Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | 0.0433 | 0.1045 | 0.1045 |
Brugia malayi | thymidylate synthase | 0.091 | 0.226 | 0.2243 |
Loa Loa (eye worm) | thymidylate synthase | 0.091 | 0.226 | 0.2244 |
Brugia malayi | hypothetical protein | 0.0433 | 0.1045 | 0.1026 |
Mycobacterium ulcerans | thymidylate synthase | 0.091 | 0.226 | 0.226 |
Onchocerca volvulus | 0.0031 | 0.0021 | 0.0093 | |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0102 | 0.0082 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2698 | 0.6806 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0261 | 0.0242 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2698 | 0.6806 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.091 | 0.226 | 0.226 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2698 | 0.6806 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2698 | 0.6806 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.091 | 0.226 | 0.2243 |
Leishmania major | pteridine reductase 1 | 0.0404 | 0.0971 | 0.1427 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0021 | 0.0001 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2698 | 0.6806 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.0535 | 0.0517 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0021 | 0.0001 |
Onchocerca volvulus | 0.091 | 0.226 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0433 | 0.1045 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2698 | 0.6806 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.091 | 0.226 | 0.2243 |
Onchocerca volvulus | 0.0031 | 0.0021 | 0.0093 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0433 | 0.1045 | 0.1535 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.0108 | 0.0217 | 0.0196 |
Trypanosoma brucei | pteridine reductase 1 | 0.0399 | 0.0958 | 0.1407 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0296 | 0.0695 | 0.0675 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0021 | 0.0001 |
Echinococcus granulosus | thymidylate synthase | 0.091 | 0.226 | 0.2243 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 10 ng/ml | Cytotoxicity against human KB cells | ChEMBL. | 2128517 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 2128517 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.