Detailed information for compound 1182955

Basic information

Technical information
  • TDR Targets ID: 1182955
  • Name: N-[(E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]o ctanamide
  • MW: 425.688 | Formula: C26H51NO3
  • H donors: 3 H acceptors: 3 LogP: 8.53 Rotable bonds: 23
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCC/C=C/[C@H]([C@@H](NC(=O)CCCCCCC)CO)O
  • InChi: 1S/C26H51NO3/c1-3-5-7-9-10-11-12-13-14-15-16-18-19-21-25(29)24(23-28)27-26(30)22-20-17-8-6-4-2/h19,21,24-25,28-29H,3-18,20,22-23H2,1-2H3,(H,27,30)/b21-19+/t24-,25+/m0/s1
  • InChiKey: APDLCSPGWPLYEQ-WRBRXSDHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]octanamide
  • N-[(E,1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadec-3-enyl]octanamide
  • N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadec-3-enyl]octanamide
  • N-[(1S,2R)-2-hydroxy-1-methylol-heptadec-3-enyl]caprylamide
  • N-[(E,1S,2R)-2-hydroxy-1-methylol-heptadec-3-enyl]caprylamide
  • Bio2_000769
  • KBioGR_000289
  • KBioSS_000289
  • Bio1_001300
  • CBiol_002036
  • BSPBio_001569
  • NCGC00161360-02
  • IDI1_034039
  • KBio2_000289
  • KBio2_002857
  • KBio2_005425
  • Bio2_000289
  • C8 Ceramide
  • D-erythro-Sphingosine, N-Octanoyl-
  • KBio3_000577
  • KBio3_000578
  • Bio1_000322
  • NCGC00161360-01
  • C8 ceramide
  • N-Octanoyl-D-sphingosine
  • O1882_SIGMA
  • Bio1_000811

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis abcb9, putative 0.0012703 0.00100871 0.00380255
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.1579 0.353766 0.353677
Loa Loa (eye worm) hypothetical protein 0.0263924 0.0575881 0.0574402
Toxoplasma gondii heat shock protein HSP90 0.00784138 0.015808 0.0167351
Entamoeba histolytica ATP-binding cassette protein, putative 0.00155521 0.00165038 0.00432901
Trichomonas vaginalis abcb9, putative 0.0012703 0.00100871 0.00380255
Leishmania major casein kinase II, putative 0.013028 0.0274892 0.0622931
Loa Loa (eye worm) hypothetical protein 0.00987135 0.0203798 0.020226
Schistosoma mansoni lip-related protein (liprin) alpha 0.00255654 0.00390554 0.00376952
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012703 0.00100871 0.000979426
Loa Loa (eye worm) hypothetical protein 0.0203944 0.0440796 0.0439296
Echinococcus granulosus SAM domain containing protein 0.00255654 0.00390554 0.00387634
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0203944 0.0440796 0.0439296
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00987135 0.0203798 0.020226
Trypanosoma brucei presenilin-like aspartic peptidase, putative 0.0281575 0.0615634 0.140951
Loa Loa (eye worm) hypothetical protein 0.0383791 0.0845843 0.0844407
Leishmania major glycerol uptake protein, putative 0.0383791 0.0845843 0.194093
Echinococcus granulosus poly ADP ribose polymerase 1 0.00384633 0.00681037 0.00678125
Trypanosoma cruzi heat shock protein 90, putative 0.00784138 0.015808 0.0353277
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0110904 0.0231253 0.0229919
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0012703 0.00100871 0.00380255
Plasmodium falciparum multidrug resistance protein 1 0.0012703 0.00100871 0.000551707
Plasmodium falciparum DNA topoisomerase 3, putative 0.0169066 0.0362244 0.0390612
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0203944 0.0440796 0.0440516
Echinococcus multilocularis sterol O acyltransferase 1 0.0383791 0.0845843 0.0845575
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0203944 0.0440796 0.0440516
Entamoeba histolytica P-glycoprotein-2 0.0012703 0.00100871 0.00190551
Leishmania major p-glycoprotein e 0.00155521 0.00165038 0.00264589
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0263924 0.0575881 0.0575605
Trichomonas vaginalis CMGC family protein kinase 0.013028 0.0274892 0.103626
Brugia malayi DNA topoisomerase III 0.0169066 0.0362244 0.0360731
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.00987135 0.0203798 0.020226
Plasmodium vivax DNA gyrase subunit B, putative 0.227045 0.509493 0.556595
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0203944 0.0440796 0.0439296
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0169066 0.0362244 0.0361961
Trichomonas vaginalis casein kinase II beta chain, putative 0.00671322 0.0132671 0.0500131
Brugia malayi hypothetical protein 0.00998102 0.0206268 0.0204731
Trypanosoma brucei DNA topoisomerase ii 0.193391 0.433699 1
Trichomonas vaginalis conserved hypothetical protein 0.00384633 0.00681037 0.0256731
Brugia malayi Cation transporter family protein 0.0203944 0.0440796 0.0439296
Entamoeba histolytica heat shock protein 90, putative 0.00784138 0.015808 0.0578004
Loa Loa (eye worm) hypothetical protein 0.00255654 0.00390554 0.00374921
Schistosoma mansoni smdr2 0.0012703 0.00100871 0.000872289
Loa Loa (eye worm) hypothetical protein 0.061161 0.135893 0.135758
Loa Loa (eye worm) hypothetical protein 0.0203944 0.0440796 0.0439296
Trypanosoma brucei heat shock protein, putative 0.00784138 0.015808 0.0353277
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.00784138 0.015808 0.0171303
Loa Loa (eye worm) hypothetical protein 0.00987135 0.0203798 0.020226
Echinococcus granulosus nAChR subunit 0.0105231 0.0218476 0.0218189
Trichomonas vaginalis casein kinase II beta chain, putative 0.00671322 0.0132671 0.0500131
Loa Loa (eye worm) hypothetical protein 0.0383791 0.0845843 0.0844407
Loa Loa (eye worm) hypothetical protein 0.0110904 0.0231253 0.022972
Chlamydia trachomatis DNA gyrase subunit A 0.407084 0.914973 1
Trichomonas vaginalis taga, putative 0.0012703 0.00100871 0.00380255
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0203944 0.0440796 0.0440516
Echinococcus multilocularis glycine receptor subunit beta 0.0203944 0.0440796 0.0440516
Echinococcus granulosus multidrug resistance protein 1 0.0012703 0.00100871 0.000979426
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.192295 0.43123 0.471224
Trichomonas vaginalis casein kinase II beta chain, putative 0.00671322 0.0132671 0.0500131
Trichomonas vaginalis CMGC family protein kinase 0.013028 0.0274892 0.103626
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.00155521 0.00165038 0.00264589
Echinococcus granulosus dihydrofolate reductase 0.192295 0.43123 0.431213
Brugia malayi gamma-secretase subunit pen-2 0.026138 0.0570152 0.0568672
Brugia malayi DNA topoisomerase II, alpha isozyme 0.118607 0.265273 0.265158
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0822496 0.183388 0.200311
Brugia malayi ABC transporter family protein 0.0012703 0.00100871 0.000851924
Loa Loa (eye worm) hypothetical protein 0.0203944 0.0440796 0.0439296
Loa Loa (eye worm) hypothetical protein 0.0203944 0.0440796 0.0439296
Echinococcus multilocularis ATP binding cassette sub family B 0.00126126 0.000988334 0.000959045
Echinococcus multilocularis liprin alpha 2 0.00255654 0.00390554 0.00387634
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0110904 0.0231253 0.0229919
Loa Loa (eye worm) hypothetical protein 0.0203944 0.0440796 0.0439296
Trypanosoma cruzi glycerol uptake protein, putative 0.0383791 0.0845843 0.194093
Trypanosoma cruzi glycerol uptake protein, putative 0.0383791 0.0845843 0.194093
Trypanosoma brucei p-glycoprotein 0.00155521 0.00165038 0.00264589
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0169066 0.0362244 0.0390612
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0383791 0.0845843 0.0845575
Leishmania major glycerol uptake protein, putative 0.0383791 0.0845843 0.194093
Brugia malayi GRF zinc finger family protein 0.0169066 0.0362244 0.0360731
Leishmania major developmentally regulated phosphoprotein-like protein 0.00784138 0.015808 0.0353277
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.407084 0.914973 1
Mycobacterium ulcerans thymidylate synthase 0.0822496 0.183388 0.19999
Trichomonas vaginalis casein kinase II beta chain, putative 0.00671322 0.0132671 0.0500131
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.00987135 0.0203798 0.0203511
Treponema pallidum DNA topoisomerase I (topA) 0.0169066 0.0362244 0.032609
Brugia malayi casein kinase II, putaitve 0.00190986 0.00244911 0.00229255
Toxoplasma gondii hypothetical protein 0.00795497 0.0160638 0.0170149
Brugia malayi prolyl oligopeptidase family protein 0.0110904 0.0231253 0.022972
Schistosoma mansoni nAChR subunit 0.0203944 0.0440796 0.0439491
Trypanosoma brucei heat shock protein 90, putative 0.00784138 0.015808 0.0353277
Trichomonas vaginalis Nicastrin precursor, putative 0.0137097 0.0290244 0.109413
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012703 0.00100871 0.000979426
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0012703 0.00100871 0.000851924
Brugia malayi Casein kinase II, alpha chain 0.013028 0.0274892 0.0273366
Giardia lamblia Casein kinase II beta chain 0.00190986 0.00244911 0.00795251
Leishmania major heat shock protein 83-1 0.00784138 0.015808 0.0353277
Loa Loa (eye worm) hypothetical protein 0.0816189 0.181968 0.18184
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0169066 0.0362244 0.0361961
