623 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0229 | 0.0229 |
Schistosoma mansoni | nuclear receptor | 0.077 | 0.4651 | 0.4643 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.0625 ug ml-1 | Antifungal activity against Candida albicans Y0109 after 24 hrs by micro-broth dilution method | ChEMBL. | 20675019 |
MIC (functional) | < 0.125 ug ml-1 | Antifungal activity against Candida albicans SC5314 after 24 hrs by micro-broth dilution method | ChEMBL. | 20675019 |
MIC (functional) | = 32 ug ml-1 | Antifungal activity against Cryptococcus neoformans after 72 hrs by micro-broth dilution method | ChEMBL. | 20675019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.