Detailed information for compound 1181114

Basic information

Technical information
  • TDR Targets ID: 1181114
  • Name: T5560961
  • MW: 475.533 | Formula: C23H26FN3O5S
  • H donors: 1 H acceptors: 4 LogP: 1.89 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1S(=O)(=O)N1CCCCC1)NC(=O)C1CC(=O)N(C1)c1ccccc1F
  • InChi: 1S/C23H26FN3O5S/c1-32-20-10-9-17(14-21(20)33(30,31)26-11-5-2-6-12-26)25-23(29)16-13-22(28)27(15-16)19-8-4-3-7-18(19)24/h3-4,7-10,14,16H,2,5-6,11-13,15H2,1H3,(H,25,29)
  • InChiKey: DACVUMYCMCZLFM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni apoferritin-2 0.001 0.0062 0.0062
Schistosoma mansoni cpg binding protein 0.0031 0.0376 0.0376
Mycobacterium leprae Probable lipase LipE 0.0036 0.0453 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0528 0.1588
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0705 0.2119
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0528 0.0528
Echinococcus multilocularis tar DNA binding protein 0.019 0.2681 0.2681
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0182 0.0182
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0068 0.0068
Toxoplasma gondii ABC1 family protein 0.0036 0.0453 0.4471
Schistosoma mansoni ferritin 0.001 0.0062 0.0062
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0787 0.0787
Loa Loa (eye worm) hypothetical protein 0.0204 0.2889 0.8684
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0068 0.0205
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.1037 0.1037
Echinococcus granulosus ferritin 0.001 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0168 0.2373 0.2373
Brugia malayi beta-lactamase family protein 0.0036 0.0453 0.1361
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0068 0.0068
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0787 0.0787
Schistosoma mansoni cpg binding protein 0.0031 0.0376 0.0376
Brugia malayi RNA recognition motif domain containing protein 0.019 0.2681 0.806
Schistosoma mansoni thyroid hormone receptor 0.0134 0.1869 0.1869
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0528 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0306 0.336
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0306 0.2048
Schistosoma mansoni hypothetical protein 0.0064 0.0862 0.0862
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.3303 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0453 0.8512
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0306 0.6242
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0182 0.0182
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0352 0.1058
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0306 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0306 0.0752
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.003 0.003
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0453 0.1205
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0787 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0862 0.2591
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0787 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0056 0.0056
Schistosoma mansoni thyroid hormone receptor 0.0134 0.1869 0.1869
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0453 0.1205
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0453 0.8512
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0453 0.1205
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.1724 0.1724
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.1283 0.3856
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0205
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0528 0.0528
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0068 0.0205
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0787 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.003 0.003
Leishmania major hypothetical protein, conserved 0.0036 0.0453 0.4471
Loa Loa (eye worm) hypothetical protein 0.0064 0.0862 0.2591
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0832 0.0832
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0528 0.0528
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0068 0.0068
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0306 0.5
Loa Loa (eye worm) beta-lactamase 0.0036 0.0453 0.1361
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0306 0.2048
Loa Loa (eye worm) hypothetical protein 0.0093 0.1283 0.3856
Schistosoma mansoni ferritin 0.001 0.0062 0.0062
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0068 0.0068
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0306 0.2048
Loa Loa (eye worm) hypothetical protein 0.0139 0.1951 0.5863
Brugia malayi isocitrate dehydrogenase 0.0018 0.0182 0.0547
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0068 0.0068
Brugia malayi ecdysteroid receptor 0.001 0.0068 0.0205
Brugia malayi follicle stimulating hormone receptor 0.0234 0.3327 1
Brugia malayi beta-lactamase family protein 0.0036 0.0453 0.1361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0068 0.0205
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0068 0.0068
Schistosoma mansoni tar DNA-binding protein 0.019 0.2681 0.2681
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0205
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0182 0.0182
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0528 0.5718
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0453 0.8512
Mycobacterium ulcerans hypothetical protein 0.0036 0.0453 0.5383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0068 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0068 0.0205
Trichomonas vaginalis ferritin, putative 0.001 0.0062 0.0819
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0528 0.0528
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0453 0.1205
Schistosoma mansoni hypothetical protein 0.0124 0.1724 0.1724
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0453 0.7819
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0068 0.0205