Schistosoma mansoni multidrug resistance protein 0.00155521 0.00165038 0.00151404
Loa Loa (eye worm) Csnk2b protein 0.00671322 0.0132671 0.0131123
Loa Loa (eye worm) MBOAT family protein 0.0383791 0.0845843 0.0844407
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.00987135 0.0203798 0.020226
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.00784138 0.015808 0.0595912
Schistosoma mansoni multidrug resistance protein 0.00155521 0.00165038 0.00151404
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.00784138 0.015808 0.0157791
Loa Loa (eye worm) prolyl oligopeptidase 0.0110904 0.0231253 0.022972
Loa Loa (eye worm) prolyl oligopeptidase 0.1579 0.353766 0.353664
Brugia malayi prolyl oligopeptidase family protein 0.0110904 0.0231253 0.022972
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.00384633 0.00681037 0.00678125
Brugia malayi multidrug resistance protein 3 0.0012703 0.00100871 0.000851924
Echinococcus multilocularis ATP binding cassette sub family G 0.00104629 0.000504195 0.000474892
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.00671322 0.0132671 0.0294624
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0383791 0.0845843 0.0845575
Entamoeba histolytica hypothetical protein 0.00384633 0.00681037 0.0238177
Trypanosoma brucei Aph-1 protein, putative 0.174407 0.390943 0.9013
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.00784138 0.015808 0.0157791
Toxoplasma gondii heat shock protein 90, putative 0.00784138 0.015808 0.0167351
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.00126126 0.000988334 0.000959045
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0263924 0.0575881 0.0575605
Trichomonas vaginalis Nicastrin precursor, putative 0.0137097 0.0290244 0.109413
Echinococcus multilocularis prolyl endopeptidase 0.0110904 0.0231253 0.0230967
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.224398 0.503531 0.550076
Schistosoma mansoni subfamily A22A unassigned peptidase (A22 family) 0.0281575 0.0615634 0.0614352
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0012703 0.00100871 0.00380255
Plasmodium vivax endoplasmin, putative 0.00784138 0.015808 0.0167351
Echinococcus multilocularis Nicastrin 0.0137097 0.0290244 0.0289959
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0690138 0.153579 0.153446
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0383791 0.0845843 0.317561
Loa Loa (eye worm) hypothetical protein 0.00155521 0.00165038 0.00149369
Trichomonas vaginalis casein kinase II beta chain, putative 0.00190986 0.00244911 0.00923242
Toxoplasma gondii ck2 beta subunit 0.00671322 0.0132671 0.0139567
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0383791 0.0845843 0.0844593
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.224398 0.503531 0.503517
Trypanosoma cruzi multidrug resistance protein E, putative 0.00155521 0.00165038 0.00264589
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0012703 0.00100871 0.00380255
Trypanosoma cruzi heat shock protein 85, putative 0.00784138 0.015808 0.0353277
Brugia malayi DNA topoisomerase III beta-1 0.0169066 0.0362244 0.0360731
Onchocerca volvulus 0.0203944 0.0440796 0.0986615
Brugia malayi hypothetical protein 0.00998102 0.0206268 0.0204731
Onchocerca volvulus 0.0383791 0.0845843 0.191445
Trypanosoma cruzi Vacuolar proton pump subunit B, putative 0.00375441 0.00660337 0.0140795
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0012703 0.00100871 0.000551707
Onchocerca volvulus 0.0203944 0.0440796 0.0986615
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.1579 0.353766 0.353747
Echinococcus granulosus multidrug resistance associated protein 7 0.00155521 0.00165038 0.00162111
Brugia malayi MBOAT family protein 0.0383791 0.0845843 0.0844407
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0012703 0.00100871 0.00380255
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.00784138 0.015808 0.0171303
Schistosoma mansoni nAChR subunit 0.00987135 0.0203798 0.020246
Brugia malayi hypothetical protein 0.00987135 0.0203798 0.020226
Echinococcus multilocularis dihydrofolate reductase 0.192295 0.43123 0.431213
Mycobacterium tuberculosis Possible two component sensor kinase 0.00784138 0.015808 0.0171303
Echinococcus granulosus presenilin 0.0281575 0.0615634 0.0615359
Entamoeba histolytica hypothetical protein 0.0383791 0.0845843 0.317561
Echinococcus multilocularis gamma secretase subunit aph 1 0.444837 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0263924 0.0575881 0.0575605
Entamoeba histolytica P-glycoprotein-5 0.0012703 0.00100871 0.00190551
Entamoeba histolytica prolyl oligopeptidase family protein 0.0110904 0.0231253 0.0854372
Leishmania major heat shock protein 83-1 0.00784138 0.015808 0.0353277
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0203944 0.0440796 0.0439296
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.174305 0.390713 0.902469
Toxoplasma gondii CMGC kinase, CK2 family 0.013028 0.0274892 0.029509
Plasmodium falciparum V-type proton ATPase subunit B 0.00375441 0.00660337 0.00666963
Trichomonas vaginalis conserved hypothetical protein 0.00384633 0.00681037 0.0256731
Loa Loa (eye worm) hypothetical protein 0.00255654 0.00390554 0.00374921
Plasmodium falciparum casein kinase II beta chain 0.00671322 0.0132671 0.0139567
Brugia malayi Cation transporter family protein 0.0203944 0.0440796 0.0439296
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.00384633 0.00681037 0.00665449
Trypanosoma brucei heat shock protein, putative 0.00784138 0.015808 0.0353277
Entamoeba histolytica heat shock protein 90, putative 0.00784138 0.015808 0.0578004
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0203944 0.0440796 0.0440516
Plasmodium vivax heat shock protein 86, putative 0.00784138 0.015808 0.0167351
Echinococcus multilocularis glycine receptor subunit beta 0.0203944 0.0440796 0.0440516
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.00784138 0.015808 0.0167351
Leishmania major heat shock protein 83-1 0.00784138 0.015808 0.0353277
Trypanosoma cruzi DNA topoisomerase III, putative 0.0169066 0.0362244 0.0824577
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012703 0.00100871 0.000979426
Schistosoma mansoni multidrug resistance protein 0.0012703 0.00100871 0.000872289
Loa Loa (eye worm) hypothetical protein 0.0203455 0.0439694 0.0438194
Plasmodium vivax casein kinase II beta chain, putative 0.00671322 0.0132671 0.0139567
Loa Loa (eye worm) hypothetical protein 0.0203944 0.0440796 0.0439296
Trypanosoma brucei Vacuolar proton pump subunit B, putative 0.00375441 0.00660337 0.0140795
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0012703 0.00100871 0.00380255
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0203944 0.0440796 0.0439491
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0822496 0.183388 0.183277
Leishmania major heat shock protein 83-1 0.00784138 0.015808 0.0353277
Onchocerca volvulus 0.0105231 0.0218476 0.0477351
Toxoplasma gondii hypothetical protein 0.0383791 0.0845843 0.0919443
Brugia malayi MBOAT family protein 0.0383791 0.0845843 0.0844407
Schistosoma mansoni protein kinase 0.013028 0.0274892 0.0273564
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0203944 0.0440796 0.0439491
Echinococcus multilocularis Nicastrin 0.0137097 0.0290244 0.0289959
Giardia lamblia Pms1-like protein 0.00784138 0.015808 0.0620086
Loa Loa (eye worm) casein kinase II 0.00190986 0.00244911 0.00229255
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0169066 0.0362244 0.136555
Entamoeba histolytica P-glycoprotein-2 0.0012703 0.00100871 0.00190551
Echinococcus multilocularis multidrug resistance protein 1 0.0012703 0.00100871 0.000979426
Trichomonas vaginalis casein kinase II beta chain, putative 0.00671322 0.0132671 0.0500131
Echinococcus granulosus glycine receptor subunit alpha 1 0.0203944 0.0440796 0.0440516
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.00784138 0.015808 0.0167351
Trichomonas vaginalis ABC transporter, putative 0.0012703 0.00100871 0.00380255
Plasmodium vivax vacuolar ATP synthase subunit b, putative 0.00375441 0.00660337 0.00666963
Chlamydia trachomatis V-type ATP synthase subunit B 0.00375441 0.00660337 0.0061213
Treponema pallidum chemotaxis histidine kinase (cheA) 0.00784138 0.015808 0.0101331
Echinococcus granulosus sterol O acyltransferase 1 0.0383791 0.0845843 0.0845575
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0169066 0.0362244 0.0491464
Brugia malayi Endoplasmin precursor 0.00784138 0.015808 0.0156535
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.00784138 0.015808 0.0171303
Brugia malayi hypothetical protein 0.00255654 0.00390554 0.00374921
Loa Loa (eye worm) hypothetical protein 0.04097 0.0904195 0.0902767
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.00155521 0.00165038 0.00264589
Trichomonas vaginalis casein kinase II beta chain, putative 0.00190986 0.00244911 0.00923242
Trichomonas vaginalis protein kinase ck2-beta, putative 0.00190986 0.00244911 0.00923242
Echinococcus granulosus multidrug resistance protein 1 0.0012703 0.00100871 0.000979426
