Detailed information for compound 1181594

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 410.546 | Formula: C26H34O4
  • H donors: 1 H acceptors: 2 LogP: 5.73 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)C[C@@H]1[C@](O2)(C)CC[C@H]2[C@@]1(C)CC[C@@H]1[C@@]32CCC[C@@]1(C)C(=O)OC3
  • InChi: 1S/C26H34O4/c1-23-11-7-20-24(2)9-4-10-26(20,15-29-22(24)28)19(23)8-12-25(3)21(23)14-16-13-17(27)5-6-18(16)30-25/h5-6,13,19-21,27H,4,7-12,14-15H2,1-3H3/t19-,20-,21-,23+,24+,25-,26-/m0/s1
  • InChiKey: HFVKLEZASUROTL-PFCQETGDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0564 0.8749
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0892
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0045 0.1893
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.004 0.0137 0.0347
Schistosoma mansoni hypothetical protein 0.0107 0.0527 0.1331
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0116 0.0585 0.1478
Brugia malayi hypothetical protein 0.0107 0.0527 0.1331
Entamoeba histolytica hypothetical protein 0.0038 0.0121 0.1641
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0239 0.0602
Loa Loa (eye worm) neuropeptide F receptor 0.0107 0.0527 0.1313
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0107 0.0527 0.1313
Brugia malayi Dopamine receptor 0.0107 0.0527 0.1331
Echinococcus granulosus uncharacterized sodium dependent transporter 0.004 0.0137 0.0347
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0008 0.0128
Onchocerca volvulus 0.0107 0.0527 0.3954
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Schistosoma mansoni peroxidasin 0.0078 0.0361 0.0911
Loa Loa (eye worm) hypothetical protein 0.0116 0.0585 0.146
Onchocerca volvulus 0.0116 0.0585 0.4406
Echinococcus granulosus sex peptide receptor 0.0107 0.0527 0.1331
Brugia malayi RE15519p 0.0107 0.0527 0.1331
Schistosoma mansoni neuropeptide f receptor 76f 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Echinococcus multilocularis neuropeptide receptor 0.0107 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0029
Schistosoma mansoni growth hormone secretagogue receptor 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0107 0.0527 0.1313
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.0239 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0239 0.0583
Schistosoma mansoni opsin-like receptor 0.0107 0.0527 0.1331
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0239 1
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0008 0.043
Echinococcus granulosus allatostatin A receptor 0.0107 0.0527 0.1331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.002 0.0029
Schistosoma mansoni neuropeptide receptor 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0892
Plasmodium falciparum glutathione reductase 0.0049 0.0191 1
Schistosoma mansoni myosin xvIII 0.0107 0.0527 0.1331
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.002 0.005
Schistosoma mansoni hypothetical protein 0.0032 0.0088 0.0221
Loa Loa (eye worm) solute carrier family 6 member 4 0.0238 0.1304 0.3277
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0105 0.0518 0.1307
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.0137 0.0137
Schistosoma mansoni alpha-1 adrenergic receptor 0.0107 0.0527 0.1331
Echinococcus granulosus hypothetical protein 0.0107 0.0527 0.1331
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0116 0.0585 0.0585
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.002 0.005
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.002 0.005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0107 0.0527 0.0527
Brugia malayi hypothetical protein 0.0107 0.0527 0.1331
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0564 0.8837
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0116 0.0585 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0045 0.0114
Onchocerca volvulus 0.0107 0.0527 0.3954
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.002 0.005
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0892
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0191 0.0191
Loa Loa (eye worm) acetylcholinesterase 1 0.0689 0.3962 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0002 0.0035
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0002 0.0035
Brugia malayi G-protein coupled receptor 0.0107 0.0527 0.1331
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0107 0.0527 0.0527
Brugia malayi larval opioid receptor 0.0107 0.0527 0.1331
Schistosoma mansoni BC026374 protein (S09 family) 0.0116 0.0585 0.1478
Echinococcus granulosus serotonin receptor 0.0107 0.0527 0.1331
Loa Loa (eye worm) TYRA-2 protein 0.0107 0.0527 0.1313
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0002 0.0035
