Detailed information for compound 1181865

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 314.289 | Formula: C17H14O6
  • H donors: 1 H acceptors: 3 LogP: 2.47 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1=CC(=O)c2c(C1=O)c1c(cc2)cc(c(c1O)OC)OC
  • InChi: 1S/C17H14O6/c1-21-11-7-10(18)9-5-4-8-6-12(22-2)17(23-3)16(20)13(8)14(9)15(11)19/h4-7,20H,1-3H3
  • InChiKey: SSUYXMUVFIRPDJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0022 0.0081 0.0532
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.07 0.4594
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0376 0.2465
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.002 0.0286
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.002 0.0286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0699 1
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0301
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0527 0.2985
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.015 0.3585
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0381 0.5574 0.5574
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0211 0.4006
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0527 0.3455
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0067 0.0692
Echinococcus multilocularis musashi 0.0056 0.0605 0.0605
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0706 0.4631
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0046 0.0046
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0419 0.5875
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0419 0.0419
Plasmodium falciparum glutathione reductase 0.0051 0.0527 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.002 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0376 0.2465
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0081 0.0532
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0248 0.5916
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0081 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0706 0.0706
Loa Loa (eye worm) hypothetical protein 0.0041 0.0376 0.2465
Brugia malayi PHD-finger family protein 0.003 0.0211 0.1384
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0699 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0496 0.7098
Brugia malayi nuclear receptor RXR 0.0019 0.0046 0.0301
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0532
Schistosoma mansoni nuclear receptor 0.0019 0.0046 0.0046
Brugia malayi nuclear hormone receptor 0.0041 0.0376 0.2465
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0376 0.2465
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0605 0.3968
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.002 0.0286
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0376 0.0376
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0527 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.003 0.0211 0.1384
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0376 0.2465
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0301
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0527 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0111 0.2655
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0376 0.0376
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0376 0.2465
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0419 0.5993
Onchocerca volvulus 0.0041 0.0376 0.621
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1524 1
Onchocerca volvulus Alhambra homolog 0.003 0.0211 0.3487
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0029 0.0126
Schistosoma mansoni zinc finger protein 0.0019 0.0046 0.0046
Brugia malayi nuclear receptor NHR-88 0.0041 0.0376 0.2465
Brugia malayi steroid hormone receptor 0.0041 0.0376 0.2465
Loa Loa (eye worm) RNA binding protein 0.0062 0.0706 0.4631
Leishmania major cathepsin L-like protease 0.0062 0.0699 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0046 0.0046
Echinococcus multilocularis tumor protein p63 0.0343 0.4998 0.4998
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.152 0.8837
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0211 0.1384
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0605 0.3968
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.1717 1
Onchocerca volvulus 0.0056 0.0605 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0321 0.7669
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0532
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.002 0.5
Brugia malayi Thioredoxin reductase 0.0051 0.0527 0.3455
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0376 0.2465
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0211 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0699 1
Echinococcus granulosus peregrin 0.003 0.0211 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0699 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0376 0.0376
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.002 0.038
Onchocerca volvulus 0.0019 0.0046 0.0758
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0376 0.0376
Plasmodium falciparum thioredoxin reductase 0.0018 0.002 0.038
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.002 0.5
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0046 0.0758
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0699 1
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0376 0.0376
Echinococcus multilocularis lamin 0.0056 0.0605 0.0605
Echinococcus multilocularis lamin dm0 0.0056 0.0605 0.0605
Brugia malayi ecdysone receptor 0.0019 0.0046 0.0301
Brugia malayi nuclear receptor RXR 0.0022 0.0081 0.0532
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0419 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0046 0.0046
Brugia malayi ecdysteroid receptor 0.0041 0.0376 0.2465
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0391 0.0391
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0376 0.0376
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0706 0.4631
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0046 0.0046
Echinococcus multilocularis peregrin 0.003 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0301
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0706 0.4631
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0532
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0308 0.0308
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0376 0.0376
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0081 0.0081
Schistosoma mansoni coup transcription factor 0.0041 0.0376 0.0376
Echinococcus multilocularis thyroid hormone receptor alpha 0.0422 0.6198 0.6198
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0248 0.4704
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.002 0.0286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0112 0.2668
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.002 0.0286
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0081 0.0081
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.152 0.8837
Brugia malayi tailless protein 0.0019 0.0046 0.0301
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0376 0.0376
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0308 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0419 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0532
Brugia malayi nuclear receptor NHR-67 0.0019 0.0046 0.0301
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0376 0.0376
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0211 0.4006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0112 0.2668
Plasmodium falciparum glutathione reductase 0.0018 0.002 0.038
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0046 0.0046
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0376 0.0376
Echinococcus granulosus tar DNA binding protein 0.0062 0.0706 0.0706
