Detailed information for compound 1183737

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 433.455 | Formula: C21H27N3O7
  • H donors: 1 H acceptors: 6 LogP: 1.23 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@H]1[C@]2(C)C[C@H](OC1=O)c1c[nH]nn1
  • InChi: 1S/C21H27N3O7/c1-10(25)30-14-7-12(18(27)29-4)20(2)6-5-11-19(28)31-15(13-9-22-24-23-13)8-21(11,3)17(20)16(14)26/h9,11-12,14-15,17H,5-8H2,1-4H3,(H,22,23,24)/t11-,12+,14+,15+,17+,20+,21+/m1/s1
  • InChiKey: WEHYIFKRVMCWNG-MPZWKKTFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid receptor, kappa 1 Starlite/ChEMBL References
Rattus norvegicus Mu opioid receptor Starlite/ChEMBL References
Mus musculus opioid receptor, delta 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus thyrotropin releasing hormone receptor Mu opioid receptor   398 aa 370 aa 27.3 %
Schistosoma mansoni neuropeptide F-like receptor Mu opioid receptor   398 aa 335 aa 20.6 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Mu opioid receptor   398 aa 397 aa 22.7 %
Onchocerca volvulus Programmed cell death protein 5 homolog Mu opioid receptor   398 aa 323 aa 24.1 %
Onchocerca volvulus Mu opioid receptor   398 aa 376 aa 26.3 %
Onchocerca volvulus Mu opioid receptor   398 aa 356 aa 23.9 %
Echinococcus granulosus allatostatin A receptor Mu opioid receptor   398 aa 346 aa 29.5 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Mu opioid receptor   398 aa 371 aa 27.0 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Mu opioid receptor   398 aa 334 aa 23.1 %
Schistosoma japonicum Rhodopsin, putative Mu opioid receptor   398 aa 328 aa 23.2 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Mu opioid receptor   398 aa 334 aa 24.9 %
Onchocerca volvulus Mu opioid receptor   398 aa 333 aa 26.4 %
Echinococcus multilocularis allatostatin A receptor Mu opioid receptor   398 aa 341 aa 29.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0666 0.0666
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0009 0.0014 0.0014
Schistosoma mansoni smad1 5 8 and 0.0009 0.0013 0.0018
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0009 0.0014 0.0002
Loa Loa (eye worm) TAR-binding protein 0.0212 0.3266 0.4093
Mycobacterium tuberculosis Probable reductase 0.0119 0.1781 0.8837
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Brugia malayi hypothetical protein 0.0009 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Schistosoma mansoni neuropeptide f receptor 76f 0.0009 0.0014 0.0021
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0014 0.0014
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0014 0.0096 0.0096
Schistosoma mansoni opsin-like receptor 0.0009 0.0014 0.0021
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0009 0.0014 0.0014
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0015 0.011 0.011
Brugia malayi neuropeptide F receptor 0.0009 0.0014 0.0002
Schistosoma mansoni amine GPCR 0.0009 0.0014 0.0021
Brugia malayi hypothetical protein 0.0009 0.0014 0.0002
Plasmodium falciparum glutathione reductase 0.0018 0.0166 0.114
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0328 0.2802
Schistosoma mansoni biogenic amine receptor 0.0009 0.0014 0.0021
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0182 0.2787 0.4018
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0013 0.0018
Echinococcus granulosus orexin receptor type 2 0.0009 0.0014 0.0014
Schistosoma mansoni biogenic amine receptor 0.0009 0.0014 0.0021
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0666 0.0822
Schistosoma mansoni cpg binding protein 0.0033 0.0401 0.0578
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0182 0.2787 0.4018
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0014 0.0014
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0328 0.3774
Echinococcus multilocularis g-protein coupled receptor 0.0009 0.0014 0.0014
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0925 0.0925
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0009 0.0014 0.0021
Schistosoma mansoni hypothetical protein 0.0052 0.0703 0.1014
Brugia malayi RE15519p 0.0009 0.0014 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0166 0.114
Onchocerca volvulus 0.0031 0.0373 0.0451
Schistosoma mansoni tar DNA-binding protein 0.0212 0.3266 0.4708
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0666 0.0961
Toxoplasma gondii thioredoxin reductase 0.0052 0.0711 0.7425
Echinococcus granulosus dro:myosuppressin receptor 0.0009 0.0014 0.0014
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0015 0.011 0.0176
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0015 0.011 0.0123
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0014 0.0014
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.011 0.0237
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0014 0.0021
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0015 0.011 0.0031
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0711 0.0711
Brugia malayi hypothetical protein 0.0009 0.0014 0.0002
Schistosoma mansoni cpg binding protein 0.0033 0.0401 0.0578
Brugia malayi Serotonin receptor 0.0009 0.0014 0.0002
Schistosoma mansoni biogenic amine receptor 0.0009 0.0014 0.0021
Plasmodium falciparum thioredoxin reductase 0.0018 0.0166 0.114
Brugia malayi hypothetical protein 0.0009 0.0014 0.0002
Trichomonas vaginalis ran, putative 0.0023 0.0251 0.0333
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0703 0.7325
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0015 0.011 0.0031
Echinococcus multilocularis neuropeptide s receptor 0.0009 0.0014 0.0014
Echinococcus multilocularis G protein coupled receptor 139 0.0009 0.0014 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0021
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0079 0.0079
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0009 0.0014 0.0002
Schistosoma mansoni growth hormone secretagogue receptor 0.0009 0.0014 0.0021
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0166 0.4513
Loa Loa (eye worm) hypothetical protein 0.0014 0.0096 0.0105
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0014 0.0021
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0328 0.3774
Echinococcus granulosus 7TM GPCR rhodopsin 0.0009 0.0014 0.0014
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0013 0.0013
Schistosoma mansoni amine GPCR 0.0009 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0015 0.011 0.0176