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0203944 0.0440796 0.0440516
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.00784138 0.015808 0.0167351
Loa Loa (eye worm) hypothetical protein 0.0203944 0.0440796 0.0439296
Brugia malayi dihydrofolate reductase family protein 0.192295 0.43123 0.43114
Echinococcus granulosus ATP binding cassette sub family G 0.00104629 0.000504195 0.000474892
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0520604 0.115397 0.265222
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0110904 0.0231253 0.0229919
Trypanosoma cruzi DNA topoisomerase III, putative 0.0169066 0.0362244 0.0824577
Brugia malayi hypothetical protein 0.00987135 0.0203798 0.020226
Loa Loa (eye worm) hypothetical protein 0.00987135 0.0203798 0.020226
Trypanosoma cruzi Aph-1 protein, putative 0.174407 0.390943 0.9013
Leishmania major heat shock protein 83-1 0.00784138 0.015808 0.0353277
Loa Loa (eye worm) hypothetical protein 0.00987135 0.0203798 0.020226
Entamoeba histolytica prolyl oligopeptidase family protein 0.0110904 0.0231253 0.0854372
Trypanosoma brucei Heat shock protein 83, putative 0.00784138 0.015808 0.0353277
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012703 0.00100871 0.000979426
Onchocerca volvulus 0.00987135 0.0203798 0.0443729
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.227045 0.509493 0.553618
Trypanosoma brucei glycerol uptake protein, putative 0.0383791 0.0845843 0.194093
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.00104629 0.000504195 0.000367701
Trichomonas vaginalis conserved hypothetical protein 0.0110904 0.0231253 0.0871754
Trypanosoma brucei heat shock protein, putative 0.00784138 0.015808 0.0353277
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.00784138 0.015808 0.0167351
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.00784138 0.015808 0.0595912
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.00155521 0.00165038 0.00264589
Entamoeba histolytica protein kinase domain containing protein 0.013028 0.0274892 0.101919
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0203944 0.0440796 0.0439296
Trichomonas vaginalis porcupine, putative 0.0383791 0.0845843 0.318858
Plasmodium vivax multidrug resistance protein 1, putative 0.0012703 0.00100871 0.000551707
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0012703 0.00100871 0.00380255
Plasmodium falciparum heat shock protein 90 0.00784138 0.015808 0.0167351
Loa Loa (eye worm) hypothetical protein 0.00155521 0.00165038 0.00149369
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.00384633 0.00681037 0.0145574
Trichomonas vaginalis casein kinase II beta chain, putative 0.00671322 0.0132671 0.0500131
Plasmodium vivax tyrosine kinase-like protein, putative 0.00255654 0.00390554 0.00371948
Mycobacterium ulcerans putative regultory protein 0.00784138 0.015808 0.0167351
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0383791 0.0845843 0.0844593
Mycobacterium ulcerans two component regulator - sensor kinase 0.00784138 0.015808 0.0167351
Echinococcus granulosus Nicastrin 0.0137097 0.0290244 0.0289959
Echinococcus multilocularis liprin beta 1 0.00255654 0.00390554 0.00387634
Loa Loa (eye worm) hypothetical protein 0.186019 0.417095 0.417003
Toxoplasma gondii vacuolar ATP synthase subunit b, putative 0.00375441 0.00660337 0.00666963
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0012703 0.00100871 0.00380255
Schistosoma mansoni multidrug resistance protein 0.0012703 0.00100871 0.000872289
Giardia lamblia DNA topoisomerase III 0.0169066 0.0362244 0.144623
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.00784138 0.015808 0.0353277
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0383791 0.0845843 0.0845575
Leishmania major heat shock protein 83-1 0.00784138 0.015808 0.0353277
Leishmania major heat shock protein 83-1 0.00784138 0.015808 0.0353277
Entamoeba histolytica hypothetical protein 0.00384633 0.00681037 0.0238177
Schistosoma mansoni hypothetical protein 0.0137097 0.0290244 0.0288918
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0203944 0.0440796 0.0439491
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0110904 0.0231253 0.0522193
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.1579 0.353766 0.353747
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.407084 0.914973 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0012703 0.00100871 0.00380255
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.00384633 0.00681037 0.0145574
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0203944 0.0440796 0.0439491
Trichomonas vaginalis conserved hypothetical protein 0.00255654 0.00390554 0.0147227
Trypanosoma brucei poly(adp-ribose) polymerase 0.00384633 0.00681037 0.0145574
Schistosoma mansoni nAChR subunit 0.00987135 0.0203798 0.020246
Giardia lamblia Alanyl dipeptidyl peptidase 0.0110904 0.0231253 0.0916181
Brugia malayi vacuolar ATP synthase subunit B 0.00375441 0.00660337 0.00644745
Trichomonas vaginalis sensor histidine kinase, putative 0.00784138 0.015808 0.0595912
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.013028 0.0274892 0.029509
Loa Loa (eye worm) heat shock protein 90 0.00784138 0.015808 0.0156535
Schistosoma mansoni gamma-secretase subunit aph-1 0.444837 1 1
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.00784138 0.015808 0.0157791
Leishmania major hypothetical protein, conserved 0.00795497 0.0160638 0.0359182
Trypanosoma brucei Casein kinase II subunit beta, putative 0.00671322 0.0132671 0.0294624
Trypanosoma cruzi Nicastrin, putative 0.00508881 0.00960868 0.0210171
Brugia malayi kinase, mitochondrial precursor 0.00784138 0.015808 0.0156535
Echinococcus granulosus multidrug resistance protein 1 0.0012703 0.00100871 0.000979426
Loa Loa (eye worm) diacylglycerol acyltransferase 0.224398 0.503531 0.503453
Entamoeba histolytica hypothetical protein, conserved 0.0110904 0.0231253 0.0854372
Loa Loa (eye worm) hypothetical protein 0.00255654 0.00390554 0.00374921
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.192295 0.43123 1
Brugia malayi Presenilin-like protein At2g29900 0.00998102 0.0206268 0.0204731
Trichomonas vaginalis conserved hypothetical protein 0.00384633 0.00681037 0.0256731
Trichomonas vaginalis ATP synthase alpha subunit mitochondrial, putative 0.00375441 0.00660337 0.0248927
Brugia malayi excitatory GABA receptor EXP-1A 0.0203944 0.0440796 0.0439296
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0012703 0.00100871 0.00380255
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0203944 0.0440796 0.0440516
Trypanosoma cruzi Nicastrin, putative 0.00508881 0.00960868 0.0210171
Echinococcus granulosus o acyltransferase membrane bound domain 0.0383791 0.0845843 0.0845575
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0110965 0.023139 0.0230056
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.00987135 0.0203798 0.0203511
Entamoeba histolytica hypothetical protein 0.00508881 0.00960868 0.0343865
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0383791 0.0845843 0.0845575
Loa Loa (eye worm) hypothetical protein 0.0105231 0.0218476 0.0216941
Echinococcus granulosus vacuolar ATP synthase subunit b 0.00375441 0.00660337 0.00657424
Loa Loa (eye worm) hypothetical protein 0.00987135 0.0203798 0.020226
Schistosoma mansoni sterol O-acyltransferase 1 0.0383791 0.0845843 0.0844593
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0012703 0.00100871 0.00380255
Brugia malayi hypothetical protein 0.00987135 0.0203798 0.020226
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.00255654 0.00390554 0.0147227
Trichomonas vaginalis casein kinase II beta chain, putative 0.00671322 0.0132671 0.0500131
Entamoeba histolytica vacuolar protein sorting 26 0.0383791 0.0845843 0.317561
Schistosoma mansoni acetylcholine receptor-related 0.00987135 0.0203798 0.020246
Echinococcus multilocularis nicalin 0.00508881 0.00960868 0.00957964
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0783213 0.174541 0.382102
Mycobacterium ulcerans DNA topoisomerase I 0.0169066 0.0362244 0.0390612
Trypanosoma cruzi oligopeptidase b 0.0110904 0.0231253 0.0522193
Loa Loa (eye worm) acetylcholine receptor protein 0.00987135 0.0203798 0.020226
Schistosoma mansoni nAChR subunit 0.0203944 0.0440796 0.0439491
Echinococcus multilocularis SAM domain containing protein 0.00255654 0.00390554 0.00387634
Giardia lamblia Alanyl dipeptidyl peptidase 0.0110904 0.0231253 0.0916181
Entamoeba histolytica P-glycoprotein 5, putative 0.0012703 0.00100871 0.00190551
Trichomonas vaginalis CMGC family protein kinase 0.013028 0.0274892 0.103626
Brugia malayi Hhat protein 0.0383791 0.0845843 0.0844407
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0203944 0.0440796 0.0440516
Leishmania major mitochondrial DNA topoisomerase II 0.193391 0.433699 1
Echinococcus granulosus Lipid transport protein N terminal 0.195106 0.437561 0.437544
Loa Loa (eye worm) DNA topoisomerase III 0.0169066 0.0362244 0.0360731
Trypanosoma brucei oligopeptidase b 0.0110904 0.0231253 0.0522193
Loa Loa (eye worm) multidrug resistance protein 3 0.0012703 0.00100871 0.000851924