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0419 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0376 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0282 0.6739
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.152 0.8837
Brugia malayi conserved hypotetical protein 0.0019 0.0046 0.0301
Onchocerca volvulus 0.0019 0.0046 0.0758
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0376 0.2465
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0376 0.2465
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.002 0.038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0419 1
Onchocerca volvulus 0.005 0.0519 0.8583
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0419 0.0419
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0046 0.0046
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0046 0.0301
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0308 0.2018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0046 0.0046
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.152 0.8837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0248 0.5916
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0699 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0376 0.2465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0282 0.6739
Schistosoma mansoni hypothetical protein 0.0381 0.5574 0.5574
Onchocerca volvulus 0.0056 0.0605 1
Brugia malayi Bromodomain containing protein 0.003 0.0211 0.1384
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.1257 0.1257
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0376 0.2465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0185 0.4408
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.1717 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0706 0.0706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0282 0.6739
Loa Loa (eye worm) hypothetical protein 0.0055 0.0589 0.3866
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0376 0.0376
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0519 0.0519
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0376 0.0376
Schistosoma mansoni thyroid hormone receptor 0.0422 0.6198 0.6198
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0376 0.0376
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.002 0.0286
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0376 0.621
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0376 0.621
Schistosoma mansoni lamin 0.0056 0.0605 0.0605
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0308 0.0308
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0376 0.621
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0376 0.2465
Brugia malayi hypothetical protein 0.0019 0.0046 0.0301
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0376 0.0376
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0527 0.7536
Echinococcus granulosus intermediate filament protein 0.0056 0.0605 0.0605
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0527 0.0527
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0046 0.0758
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0041 0.0376 0.2465
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0376 0.0376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0376 0.2465
Brugia malayi TAR-binding protein 0.0062 0.0706 0.4631
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0046 0.0046
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.002 0.038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0111 0.2655
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0419 0.2747
Schistosoma mansoni hypothetical protein 0.003 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0041 0.0376 0.2465
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0699 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0706 0.0706
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.002 0.038
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0301
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.002 0.038
Toxoplasma gondii thioredoxin reductase 0.0051 0.0527 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0046 0.0301
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0301
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0376 0.0376
Brugia malayi jmjC domain containing protein 0.0036 0.0308 0.2018
Schistosoma mansoni nuclear receptor 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0041 0.0376 0.2465
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.002 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0376 0.2465
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0376 0.2465
Echinococcus granulosus tumor protein p63 0.0343 0.4998 0.4998
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.002 0.038
Loa Loa (eye worm) hypothetical protein 0.005 0.0519 0.3406
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0046 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0248 0.5916
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0046 0.0046
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0046 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0699 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.1717 1
Echinococcus granulosus lamin dm0 0.0056 0.0605 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0199 0.4753
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0699 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0539 0.3538
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0419 0.5993
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0532
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0376 0.0376
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0699 1
Leishmania major cathepsin L-like protease 0.0062 0.0699 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0046 0.0301
Brugia malayi glutathione reductase 0.0051 0.0527 0.3455
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0376 0.2465
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0081 0.0532
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0391 0.0391
Loa Loa (eye worm) glutathione reductase 0.0051 0.0527 0.3455
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0046 0.0046
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0419 0.0419
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0209 0.1368
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0376 0.0376
Giardia lamblia PHD finger protein 15 0.003 0.0211 0.4789
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0419 0.5875
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.002 0.0286
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0376 0.0376
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1524 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0112 0.2668
Plasmodium vivax glutathione reductase, putative 0.0051 0.0527 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.002 0.0131
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0248 0.5916
Loa Loa (eye worm) hypothetical protein 0.0041 0.0376 0.2465
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0308 0.0308
Schistosoma mansoni intermediate filament proteins 0.0056 0.0605 0.0605
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0699 1
Plasmodium vivax hypothetical protein, conserved 0.003 0.0211 0.4006
Schistosoma mansoni thyroid hormone receptor 0.0422 0.6198 0.6198
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0617 0.8824
Trypanosoma brucei trypanothione reductase 0.0051 0.0527 0.7464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0248 0.5916
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.002 0.0286
Loa Loa (eye worm) hypothetical protein 0.0056 0.0605 0.3968
Brugia malayi RNA binding protein 0.0062 0.0706 0.4631
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0046 0.0301
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0046 0.0301
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0419 0.2747