Echinococcus granulosus g protein coupled receptor 0.0107 0.0527 0.1331
Brugia malayi hypothetical protein 0.0514 0.2933 0.7403
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Brugia malayi hypothetical protein 0.004 0.0137 0.0347
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0361 0.0911
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0137 0.0327
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0239 1
Brugia malayi G-protein coupled receptor 0.0107 0.0527 0.1331
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Brugia malayi AKH receptor 0.0107 0.0527 0.1331
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.0767 0.1935
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.0137 0.0347
Plasmodium vivax glutathione reductase, putative 0.0049 0.0191 1
Echinococcus granulosus neuropeptide receptor A26 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0107 0.0527 0.1331
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0107 0.0527 0.1313
Brugia malayi hypothetical protein 0.0107 0.0527 0.1331
Echinococcus multilocularis fmrfamide receptor 0.0107 0.0527 0.0527
Echinococcus granulosus rhodopsin orphan GPCR 0.0107 0.0527 0.1331
Brugia malayi Serotonin receptor 0.0107 0.0527 0.1331
Schistosoma mansoni opsin-like receptor 0.0107 0.0527 0.1331
Onchocerca volvulus 0.0107 0.0527 0.3954
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.002 0.0029
Trypanosoma brucei protein kinase, putative 0.0058 0.0239 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0107 0.0527 0.1331
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Loa Loa (eye worm) hypothetical protein 0.0689 0.3962 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.004 0.0137 0.0327
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.0137 0.0137
Loa Loa (eye worm) serotonin transporter b 0.0238 0.1304 0.3277
Brugia malayi hypothetical protein 0.0078 0.0361 0.0911
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0107 0.0527 0.1331
Onchocerca volvulus 0.0107 0.0527 0.3954
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Schistosoma mansoni neuropeptide F-like receptor 0.0107 0.0527 0.1331
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0137 0.0327
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0638 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0107 0.0527 0.0527
Echinococcus granulosus biogenic amine 5HT receptor 0.0107 0.0527 0.1331
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0045 0.0771
Brugia malayi CHE-14 protein 0.0044 0.0159 0.0403
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.002 0.005
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Onchocerca volvulus 0.0078 0.0361 0.2657
Onchocerca volvulus 0.0116 0.0585 0.4406
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0892
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Brugia malayi MAP kinase sur-1 0.0058 0.0239 0.0602
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.002 0.005
Mycobacterium tuberculosis Probable reductase 0.0113 0.0564 0.8837
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0107 0.0527 0.1331
Schistosoma mansoni acetylcholinesterase 0.0116 0.0585 0.1478
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0564 0.8837
Onchocerca volvulus 0.0107 0.0527 0.3954
Brugia malayi Blistered cuticle protein 3 0.0078 0.0361 0.0911
Brugia malayi Dopamine receptor protein 2 0.0107 0.0527 0.1331
Onchocerca volvulus 0.0107 0.0527 0.3954
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0045 0.0771
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.004 0.0137 0.0347
Schistosoma mansoni opsin-like receptor 0.0107 0.0527 0.1331
Echinococcus granulosus carboxylesterase 5A 0.0689 0.3962 1
Echinococcus multilocularis neuropeptide s receptor 0.0107 0.0527 0.0527
Plasmodium vivax amine transporter, putative 0.004 0.0137 0.7211
Echinococcus multilocularis rhodopsin orphan GPCR 0.0107 0.0527 0.0527
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0137 0.0347
Echinococcus granulosus rhodopsin orphan GPCR 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0069 0.0307 0.0754
Schistosoma mansoni hypothetical protein 0.0043 0.015 0.0379
Loa Loa (eye worm) carboxylesterase 0.0689 0.3962 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0107 0.0527 0.0527
Onchocerca volvulus 0.0116 0.0585 0.4406
Loa Loa (eye worm) hypothetical protein 0.004 0.0137 0.0327
Echinococcus multilocularis g-protein coupled receptor 0.0107 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.004 0.0137 0.0327
Echinococcus granulosus serotonin transporter 0.0238 0.1304 0.329
Loa Loa (eye worm) hypothetical protein 0.0116 0.0585 0.146
Onchocerca volvulus 0.0116 0.0585 0.4406
