Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.1253 | 0.2458 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0013 | 0.0112 | 0.0099 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.1372 | 0.2692 |
Trypanosoma brucei | protein kinase, putative | 0.0049 | 0.1495 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0043 | 0.1253 | 0.1241 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0318 | 0.0438 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.1816 | 0.2498 |
Echinococcus granulosus | geminin | 0.0203 | 0.7269 | 1 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0021 | 0.042 | 0.0407 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0455 | 0.0626 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.0578 | 0.0703 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.1431 | 0.1988 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0012 | 0.0089 | 0.0174 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0025 | 0.0578 | 0.0566 |
Trypanosoma brucei | trypanothione reductase | 0.0048 | 0.1431 | 0.9537 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.1853 | 0.2627 |
Plasmodium falciparum | glutathione reductase | 0.0017 | 0.0254 | 0.0214 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.1253 | 0.1724 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.1253 | 0.1241 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.1853 | 0.2549 |
Onchocerca volvulus | 0.0043 | 0.1253 | 0.9355 | |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0027 | 0.0637 | 0.0791 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0017 | 0.0254 | 0.0214 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0385 | 0.053 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.2376 | 0.4659 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.1253 | 0.2458 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0013 | 0.0112 | 0.022 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0043 | 0.1253 | 0.1241 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0027 | 0.0637 | 0.0791 |
Loa Loa (eye worm) | acyl carrier protein | 0.0012 | 0.0066 | 0.013 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0347 | 0.0477 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0945 | 0.1301 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.1853 | 0.2549 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0161 | 0.0316 |
Onchocerca volvulus | 0.0013 | 0.0112 | 0.0837 | |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0318 | 0.0438 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0049 | 0.1495 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0014 | 0.0169 | 0.0156 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0025 | 0.0578 | 0.0703 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0189 | 0.6748 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0043 | 0.1253 | 0.1241 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0017 | 0.0254 | 0.0817 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.1253 | 0.172 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0025 | 0.0578 | 0.1134 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.1253 | 0.1724 |
Onchocerca volvulus | 0.0043 | 0.1253 | 0.9355 | |
Onchocerca volvulus | 0.0013 | 0.0112 | 0.0837 | |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1223 | 0.2399 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0017 | 0.0254 | 0.0817 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0017 | 0.0254 | 0.0214 |
Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0013 | 0.0112 | 0.0099 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0049 | 0.1495 | 0.2057 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1372 | 0.1888 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0145 | 0.5099 | 0.7014 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0017 | 0.0254 | 0.0214 |
Mycobacterium ulcerans | polyketide synthase | 0.0025 | 0.0578 | 0.0703 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0.019 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5099 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0254 | 0.1028 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0254 | 0.035 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.1431 | 0.1988 |
Mycobacterium ulcerans | polyketide synthase | 0.0027 | 0.0637 | 0.0791 |
Onchocerca volvulus | 0.0044 | 0.1281 | 0.956 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1372 | 0.1888 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1253 | 0.2458 |
Schistosoma mansoni | zinc finger protein | 0.0015 | 0.019 | 0.0261 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0013 | 0.0112 | 0.022 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.1253 | 0.172 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1253 | 0.2458 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0013 | 0.0112 | 0.0004 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.1853 | 0.1842 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0049 | 0.1495 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.1253 | 0.8249 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0189 | 0.6748 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0017 | 0.0257 | 0.0219 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0013 | 0.0112 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5099 | 1 |
Schistosoma mansoni | dihydropteridine reductase | 0.0013 | 0.0112 | 0.0154 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0189 | 0.6748 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0145 | 0.5099 | 0.7014 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.1253 | 0.2458 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0.1431 | 0.9537 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0254 | 0.0214 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.1372 | 0.2692 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.3739 | 0.373 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1372 | 0.1888 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 0.7269 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0189 | 0.6748 | 0.6743 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.1431 | 0.1969 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1372 | 0.1888 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0017 | 0.0254 | 0.0218 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0049 | 0.1495 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1253 | 0.1538 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.3739 | 0.373 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1853 | 0.2623 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0017 | 0.0254 | 0.1028 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0112 | 0.022 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0347 | 0.0477 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0013 | 0.0112 | 0.0099 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0049 | 0.1495 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0189 | 0.6748 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0318 | 0.0518 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0318 | 0.1492 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0254 | 0.0817 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0025 | 0.0578 | 0.0703 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.1853 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0027 | 0.0637 | 0.0791 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.1431 | 0.2807 |
