Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | bloom syndrome protein | 0.0025 | 0.052 | 0.0388 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.002 | 0.0388 | 0.0255 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.002 | 0.0388 | 0.1009 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.001 | 0.0137 | 0.0347 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.002 | 0.0388 | 0.1009 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0044 | 0.1025 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0044 | 0.1025 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.3148 | 0.8277 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.1025 | 0.09 |
Loa Loa (eye worm) | acetyltransferase | 0.0149 | 0.3802 | 1 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.002 | 0.0388 | 0.0255 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0216 | 0.2328 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0216 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0388 | 0.2129 |
Schistosoma mansoni | regulator of G protein signaling | 0.002 | 0.0388 | 0.1009 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0388 | 0.1009 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.1025 | 1 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.002 | 0.0388 | 0.1009 |
Schistosoma mansoni | serine/threonine protein kinase | 0.002 | 0.0388 | 0.1009 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.002 | 0.0388 | 0.0255 |
Schistosoma mansoni | DNA helicase recq1 | 0.001 | 0.0137 | 0.0347 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0019 | 0.0383 | 0.0994 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0005 | 0.0005 | 0.5 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0025 | 0.052 | 0.3752 |
Schistosoma mansoni | axis inhibition protein axin | 0.002 | 0.0388 | 0.1009 |
Brugia malayi | hypothetical protein | 0.002 | 0.0388 | 0.0686 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0022 | 0.0441 | 0.3834 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0025 | 0.052 | 0.1044 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.002 | 0.0388 | 0.0686 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.002 | 0.0388 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0388 | 0.1009 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.002 | 0.0388 | 0.0255 |
Echinococcus granulosus | bloom syndrome protein | 0.0025 | 0.052 | 0.0388 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0149 | 0.3802 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.002 | 0.0388 | 0.1009 |
Brugia malayi | PXA domain containing protein | 0.002 | 0.0388 | 0.0686 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0388 | 0.2129 |
Entamoeba histolytica | hypothetical protein | 0.002 | 0.0388 | 0.4183 |
Brugia malayi | hypothetical protein | 0.002 | 0.0388 | 0.0686 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0017 | 0.0309 | 0.3012 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0216 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0137 | 0.1293 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.002 | 0.0388 | 0.0255 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0137 | 0.1293 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.002 | 0.0388 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0388 | 0.1009 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0145 | 0.3692 | 0.3604 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.002 | 0.0388 | 0.0686 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.002 | 0.0388 | 0.0255 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.002 | 0.0388 | 0.1009 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.002 | 0.0388 | 0.0255 |
Schistosoma mansoni | regulator of G protein signaling | 0.002 | 0.0388 | 0.1009 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0149 | 0.3802 | 0.3716 |
Schistosoma mansoni | DNA helicase recq5 | 0.001 | 0.0137 | 0.0347 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.002 | 0.0388 | 0.0686 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.002 | 0.0388 | 0.0255 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.002 | 0.0388 | 0.0255 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.002 | 0.0388 | 0.2129 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.0929 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0044 | 0.1025 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0025 | 0.052 | 0.1355 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.002 | 0.0388 | 0.0686 |
Echinococcus granulosus | axis inhibition protein axin | 0.002 | 0.0388 | 0.0255 |
Schistosoma mansoni | serine/threonine protein kinase | 0.002 | 0.0388 | 0.1009 |
Echinococcus multilocularis | axis inhibition protein axin | 0.002 | 0.0388 | 0.0255 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0388 | 0.2129 |
Echinococcus granulosus | axis inhibition protein axin | 0.002 | 0.0388 | 0.0255 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.002 | 0.0388 | 0.0255 |
Schistosoma mansoni | regulator of G protein signaling | 0.002 | 0.0388 | 0.1009 |
Entamoeba histolytica | hypothetical protein | 0.002 | 0.0388 | 0.4183 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0149 | 0.3802 | 1 |
Entamoeba histolytica | recQ family DNA helicase | 0.0005 | 0.0005 | 0.0056 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0044 | 0.1025 | 1 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.002 | 0.0388 | 0.0686 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0137 | 0.0347 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0388 | 0.2129 |
Schistosoma mansoni | z-protein (S1r protein) | 0.002 | 0.0388 | 0.1009 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0388 | 0.1009 |
Brugia malayi | PXA domain containing protein | 0.002 | 0.0388 | 0.0686 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0025 | 0.052 | 0.3752 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0388 | 0.1009 |
Loa Loa (eye worm) | RGS-3 protein | 0.002 | 0.0388 | 0.1009 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.002 | 0.0388 | 0.0255 |
Schistosoma mansoni | axis inhibition protein axin | 0.002 | 0.0388 | 0.1009 |
Schistosoma mansoni | regulator of G protein signaling | 0.002 | 0.0388 | 0.1009 |
Entamoeba histolytica | hypothetical protein | 0.002 | 0.0388 | 0.4183 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.002 | 0.0388 | 0.1009 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0388 | 0.2129 |
Echinococcus multilocularis | regulator of G protein signaling | 0.002 | 0.0388 | 0.0255 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0016 | 0.0303 | 0.2925 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.0929 | 1 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.002 | 0.0388 | 0.0686 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.0929 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0388 | 0.1009 |
Schistosoma mansoni | regulator of G protein signaling | 0.002 | 0.0388 | 0.1009 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.002 | 0.0388 | 0.1009 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0216 | 1 |
Echinococcus multilocularis | axis inhibition protein axin | 0.002 | 0.0388 | 0.0255 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.002 | 0.0388 | 0.0255 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.002 | 0.0388 | 0.1009 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0388 | 0.2129 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.5 ug ml-1 | Cytotoxicity against human SF268 cells | ChEMBL. | 15787438 |
GI50 (functional) | = 0.6 ug ml-1 | Cytotoxicity against human H460 cells | ChEMBL. | 15787438 |
GI50 (functional) | = 0.9 ug ml-1 | Cytotoxicity against human MCF7 cells | ChEMBL. | 15787438 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.