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.00784138 0.015808 0.0171303
Leishmania major DNA topoisomerase III, putative 0.0169066 0.0362244 0.0824577
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0281575 0.0615634 0.232075
Schistosoma mansoni hypothetical protein 0.00255654 0.00390554 0.00376952
Loa Loa (eye worm) hypothetical protein 0.0383791 0.0845843 0.0844407
Brugia malayi ABC transporter transmembrane region family protein 0.00155521 0.00165038 0.00149369
Loa Loa (eye worm) gamma-secretase subunit pen-2 0.026138 0.0570152 0.0568672
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0110904 0.0231253 0.0871754
Loa Loa (eye worm) hypothetical protein 0.00353788 0.0061157 0.00595972
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0110904 0.0231253 0.0247369
Trichomonas vaginalis protein kinase ck2-beta, putative 0.00190986 0.00244911 0.00923242
Loa Loa (eye worm) tnks protein 0.0247467 0.0538817 0.0537332
Schistosoma mansoni ABC transporter 0.000892097 0.000156924 0.0000203827
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.00784138 0.015808 0.0171303
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.00784138 0.015808 0.0167351
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.224398 0.503531 0.550076
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0383791 0.0845843 0.0844407
Loa Loa (eye worm) hypothetical protein 0.00255654 0.00390554 0.00374921
Echinococcus granulosus nAChR subunit 0.0203944 0.0440796 0.0440516
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0383791 0.0845843 0.0845575
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0012703 0.00100871 0.00380255
Echinococcus multilocularis multidrug resistance associated protein 4 0.0011113 0.000650605 0.000621306
Leishmania major pentamidine resistance protein 1 0.00155521 0.00165038 0.00264589
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0169066 0.0362244 0.0360731
Schistosoma mansoni hypothetical protein 0.00255654 0.00390554 0.00376952
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0520604 0.115397 0.265222
Onchocerca volvulus 0.0822496 0.183388 0.417773
Plasmodium vivax hypothetical protein, conserved 0.0110904 0.0231253 0.0247369
Loa Loa (eye worm) hypothetical protein 0.0203944 0.0440796 0.0439296
Loa Loa (eye worm) hypothetical protein 0.0105231 0.0218476 0.0216941
Plasmodium falciparum endoplasmin, putative 0.00784138 0.015808 0.0167351
Loa Loa (eye worm) hypothetical protein 0.0203944 0.0440796 0.0439296
Trichomonas vaginalis casein kinase II beta chain, putative 0.00671322 0.0132671 0.0500131
Trypanosoma brucei heat shock protein 90, putative 0.00784138 0.015808 0.0353277
Loa Loa (eye worm) hypothetical protein 0.0440778 0.0974189 0.0972772
Loa Loa (eye worm) hhat protein 0.0383791 0.0845843 0.0844407
Echinococcus granulosus sterile alpha and tir motif containing protein 0.00255654 0.00390554 0.00387634
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.224398 0.503531 0.550076
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0203944 0.0440796 0.0439296
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0169066 0.0362244 0.0824577
Loa Loa (eye worm) hypothetical protein 0.0203944 0.0440796 0.0439296
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0520604 0.115397 0.265222
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0391284 0.0862719 0.197989
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.224398 0.503531 0.503464
Loa Loa (eye worm) hypothetical protein 0.195106 0.437561 0.437473
Trypanosoma brucei DNA topoisomerase IA, putative 0.0169066 0.0362244 0.0824577
Loa Loa (eye worm) LGC-31 protein 0.0203944 0.0440796 0.0439296
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0169066 0.0362244 0.022706
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.118607 0.265273 0.265251
Loa Loa (eye worm) hypothetical protein 0.0105231 0.0218476 0.0216941
Brugia malayi Presenilin spe-4 0.00998102 0.0206268 0.0204731
Trichomonas vaginalis conserved hypothetical protein 0.00384633 0.00681037 0.0256731
Loa Loa (eye worm) MBOAT family protein 0.0383791 0.0845843 0.0844407
Trichomonas vaginalis CMGC family protein kinase 0.013028 0.0274892 0.103626
Loa Loa (eye worm) hhat protein 0.0383791 0.0845843 0.0844407
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.155774 0.348978 0.804429
Loa Loa (eye worm) hypothetical protein 0.00353788 0.0061157 0.00595972
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.000835438 0.0000293173 0.000110517
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0383791 0.0845843 0.0845575
Leishmania major glycerol uptake protein, putative 0.0383791 0.0845843 0.194093
Trichomonas vaginalis conserved hypothetical protein 0.0383791 0.0845843 0.318858
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.00255654 0.00390554 0.00374921
Brugia malayi hypothetical protein 0.00987135 0.0203798 0.020226
Brugia malayi Cation transporter family protein 0.0203944 0.0440796 0.0439296
Leishmania major glycerol uptake protein, putative 0.0383791 0.0845843 0.194093
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0105231 0.0218476 0.0216941
Brugia malayi WGR domain containing protein 0.00384633 0.00681037 0.00665449
Trichomonas vaginalis heat shock protein, putative 0.00784138 0.015808 0.0595912
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0012703 0.00100871 0.00380255
Schistosoma mansoni neurotransmitter gated ion channel 0.00987135 0.0203798 0.020246
Echinococcus multilocularis poly (ADP ribose) polymerase 0.00384633 0.00681037 0.00678125
Echinococcus multilocularis stromal interaction molecule 1 0.00255654 0.00390554 0.00387634
Leishmania major dihydrofolate reductase-thymidylate synthase 0.155774 0.348978 0.804429
Loa Loa (eye worm) hypothetical protein 0.0203944 0.0440796 0.0439296
Giardia lamblia Multidrug resistance-associated protein 1 0.00154616 0.00163 0.00463801
Loa Loa (eye worm) ACC-1 protein 0.0203944 0.0440796 0.0439296
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0105231 0.0218476 0.021714
Onchocerca volvulus 0.00255654 0.00390555 0.00663571
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0203944 0.0440796 0.0439296
Leishmania major heat shock protein 83-1 0.00784138 0.015808 0.0353277
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0383791 0.0845843 0.0845575
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.00155521 0.00165038 0.00264589
Echinococcus multilocularis nAChR subunit 0.0105231 0.0218476 0.0218189
Echinococcus granulosus stromal interaction molecule 1 0.00255654 0.00390554 0.00387634
Onchocerca volvulus Putative nachr subunit 0.0263924 0.0575881 0.129605
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012703 0.00100871 0.000979426
Echinococcus multilocularis multidrug resistance associated protein 1 0.00155521 0.00165038 0.00162111
Onchocerca volvulus 0.0203944 0.0440796 0.0986615
Leishmania major heat shock protein 83-1 0.00784138 0.015808 0.0353277
Brugia malayi MBOAT family protein 0.0383791 0.0845843 0.0844407
Echinococcus multilocularis vacuolar ATP synthase subunit b 0.00375441 0.00660337 0.00657424
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00987135 0.0203798 0.020226
Schistosoma mansoni endoplasmin 0.00784138 0.015808 0.0156735
Trichomonas vaginalis conserved hypothetical protein 0.00255654 0.00390554 0.0147227
Leishmania major glycerol uptake protein, putative 0.0383791 0.0845843 0.194093
Mycobacterium ulcerans DNA gyrase subunit B 0.227045 0.509493 0.556595
Schistosoma mansoni poly [ADP-ribose] polymerase 0.00384633 0.00681037 0.00667474
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.00784138 0.015808 0.0171303
Mycobacterium tuberculosis Probable two component sensor kinase 0.00784138 0.015808 0.0171303
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.00987135 0.0203798 0.0203511
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0110904 0.0231253 0.0522193
Loa Loa (eye worm) hypothetical protein 0.0105231 0.0218476 0.0216941
Toxoplasma gondii prolyl endopeptidase 0.0110904 0.0231253 0.0247369
Trypanosoma cruzi casein kinase II, putative 0.013028 0.0274892 0.0622931
Trichomonas vaginalis conserved hypothetical protein 0.00255654 0.00390554 0.0147227
Echinococcus multilocularis heat shock protein 90 0.00784138 0.015808 0.0157791
Schistosoma mansoni nAChR subunit 0.0203944 0.0440796 0.0439491
Trichomonas vaginalis casein kinase II beta chain, putative 0.00190986 0.00244911 0.00923242
Mycobacterium tuberculosis Two component sensor kinase MprB 0.00784138 0.015808 0.0171303
Chlamydia trachomatis DNA gyrase subunit B 0.227045 0.509493 0.556351
Trichomonas vaginalis conserved hypothetical protein 0.00384633 0.00681037 0.0256731
Loa Loa (eye worm) MBOAT family protein 0.0383791 0.0845843 0.0844407
Loa Loa (eye worm) presenilin spe-4 0.00998102 0.0206268 0.0204731
Loa Loa (eye worm) hypothetical protein 0.061161 0.135893 0.135758
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0012703 0.00100871 0.00380255
Loa Loa (eye worm) hypothetical protein 0.0105231 0.0218476 0.0216941