Echinococcus multilocularis acetylcholinesterase 0.0689 0.3962 0.3962
Echinococcus multilocularis neuropeptide receptor A26 0.0107 0.0527 0.0527
Onchocerca volvulus 0.0107 0.0527 0.3954
Echinococcus granulosus survival motor neuron protein 1 0.0514 0.2933 0.7403
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0191 0.0461
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Echinococcus multilocularis sex peptide receptor 0.0107 0.0527 0.0527
Echinococcus multilocularis protein patched 0.0044 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Brugia malayi Steroid receptor seven-up type 2 0.002 0.002 0.005
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.002 0.005
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Echinococcus granulosus neuropeptide receptor 0.0107 0.0527 0.1331
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.002 0.005
Loa Loa (eye worm) melatonin receptor type 1A 0.0107 0.0527 0.1313
Brugia malayi Thioredoxin reductase 0.0049 0.0191 0.0481
Schistosoma mansoni hypothetical protein 0.0107 0.0527 0.1331
Echinococcus granulosus g protein coupled receptor 0.0107 0.0527 0.1331
Brugia malayi neuropeptide F receptor 0.0107 0.0527 0.1331
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0121 0.0305
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0564 0.8837
Schistosoma mansoni patched 1 0.0044 0.0159 0.0403
Echinococcus granulosus neuropeptide Y receptor 0.0107 0.0527 0.1331
Echinococcus multilocularis GPCR, family 2 0.0032 0.0088 0.0088
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0107 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0116 0.0585 0.146
Onchocerca volvulus Peroxidasin homolog 0.0078 0.0361 0.2657
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0116 0.0585 0.9172
Onchocerca volvulus Peroxidase homolog 0.0078 0.0361 0.2657
Schistosoma mansoni thyroid hormone receptor 0.002 0.002 0.005
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0045 0.0771
Echinococcus multilocularis carboxylesterase 5A 0.0689 0.3962 0.3962
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0239 0.4074
Schistosoma mansoni hypothetical protein 0.0043 0.015 0.0379
Echinococcus multilocularis serotonin receptor 0.0107 0.0527 0.0527
Brugia malayi hypothetical protein 0.0107 0.0527 0.1331
Onchocerca volvulus 0.0107 0.0527 0.3954
Brugia malayi Serotonin receptor 0.0107 0.0527 0.1331
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0191 0.0481
Schistosoma mansoni coup transcription factor 0.002 0.002 0.005
Onchocerca volvulus Dual oxidase homolog 0.0078 0.0361 0.2657
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0101 0.0495 0.1232
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.002 0.005
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0107 0.0527 0.1331
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.002 0.002
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0045 0.0114
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0239 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0239 0.0239
Echinococcus multilocularis fmrfamide receptor 0.0107 0.0527 0.0527
Onchocerca volvulus Neuropeptide F receptor homolog 0.0107 0.0527 0.3954
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0088 0.0088
Treponema pallidum sodium- and chloride- dependent transporter 0.0238 0.1304 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Brugia malayi hypothetical protein 0.0107 0.0527 0.1331
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0239 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0116 0.0585 0.1478
Brugia malayi glutathione reductase 0.0049 0.0191 0.0481
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0191 0.2985
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.002 0.005
Schistosoma mansoni hypothetical protein 0.0069 0.0307 0.0774
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0045 0.0771
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0892
Plasmodium falciparum transporter, putative 0.004 0.0137 0.7211
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0088 0.0201
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Echinococcus granulosus 7TM GPCR rhodopsin 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.004 0.0137 0.0327
Loa Loa (eye worm) hypothetical protein 0.0689 0.3962 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.002 0.005
Echinococcus granulosus BC026374 protein S09 family 0.0116 0.0585 0.1478
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0116 0.0585 0.1478
Onchocerca volvulus 0.0078 0.0361 0.2657
Loa Loa (eye worm) hypothetical protein 0.0103 0.0506 0.1259
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0564 0.8837
Loa Loa (eye worm) hypothetical protein 0.0514 0.2933 0.7397