Loa Loa (eye worm) hypothetical protein 0.0041 0.0376 0.2465
Brugia malayi nuclear receptor NHR-88 0.0019 0.0046 0.0301
Brugia malayi jmjC domain containing protein 0.0098 0.1257 0.8244
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0376 0.0376
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.152 0.8837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0248 0.5916
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.002 0.0286
Loa Loa (eye worm) hypothetical protein 0.0027 0.0163 0.1071
Loa Loa (eye worm) DR-78 0.0019 0.0046 0.0301
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0376 0.0376
Brugia malayi hypothetical protein 0.0022 0.0081 0.0532
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0301
Plasmodium falciparum phd finger protein, putative 0.003 0.0211 0.4006
Treponema pallidum NADH oxidase 0.0018 0.002 0.5
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.1257 0.1257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.015 0.3585
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.002 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0376 0.2465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0111 0.2655
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0376 0.2465
Schistosoma mansoni lamin 0.0056 0.0605 0.0605
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0209 0.1368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0146 0.3491
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.002 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0376 0.2465
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0376 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0282 0.6739
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.002 0.002
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0046 0.0301
Plasmodium falciparum thioredoxin reductase 0.0051 0.0527 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0301
Brugia malayi intermediate filament protein 0.0056 0.0605 0.3968
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.002 0.002
Brugia malayi hypothetical protein 0.0019 0.0046 0.0301
Loa Loa (eye worm) hypothetical protein 0.0026 0.0148 0.0969
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0419 0.5993
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0301
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0376 0.2465
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0706 0.0706
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.002 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0146 0.3491
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0376 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.015 0.3585
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0706 0.0706
Giardia lamblia GTOR 0.0044 0.0419 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.002 0.0286
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0301
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0046 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0699 1
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0376 0.2465
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0376 0.2465
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.002 0.5
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0163 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0282 0.6739
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0283 0.4046
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0699 1
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.002 0.0477
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0301
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0046 0.0301
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0376 0.2465
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0301
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.002 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0376 0.2465
Leishmania major cathepsin L-like protease 0.0062 0.0699 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0211 0.0211
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0081 0.0532
Leishmania major trypanothione reductase 0.0051 0.0527 0.7536
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0947 0.0947
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0283 0.4046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.002 0.0286
Loa Loa (eye worm) hypothetical protein 0.0026 0.0148 0.0969
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0419 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0706 0.0706
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0419 0.5993
Echinococcus granulosus lamin 0.0056 0.0605 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0112 0.2668
Brugia malayi nuclear hormone receptor 0.0019 0.0046 0.0301
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0376 0.0376
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0699 1
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0046 0.0301
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0376 0.2465
Mycobacterium tuberculosis Probable reductase 0.0116 0.152 0.8837
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0301
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0605 0.3968
Loa Loa (eye worm) hypothetical protein 0.0041 0.0376 0.2465
Loa Loa (eye worm) hypothetical protein 0.0041 0.0376 0.2465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0248 0.5916
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.1717 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0699 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0283 0.3871
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0376 0.0376
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0381 0.5574 0.5574
Brugia malayi MH2 domain containing protein 0.0116 0.1524 1
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0211 0.0211
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.002 0.0477
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0046 0.0301

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) < 0.02 ug ml-1 Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay ChEMBL. 19193043
EC50 (functional) = 0.03 ug ml-1 Cytotoxicity against human MCF7 cells ChEMBL. 18640035
EC50 (functional) = 0.15 ug ml-1 Cytotoxicity against human MCF7 cells ChEMBL. 18640035
EC50 (functional) = 0.16 ug ml-1 Cytotoxicity against human PC3 cells ChEMBL. 18640035
EC50 (functional) = 0.16 ug ml-1 Cytotoxicity against human PC3 cells after 3 days by sulforhodamine B assay ChEMBL. 19193043
EC50 (functional) = 0.19 ug ml-1 Cytotoxicity against human A549 cells ChEMBL. 18640035
EC50 (functional) = 0.19 ug ml-1 Cytotoxicity against human A549 cells after 3 days by sulforhodamine B assay ChEMBL. 19193043
EC50 (functional) = 0.2 ug ml-1 Cytotoxicity against human HCT8 cells ChEMBL. 18640035
EC50 (functional) = 0.2 ug ml-1 Cytotoxicity against human HCT8 cells after 3 days by sulforhodamine B assay ChEMBL. 19193043
EC50 (functional) = 0.29 ug ml-1 Cytotoxicity against human HCT8 cells ChEMBL. 18640035
EC50 (functional) = 0.3 ug ml-1 Cytotoxicity against human KB cells ChEMBL. 18640035
EC50 (functional) = 0.31 ug ml-1 Cytotoxicity against human A549 cells ChEMBL. 18640035
EC50 (functional) = 0.32 ug ml-1 Cytotoxicity against human KB cells ChEMBL. 18640035
EC50 (functional) = 0.32 ug ml-1 Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay ChEMBL. 19193043
EC50 (functional) = 0.34 ug ml-1 Cytotoxicity against human DU145 cells ChEMBL. 18640035
EC50 (functional) = 0.34 ug ml-1 Cytotoxicity against human DU145 cells after 3 days by sulforhodamine B assay ChEMBL. 19193043
EC50 (functional) = 0.48 ug ml-1 Cytotoxicity against human DU145 cells ChEMBL. 18640035
EC50 (functional) = 0.75 ug ml-1 Cytotoxicity against human PC3 cells ChEMBL. 18640035

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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