Loa Loa (eye worm) hypothetical protein 0.00987135 0.0203798 0.020226
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0012703 0.00100871 0.00380255
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.444837 1 1
Loa Loa (eye worm) hypothetical protein 0.00987135 0.0203798 0.020226
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.101701 0.227196 0.523304
Echinococcus multilocularis presenilin 0.0281575 0.0615634 0.0615359
Leishmania major heat shock protein 83-1 0.00784138 0.015808 0.0353277
Mycobacterium tuberculosis Probable peptidase 0.0110904 0.0231253 0.0251288
Echinococcus granulosus heat shock protein 0.00784138 0.015808 0.0157791
Leishmania major heat shock protein 83-1 0.00784138 0.015808 0.0353277
Echinococcus granulosus casein kinase ii subunit alpha 0.013028 0.0274892 0.0274607
Toxoplasma gondii hypothetical protein 0.00998102 0.0206268 0.0220047
Schistosoma mansoni ATP synthase subunit beta vacuolar 0.00375441 0.00660337 0.00646771
Trypanosoma cruzi prolyl endopeptidase 0.0110904 0.0231253 0.0522193
Trypanosoma cruzi oligopeptidase b 0.0110904 0.0231253 0.0522193
Plasmodium vivax unspecified product 0.013028 0.0274892 0.029509
Schistosoma mansoni hypothetical protein 0.28444 0.638758 0.638708
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0012703 0.00100871 0.00380255
Echinococcus granulosus DNA topoisomerase 2 alpha 0.118607 0.265273 0.265251
Brugia malayi Csnk2b protein 0.00671322 0.0132671 0.0131123
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0169066 0.0362244 0.0360928
Loa Loa (eye worm) hypothetical protein 0.00154616 0.00163 0.00147331
Entamoeba histolytica ATP-binding cassette protein, putative 0.00155521 0.00165038 0.00432901
Trichomonas vaginalis CMGC family protein kinase 0.013028 0.0274892 0.103626
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.155774 0.348978 0.804429
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.192295 0.43123 0.471012
Leishmania major protein kinase ck2 regulatory subunit, putative 0.00671322 0.0132671 0.0294624
Trypanosoma brucei heat shock protein, putative 0.00784138 0.015808 0.0353277
Trypanosoma brucei prolyl endopeptidase 0.0110904 0.0231253 0.0522193
Trichomonas vaginalis conserved hypothetical protein 0.00384633 0.00681037 0.0256731
Echinococcus multilocularis heat shock protein 0.00784138 0.015808 0.0157791
Loa Loa (eye worm) vacuolar ATP synthase subunit B 0.00375441 0.00660337 0.00644745
Loa Loa (eye worm) hypothetical protein 0.0203944 0.0440796 0.0439296
Echinococcus granulosus multidrug resistance associated protein 1 0.00155521 0.00165038 0.00162111
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.00155521 0.00165038 0.00264589
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0110904 0.0231253 0.0522193
Schistosoma mansoni multidrug resistance protein 0.00155521 0.00165038 0.00151404
Brugia malayi multidrug resistance related protein 1 0.00155521 0.00165038 0.00149369
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0203944 0.0440796 0.0439296
Brugia malayi heat shock protein 90 0.00784138 0.015808 0.0156535
Schistosoma mansoni heat shock protein 0.00784138 0.015808 0.0156735
Schistosoma mansoni lar interacting protein (lip)-related protein 0.00255654 0.00390554 0.00376952
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.00784138 0.015808 0.0167351
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012703 0.00100871 0.000979426
Entamoeba histolytica prolyl oligopeptidase family protein 0.0110904 0.0231253 0.0854372
Brugia malayi coiled-coil like protein 1 0.00255654 0.00390554 0.00374921
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.00784138 0.015808 0.0161924
Entamoeba histolytica P-glycoprotein-2, putative 0.0012703 0.00100871 0.00190551
Loa Loa (eye worm) hypothetical protein 0.00353788 0.0061157 0.00595972
Loa Loa (eye worm) hypothetical protein 0.0137097 0.0290244 0.028872
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.135768 0.303921 0.331796
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0203944 0.0440796 0.0439296
Leishmania major oligopeptidase b 0.0110904 0.0231253 0.0522193
Leishmania major heat shock protein 83-1 0.00784138 0.015808 0.0353277
Trichomonas vaginalis conserved hypothetical protein 0.00384633 0.00681037 0.0256731
Loa Loa (eye worm) hypothetical protein 0.0440778 0.0974189 0.0972772
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.227045 0.509493 0.556773
Loa Loa (eye worm) hypothetical protein 0.00384633 0.00681037 0.00665449
Giardia lamblia MRP-like ABC transporter 0.00155521 0.00165038 0.00472048
Trypanosoma brucei multidrug resistance-associated protein, putative 0.00155521 0.00165038 0.00264589
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0281575 0.0615634 0.232075
Trichomonas vaginalis casein kinase II beta chain, putative 0.00190986 0.00244911 0.00923242
Echinococcus multilocularis acylamino acid releasing enzyme 0.0110904 0.0231253 0.0230967
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.407084 0.914973 1
Schistosoma mansoni heat shock protein 0.00784138 0.015808 0.0156735
Echinococcus multilocularis casein kinase ii subunit alpha 0.013028 0.0274892 0.0274607
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.155774 0.348978 0.381068
Trypanosoma cruzi heat shock protein 85, putative 0.00784138 0.015808 0.0353277
Entamoeba histolytica multidrug resistance protein, putative 0.00155521 0.00165038 0.00432901
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0110904 0.0231253 0.0522193
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.00255654 0.00390554 0.00387634
Leishmania major ABC-thiol transporter 0.00155521 0.00165038 0.00264589
Trypanosoma cruzi hypothetical protein 0.0011113 0.000650605 0.000337977
Echinococcus granulosus ATP binding cassette sub family G 0.00104629 0.000504195 0.000474892
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0203944 0.0440796 0.0439296
Loa Loa (eye worm) hypothetical protein 0.0105231 0.0218476 0.0216941
Giardia lamblia Vacuolar ATP synthase subunit B 0.00375441 0.00660337 0.0247626
Echinococcus granulosus nicalin 0.00508881 0.00960868 0.00957964
Echinococcus granulosus glycine receptor subunit alpha 1 0.0203944 0.0440796 0.0440516
Schistosoma mansoni hypothetical protein 0.0383791 0.0845843 0.0844593
Brugia malayi Neurabin protein 1 0.00255654 0.00390554 0.00374921
Entamoeba histolytica P-glycoprotein-1 0.0012703 0.00100871 0.00190551
Echinococcus granulosus casein kinase ii subunit beta 0.00671322 0.0132671 0.0132382
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0105231 0.0218476 0.0216941
Brugia malayi Presenilin family protein 0.0281575 0.0615634 0.0614161
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.00384633 0.00681037 0.00678125
Echinococcus granulosus Dipeptidyl peptidase 9 0.0520604 0.115397 0.115371
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012703 0.00100871 0.000979426
Echinococcus granulosus Sterile alpha motif SAM 0.00255654 0.00390555 0.00387634
Trypanosoma brucei DNA topoisomerase II beta, putative 0.101701 0.227196 0.523304
Echinococcus granulosus glycine receptor subunit beta 0.0203944 0.0440796 0.0440516
Entamoeba histolytica zinc finger protein, putative 0.00384633 0.00681037 0.0238177
Trypanosoma cruzi hypothetical protein, conserved 0.0110904 0.0231253 0.0522193
Leishmania major heat shock protein 83-1 0.00784138 0.015808 0.0353277
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.0706807 0.157333 0.171497
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0263924 0.0575881 0.0574402
Mycobacterium ulcerans two component sensor kinase MprB 0.00784138 0.015808 0.0167351
Brugia malayi hypothetical protein 0.04097 0.0904195 0.0902767
Trichomonas vaginalis ABC transporter, putative 0.0012703 0.00100871 0.00380255
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0263924 0.0575881 0.0575605
Giardia lamblia Heat shock protein HSP 90-alpha 0.00784138 0.015808 0.0620086
Trypanosoma cruzi GUP1, putative 0.0383791 0.0845843 0.194093
Trypanosoma cruzi Aph-1 protein, putative 0.174407 0.390943 0.9013
Trichomonas vaginalis casein kinase II beta chain, putative 0.00671322 0.0132671 0.0500131
Loa Loa (eye worm) GABA receptor subunit 0.0105231 0.0218476 0.0216941
Plasmodium vivax DNA topoisomerase II, putative 0.118607 0.265273 0.289533
Trypanosoma brucei Presenilin enhancer-2 subunit of gamma secretase, putative 0.00795497 0.0160638 0.0359182
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0203944 0.0440796 0.0439296
Trichomonas vaginalis endoplasmin, putative 0.00784138 0.015808 0.0595912
Trichomonas vaginalis conserved hypothetical protein 0.0391284 0.0862719 0.325219
Trichomonas vaginalis casein kinase II beta chain, putative 0.00190986 0.00244911 0.00923242
Echinococcus granulosus liprin alpha 2 0.00255654 0.00390554 0.00387634
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0203944 0.0440796 0.0439296
Onchocerca volvulus 0.00255654 0.00390554 0.0066357
Entamoeba histolytica hypothetical protein 0.00384633 0.00681037 0.0238177
Plasmodium vivax DNA topoisomerase 3, putative 0.0169066 0.0362244 0.0390612