Toxoplasma gondii | 3-ketoacyl-(acyl-carrier-protein) reductase | 0.0013 | 0.0112 | 0.0004 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0318 | 0.0438 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0121 | 0.4197 | 0.4189 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0023 | 0.0516 | 0.0503 |
Brugia malayi | beta-lactamase | 0.0043 | 0.1253 | 0.2458 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.1431 | 0.1988 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0254 | 0.0214 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1253 | 0.2458 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0318 | 0.0625 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.002 | 0.0393 | 0.0423 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0189 | 0.6748 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0189 | 0.6748 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0254 | 0.1028 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.1431 | 0.1988 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1372 | 0.1888 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0017 | 0.0254 | 0.035 |
Loa Loa (eye worm) | oxidoreductase | 0.0013 | 0.0112 | 0.022 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.1032 | 0.2024 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0254 | 0.035 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0455 | 0.0626 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0189 | 0.6748 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.1431 | 0.2807 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0017 | 0.0254 | 0.0214 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.1253 | 0.172 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0017 | 0.0254 | 0.0241 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1853 | 0.2623 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0121 | 0.4197 | 0.4189 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0254 | 0.035 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0254 | 0.0817 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.1253 | 0.172 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0027 | 0.0637 | 0.0625 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.3739 | 0.373 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0109 | 0.3739 | 0.5466 |
Leishmania major | trypanothione reductase | 0.0048 | 0.1431 | 0.7578 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0017 | 0.0254 | 0.0214 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0027 | 0.0637 | 0.0625 |
Plasmodium falciparum | thioredoxin reductase | 0.0017 | 0.0254 | 0.0214 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.1253 | 0.172 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0318 | 0.0311 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.1431 | 0.2807 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0018 | 0.0311 | 0.0298 |
Trypanosoma brucei | ISWI complex protein | 0.0015 | 0.019 | 0.0564 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0455 | 0.0626 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1253 | 0.1538 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.1495 | 0.1911 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.1253 | 0.1538 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0023 | 0.0516 | 0.1012 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0017 | 0.0254 | 0.1028 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.1253 | 0.1241 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.3739 | 0.373 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0.0254 | 0.0214 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0013 | 0.0112 | 0.0099 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0318 | 0.0305 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.1816 | 0.2498 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.1253 | 0.1538 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0013 | 0.0112 | 0.0154 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.3739 | 0.373 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.1253 | 0.1724 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0318 | 0.0315 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0254 | 0.1028 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0049 | 0.1495 | 0.2088 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0049 | 0.1495 | 0.7946 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.1495 | 0.1911 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1372 | 0.1888 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.1253 | 0.6555 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0385 | 0.0756 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0043 | 0.1253 | 0.1241 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.1253 | 0.1538 |
Mycobacterium tuberculosis | Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) | 0.0013 | 0.0112 | 0.0099 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0318 | 0.1492 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0017 | 0.0254 | 0.0218 |
Brugia malayi | Muscleblind-like protein | 0.0145 | 0.5099 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.002 | 0.0393 | 0.0423 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1121 | 0.2199 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0254 | 0.1028 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.1853 | 0.2549 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0017 | 0.0254 | 0.035 |
Brugia malayi | MAP kinase sur-1 | 0.0049 | 0.1495 | 0.2933 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0017 | 0.0254 | 0.035 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0025 | 0.0578 | 0.0566 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0121 | 0.4197 | 0.6157 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0013 | 0.0112 | 0.0099 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0038 | 0.1047 | 0.1035 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0318 | 1 |
Mycobacterium ulcerans | thioesterase TesA | 0.0021 | 0.042 | 0.0464 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0025 | 0.0578 | 0.0703 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0318 | 0.0438 |
Mycobacterium ulcerans | thioesterase | 0.0021 | 0.042 | 0.0464 |
Mycobacterium tuberculosis | Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) | 0.0013 | 0.0112 | 0.0099 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.1253 | 0.172 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.0578 | 0.0703 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0318 | 0.0099 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0318 | 0.1492 |