Loa Loa (eye worm) blistered cuticle protein 3 0.0078 0.0361 0.0892
Onchocerca volvulus 0.0107 0.0527 0.3954
Brugia malayi Carboxylesterase family protein 0.0116 0.0585 0.1478
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0107 0.0527 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.002 0.005
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.004 0.0137 0.0347
Loa Loa (eye worm) hypothetical protein 0.004 0.0137 0.0327
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.002 0.002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0107 0.0527 0.1331
Echinococcus granulosus peroxidasin 0.0078 0.0361 0.0911
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0107 0.0527 0.1331
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0107 0.0527 0.1331
Brugia malayi ecdysteroid receptor 0.002 0.002 0.005
Brugia malayi hypothetical protein 0.0116 0.0585 0.1478
Echinococcus granulosus uncharacterized sodium dependent transporter 0.004 0.0137 0.0347
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.0506 0.1277
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0361 0.0911
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0107 0.0527 0.1331
Entamoeba histolytica hypothetical protein 0.0038 0.0121 0.1641
Schistosoma mansoni hypothetical protein 0.0032 0.0088 0.0221
Mycobacterium tuberculosis Carboxylesterase LipT 0.0116 0.0585 0.9172
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0107 0.0527 0.1331
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.004 0.0137 0.0137
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0495 0.125
Schistosoma mansoni amine GPCR 0.0107 0.0527 0.1331
Echinococcus granulosus orexin receptor type 2 0.0107 0.0527 0.1331
Echinococcus granulosus rhodopsin orphan GPCR 0.0107 0.0527 0.1331
Onchocerca volvulus 0.0107 0.0527 0.3954
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0088 0.0221
Loa Loa (eye worm) hypothetical protein 0.0116 0.0585 0.146
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0045 0.1893
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.002 0.0029
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.004 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0892
Leishmania major trypanothione reductase 0.0049 0.0191 0.7989
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.0506 0.1277
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0045 0.0707
Echinococcus multilocularis serotonin transporter 0.0238 0.1304 0.1304
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0689 0.3962 1
Echinococcus granulosus G protein coupled receptor 139 0.0107 0.0527 0.1331
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0159 0.0383
Echinococcus multilocularis survival motor neuron protein 1 0.0514 0.2933 0.2933
Echinococcus multilocularis g protein coupled receptor 0.0107 0.0527 0.0527
Trichomonas vaginalis spcc417.12 protein, putative 0.0116 0.0585 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.002 0.005
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0239 1
Echinococcus granulosus neuroligin 0.0116 0.0585 0.1478
Echinococcus multilocularis neuropeptides capa receptor 0.0107 0.0527 0.0527
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.002 0.005
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0107 0.0527 0.1313
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0239 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.002 0.005
Schistosoma mansoni hypothetical protein 0.0038 0.0121 0.0305
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0107 0.0527 0.0527
Schistosoma mansoni amine GPCR 0.0107 0.0527 0.1331
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0239 0.0602
Echinococcus granulosus g-protein coupled receptor 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Brugia malayi sulfakinin receptor protein 0.0107 0.0527 0.1331
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.0506 1
Schistosoma mansoni amine GPCR 0.0107 0.0527 0.1331
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.002 0.005
Brugia malayi neuropeptide F receptor 0.0107 0.0527 0.1331
Echinococcus granulosus GPCR family 2 0.0032 0.0088 0.0221
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.002 0.005
Echinococcus granulosus expressed conserved protein 0.0097 0.0469 0.1184
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0137 0.5761
Echinococcus granulosus alpha 1A adrenergic receptor 0.0107 0.0527 0.1331
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0107 0.0527 0.0527
Schistosoma mansoni sodium/chloride dependent transporter 0.0041 0.014 0.0355
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0137 0.5761
Echinococcus multilocularis rhodopsin orphan GPCR 0.0107 0.0527 0.0527