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.029 0.0414
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0925 0.1333
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Loa Loa (eye worm) TYRA-2 protein 0.0009 0.0014 0.0002
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0328 0.3774
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0014 0.0014
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0015 0.011 0.0237
Schistosoma mansoni hypothetical protein 0.0009 0.0014 0.0021
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0009 0.0014 0.0014
Schistosoma mansoni alpha-1 adrenergic receptor 0.0009 0.0014 0.0021
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0711 0.0879
Echinococcus granulosus g protein coupled receptor 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Brugia malayi Dopamine receptor protein 1 0.0009 0.0014 0.0002
Echinococcus granulosus somatostatin receptor 0.0009 0.0014 0.0014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.029 0.0414
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0666 0.0666
Treponema pallidum NADH oxidase 0.0018 0.0166 0.5
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Schistosoma mansoni hypothetical protein 0.0009 0.0014 0.0021
Schistosoma mansoni Smad4 0.0009 0.0013 0.0018
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0015 0.011 0.0176
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0166 0.114
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0166 0.015
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0816 0.8686
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0014 0.0014
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0014 0.0014
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0166 0.0847
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0166 0.114
Echinococcus granulosus hypothetical protein 0.0009 0.0014 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0212 0.3266 0.4708
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0009 0.0014 0.0002
Echinococcus granulosus 7tm_1 domain containing protein 0.0009 0.0014 0.0014
Brugia malayi Dopamine receptor 0.0009 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0506 0.7963 1
Echinococcus granulosus serotonin receptor 0.0009 0.0014 0.0014
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0251 0.2527
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0014 0.0014
Echinococcus multilocularis tar DNA binding protein 0.0212 0.3266 0.3266
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0166 0.114
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.011 0.0937
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0166 0.114
Schistosoma mansoni ran 0.0023 0.0251 0.0362
Schistosoma mansoni amine GPCR 0.0009 0.0014 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0666 0.0666
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0166 0.5
Loa Loa (eye worm) glutathione reductase 0.0052 0.0711 0.0879
Brugia malayi hypothetical protein 0.0506 0.7963 1
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0096 0.0138
Echinococcus multilocularis neuropeptide FF receptor 2 0.0009 0.0014 0.0014
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0009 0.0014 0.0014
Brugia malayi Isocitrate dehydrogenase 0.0052 0.0703 0.0869
Schistosoma mansoni neuropeptide receptor 0.0009 0.0014 0.0021
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0014 0.0021
Brugia malayi G-protein coupled receptor 0.0009 0.0014 0.0002
Echinococcus granulosus importin subunit beta 1 0.0032 0.0386 0.0386
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0028 0.002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0328 0.0397
Echinococcus granulosus sex peptide receptor 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0925 0.1333
Echinococcus granulosus smad 0.0009 0.0013 0.0013
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.1781 0.8837
Echinococcus granulosus g protein coupled receptor 0.0009 0.0014 0.0014
Schistosoma mansoni adenoreceptor 0.0009 0.0014 0.0021
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0703 0.0703
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0096 0.0138
Mycobacterium ulcerans glutaminase 0.0306 0.4772 1
Echinococcus multilocularis serotonin receptor 0.0009 0.0014 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0703 0.0703
Echinococcus multilocularis dro:myosuppressin receptor 0.0009 0.0014 0.0014
Echinococcus granulosus snurportin 1 0.034 0.531 0.531
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0166 0.015
Brugia malayi Tachykinin-like peptides receptor 99D 0.0009 0.0014 0.0002
Brugia malayi neuropeptide F receptor 0.0009 0.0014 0.0002
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0166 0.0239
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0014 0.0002
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0251 0.2527
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0009 0.0014 0.0021
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0014 0.0014
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0052 0.0703 0.1014
Brugia malayi sulfakinin receptor protein 0.0009 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Loa Loa (eye worm) FYVE zinc finger family protein 0.0015 0.011 0.0123
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.1993 1
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.011 0.0237
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0014 0.0002
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.011 0.0237
Loa Loa (eye worm) histone methyltransferase 0.001 0.003 0.0022
Leishmania major GTP-binding protein, putative 0.0023 0.0251 0.1876
Schistosoma mansoni glutaminase 0.0306 0.4772 0.6878
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0182 0.2787 0.2787
Loa Loa (eye worm) pip kinase 2 0.0182 0.2787 0.349
Schistosoma mansoni hypothetical protein 0.0009 0.0014 0.0021
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0015 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0052 0.0703 0.0869
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0925 0.1648
Echinococcus multilocularis dnaJ subfamily B 0.0442 0.6938 0.6938
Loa Loa (eye worm) hypothetical protein 0.0032 0.0386 0.0469
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0014 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0166 0.114