Schistosoma mansoni casein kinase II beta subunit 0.00671322 0.0132671 0.0131324
Echinococcus multilocularis multidrug resistance protein 1 0.0012703 0.00100871 0.000979426
Trichomonas vaginalis casein kinase II beta chain, putative 0.00671322 0.0132671 0.0500131
Giardia lamblia DNA topoisomerase II 0.110766 0.247613 1
Plasmodium falciparum peptidase, putative 0.0110904 0.0231253 0.0247369
Schistosoma mansoni nAChR subunit 0.0203944 0.0440796 0.0439491
Trichomonas vaginalis ABC transporter, putative 0.0012703 0.00100871 0.00380255
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.00384633 0.00681037 0.0238177
Entamoeba histolytica ATP-binding cassette protein, putative 0.00155521 0.00165038 0.00432901
Trypanosoma brucei DNA topoisomerase III, putative 0.0169066 0.0362244 0.0824577
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0203944 0.0440796 0.0439296
Leishmania major heat shock protein 83-1 0.00784138 0.015808 0.0353277
Brugia malayi hypothetical protein 0.0137097 0.0290244 0.028872
Trypanosoma brucei heat shock protein, putative 0.00784138 0.015808 0.0353277
Schistosoma mansoni poly [ADP-ribose] polymerase 0.00384633 0.00681037 0.00667474
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0203944 0.0440796 0.0440516
Trypanosoma cruzi heat shock protein 85, putative 0.00784138 0.015808 0.0353277
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0203944 0.0440796 0.0440516
Brugia malayi Liprin-alpha 2 0.00255654 0.00390554 0.00374921
Echinococcus granulosus o acyltransferase membrane bound domain 0.0383791 0.0845843 0.0845575
Giardia lamblia Casein kinase II beta chain 0.00671322 0.0132671 0.0517273
Schistosoma mansoni neurotransmitter gated ion channel 0.0105231 0.0218476 0.021714
Leishmania major presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative 0.0281575 0.0615634 0.140951
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.407084 0.914973 1
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.227045 0.509493 0.549049
Leishmania major hypothetical protein, conserved 0.00784138 0.015808 0.0353277
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0105231 0.0218476 0.021714
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0012703 0.00100871 0.00380255
Trypanosoma cruzi DNA topoisomerase III, putative 0.0169066 0.0362244 0.0824577
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0110904 0.0231253 0.0522193
Mycobacterium tuberculosis Probable sensor protein KdpD 0.00784138 0.015808 0.0171303
Loa Loa (eye worm) hypothetical protein 0.0690138 0.153579 0.153446
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0012703 0.00100871 0.00380255
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.00671322 0.0132671 0.0294624
Entamoeba histolytica hypothetical protein 0.00155521 0.00165038 0.00432901
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.00987135 0.0203798 0.020226
Chlamydia trachomatis DNA gyrase subunit B 0.152261 0.341067 0.37207
Echinococcus multilocularis ATP binding cassette sub family G 0.00104629 0.000504195 0.000474892
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.00784138 0.015808 0.0167351
Schistosoma mansoni nAChR subunit 0.0203944 0.0440796 0.0439491
Trichomonas vaginalis transmembrane protein nessy, putative 0.0383791 0.0845843 0.318858
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.193391 0.433699 1
Trypanosoma brucei heat shock protein, putative 0.00784138 0.015808 0.0353277
Trypanosoma brucei prolyl oligopeptidase, putative 0.0110904 0.0231253 0.0522193
Echinococcus granulosus ATP binding cassette sub family G 0.00104629 0.000504195 0.000474892
Trichomonas vaginalis conserved hypothetical protein 0.00255654 0.00390554 0.0147227
Trichomonas vaginalis conserved hypothetical protein 0.0383791 0.0845843 0.318858
Echinococcus granulosus microsomal triglyceride transfer protein large 0.28444 0.638758 0.638747
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.00671322 0.0132671 0.0482041
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.00384633 0.00681037 0.006896
Loa Loa (eye worm) hypothetical protein 0.00987135 0.0203798 0.020226
Brugia malayi hypothetical protein 0.0137097 0.0290244 0.028872
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0203944 0.0440796 0.0439296
Leishmania major DNA topoisomerase ii 0.101701 0.227196 0.523304
Leishmania major heat shock protein 83-1 0.00784138 0.015808 0.0353277
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.118607 0.265273 0.265158
Chlamydia trachomatis DNA topoisomerase I 0.0169066 0.0362244 0.0385307
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.00987135 0.0203798 0.0203511
Brugia malayi Presenilin spe-4 0.00998102 0.0206268 0.0204731
Trichomonas vaginalis casein kinase II beta chain, putative 0.00190986 0.00244911 0.00923242
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0203944 0.0440796 0.0439296
Plasmodium falciparum casein kinase 2, alpha subunit 0.013028 0.0274892 0.029509
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.1579 0.353766 0.808052
Loa Loa (eye worm) endoplasmin 0.00784138 0.015808 0.0156535
Trichomonas vaginalis casein kinase II beta chain, putative 0.00671322 0.0132671 0.0500131
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012703 0.00100871 0.000979426
Echinococcus granulosus multidrug resistance associated protein 4 0.0011113 0.000650605 0.000621306
Trypanosoma brucei heat shock protein, putative 0.00784138 0.015808 0.0353277
Echinococcus granulosus tankyrase 0.0272944 0.0596196 0.059592
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.00784138 0.015808 0.0595912
Trichomonas vaginalis conserved hypothetical protein 0.0383791 0.0845843 0.318858
Brugia malayi hypothetical protein 0.00255654 0.00390554 0.00374921
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0520604 0.115397 0.115371
Entamoeba histolytica presenilin 1 peptidase, putative 0.0281575 0.0615634 0.230613
Onchocerca volvulus 0.0169066 0.0362244 0.0806678
Trichomonas vaginalis casein kinase II beta chain, putative 0.00190986 0.00244911 0.00923242
Trichomonas vaginalis casein kinase II beta chain, putative 0.00190986 0.00244911 0.00923242
Trypanosoma brucei developmentally regulated phosphoprotein 0.00784138 0.015808 0.0353277
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.00987135 0.0203798 0.0203511
Loa Loa (eye worm) hypothetical protein 0.00987135 0.0203798 0.020226
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0383791 0.0845843 0.0845575
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.193391 0.433699 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0012703 0.00100871 0.00380255
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.00784138 0.015808 0.0167351
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0012703 0.00100871 0.00380255
Onchocerca volvulus Tankyrase homolog 0.0241769 0.0525985 0.118175
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0203944 0.0440796 0.0439296
Onchocerca volvulus Apolipophorins homolog 0.195106 0.437561 1
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0169066 0.0362244 0.0361961
Trichomonas vaginalis CMGC family protein kinase 0.013028 0.0274892 0.103626
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.00987135 0.0203798 0.020226
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0012703 0.00100871 0.00116465
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0520604 0.115397 0.265222
Trypanosoma cruzi V-type proton ATPase subunit B, putative 0.00375441 0.00660337 0.0140795
Trypanosoma cruzi Heat shock protein 83, putative 0.00784138 0.015808 0.0353277
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.00190986 0.00244911 0.00734572
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0110904 0.0231253 0.0854372
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0169066 0.0362244 0.0824577
Plasmodium falciparum casein kinase II beta chain 0.00671322 0.0132671 0.0139567
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0281575 0.0615634 0.140951
Loa Loa (eye worm) hypothetical protein 0.0203944 0.0440796 0.0439296
Treponema pallidum alginate O-acetylation protein (algI) 0.0383791 0.0845843 0.0858472
Trypanosoma brucei glycerol uptake protein, putative 0.0383791 0.0845843 0.194093
Loa Loa (eye worm) dihydrofolate reductase 0.192295 0.43123 0.43114
Mycobacterium tuberculosis Conserved protein 0.00784138 0.015808 0.0171303
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.00784138 0.015808 0.0167351
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.00155521 0.00165038 0.00264589
Loa Loa (eye worm) hypothetical protein 0.0203944 0.0440796 0.0439296
Brugia malayi prolyl oligopeptidase family protein 0.0110904 0.0231253 0.022972
Mycobacterium ulcerans DNA gyrase subunit A 0.407084 0.914973 1
Echinococcus multilocularis tankyrase 0.0272944 0.0596196 0.059592
Trichomonas vaginalis ABC transporter, putative 0.0012703 0.00100871 0.00380255
Entamoeba histolytica hypothetical protein 0.0105231 0.0218476 0.0806114
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0203944 0.0440796 0.0440516
Trypanosoma cruzi DNA topoisomerase II, putative 0.101701 0.227196 0.523304