Brugia malayi putative neuropeptide receptor 0.0107 0.0527 0.1331
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0107 0.0527 0.0527
Echinococcus multilocularis peroxidasin 0.0078 0.0361 0.0361
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0137 0.0347
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0638 1
Onchocerca volvulus Chorion peroxidase homolog 0.0078 0.0361 0.2657
Echinococcus granulosus tachykinin peptides receptor 99D 0.0107 0.0527 0.1331
Schistosoma mansoni neuroligin 3 (S09 family) 0.0116 0.0585 0.1478
Echinococcus multilocularis neuropeptides capa receptor 0.0107 0.0527 0.0527
Plasmodium vivax hypothetical protein, conserved 0.004 0.0137 0.7211
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0191 0.7989
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0107 0.0527 0.1331
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.004 0.0137 0.0327
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0239 1
Brugia malayi nuclear receptor NHR-88 0.002 0.002 0.005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0093
Schistosoma mansoni peroxidasin 0.0078 0.0361 0.0911
Brugia malayi Carboxylesterase family protein 0.0689 0.3962 1
Brugia malayi nuclear hormone receptor 0.002 0.002 0.005
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.004 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0116 0.0585 0.146
Brugia malayi G protein-coupled receptor F59B2.13 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0892
Loa Loa (eye worm) hypothetical protein 0.0238 0.1304 0.3277
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0088 0.0221
Schistosoma mansoni neuropeptide receptor 0.0107 0.0527 0.1331
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0495 0.125
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0088 0.0221
Schistosoma mansoni hypothetical protein 0.0032 0.0088 0.0221
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0107 0.0527 0.0527
Loa Loa (eye worm) steroid hormone receptor 0.002 0.002 0.0029
Schistosoma mansoni survival motor neuron protein 0.0105 0.0518 0.1307
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0892
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.002 0.005
Brugia malayi Carboxylesterase family protein 0.0116 0.0585 0.1478
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.004 0.0137 1
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0307 0.0774
Echinococcus multilocularis rhodopsin orphan GPCR 0.0107 0.0527 0.0527
Echinococcus granulosus acetylcholinesterase 0.0689 0.3962 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0239 0.0602
Loa Loa (eye worm) hypothetical protein 0.0116 0.0585 0.146
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0045 0.0771
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0361 0.0892
Loa Loa (eye worm) hypothetical protein 0.0238 0.1304 0.3277
Loa Loa (eye worm) hypothetical protein 0.004 0.0137 0.0327
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.0137 0.0347
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.002 0.005
Schistosoma mansoni gliotactin 0.0116 0.0585 0.1478
Toxoplasma gondii hypothetical protein 0.004 0.0137 0.5761
Entamoeba histolytica hypothetical protein 0.0038 0.0121 0.1641
Echinococcus granulosus neuropeptides capa receptor 0.0107 0.0527 0.1331
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.002 0.005
Onchocerca volvulus 0.0107 0.0527 0.3954
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.002 0.005
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0361 0.0892
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0107 0.0527 0.1331
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0045 0.0114
Loa Loa (eye worm) hypothetical protein 0.0032 0.0088 0.0201
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0361 0.0892
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0107 0.0527 0.0527
Schistosoma mansoni nuclear hormone receptor 0.002 0.002 0.005
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0008 0.043
Echinococcus multilocularis neuropeptide receptor 0.0107 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0238 0.1304 0.3277
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0892
Toxoplasma gondii hypothetical protein 0.004 0.0137 0.5761
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0239 0.4074
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0029
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0159 0.0403
Echinococcus granulosus FTZ F1 alpha 0.002 0.002 0.005
Echinococcus granulosus rhodopsin orphan GPCR 0.0107 0.0527 0.1331
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0045 0.0707
Schistosoma mansoni sodium-dependent amino acid transporter 0.004 0.0137 0.0347