Toxoplasma gondii | short chain dehydrogenase family protein, putative | 0.0013 | 0.0112 | 0.0004 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1253 | 0.1538 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1372 | 0.1888 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0013 | 0.0112 | 0.022 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2219 | 0.4352 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0049 | 0.1495 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0013 | 0.0112 | 0.022 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1253 | 0.2458 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0012 | 0.0089 | 0.0174 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0254 | 0.1028 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0318 | 0.0311 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.0542 | 0.1063 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0048 | 0.1431 | 0.142 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0049 | 0.1495 | 0.2057 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0038 | 0.1047 | 0.1409 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1853 | 0.2623 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0049 | 0.1495 | 0.2057 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0017 | 0.0254 | 0.1028 |
Onchocerca volvulus | 0.0043 | 0.1253 | 0.9355 | |
Echinococcus multilocularis | geminin | 0.0203 | 0.7269 | 1 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0021 | 0.042 | 0.0464 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0043 | 0.1253 | 0.1241 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0048 | 0.1427 | 0.28 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1191 | 0.2336 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0318 | 0.1186 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.1253 | 0.172 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0017 | 0.0254 | 0.035 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.1253 | 0.1723 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0017 | 0.0254 | 0.1028 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.1253 | 0.172 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0024 | 0.0549 | 0.0536 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0.019 | 0.0564 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0027 | 0.0637 | 0.0791 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0049 | 0.1495 | 0.2057 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0049 | 0.1495 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0254 | 0.035 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.1853 | 0.2549 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.019 | 0.0261 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0013 | 0.0112 | 0.0099 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.1253 | 0.1241 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0043 | 0.1253 | 0.1241 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0017 | 0.0254 | 0.1028 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0038 | 0.1047 | 0.1035 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0017 | 0.0254 | 0.0214 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0049 | 0.1495 | 0.2933 |
Schistosoma mansoni | bromodomain containing protein | 0.0061 | 0.1947 | 0.2678 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1035 | 0.2029 |
Onchocerca volvulus | 0.0023 | 0.0516 | 0.3852 | |
Brugia malayi | glutathione reductase | 0.0048 | 0.1431 | 0.2807 |
Echinococcus granulosus | muscleblind protein | 0.0145 | 0.5099 | 0.7014 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0516 | 0.1012 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0049 | 0.1495 | 0.7946 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.1431 | 0.1969 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.3739 | 0.373 |
Loa Loa (eye worm) | fatty acid synthase | 0.0025 | 0.0566 | 0.111 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0027 | 0.0637 | 0.0795 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0017 | 0.0254 | 0.1028 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0017 | 0.0254 | 0.035 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0027 | 0.0637 | 0.0791 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0045 | 0.1339 | 1 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0038 | 0.1047 | 0.1409 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.1253 | 0.8249 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0049 | 0.1495 | 0.2057 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.0578 | 0.0703 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.002 | 0.0393 | 0.0423 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0254 | 0.0499 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0017 | 0.0254 | 0.035 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0347 | 0.0477 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.1253 | 0.2458 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.1253 | 0.8249 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0016 | 0.0245 | 0.0205 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0277 | 0.0543 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1253 | 0.2458 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0017 | 0.0257 | 0.0219 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0189 | 0.6748 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 0.7269 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0024 | 0.0549 | 0.0536 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0027 | 0.0637 | 0.0625 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.1495 | 0.1911 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0017 | 0.0254 | 0.1028 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0318 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.1431 | 0.1991 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0013 | 0.0112 | 0.0154 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0017 | 0.0254 | 0.0499 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0017 | 0.0257 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1253 | 0.2458 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0049 | 0.1495 | 0.1911 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0945 | 0.1301 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.1253 | 0.1724 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0017 | 0.0254 | 0.035 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0017 | 0.0254 | 0.0214 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0121 | 0.4197 | 0.4189 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0318 | 0.0625 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0.019 | 0.0564 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0043 | 0.1253 | 0.1241 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.1253 | 0.2458 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0017 | 0.0254 | 0.1028 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0018 | 0.0305 | 0.0295 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0013 | 0.0112 | 0.0154 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0318 | 0.0311 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0318 | 0.0311 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0025 | 0.0578 | 0.0566 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0318 | 0.0099 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0021 | 0.0406 | 0.0393 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 4 % | Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells at 1 uM by SPA | ChEMBL. | 18539035 |
Inhibition (functional) | = 7 % | Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells at 1 uM by [35S]GTPgammaS binding assay | ChEMBL. | 18539035 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.