Detailed information for compound 1183406

Basic information

Technical information
  • TDR Targets ID: 1183406
  • Name: 2-amino-7-furan-2-yl-5-oxo-4-phenyl-4,6,7,8-t etrahydrochromene-3-carbonitrile
  • MW: 332.353 | Formula: C20H16N2O3
  • H donors: 1 H acceptors: 2 LogP: 2.49 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)OC2=C(C1c1ccccc1)C(=O)CC(C2)c1ccco1
  • InChi: 1S/C20H16N2O3/c21-11-14-18(12-5-2-1-3-6-12)19-15(23)9-13(16-7-4-8-24-16)10-17(19)25-20(14)22/h1-8,13,18H,9-10,22H2
  • InChiKey: TZHOXPGRQKCHJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-amino-7-(2-furyl)-5-oxo-4-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile
  • 2-amino-7-(2-furyl)-5-keto-4-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile
  • BAS 02232409
  • STOCK1S-70163
  • AJ-292/14921076

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 1 (glial high affinity glutamate transporter), member 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma japonicum ko:K05614 solute carrier family 1 (glial high affinity glutamate transporter),, putative Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma japonicum Excitatory amino acid transporter 2, putative Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis sodium:dicarboxylate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Brugia malayi Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Chlamydia trachomatis glutamate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Loa Loa (eye worm) excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus neutral amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA Get druggable targets OG5_126739 All targets in OG5_126739
Onchocerca volvulus Excitatory amino acid transporter homolog Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma japonicum ko:K05613 solute carrier family 1 (glial high affinity glutamate transporter),, putative Get druggable targets OG5_126739 All targets in OG5_126739
Theileria parva glutamate transporter, putative Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis excitatory amino acid transporter 3 Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus sodium:dicarboxylate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus excitatory amino acid transporter 3 Get druggable targets OG5_126739 All targets in OG5_126739
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter Get druggable targets OG5_126739 All targets in OG5_126739
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0078 0.2221 0.4192
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0021 0.0311 0.172
Echinococcus multilocularis peroxidasin 0.0078 0.2221 0.2221
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0152 0.4708 0.4708
Mycobacterium leprae Polyketide synthase Pks13 0.0039 0.0922 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0495 0.894
Leishmania major hypothetical protein, conserved 0.0027 0.0495 1
Mycobacterium ulcerans thioesterase 0.0022 0.0336 0.2064
Loa Loa (eye worm) TAR-binding protein 0.0061 0.1652 0.1648
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Mycobacterium leprae Probable polyketide synthase Pks1 0.0028 0.0539 0.481
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1226 0.1226
Echinococcus granulosus Excitatory amino acid transporter 0.0152 0.4708 0.4708
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.0522 0.0351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0522 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0543 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0495 0.9469
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Loa Loa (eye worm) hypothetical protein 0.0146 0.4499 0.4496
Loa Loa (eye worm) excitatory amino acid transporter 0.0152 0.4708 0.4706
Echinococcus granulosus neutral amino acid transporter 0.0152 0.4708 0.4708
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0013 0.0045 0.0481
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Loa Loa (eye worm) hypothetical protein 0.0048 0.1219 0.1214
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0026 0.0484 0.083
Loa Loa (eye worm) hypothetical protein 0.0078 0.2221 0.2217
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0742 0.1576
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1652 0.3509
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.002 0.027 0.4987
Brugia malayi Excitatory amino acid transporter 0.0152 0.4708 0.4613
Brugia malayi Animal haem peroxidase family protein 0.0078 0.2221 0.2081
Loa Loa (eye worm) hypothetical protein 0.0078 0.2221 0.2217
Loa Loa (eye worm) hypothetical protein 0.0078 0.2221 0.2217
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0022 0.0322 0.048
Brugia malayi Blistered cuticle protein 3 0.0078 0.2221 0.2081
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.2221 0.2217
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Brugia malayi hypothetical protein 0.0027 0.0495 0.0324
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.2221 0.2217
Echinococcus granulosus excitatory amino acid transporter 2 0.0152 0.4708 0.4708
Toxoplasma gondii target of rapamycin (TOR), putative 0.002 0.027 0.4781
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0028 0.0539 0.481
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0028 0.0539 0.095
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1226 0.1226
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.002 0.027 0.4987
Schistosoma mansoni peroxidasin 0.0078 0.2221 0.4717
Brugia malayi jmjC domain containing protein 0.0092 0.2695 0.2563
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.002 0.027 0.4987
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0067 0.1863 0.1863
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1652 0.3509
Onchocerca volvulus 0.0146 0.4499 0.9512
Brugia malayi jmjC domain containing protein 0.0034 0.0742 0.0576
Echinococcus multilocularis neutral amino acid transporter A 0.0152 0.4708 0.4708
Brugia malayi Animal haem peroxidase family protein 0.0078 0.2221 0.2081