Brugia malayi follicle stimulating hormone receptor 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Schistosoma mansoni hypothetical protein 0.0043 0.015 0.0379
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0137 0.0347
Echinococcus granulosus tm gpcr rhodopsin 0.0107 0.0527 0.1331
Onchocerca volvulus 0.004 0.0137 0.0916
Echinococcus granulosus neuropeptide s receptor 0.0107 0.0527 0.1331
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0002 0.0035
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0238 0.1304 0.329
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0361 0.0892
Brugia malayi hypothetical protein 0.0107 0.0527 0.1331
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.002 0.005
Onchocerca volvulus 0.0107 0.0527 0.3954
Onchocerca volvulus 0.004 0.0137 0.0916
Schistosoma mansoni neuropeptide F-like receptor 0.0107 0.0527 0.1331
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.004 0.0137 0.0347
Echinococcus multilocularis G protein coupled receptor 139 0.0107 0.0527 0.0527
Schistosoma mansoni hypothetical protein 0.0032 0.0088 0.0221
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.0044 0.0159 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0159 0.2724
Brugia malayi hypothetical protein 0.0107 0.0527 0.1331
Brugia malayi Melatonin receptor type 1A 0.0107 0.0527 0.1331
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0116 0.0585 0.9172
Brugia malayi hypothetical protein 0.0038 0.0121 0.0305
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0045 0.0771
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0107 0.0527 0.1331
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.0506 0.0506
Schistosoma mansoni neuropeptide receptor 0.0107 0.0527 0.1331
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0564 0.8837
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Echinococcus multilocularis allatostatin A receptor 0.0107 0.0527 0.0527
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0638 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0107 0.0527 0.1331
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0638 1
Echinococcus granulosus tm gpcr rhodopsin 0.0107 0.0527 0.1331
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0107 0.0527 0.1331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.002 0.0029
Schistosoma mansoni hypothetical protein 0.0105 0.0518 0.1307
Onchocerca volvulus 0.0238 0.1304 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0107 0.0527 0.1331
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0107 0.0527 0.1331
Echinococcus multilocularis neuropeptide Y receptor 0.0107 0.0527 0.0527
Echinococcus multilocularis g protein coupled receptor 0.0107 0.0527 0.0527
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0107 0.0527 0.3954
Echinococcus granulosus neuropeptide Y receptor 0.0107 0.0527 0.1331
Echinococcus multilocularis orexin receptor type 2 0.0107 0.0527 0.0527
Onchocerca volvulus 0.0116 0.0585 0.4406
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0361 0.0911
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0159 0.0403
Onchocerca volvulus 0.004 0.0137 0.0916
Loa Loa (eye worm) norepinephrine transporter 0.0238 0.1304 0.3277
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0008 0.0597
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.002 0.0029
Onchocerca volvulus 0.0107 0.0527 0.3954
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0361 0.0911
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Loa Loa (eye worm) hypothetical protein 0.0054 0.0218 0.0531
Echinococcus multilocularis g protein coupled receptor 0.0107 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0107 0.0527 0.1331
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0361 0.0911
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0107 0.0527 0.1331
Brugia malayi steroid hormone receptor 0.002 0.002 0.005
Brugia malayi G protein-coupled receptor 0.0107 0.0527 0.1331
Loa Loa (eye worm) glutathione reductase 0.0049 0.0191 0.0461
Brugia malayi hypothetical protein 0.0107 0.0527 0.1331
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0137 0.0347
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0029
Schistosoma mansoni histamine h1 receptor 0.0107 0.0527 0.1331
Echinococcus granulosus neuropeptide receptor 0.0107 0.0527 0.1331
Echinococcus granulosus neuropeptide FF receptor 2 0.0107 0.0527 0.1331
Echinococcus granulosus rhodopsin orphan GPCR 0.0107 0.0527 0.1331
Schistosoma mansoni hypothetical protein 0.0107 0.0527 0.1331
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Echinococcus granulosus somatostatin receptor 0.0107 0.0527 0.1331