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0110904 0.0231253 0.0247369
Onchocerca volvulus 0.00987135 0.0203798 0.0443729
Giardia lamblia Kinase, CMGC CK2 0.013028 0.0274892 0.109277
Brugia malayi MBOAT family protein 0.0383791 0.0845843 0.0844407
Plasmodium vivax casein kinase II beta chain, putative 0.00671322 0.0132671 0.0139567
Onchocerca volvulus Casein kinase II subunit beta homolog 0.00671322 0.0132671 0.0280801
Echinococcus multilocularis microsomal triglyceride transfer protein large 0.28444 0.638758 0.638747
Brugia malayi hypothetical protein 0.00998102 0.0206268 0.0204731
Loa Loa (eye worm) thymidylate synthase 0.0822496 0.183388 0.18326
Trypanosoma brucei heat shock protein, putative 0.00784138 0.015808 0.0353277
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0263924 0.0575881 0.0574402
Brugia malayi Presenilin spe-4 0.00998102 0.0206268 0.0204731
Schistosoma mansoni tankyrase 0.0273093 0.0596532 0.0595247
Chlamydia trachomatis dihydrofolate reductase 0.192295 0.43123 0.47072
Echinococcus multilocularis multidrug resistance associated protein 7 0.00155521 0.00165038 0.00162111
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0520604 0.115397 0.125639
Echinococcus granulosus glycine receptor subunit beta 0.0203944 0.0440796 0.0440516
Entamoeba histolytica hypothetical protein 0.00384633 0.00681037 0.0238177
Giardia lamblia DNA topoisomerase III 0.0169066 0.0362244 0.144623
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.00671322 0.0132671 0.0139567
Loa Loa (eye worm) multidrug resistance-associated protein 0.00112035 0.000670985 0.000514142
Brugia malayi WGR domain containing protein 0.00384633 0.00681037 0.00665449
Giardia lamblia Multidrug resistance-associated protein 1 0.00155521 0.00165038 0.00472048
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.224398 0.503531 0.503517
Brugia malayi Tnks protein 0.0269949 0.0589451 0.0587974
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.00784138 0.015808 0.0167351
Schistosoma mansoni multidrug resistance protein 0.00155521 0.00165038 0.00151404
Echinococcus granulosus acylamino acid releasing enzyme 0.0110904 0.0231253 0.0230967
Plasmodium falciparum DNA topoisomerase 2 0.118607 0.265273 0.289533
Leishmania major heat shock protein 83-1 0.00784138 0.015808 0.0353277
Trypanosoma cruzi GUP1, putative 0.0383791 0.0845843 0.194093
Schistosoma mansoni pyruvate dehydrogenase 0.00784138 0.015808 0.0156735
Leishmania major DNA topoisomerase III, putative 0.0169066 0.0362244 0.0824577
Onchocerca volvulus DNA topoisomerase 2 homolog 0.112036 0.250474 0.571443
Trichomonas vaginalis casein kinase II beta chain, putative 0.00671322 0.0132671 0.0500131
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0012703 0.00100871 0.000953362
Loa Loa (eye worm) hypothetical protein 0.0012703 0.00100871 0.000851924
Trypanosoma cruzi glycerol uptake protein, putative 0.0383791 0.0845843 0.194093
Echinococcus granulosus heat shock protein 90 0.00784138 0.015808 0.0157791
Trypanosoma cruzi hypothetical protein, conserved 0.0110904 0.0231253 0.0522193
Toxoplasma gondii hypothetical protein 0.0110904 0.0231253 0.0247369
Trypanosoma cruzi DNA topoisomerase II, putative 0.101701 0.227196 0.523304
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0203944 0.0440796 0.0439296
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0203944 0.0440796 0.0439491
Trichomonas vaginalis receptor histidine kinase, putative 0.00784138 0.015808 0.0595912
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0263924 0.0575881 0.0575605
Trichomonas vaginalis casein kinase II beta chain, putative 0.00190986 0.00244911 0.00923242
Trichomonas vaginalis conserved hypothetical protein 0.00384633 0.00681037 0.0256731
Echinococcus multilocularis ATP binding cassette sub family G 0.00104629 0.000504195 0.000474892
Loa Loa (eye worm) hypothetical protein 0.00255654 0.00390554 0.00374921
Onchocerca volvulus DNA topoisomerase 2 homolog 0.112036 0.250474 0.571443
Onchocerca volvulus 0.0203944 0.0440796 0.0986615
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0012703 0.00100871 0.00380255
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.155774 0.348978 0.381068
Entamoeba histolytica casein kinase, putative 0.013028 0.0274892 0.101919
Schistosoma mansoni dihydrofolate reductase 0.192295 0.43123 0.431152
Entamoeba histolytica ATP-binding cassette protein, putative 0.00155521 0.00165038 0.00432901
Onchocerca volvulus 0.0203944 0.0440796 0.0986615
Loa Loa (eye worm) hypothetical protein 0.0012703 0.00100871 0.000851924
Echinococcus multilocularis thymidylate synthase 0.0822496 0.183388 0.183364
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0203944 0.0440796 0.0440516
Trichomonas vaginalis heat shock protein, putative 0.00784138 0.015808 0.0595912
Loa Loa (eye worm) hypothetical protein 0.0105231 0.0218476 0.0216941
Leishmania major heat shock protein 83-1 0.00784138 0.015808 0.0353277
Entamoeba histolytica ABC transporter, putative 0.00155521 0.00165038 0.00432901
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.00784138 0.015808 0.0171303
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.00784138 0.015808 0.0595912
Brugia malayi hypothetical protein 0.0391284 0.0862719 0.0861285
Trypanosoma brucei Casein kinase II 0.013028 0.0274892 0.0622931
Entamoeba histolytica DNA topoisomerase III, putative 0.0169066 0.0362244 0.134911
Trypanosoma brucei DNA topoisomerase III, putative 0.0169066 0.0362244 0.0824577
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0110904 0.0231253 0.0522193
Echinococcus multilocularis nAChR subunit 0.0203944 0.0440796 0.0440516
Onchocerca volvulus 0.00987135 0.0203798 0.0443729
Entamoeba histolytica P-glyco protein 6, putative 0.0012703 0.00100871 0.00190551
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.155774 0.348978 0.381068
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0169066 0.0362244 0.136555
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0012703 0.00100871 0.00380255
Schistosoma mansoni DNA topoisomerase II 0.118607 0.265273 0.265173
Trypanosoma brucei Nicastrin, putative 0.00508881 0.00960868 0.0210171
Trichomonas vaginalis CMGC family protein kinase 0.013028 0.0274892 0.103626
Schistosoma mansoni endoplasmin 0.00784138 0.015808 0.0156735
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.112036 0.250474 0.571443
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0383791 0.0845843 0.0845575
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0281575 0.0615634 0.232075
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.00784138 0.015808 0.0171303
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0012703 0.00100871 0.000551707
Echinococcus multilocularis presenilin enhancer 2 0.026138 0.0570152 0.0569875
Loa Loa (eye worm) hypothetical protein 0.0110904 0.0231253 0.022972
Schistosoma mansoni hypothetical protein 0.00255654 0.00390554 0.00376952
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.00987135 0.0203798 0.020226
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0203944 0.0440796 0.0439296
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0822496 0.183388 0.403398
Brugia malayi hypothetical protein 0.00987135 0.0203798 0.020226
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0383791 0.0845843 0.0844593
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.00264586 0.00410671 0.00393947
Loa Loa (eye worm) hypothetical protein 0.28444 0.638758 0.638701
Brugia malayi Dihydrofolate reductase 0.192295 0.43123 0.43114
Trichomonas vaginalis casein kinase II beta chain, putative 0.00190986 0.00244911 0.00923242
Echinococcus granulosus liprin beta 1 0.00255654 0.00390554 0.00387634
Leishmania major hypothetical protein, conserved 0.0383791 0.0845843 0.194093
Entamoeba histolytica DNA topoisomerase II, putative 0.118607 0.265273 1
Trypanosoma brucei multidrug resistance protein E 0.00155521 0.00165038 0.00264589
Plasmodium falciparum DNA gyrase subunit A 0.407084 0.914973 1
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.00987135 0.0203798 0.020226
Plasmodium falciparum DNA gyrase subunit B 0.227045 0.509493 0.556595
Schistosoma mansoni neurotransmitter gated ion channel 0.00987135 0.0203798 0.020246
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0383791 0.0845843 0.317561
Giardia lamblia ABC transporter, putative 0.00155521 0.00165038 0.00472048
Trichomonas vaginalis conserved hypothetical protein 0.00384633 0.00681037 0.0256731
Plasmodium vivax DNA gyrase subunit A, putative 0.407084 0.914973 1
Loa Loa (eye worm) hypothetical protein 0.0105231 0.0218476 0.0216941
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.00155521 0.00165038 0.00149369
Toxoplasma gondii DNA topoisomerase 2, putative 0.118607 0.265273 0.289533
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.00255654 0.00390554 0.00374921
Entamoeba histolytica hypothetical protein, conserved 0.0383791 0.0845843 0.317561
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.00671322 0.0132671 0.0482041
