TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 473.267 | Formula: C17H12BrF3N4O2S
H donors: 2 H acceptors: 1 LogP: 5.1 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: S=C(Nc1ccc(cc1)Br)N/N=C/1\C(=O)N(c2c1cc(cc2)OC(F)(F)F)C
InChi: 1S/C17H12BrF3N4O2S/c1-25-13-7-6-11(27-17(19,20)21)8-12(13)14(15(25)26)23-24-16(28)22-10-4-2-9(18)3-5-10/h2-8H,1H3,(H2,22,24,28)/b23-14-
InChiKey: JRTIGBSUCDVYTP-UCQKPKSFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0188	0.0226
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0078	0.306	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.1018	0.1225
Echinococcus granulosus	lamin dm0	0.0027	0.0857	0.1031
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0099	0.3971	0.4537
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.1049	0.1199
Schistosoma mansoni	apoferritin-2	0.0008	0.0062	0.0074
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.1049	0.1262
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0122	0.0139
Schistosoma mansoni	hypothetical protein	0.0188	0.78	0.938
Schistosoma mansoni	dishevelled	0.001	0.0122	0.0147
Schistosoma mansoni	hypothetical protein	0.0031	0.1049	0.1262
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.1018	0.3051
Schistosoma mansoni	ferritin light chain	0.0008	0.0062	0.0074
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.001	0.0122	0.0122
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.306	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.1246	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.1018	0.1164
Onchocerca volvulus		0.0028	0.0901	0.0901
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0229	0.959	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.1049	0.1262
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0117	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0031	0.1049	0.1199
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0078	0.306	1
Schistosoma mansoni	tar DNA-binding protein	0.02	0.8315	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0044	0.0053
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.1246	0.3948
Trichomonas vaginalis	esterase, putative	0.0036	0.1246	0.1246
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0044	0.0053
Schistosoma mansoni	dishevelled	0.001	0.0122	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0148	0.6079	0.6946
Schistosoma mansoni	hypothetical protein	0.0011	0.0188	0.0226
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.1246	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.1018	0.1225
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0257	0.0309
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.306	1
Onchocerca volvulus		0.0031	0.1018	0.1018
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0857	0.0979
Echinococcus granulosus	GPCR family 2	0.0031	0.1049	0.1262
Brugia malayi	hypothetical protein	0.0016	0.0403	0.0461
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0117	0.0141
Echinococcus multilocularis	cpg binding protein	0.003	0.097	0.1166
Plasmodium vivax	SET domain protein, putative	0.0031	0.1018	0.1004
Schistosoma mansoni	cpg binding protein	0.003	0.097	0.1166
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.1246	0.1246
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1423
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1423
Schistosoma mansoni	regulator of G protein signaling	0.001	0.0122	0.0147
Loa Loa (eye worm)	DIX domain-containing protein	0.001	0.0122	0.0139
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.1049	0.1199
Echinococcus granulosus	ferritin	0.0008	0.0062	0.0074
Schistosoma mansoni	dep domain containing protein	0.001	0.0122	0.0147
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.1018	0.1225
Schistosoma mansoni	lamin	0.0027	0.0857	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0099	0.3971	0.4537
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.306	0.5
Schistosoma mansoni	tar DNA-binding protein	0.02	0.8315	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.306	1
Loa Loa (eye worm)	TAR-binding protein	0.02	0.8315	0.95
Echinococcus granulosus	tar DNA binding protein	0.02	0.8315	1
Schistosoma mansoni	ferritin	0.0008	0.0062	0.0074
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.1246	0.1242
Brugia malayi	beta-lactamase	0.0036	0.1246	0.1423
Loa Loa (eye worm)	beta-lactamase	0.0036	0.1246	0.1423
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.1246	0.2004
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.1902	0.1931
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.1018	0.1225
Schistosoma mansoni	hypothetical protein	0.0031	0.1049	0.1262
Echinococcus multilocularis	musashi	0.0027	0.0857	0.1031
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.1049	0.1262
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.1018	0.1225
Brugia malayi	Muscleblind-like protein	0.0148	0.6079	0.6946
Schistosoma mansoni	peptidase Clp (S14 family)	0.0078	0.306	0.368
Onchocerca volvulus		0.001	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0236	0.0269
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0791	0.6348