Schistosoma mansoni thyroid hormone receptor 0.002 0.002 0.005
Onchocerca volvulus Peroxidase homolog 0.0078 0.0361 0.2657
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.002 0.002
Onchocerca volvulus 0.0078 0.0361 0.2657
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0107 0.0527 0.1331
Trypanosoma brucei trypanothione reductase 0.0049 0.0191 0.7989
Echinococcus multilocularis protein dispatched 1 0.005 0.0196 0.0196
Echinococcus granulosus para nitrobenzyl esterase 0.0116 0.0585 0.1478
Toxoplasma gondii thioredoxin reductase 0.0049 0.0191 0.7989
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0137 0.0347
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0088 0.0221
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0045 0.0771
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0107 0.0527 0.0527
Loa Loa (eye worm) neuropeptide F receptor 0.0107 0.0527 0.1313
Echinococcus multilocularis BC026374 protein (S09 family) 0.0116 0.0585 0.0585
Loa Loa (eye worm) G-protein coupled receptor 0.0107 0.0527 0.1313
Onchocerca volvulus Peroxidasin homolog 0.0078 0.0361 0.2657
Echinococcus granulosus 7tm_1 domain containing protein 0.0107 0.0527 0.1331
Brugia malayi Carboxylesterase family protein 0.0116 0.0585 0.1478
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0116 0.0585 0.1478
Brugia malayi ORL1-like opioid receptor 0.0107 0.0527 0.1331
Brugia malayi hypothetical protein 0.0107 0.0527 0.1331
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0107 0.0527 0.1331
Plasmodium falciparum amino acid transporter, putative 0.004 0.0137 0.7211
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0121 0.0305
Echinococcus multilocularis serotonin receptor 0.0107 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Schistosoma mansoni biogenic amine (5HT) receptor 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Echinococcus multilocularis acetylcholinesterase 0.0689 0.3962 0.3962
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0093
Onchocerca volvulus 0.0105 0.0518 0.3879
Echinococcus granulosus peptide allatostatin:somatostatin 0.0107 0.0527 0.1331
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0107 0.0527 0.1331
Onchocerca volvulus 0.0107 0.0527 0.3954
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0239 0.0239
Schistosoma mansoni sodium/chloride dependent transporter 0.0238 0.1304 0.329
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0137 0.0347
Echinococcus multilocularis somatostatin receptor 0.0107 0.0527 0.0527
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0892
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Schistosoma mansoni neuropeptide receptor 0.0107 0.0527 0.1331
Schistosoma mansoni biogenic amine receptor 0.0107 0.0527 0.1331
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0107 0.0527 0.0527
Schistosoma mansoni biogenic amine (5HT) receptor 0.0107 0.0527 0.1331
Brugia malayi Carboxylesterase family protein 0.0689 0.3962 1
Echinococcus granulosus fmrfamide receptor 0.0107 0.0527 0.1331
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0239 0.4074
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0137 0.5761
Schistosoma mansoni hypothetical protein 0.0043 0.015 0.0379
Brugia malayi putative neuropeptide receptor NPR1 0.0107 0.0527 0.1331
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.002 0.005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.002 0.005
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0029
Brugia malayi hypothetical protein 0.0107 0.0527 0.1331
Schistosoma mansoni hypothetical protein 0.0107 0.0527 0.1331
Echinococcus multilocularis neuroligin 0.0116 0.0585 0.0585
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0137 0.0347
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0892
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.004 0.0137 0.0347
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.002 0.002
Echinococcus multilocularis para nitrobenzyl esterase 0.0116 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.002 0.005
Onchocerca volvulus 0.0107 0.0527 0.3954
Echinococcus granulosus tm gpcr rhodopsin 0.0107 0.0527 0.1331
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0137 0.0347
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0239 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0107 0.0527 0.1331
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0107 0.0527 0.0527
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0029
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.002 0.002
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0107 0.0527 0.0527
Schistosoma mansoni adenoreceptor 0.0107 0.0527 0.1331
