Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Rap guanine nucleotide exchange factor (GEF) 3 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | N-terminal motif family protein | Get druggable targets OG5_131726 | All targets in OG5_131726 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | Get druggable targets OG5_131726 | All targets in OG5_131726 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131726 | All targets in OG5_131726 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.2985 | 0.3188 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.2985 | 0.3188 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0472 | 1 |
Brugia malayi | RNA binding protein | 0.007 | 0.2985 | 0.2985 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2985 | 0.3188 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.9364 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0472 | 0.0472 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0011 | 0.0146 | 0.0156 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0472 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0146 | 0.0156 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0146 | 0.0156 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2985 | 0.3188 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0146 | 0.0146 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0146 | 0.0146 |
Onchocerca volvulus | 0.0011 | 0.0146 | 0.0146 | |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0011 | 0.0146 | 0.0146 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0146 | 0.0156 |
Echinococcus granulosus | geminin | 0.0205 | 0.9364 | 1 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0146 | 0.0156 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0146 | 0.0156 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0011 | 0.0146 | 0.0146 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0146 | 0.0156 |
Brugia malayi | DIX domain containing protein | 0.0011 | 0.0146 | 0.0146 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0472 | 0.0504 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0472 | 0.0472 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.2985 | 0.2985 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0472 | 0.0504 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0146 | 0.0146 |
Schistosoma mansoni | regulator of G protein signaling | 0.0011 | 0.0146 | 0.0156 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0472 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0472 | 1 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0011 | 0.0146 | 0.0156 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0472 | 0.5 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0146 | 0.0146 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0472 | 0.0504 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0011 | 0.0146 | 0.0156 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.2985 | 0.2985 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0146 | 0.0146 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0472 | 0.5 |
Schistosoma mansoni | dep domain containing protein | 0.0011 | 0.0146 | 0.0156 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0472 | 0.0504 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0146 | 0.0146 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2985 | 0.3188 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0011 | 0.0146 | 0.0156 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0146 | 0.0156 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0.0472 | 0.5 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0472 | 0.0504 |
Echinococcus multilocularis | geminin | 0.0205 | 0.9364 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.2985 | 0.2985 |
Brugia malayi | TAR-binding protein | 0.007 | 0.2985 | 0.2985 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2985 | 0.3188 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2985 | 0.3188 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0146 | 0.0156 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0.0472 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0.0472 | 1 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0011 | 0.0146 | 0.0146 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0472 | 0.0504 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0472 | 0.0504 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0146 | 0.0156 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.2985 | 0.2985 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.9364 | 1 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0146 | 0.0156 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0011 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0472 | 0.0472 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0472 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.4611 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.7783 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.