Echinococcus multilocularis	tar DNA binding protein	0.02	0.8315	1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0188	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0836	0.0955
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.1902	0.6136
Onchocerca volvulus		0.0036	0.1246	0.1246
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.1246	1
Brugia malayi	Pre-SET motif family protein	0.0031	0.1018	0.1164
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0318	0.0364
Brugia malayi	Pre-SET motif family protein	0.021	0.8753	1
Mycobacterium ulcerans	lipase LipD	0.0036	0.1246	0.3948
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0791	0.6348
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0857	0.1031
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.1246	0.1423
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0236	0.0269
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0122	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0148	0.6079	0.6946
Schistosoma mansoni	ferritin light chain	0.0008	0.0062	0.0074
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0856	0.0287
Schistosoma mansoni	hypothetical protein	0.0188	0.78	0.938
Brugia malayi	RNA recognition motif domain containing protein	0.02	0.8315	0.95
Echinococcus multilocularis	muscleblind protein	0.0148	0.6079	0.7311
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0112	0.0128
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.1246	0.3948
Onchocerca volvulus		0.0036	0.1246	0.1246
Echinococcus multilocularis	lamin	0.0027	0.0857	0.1031
Brugia malayi	DIX domain containing protein	0.001	0.0122	0.0139
Schistosoma mansoni	tar DNA-binding protein	0.02	0.8315	1
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0857	0.0979
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0122	0.0147
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.2026	0.6478
Schistosoma mansoni	hypothetical protein	0.0068	0.2619	0.3149
Trichomonas vaginalis	ferritin, putative	0.0008	0.0062	0.0062
Schistosoma mansoni	cpg binding protein	0.0028	0.0901	0.1084
Brugia malayi	hypothetical protein	0.001	0.0122	0.0139
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0044	0.0053
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.02	0.8315	0.95
Toxoplasma gondii	ABC1 family protein	0.0036	0.1246	0.3824
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.1246	0.1246
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.1049	0.1262
Mycobacterium tuberculosis	Conserved protein	0.0036	0.1246	0.1242
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.1246	0.1246
Brugia malayi	hypothetical protein	0.0025	0.0791	0.0903
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0122	0.0139
Brugia malayi	regulator of G-protein signaling egl-10	0.001	0.0122	0.0139
Brugia malayi	intermediate filament protein	0.0027	0.0857	0.0979
Echinococcus multilocularis	lamin dm0	0.0027	0.0857	0.1031
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0099	0.3971	0.4537
Leishmania major	hypothetical protein, conserved	0.0036	0.1246	1
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0122	0.0147
Schistosoma mansoni	hypothetical protein	0.0031	0.1049	0.1262
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0257	0.0293
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.1246	0.1242
Echinococcus multilocularis	expressed protein	0.0008	0.0062	0.0074
Mycobacterium ulcerans	beta-lactamase	0.0036	0.1246	0.3948
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0945	0.1136
Onchocerca volvulus		0.0027	0.0857	0.0857
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.1049	0.1199
Echinococcus granulosus	intermediate filament protein	0.0027	0.0857	0.1031
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0318	0.0364
Mycobacterium leprae	Probable lipase LipE	0.0036	0.1246	0.3948
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1423
Mycobacterium ulcerans	hypothetical protein	0.0036	0.1246	0.3948
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0901	0.1029
Schistosoma mansoni	hypothetical protein	0.0031	0.1049	0.1262
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.306	0.5
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0044	0.0053
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0078	0.306	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.1246	0.1242
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.1246	0.1242
Onchocerca volvulus		0.0036	0.1246	0.1246
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0027	0.0856	0.0287
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0257	0.0309
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.1902	0.2287
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.2298	0.2764
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0122	0.0147
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.306	1
Schistosoma mansoni	ferritin	0.0008	0.0062	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1423
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.1246	0.3948
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.1246	0.1498