Schistosoma mansoni biogenic amine receptor 0.0107 0.0527 0.1331
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0045 0.1893
Echinococcus granulosus dro:myosuppressin receptor 0.0107 0.0527 0.1331
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0239 0.4074
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.002 0.0029
Loa Loa (eye worm) carboxylesterase 0.0116 0.0585 0.146
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0107 0.0527 0.0527
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0107 0.0527 0.0527
Echinococcus granulosus rhodopsin orphan GPCR 0.0107 0.0527 0.1331
Brugia malayi Tachykinin-like peptides receptor 99D 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Echinococcus multilocularis dro:myosuppressin receptor 0.0107 0.0527 0.0527
Brugia malayi Dopamine receptor protein 1 0.0107 0.0527 0.1331
Schistosoma mansoni amine GPCR 0.0107 0.0527 0.1331
Brugia malayi Peroxidasin 0.0078 0.0361 0.0911
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0892
Echinococcus multilocularis neuropeptide Y receptor 0.0107 0.0527 0.0527
Schistosoma mansoni amine GPCR 0.0107 0.0527 0.1331
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.002 0.005
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.002 0.005
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0107 0.0527 0.1313
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0191 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0892
Loa Loa (eye worm) hypothetical protein 0.0107 0.0527 0.1313
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0107 0.0527 0.1331
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.002 0.005
Entamoeba histolytica hypothetical protein 0.0038 0.0121 0.1641
Echinococcus granulosus acetylcholinesterase 0.0689 0.3962 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0008 0.014
Brugia malayi Carboxylesterase family protein 0.0116 0.0585 0.1478
Onchocerca volvulus 0.0107 0.0527 0.3954
Echinococcus multilocularis rhodopsin orphan GPCR 0.0107 0.0527 0.0527
Echinococcus granulosus neuropeptides capa receptor 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0029
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.0137 0.0347
Loa Loa (eye worm) carboxylesterase 0.0116 0.0585 0.146
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0107 0.0527 0.1331
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.002 0.005
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.002 0.005
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0107 0.0527 0.1331
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.002 0.002
Mycobacterium ulcerans hypothetical protein 0.0025 0.0045 0.0771
Schistosoma mansoni biogenic amine receptor 0.0107 0.0527 0.1331
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.002 0.002
Brugia malayi GnHR receptor homolog 0.0107 0.0527 0.1331
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0892
Mycobacterium ulcerans carboxylesterase, LipT 0.0116 0.0585 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0495 0.1232
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.002 0.005
Echinococcus granulosus g protein coupled receptor 0.0107 0.0527 0.1331
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0238 0.1304 0.329
Onchocerca volvulus 0.0107 0.0527 0.3954
Plasmodium falciparum thioredoxin reductase 0.0049 0.0191 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.002 0.005
Onchocerca volvulus 0.0025 0.0045 0.0197
Loa Loa (eye worm) G-protein coupled receptor 0.0107 0.0527 0.1313
Loa Loa (eye worm) hypothetical protein 0.0116 0.0585 0.146
Echinococcus multilocularis expressed conserved protein 0.0097 0.0469 0.0469
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0107 0.0527 0.1331
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0107 0.0527 0.1331
Echinococcus multilocularis rhodopsin orphan GPCR 0.0107 0.0527 0.0527
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0137 0.0347
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.0515 0.1301
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.0767 0.0767
Echinococcus multilocularis FTZ F1 alpha 0.002 0.002 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0107 0.0527 0.0527
Echinococcus multilocularis neuropeptide FF receptor 2 0.0107 0.0527 0.0527

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antibacterial activity against Escherichia coli ATCC 25922 at 100 ug/disk after 24 hrs by agar plate diffusion method ChEMBL. 9677282
IC50 (binding) > 24.4 uM Inhibition of PTP1B (unknown origin) pre-incubated for 10 mins before addition of p-nitrophenyl phosphate substrate and measured 30 mins post substrate addition ChEMBL. 26253631

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.