Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.5722 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0077 | 0.0195 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.0175 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.0175 | 0.0442 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.3545 | 0.8955 |
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0.0175 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0175 | 0.0175 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0123 | 0.3867 | 0.6758 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0876 | 0.2213 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0175 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.0175 | 0.0442 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0123 | 0.3867 | 0.6758 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0175 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0077 | 0.0195 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0175 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0876 | 0.2213 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0341 | 0.0862 |
Brugia malayi | hypothetical protein | 0.0125 | 0.3958 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.5722 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0125 | 0.3958 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.3958 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.3958 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0175 | 0.0442 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0175 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0041 | 0.0175 | 0.0175 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.3545 | 0.8955 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.0175 | 0.0442 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0175 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0.0175 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0175 | 0.0305 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.3867 | 0.6758 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.0175 | 0.0305 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0341 | 0.0862 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0077 | 0.0135 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0175 | 0.0305 |
Entamoeba histolytica | hypothetical protein | 0.0123 | 0.3867 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0341 | 0.0596 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0175 | 0.0175 |
Brugia malayi | beta-lactamase | 0.0041 | 0.0175 | 0.0442 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0175 | 0.0175 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0041 | 0.0175 | 0.0175 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0175 | 0.0442 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0175 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.3545 | 0.8955 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0175 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0341 | 0.0596 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0175 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0876 | 0.2213 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0175 | 0.0442 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0041 | 0.0175 | 0.0175 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0876 | 0.2213 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0041 | 0.0175 | 0.0175 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0175 | 0.0442 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0041 | 0.0175 | 0.0175 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0175 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0341 | 0.0596 |
Brugia malayi | hypothetical protein | 0.0123 | 0.3867 | 0.977 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0341 | 0.0596 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0.0175 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0041 | 0.0175 | 0.0175 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0041 | 0.0175 | 0.0175 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.0175 | 0.0305 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0175 | 1 |
Echinococcus multilocularis | geminin | 0.0164 | 0.5722 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0125 | 0.3958 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0.0175 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0175 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0175 | 0.0442 |
Echinococcus granulosus | geminin | 0.0164 | 0.5722 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0341 | 0.0596 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0123 | 0.3867 | 0.6758 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0341 | 0.0596 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0175 | 0.0442 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0.0175 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0175 | 0.0442 |
Entamoeba histolytica | hypothetical protein | 0.0123 | 0.3867 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0.0175 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0.0175 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0123 | 0.3867 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0341 | 0.0596 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0175 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0123 | 0.3867 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.0092 ug ml-1 | Cytotoxicity against mouse L1210 cells | ChEMBL. | No reference |
IC50 (functional) | = 0.013 ug ml-1 | Cytotoxicity against human KB cells | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Mus musculus | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.