Mycobacterium tuberculosis	Conserved protein	0.0036	0.1246	0.1242
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.1246	0.1498
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0078	0.306	0.368
Echinococcus granulosus	expressed protein	0.0008	0.0062	0.0074
Mycobacterium tuberculosis	Conserved protein	0.0036	0.1246	0.1242
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.1246	0.1242
Brugia malayi	N-terminal motif family protein	0.02	0.833	0.9517
Brugia malayi	Probable ClpP-like protease	0.0078	0.306	0.3496
Schistosoma mansoni	ferritin	0.0008	0.0062	0.0074
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.02	0.833	0.833
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0099	0.3971	0.4537
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0857	0.0979
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.1018	0.1225
Echinococcus granulosus	lamin	0.0027	0.0857	0.1031
Loa Loa (eye worm)	RNA binding protein	0.02	0.8315	0.95
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.1246	0.1423
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2619	0.2992
Echinococcus granulosus	Pleckstrin G protein interacting region	0.001	0.0122	0.0147
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.001	0.0122	0.0147
Brugia malayi	hypothetical protein	0.001	0.0122	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0857	0.0979
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0791	0.0903
Echinococcus multilocularis	muscleblind protein 1	0.0148	0.6079	0.7311
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0044	0.0053
Echinococcus granulosus	muscleblind protein	0.0148	0.6079	0.7311
Echinococcus multilocularis	ferritin	0.0008	0.0062	0.0074
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.2619	0.2992
Schistosoma mansoni	ferritin	0.0008	0.0062	0.0074
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0856	0.2648
Loa Loa (eye worm)	hypothetical protein	0.001	0.0122	0.0139
Echinococcus multilocularis	GPCR, family 2	0.0031	0.1049	0.1262
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0078	0.306	0.368
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0122	0.0147
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.1246	0.1498
Brugia malayi	beta-lactamase family protein	0.0036	0.1246	0.1423
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.1018	0.1225
Echinococcus granulosus	geminin	0.0188	0.78	0.938
Toxoplasma gondii	hypothetical protein	0.0027	0.0856	0.2497
Echinococcus granulosus	cpg binding protein	0.003	0.097	0.1166
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0122	0.0147
Schistosoma mansoni	tar DNA-binding protein	0.02	0.8315	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0122	0.0139
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.1246	0.1246
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.1246	0.1246
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.306	1
Brugia malayi	RNA binding protein	0.02	0.8315	0.95
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.1246	0.1498
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0122	0.0147
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.1902	0.1931
Brugia malayi	TAR-binding protein	0.02	0.8315	0.95
Echinococcus multilocularis	geminin	0.0188	0.78	0.938
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.001	0.0122	0.0139
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.021	0.8753	1
Schistosoma mansoni	apoferritin-2	0.0008	0.0062	0.0074
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.1902	0.2287
Schistosoma mansoni	lamin	0.0027	0.0857	0.1031
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0027	0.0856	0.2648
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0117	0.0134
Brugia malayi	beta-lactamase family protein	0.0036	0.1246	0.1423
Loa Loa (eye worm)	hypothetical protein	0.0078	0.306	0.3496
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0901	0.1029
Loa Loa (eye worm)	hypothetical protein	0.001	0.0122	0.0139
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.001	0.0122	0.0147
Onchocerca volvulus		0.0027	0.0857	0.0857
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1423
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.306	1
Schistosoma mansoni	cpg binding protein	0.003	0.097	0.1166
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0122	0.0147
Schistosoma mansoni	tar DNA-binding protein	0.02	0.8315	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.1246	0.1242
Loa Loa (eye worm)	hypothetical protein	0.02	0.833	0.9517
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0791	0.2276
Schistosoma mansoni	z-protein (S1r protein)	0.001	0.0122	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1423
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.1246	0.1242

Activities

Activity type	Activity value	Assay description	Source	Reference
IC90 (functional)	> 100 ug ml-1	Antitubercular activity against Mycobacterium tuberculosis H37Rv after 4 days by microplate alamar blue assay	ChEMBL.	18804379

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL477168

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1183577