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0383791 0.0845843 0.317561
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0105231 0.0218476 0.0216941
Plasmodium falciparum tyrosine kinase-like protein 0.00255654 0.00390554 0.00371948
Trichomonas vaginalis casein kinase II beta chain, putative 0.00671322 0.0132671 0.0500131
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.00190986 0.00244911 0.00734572
Echinococcus granulosus thymidylate synthase 0.0822496 0.183388 0.183364
Trichomonas vaginalis casein kinase II beta chain, putative 0.00190986 0.00244911 0.00923242
Leishmania major vacuolar ATP synthase subunit b, putative 0.00375441 0.00660337 0.0140795
Loa Loa (eye worm) hypothetical protein 0.0110904 0.0231253 0.022972
Loa Loa (eye worm) TOPoisomerase family member 0.118607 0.265273 0.265158
Brugia malayi prolyl oligopeptidase family protein 0.1579 0.353766 0.353664
Schistosoma mansoni nAChR subunit 0.0203944 0.0440796 0.0439491
Trichomonas vaginalis DNA topoisomerase II, putative 0.118607 0.265273 1
Echinococcus granulosus poly adp ribose polymerase 2 0.00384633 0.00681037 0.00678125
Mycobacterium tuberculosis Hypothetical protein 0.0391284 0.0862719 0.0941539
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0012703 0.00100871 0.00380255
Trichomonas vaginalis abcb9, putative 0.0012703 0.00100871 0.00380255
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.00155521 0.00165038 0.00125339
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0110904 0.0231253 0.0176143
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0263924 0.0575881 0.0575605
Plasmodium vivax hypothetical protein, conserved 0.00784138 0.015808 0.0167351
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.00784138 0.015808 0.0167351
Schistosoma mansoni multidrug resistance protein 0.0012703 0.00100871 0.000872289
Brugia malayi thymidylate synthase 0.0822496 0.183388 0.18326
Echinococcus granulosus prolyl endopeptidase 0.0110904 0.0231253 0.0230967
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.00784138 0.015808 0.0353277
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0383791 0.0845843 0.0845575
Echinococcus granulosus gamma secretase subunit aph 1 0.444837 1 1
Schistosoma mansoni acetylcholine receptor subunit beta 0.00987135 0.0203798 0.020246
Entamoeba histolytica DNA topoisomerase III, putative 0.0169066 0.0362244 0.134911
Loa Loa (eye worm) hypothetical protein 0.00987135 0.0203798 0.020226
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0383791 0.0845843 0.0845575
Trichomonas vaginalis casein kinase II beta chain, putative 0.00190986 0.00244911 0.00923242
Loa Loa (eye worm) hypothetical protein 0.00987135 0.0203798 0.020226
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0110904 0.0231253 0.0251288
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.00784138 0.015808 0.0595912
Schistosoma mansoni zinc finger protein 0.0383791 0.0845843 0.0844593
Loa Loa (eye worm) hypothetical protein 0.0203944 0.0440796 0.0439296
Plasmodium falciparum protein kinase, putative 0.00255654 0.00390554 0.00371948
Trichomonas vaginalis casein kinase II beta chain, putative 0.00671322 0.0132671 0.0500131
Brugia malayi prolyl oligopeptidase family protein 0.0520604 0.115397 0.115258
Loa Loa (eye worm) hypothetical protein 0.00784138 0.015808 0.0156535
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0383791 0.0845843 0.0844593
Echinococcus multilocularis Lipid transport protein, N terminal 0.195106 0.437561 0.437544
Loa Loa (eye worm) hypothetical protein 0.00987135 0.0203798 0.020226
Onchocerca volvulus 0.0203944 0.0440796 0.0986615
Echinococcus granulosus presenilin enhancer 2 0.026138 0.0570152 0.0569875
Loa Loa (eye worm) hypothetical protein 0.00126126 0.000988334 0.000831541
Echinococcus granulosus glycine receptor subunit alpha 1 0.0203944 0.0440796 0.0440516
Plasmodium falciparum diacylglycerol O-acyltransferase 0.224398 0.503531 0.550076
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0110904 0.0231253 0.0871754
Loa Loa (eye worm) hypothetical protein 0.00987135 0.0203798 0.020226
Loa Loa (eye worm) hypothetical protein 0.00987135 0.0203798 0.020226
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0383791 0.0845843 0.0844593
Brugia malayi MBOAT family protein 0.0383791 0.0845843 0.0844407
Echinococcus multilocularis casein kinase ii subunit beta 0.00671322 0.0132671 0.0132382
Brugia malayi Probable DNA topoisomerase II 0.118607 0.265273 0.265158
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0110904 0.0231253 0.0854372
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.013028 0.0274892 0.0273366
Trichomonas vaginalis receptor histidine kinase, putative 0.00784138 0.015808 0.0595912
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0520604 0.115397 0.115276
Onchocerca volvulus 0.0105231 0.0218476 0.0477351
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012703 0.00100871 0.000979426
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0203944 0.0440796 0.0439491
Trichomonas vaginalis casein kinase II beta chain, putative 0.00671322 0.0132671 0.0500131
Giardia lamblia Multidrug resistance-associated protein 1 0.00155521 0.00165038 0.00472048
Leishmania major DNA topoisomerase 1A 0.0169066 0.0362244 0.0824577
Leishmania major p-glycoprotein 0.0012703 0.00100871 0.00116465
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0105231 0.0218476 0.0216941
Loa Loa (eye worm) hypothetical protein 0.00987135 0.0203798 0.020226
Trypanosoma brucei multidrug resistance-associated protein, putative 0.00155521 0.00165038 0.00264589
Brugia malayi diacylglycerol acyltransferase 0.224398 0.503531 0.503453
Loa Loa (eye worm) hypothetical protein 0.0591425 0.131347 0.131211
Trichomonas vaginalis casein kinase II beta chain, putative 0.00190986 0.00244911 0.00923242
Onchocerca volvulus Casein kinase II subunit beta homolog 0.00671322 0.0132671 0.0280801
Chlamydia trachomatis DNA gyrase subunit A 0.0510519 0.113126 0.122671
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.00671322 0.0132671 0.0482041
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0203944 0.0440796 0.0439296
Onchocerca volvulus Prolyl endopeptidase homolog 0.0110904 0.0231253 0.0506619
Brugia malayi gamma-secretase subunit aph-1 0.444837 1 1
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0520604 0.115397 0.265222
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0281575 0.0615634 0.140951
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0169066 0.0362244 0.0360928
Trypanosoma cruzi heat shock protein 90, putative 0.00784138 0.015808 0.0353277
Loa Loa (eye worm) ACC-1 protein 0.0203944 0.0440796 0.0439296
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0203944 0.0440796 0.0440516
Schistosoma mansoni hypothetical protein 0.00255654 0.00390554 0.00376952
Toxoplasma gondii DNA topoisomerase family protein 0.0169066 0.0362244 0.0390612
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.00784138 0.015808 0.0353277
Entamoeba histolytica V-type ATPase, B subunit, putative 0.00375441 0.00660337 0.0230358
Loa Loa (eye worm) hypothetical protein 0.0203944 0.0440796 0.0439296
Schistosoma mansoni sarm1 0.00255654 0.00390554 0.00376952
Echinococcus granulosus o acyltransferase membrane bound domain 0.0383791 0.0845843 0.0845575
Echinococcus multilocularis rho GTPase activating protein 20 0.0169066 0.0362244 0.0361961
Trichomonas vaginalis ATP synthase, putative 0.00375441 0.00660337 0.0248927
Schistosoma mansoni nAChR subunit 0.0203944 0.0440796 0.0439491
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0203944 0.0440796 0.0439296
Loa Loa (eye worm) hypothetical protein 0.0383791 0.0845843 0.0844407

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 29.08 % Antiproliferative activity against human MDA-MB-468 cells assessed as decrease in Ki-67 staining after 48 hrs by immunofluorescence staining ChEMBL. 22366655
EC50 (functional) = 13 uM Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in BESM cells measured after 88 hrs postinfection by HTS assay ChEMBL. 20547819
IC50 (functional) = 1.2 uM Antiproliferative activity against tumor necrosis factor-resistant human MCF7 cells after 24 hrs by MTT assay ChEMBL. 19694470
IC50 (functional) = 1.8 uM Antiproliferative activity against endocrine-resistant human MDA-MB-231 cells after 24 hrs by MTT assay ChEMBL. 19694470
IC50 (functional) = 3 uM Inhibition of clonogenic survival of endocrine-resistant human MDA-MB-231 cells after 10 days by microscopy ChEMBL. 19694470
IC50 (functional) = 4.2 uM Inhibition of clonogenic survival of human MCF7 cells after 10 days by microscopy ChEMBL. 19694470
IC50 (functional) = 4.5 uM Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay ChEMBL. 19694470
IC50 (functional) = 8.6 uM Inhibition of clonogenic survival of tumor necrosis factor-resistant human MCF7 cells after 10 days by microscopy ChEMBL. 19694470
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19694470
Trypanosoma cruzi ChEMBL23 20547819

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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