Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0215 | 0.0192 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.1021 | 0.1135 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0052 | 0.0723 | 0.1535 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0051 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0045 | 0.0427 | 0.0891 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0039 | 0.0175 | 0.0366 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0073 | 0.1628 | 0.3401 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0051 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0051 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0058 | 0.0959 | 0.1062 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0225 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0088 | 0.2294 | 0.2624 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0051 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0048 | 0.0532 | 0.0563 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.2538 | 0.2908 |
Echinococcus multilocularis | zinc finger protein | 0.0045 | 0.0427 | 0.0859 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0039 | 0.0175 | 0.0366 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0225 | 0.0469 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0039 | 0.0175 | 0.0284 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1021 | 0.1135 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0039 | 0.0175 | 0.0284 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0225 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5528 | 0.6407 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0051 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0235 | 0.8601 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0051 | 0.0106 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0051 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0225 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0225 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0051 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.2728 | 0.3131 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.2301 | 0.2632 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.1021 | 0.1135 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0051 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0083 | 0.2058 | 0.4585 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0225 | 0.0397 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0225 | 0.0397 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0051 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.0045 | 0.0427 | 0.0859 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0138 | 0.4429 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0052 | 0.0723 | 0.1535 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0233 | 0.8548 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0083 | 0.2058 | 0.4585 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0051 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0051 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0073 | 0.1628 | 0.3601 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1628 | 0.1844 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0215 | 0.0449 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0073 | 0.1628 | 0.3601 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0041 | 0.0236 | 0.0217 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0225 | 0.0469 |
Brugia malayi | Pre-SET motif family protein | 0.0235 | 0.8601 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0052 | 0.0723 | 0.151 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.1021 | 0.1135 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0073 | 0.1628 | 0.3401 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0225 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0051 | 0.0106 |
Onchocerca volvulus | 0.0156 | 0.5196 | 0.5172 | |
Brugia malayi | hypothetical protein | 0.0156 | 0.5196 | 0.6018 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.5196 | 0.6018 |
Brugia malayi | Bromodomain containing protein | 0.0173 | 0.5955 | 0.6906 |
Schistosoma mansoni | bromodomain containing protein | 0.0146 | 0.4786 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0532 | 0.1112 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0215 | 0.0192 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0138 | 0.4429 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0051 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0051 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of human recombinant 17beta-HSD5 expressed in intact HEK293 cells assessed as conversion of androstenedione to testosterone at 20 uM after 24 hrs | ChEMBL. | 18533708 | |
Activity (binding) | = 55 % | Inhibition of human recombinant 17beta-HSD2 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol at 20 uM | ChEMBL. | 18533708 |
Activity (binding) | = 68 % | Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol at 20 uM | ChEMBL. | 18533708 |
Activity (binding) | = 88 % | Inhibition of human recombinant 17beta-HSD1 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol at 20 uM | ChEMBL. | 18533708 |
Activity (binding) | = 95 % | Inhibition of human recombinant 17beta-HSD3 expressed in intact HEK293 cells assessed as conversion of androstenedione to testosterone at 20 uM | ChEMBL. | 18533708 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.