Schistosoma mansoni tar DNA-binding protein 0.019 0.2681 0.2681
Brugia malayi CXXC zinc finger family protein 0.0029 0.0352 0.1058
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0068 0.0068
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.003 0.003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0735 0.9133
Mycobacterium ulcerans lipase LipD 0.0036 0.0453 0.5383
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0068 0.0068
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0182 0.0182
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0528 1
Loa Loa (eye worm) RNA binding protein 0.019 0.2681 0.806
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0453 0.1205
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0068 0.0205
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0453 0.5383
Entamoeba histolytica hypothetical protein 0.0077 0.1037 1
Echinococcus granulosus cpg binding protein 0.0031 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0205
Entamoeba histolytica hypothetical protein 0.0077 0.1037 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.2889 0.8684
Echinococcus multilocularis geminin 0.0168 0.2373 0.2373
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0862 0.0862
Brugia malayi nuclear hormone receptor 0.001 0.0068 0.0205
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0182 0.0547
Schistosoma mansoni tar DNA-binding protein 0.019 0.2681 0.2681
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0787 0.2238
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0761 0.2157
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0068 0.0068
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0453 0.1361
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0068 0.0205
Schistosoma mansoni hypothetical protein 0.0077 0.1037 0.1037
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0453 0.7819
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1264 0.1264
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0068 0.0068
Brugia malayi steroid hormone receptor 0.001 0.0068 0.0205
Schistosoma mansoni cpg binding protein 0.0029 0.0352 0.0352
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0056 0.0169
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.1951 0.5863
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0068 0.0068
Echinococcus multilocularis thyroid hormone receptor alpha 0.0134 0.1869 0.1869
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0453 0.1205
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.1037 0.1037
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.2889 0.8684
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0068 0.0068
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0761 0.0761
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0068 0.0205
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0761 0.2288
Schistosoma mansoni apoferritin-2 0.001 0.0062 0.0062
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0068 0.0068
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0528 0.304
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0862 0.2591
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1264 0.1264
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0453 0.0453
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0761 0.0761
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0528 0.0528
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0068 0.0068
Echinococcus multilocularis ferritin 0.001 0.0062 0.0062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1264 0.1264
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0036 0.0453 0.1361
Loa Loa (eye worm) hypothetical protein 0.0042 0.0528 0.1588
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0068 0.0068
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.1283 0.1283
Echinococcus multilocularis cpg binding protein 0.0031 0.0376 0.0376
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0068 0.0068
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0862 0.0862
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0306 1
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0306 0.3581
Mycobacterium ulcerans beta-lactamase 0.0036 0.0453 0.5383
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0787 0.0787
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0182 0.0369
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0182 0.0182
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.1724 0.1724
Schistosoma mansoni ferritin 0.001 0.0062 0.0062
Onchocerca volvulus 0.0029 0.0352 0.2335
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0068 0.0068
Schistosoma mansoni coup transcription factor 0.001 0.0068 0.0068
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0453 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0205
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0761 0.9639
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.1037 0.1037
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0068 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0068 0.0205
Schistosoma mansoni hypothetical protein 0.0139 0.1951 0.1951
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0068 0.0205
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0528 1
Entamoeba histolytica hypothetical protein 0.0077 0.1037 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0528 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0068 0.0205
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0453 0.1361
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0862 0.2591
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1264 0.1264
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.003 0.003
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0306 0.336
Brugia malayi RNA binding protein 0.019 0.2681 0.806
Schistosoma mansoni hypothetical protein 0.0064 0.0862 0.0862
Schistosoma mansoni ferritin light chain 0.001 0.0062 0.0062