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.027 0.0095
Brugia malayi RNA binding protein 0.0061 0.1652 0.1502
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.1652 0.1502
Schistosoma mansoni jumonji domain containing protein 0.0073 0.2058 0.4372
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0067 0.1863 0.3956
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0028 0.0539 0.481
Loa Loa (eye worm) hypothetical protein 0.0024 0.0392 0.0387
Loa Loa (eye worm) hypothetical protein 0.0078 0.2221 0.2217
Loa Loa (eye worm) hypothetical protein 0.0078 0.2221 0.2217
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0484 0.4065
Schistosoma mansoni hypothetical protein 0.0028 0.0543 0.1154
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.002 0.027 0.027
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0392 0.4849
Mycobacterium ulcerans polyketide synthase Pks13 0.0039 0.0922 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1226 0.2604
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0543 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0484 0.083
Loa Loa (eye worm) hypothetical protein 0.0078 0.2221 0.2217
Onchocerca volvulus Alhambra homolog 0.0028 0.0543 0.0275
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1652 0.3509
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0914 0.0914
Echinococcus multilocularis excitatory amino acid transporter 3 0.0152 0.4708 0.4708
Mycobacterium ulcerans polyketide synthase 0.0028 0.0539 0.481
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.002 0.027 0.027
Onchocerca volvulus Fatty acid synthase homolog 0.0048 0.1195 0.1797
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0484 0.4065
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Echinococcus multilocularis neutral amino acid transporter A 0.0152 0.4708 0.4708
Loa Loa (eye worm) hypothetical protein 0.0078 0.2221 0.2217
Echinococcus multilocularis excitatory amino acid transporter 2 0.0152 0.4708 0.4708
Echinococcus multilocularis neutral amino acid transporter A 0.0152 0.4708 0.4708
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.0457 0.0771
Onchocerca volvulus Peroxidase homolog 0.0078 0.2221 0.4192
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Echinococcus granulosus serine protein kinase ATM 0.0028 0.0522 0.0522
Onchocerca volvulus 0.0046 0.114 0.1668
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0026 0.0484 0.0312
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0015
Schistosoma mansoni peroxidasin 0.0078 0.2221 0.4717
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1226 0.1226
Loa Loa (eye worm) hypothetical protein 0.0078 0.2221 0.2217
Loa Loa (eye worm) hypothetical protein 0.0078 0.2221 0.2217
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.002 0.027 0.0574
Echinococcus granulosus Excitatory amino acid transporter 0.0152 0.4708 0.4708
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0028 0.0539 0.095
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0026 0.0484 0.4065
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.2695 0.2695
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.0522 0.1108
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0484 0.4065
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0484 0.4065
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Echinococcus granulosus tar DNA binding protein 0.0061 0.1652 0.1652
Trypanosoma brucei target of rapamycin kinase 3, putative 0.002 0.027 0.4987
Onchocerca volvulus Chorion peroxidase homolog 0.0078 0.2221 0.4192
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.2695 0.2695
Chlamydia trachomatis glutamate symporter 0.0152 0.4708 1
Treponema pallidum glutamate transporter 0.0067 0.1863 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Echinococcus granulosus excitatory amino acid transporter 3 0.0152 0.4708 0.4708
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0742 0.0738
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.1226 0.1068
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0152 0.4708 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0543 0.0543
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0021 0.0311 0.172
Entamoeba histolytica hypothetical protein 0.0028 0.0522 1
Loa Loa (eye worm) fatty acid synthase 0.0026 0.0472 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0039 0.0922 0.1782
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0543 0.1154
Loa Loa (eye worm) hypothetical protein 0.0044 0.1086 0.1082
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.155 0.1546
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0742 0.0742
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.002 0.027 0.0574
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0543 0.0543
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.002 0.027 0.4987
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1226 0.2604
Loa Loa (eye worm) hypothetical protein 0.0078 0.2221 0.2217
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.027 0.0265
Echinococcus multilocularis peregrin 0.0028 0.0543 0.0543
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0914 0.0914
Loa Loa (eye worm) hypothetical protein 0.0078 0.2221 0.2217
Echinococcus multilocularis tar DNA binding protein 0.0061 0.1652 0.1652
Loa Loa (eye worm) hypothetical protein 0.0027 0.0495 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Onchocerca volvulus Peroxidasin homolog 0.0078 0.2221 0.4192
Mycobacterium tuberculosis Probable thioesterase TesA 0.0022 0.0336 0.0509
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.005 0.1277 0.112
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0522 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0094 0.0089
Toxoplasma gondii type I fatty acid synthase, putative 0.0028 0.0539 0.9917
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Echinococcus granulosus neutral amino acid transporter A 0.0152 0.4708 0.4708
