Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.032019 | 0.5 | 0.5 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.032019 | 0.5 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.032019 | 0.5 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.032019 | 0.5 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.032019 | 0.5 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.032019 | 0.5 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.032019 | 0.5 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.032019 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antitrypanocidal activity against suramin-sensitive Trypanosoma brucei rhodesiense STIB-900 assessed as reduction in parasite growth after 72 hrs | ChEMBL. | 25199582 | |
IC50 (functional) | 0 uM | Inhibitory activity against 103N strain and 181C strain of HIV-I in MT-4 cell was determined; Not determined | ChEMBL. | 11527704 |
IC50 (functional) | = 0.0005 uM | Inhibitory activity against LAI strain of HIV-I in MT-4 cell was determined | ChEMBL. | 11527704 |
IC50 (functional) | = 0.003 uM | Inhibitory activity against 100I strain of HIV-I in MT-4 cell was determined | ChEMBL. | 11527704 |
IC50 (functional) | = 0.003 uM | Inhibitory activity against 103N strain of HIV-I in MT-4 cell was determined | ChEMBL. | 11527704 |
IC50 (functional) | = 0.003 uM | Inhibitory activity against 181C strain of HIV-I in MT-4 cell was determined | ChEMBL. | 11527704 |
IC50 (functional) | = 0.079 uM | Inhibitory activity against 188L strain of HIV-1 in MT-4 cell was determined | ChEMBL. | 11527704 |
IC50 (functional) | = 0.96 uM | Antitrypanocidal activity against suramin-sensitive Trypanosoma brucei brucei Squib427 assessed as reduction in parasite growth after 72 hrs | ChEMBL. | 25199582 |
IC50 (functional) | > 10 uM | Inhibitory activity against 100I strain and 103N strain of HIV-I in MT-4 cell was determined | ChEMBL. | 11527704 |
IC50 (functional) | > 10 uM | Inhibitory activity against 100I strain and 103N strain of HIV-I in MT-4 cell was determined | ChEMBL. | 11527704 |
IC50 (functional) | = 17.5 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human O positive erythrocyte assessed as reduction in parasitemia after 72 hrs | ChEMBL. | 25199582 |
IC50 (functional) | = 28.46 uM | Antileishmanial activity against Leishmania infantum MHOM/MA (BE)/67 infected in primary peritoneal mouse macrophages assessed as reduction in parasite burdun | ChEMBL. | 25199582 |
IC50 (functional) | > 64 uM | Trypanocidal activity against nifurtimox-sensitive Trypanosoma cruzi Tulahuen CL2 infected in human MRC5 SV2 cells assessed as parasite growth inhibition after 168 hrs by beta-galactosidase assay | ChEMBL. | 25199582 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 11527704 | |
Plasmodium falciparum | 25199582 | ||
Trypanosoma brucei gambiense | 25199582 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.