Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.9713 | 0.9713 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0046 | 0.9713 | 1 |
Onchocerca volvulus | 0.0028 | 0.4263 | 0.4364 | |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.9713 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.9713 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0046 | 0.9713 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0438 | 0.0438 |
Loa Loa (eye worm) | oxidoreductase | 0.0014 | 0.0043 | 0.0043 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.0438 | 0.0396 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.4113 | 0.4113 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0043 | 0.0043 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.3725 | 0.3808 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.5694 | 0.5844 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.9713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.6252 | 0.6252 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0035 | 0.6252 | 0.6421 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.4263 | 0.4263 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0046 | 0.9713 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.5694 | 0.5844 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0046 | 0.9713 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0046 | 0.9713 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0035 | 0.6252 | 0.5 |
Echinococcus multilocularis | lamin | 0.0028 | 0.4263 | 0.4263 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.3725 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.4263 | 0.4263 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.3725 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0046 | 0.9713 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.3725 | 0.593 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.4263 | 0.4263 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0035 | 0.6252 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.9713 | 0.9712 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.9713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.6252 | 0.6252 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0014 | 0.0043 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0046 | 0.9713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.9713 | 0.9713 |
Onchocerca volvulus | 0.0046 | 0.9713 | 1 | |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.4263 | 0.4263 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.9713 | 1 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.4263 | 0.4239 |
Echinococcus granulosus | lamin | 0.0028 | 0.4263 | 0.4263 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.4263 | 0.4239 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0014 | 0.0043 | 0.0043 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0046 | 0.9713 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.3725 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.9713 | 0.9712 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.9713 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0035 | 0.6252 | 0.6421 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0014 | 0.0043 | 0.0043 |
Schistosoma mansoni | lamin | 0.0028 | 0.4263 | 0.4239 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.4263 | 0.4263 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.5694 | 0.5844 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.3725 | 0.593 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0046 | 0.9713 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.4263 | 0.4239 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.9713 | 0.9712 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.9713 | 0.9713 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0014 | 0.0043 | 0.0043 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.5694 | 0.5844 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.6252 | 0.6252 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3725 | 0.3725 |
Schistosoma mansoni | lamin | 0.0028 | 0.4263 | 0.4239 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.6252 | 0.6252 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0046 | 0.9713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0043 | 0.0043 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.3725 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.3725 | 0.593 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.6252 | 0.6252 |
Brugia malayi | hypothetical protein | 0.0026 | 0.3725 | 0.3698 |
Echinococcus multilocularis | musashi | 0.0028 | 0.4263 | 0.4263 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0014 | 0.0043 | 0.0043 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0996 | 0.0957 |
Onchocerca volvulus | 0.0028 | 0.4263 | 0.4364 | |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0014 | 0.0043 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0035 | 0.6252 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.4263 | 0.4263 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0046 | 0.9713 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0046 | 0.9713 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.