Mycobacterium tuberculosis Conserved protein 0.0036 0.0453 0.1205
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0453 0.5383
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1264 0.1264
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0068 0.0205
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0453 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.019 0.2681 0.806
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.2889 0.8684
Schistosoma mansoni tar DNA-binding protein 0.019 0.2681 0.2681
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0068 0.0205
Echinococcus multilocularis expressed protein 0.001 0.0062 0.0062
Echinococcus granulosus expressed protein 0.001 0.0062 0.0062
Onchocerca volvulus 0.0036 0.0453 0.3165
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0453 0.0453
Brugia malayi nuclear receptor NHR-88 0.001 0.0068 0.0205
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0862 0.0862
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0068 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0068 0.0205
Onchocerca volvulus 0.0036 0.0453 0.3165
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0453 0.8512
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0761 0.9568
Schistosoma mansoni hypothetical protein 0.0064 0.0862 0.0862
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0068 0.0068
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0528 0.0528
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0453 0.1205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0068 0.0205
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.1283 0.1283
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0068 0.0205
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.1264 0.3798
Brugia malayi beta-lactamase 0.0036 0.0453 0.1361
Trichomonas vaginalis esterase, putative 0.0036 0.0453 0.8512
Schistosoma mansoni ferritin 0.001 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0205
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.1283 0.1283
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0306 0.458
Loa Loa (eye worm) hypothetical protein 0.0036 0.0453 0.1361
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0205
Schistosoma mansoni tar DNA-binding protein 0.019 0.2681 0.2681
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0787 1
Echinococcus multilocularis GPCR, family 2 0.0064 0.0862 0.0862
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.1264 0.3798
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0453 0.0453
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0068 0.0205
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0182 0.0547
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.3327 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0064 0.0862 0.0862
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0205
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0761 0.0761
Onchocerca volvulus 0.0093 0.1283 1
Echinococcus granulosus GPCR family 2 0.0064 0.0862 0.0862
Mycobacterium tuberculosis Conserved protein 0.0036 0.0453 0.1205
Schistosoma mansoni hypothetical protein 0.0168 0.2373 0.2373
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0528 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0453 0.8512
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0068 0.0205
Loa Loa (eye worm) TAR-binding protein 0.019 0.2681 0.806
Echinococcus granulosus FTZ F1 alpha 0.001 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0205
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0054 0.0164
Loa Loa (eye worm) hypothetical protein 0.0036 0.0453 0.1361
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0068 0.0205
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0068 0.0068
Echinococcus granulosus geminin 0.0168 0.2373 0.2373
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0182 0.0182
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0182 0.0182
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0453 0.0453
Brugia malayi TAR-binding protein 0.019 0.2681 0.806
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0528 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0453 0.1361
Loa Loa (eye worm) hypothetical protein 0.0036 0.0453 0.1361
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0068 0.0205
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0068 0.0068
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0056 0.0056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1264 0.1264
Echinococcus granulosus tar DNA binding protein 0.019 0.2681 0.2681
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0787 0.0787
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0528 0.0528
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1264 0.1264
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0862 0.0862
Schistosoma mansoni nuclear hormone receptor 0.001 0.0068 0.0068
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0068 0.0068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0068 0.0068
Entamoeba histolytica hypothetical protein 0.0077 0.1037 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0306 1
Brugia malayi hypothetical protein 0.0077 0.1037 0.3118
Mycobacterium tuberculosis Conserved protein 0.0036 0.0453 0.1205
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0787 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0453 0.7819
Schistosoma mansoni ferritin light chain 0.001 0.0062 0.0062
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.003 0.003
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0761 0.9639
Onchocerca volvulus 0.0036 0.0453 0.3165
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0528 0.0528
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0036 0.0453 0.1361
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0528 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0068 0.0205

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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