Onchocerca volvulus Dual oxidase homolog 0.0078 0.2221 0.4192
Brugia malayi PHD-finger family protein 0.0028 0.0543 0.0373
Onchocerca volvulus Peroxidasin homolog 0.0078 0.2221 0.4192
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.027 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0067 0.1863 0.1863
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.2221 0.2217
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0152 0.4708 0.4708
Loa Loa (eye worm) blistered cuticle protein 3 0.0078 0.2221 0.2217
Brugia malayi Peroxidasin 0.0078 0.2221 0.2081
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0039 0.0922 0.1782
Loa Loa (eye worm) RNA binding protein 0.0061 0.1652 0.1648
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0484 0.083
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0152 0.4708 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.002 0.027 0.027
Giardia lamblia PHD finger protein 15 0.0028 0.0543 1
Brugia malayi hypothetical protein 0.0146 0.4499 0.44
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1226 0.1226
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1652 0.3509
Loa Loa (eye worm) hypothetical protein 0.0028 0.0543 0.0538
Echinococcus granulosus sodium:dicarboxylate symporter 0.0152 0.4708 0.4708
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.1226 0.1222
Brugia malayi TAR-binding protein 0.0061 0.1652 0.1502
Brugia malayi Animal haem peroxidase family protein 0.0078 0.2221 0.2081
Brugia malayi Animal haem peroxidase family protein 0.0078 0.2221 0.2081
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0742 0.1576
Onchocerca volvulus Peroxidase homolog 0.0078 0.2221 0.4192
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0426 0.0253
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0539 0.095
Mycobacterium ulcerans polyketide synthase 0.0026 0.0484 0.4065
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Brugia malayi hypothetical protein 0.0078 0.2221 0.2081
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0495 0.894
Echinococcus granulosus excitatory amino acid transporter 2 0.0152 0.4708 0.4708
Leishmania major phosphatidylinositol kinase related protein, putative 0.002 0.0272 0.0058
Onchocerca volvulus 0.0078 0.2221 0.4192
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.0426 0.0704
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0272 0.0052
Loa Loa (eye worm) hypothetical protein 0.0078 0.2221 0.2217
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.0522 1
Echinococcus granulosus neutral amino acid transporter A 0.0152 0.4708 0.4708
Brugia malayi Animal haem peroxidase family protein 0.0078 0.2221 0.2081
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0539 0.481
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0543 0.0538
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0495 0.9077
Echinococcus granulosus peroxidasin 0.0078 0.2221 0.2221
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.0457 0.0771
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.027 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Brugia malayi Bromodomain containing protein 0.0028 0.0543 0.0373
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0234 0.0288
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Echinococcus multilocularis Excitatory amino acid transporter 0.0152 0.4708 0.4708
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.1652 0.1648
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.0426 0.0421
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.0522 0.0522
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.2221 0.2217
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0017 0.0172 0.291
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0152 0.4708 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0021 0.0311 0.172
Loa Loa (eye worm) hypothetical protein 0.0078 0.2221 0.2217
Loa Loa (eye worm) hypothetical protein 0.0078 0.2221 0.2217
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0067 0.1863 0.3956
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0543 1
Toxoplasma gondii FATC domain-containing protein 0.0028 0.0522 0.9586
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0026 0.0484 0.4065
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0742 0.0742
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.027 0.4987
Echinococcus multilocularis excitatory amino acid transporter 2 0.0152 0.4708 0.4708
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0028 0.0539 0.481
Echinococcus multilocularis Excitatory amino acid transporter 0.0152 0.4708 0.4708
Onchocerca volvulus 0.0078 0.2221 0.4192
Echinococcus granulosus peregrin 0.0028 0.0543 0.0543
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0152 0.4708 0.5
Treponema pallidum glutamate/aspartate transporter 0.0067 0.1863 0.5
Plasmodium falciparum phd finger protein, putative 0.0028 0.0543 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.002 0.027 0.027
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1652 0.3509
Mycobacterium ulcerans thioesterase TesA 0.0022 0.0336 0.2064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1226 0.2604
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0228 0.398
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0022 0.0336 0.2064

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 3.5 Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells ChEMBL. 19161278
IC50 (binding) > 3.5 Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells ChEMBL. 19161278
IC50 (binding) = 5.13 Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells ChEMBL. 19161278
IC50 (binding) = 7.3 uM Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells ChEMBL. 19161278
IC50 (binding) > 300 uM Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells ChEMBL. 19161278
IC50 (binding) > 300 uM Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells ChEMBL. 19161278

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.