Brugia malayi follicle stimulating hormone receptor 0.0009 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0014 0.0021
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0015 0.011 0.0237
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0015 0.011 0.0237
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.029 0.3146
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.1993 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0014 0.0014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0666 0.0666
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0166 0.114
Echinococcus multilocularis sex peptide receptor 0.0009 0.0014 0.0014
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0014 0.0021
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0015 0.011 0.0176
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0014 0.0014
Loa Loa (eye worm) glutaminase 0.0306 0.4772 0.5986
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0014 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0666 0.0961
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0009 0.0014 0.0021
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0166 0.114
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.011 0.0237
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0009 0.0014 0.0014
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0166 0.0166
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0386 0.3497
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0021
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0013 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0079 0.0079
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0009 0.0014 0.0002
Leishmania major trypanothione reductase 0.0052 0.0711 0.7425
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0009 0.0014 0.0014
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0182 0.2787 0.2787
Brugia malayi Melatonin receptor type 1A 0.0009 0.0014 0.0002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0703 0.0703
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.1871 0.2338
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0925 0.1648
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Echinococcus multilocularis G-protein coupled receptor, putative 0.0009 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0013 0.0079 0.0114
Brugia malayi ORL1-like opioid receptor 0.0009 0.0014 0.0002
Brugia malayi putative neuropeptide receptor NPR1 0.0009 0.0014 0.0002
Entamoeba histolytica Ran family GTPase 0.0023 0.0251 0.8032
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0015 0.011 0.011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0703 0.0703
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0166 0.114
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0166 0.5
Leishmania major hypothetical protein, conserved 0.0028 0.0328 0.2802
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Echinococcus multilocularis neuropeptide receptor A26 0.0009 0.0014 0.0014
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0166 0.114
Brugia malayi AKH receptor 0.0009 0.0014 0.0002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.003 0.003
Schistosoma mansoni cpg binding protein 0.0031 0.0373 0.0537
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0052 0.0703 0.0703
Brugia malayi TAR-binding protein 0.0212 0.3266 0.4093
Leishmania major importin beta-1 subunit, putative 0.0026 0.029 0.2336
Schistosoma mansoni neuropeptide receptor 0.0009 0.0014 0.0021
Schistosoma mansoni hypothetical protein 0.0052 0.0703 0.1014
Onchocerca volvulus 0.0506 0.7963 1
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0014 0.0014
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0015 0.011 0.0159
Schistosoma mansoni hypothetical protein 0.0009 0.0014 0.0021
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0009 0.0014 0.0002
Schistosoma mansoni myosin xvIII 0.0009 0.0014 0.0021
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Loa Loa (eye worm) melatonin receptor type 1A 0.0009 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0703 0.0703
Trichomonas vaginalis importin beta-1, putative 0.0026 0.029 0.0414
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0166 0.114
Echinococcus multilocularis Smad4 0.0009 0.0013 0.0013
Brugia malayi CXXC zinc finger family protein 0.0031 0.0373 0.0453
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0014 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0666 0.0961
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0166 0.114
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0014 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0212 0.3266 0.4708
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.1871 0.2338
Echinococcus granulosus GPCR family 2 0.0052 0.0703 0.0703
Brugia malayi Calcitonin receptor-like protein seb-1 0.0164 0.2489 0.3115
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0666 0.0822
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0052 0.0703 0.9866
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0166 0.114
Plasmodium falciparum importin beta, putative 0.0032 0.0386 0.471
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Echinococcus granulosus g protein coupled receptor 0.0009 0.0014 0.0014
Echinococcus granulosus neuropeptide s receptor 0.0009 0.0014 0.0014
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.003 0.003
Echinococcus granulosus dnaJ subfamily B 0.0442 0.6938 0.6938
Entamoeba histolytica hypothetical protein 0.0026 0.029 1
Brugia malayi isocitrate dehydrogenase 0.0052 0.0703 0.0869
Brugia malayi hypothetical protein 0.0018 0.0168 0.0196
Entamoeba histolytica phosphoinositide kinase, putative 0.0015 0.011 0.0753
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0009 0.0014 0.0002
Schistosoma mansoni amine GPCR 0.0009 0.0014 0.0021
Brugia malayi larval opioid receptor 0.0009 0.0014 0.0002
Brugia malayi hypothetical protein 0.0009 0.0014 0.0002
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0328 0.3774
Loa Loa (eye worm) glutaminase 2 0.0306 0.4772 0.5986
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0166 0.0847
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0014 0.0014
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.1781 0.8837
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0925 0.4154
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0251 1
Brugia malayi G-protein coupled receptor 0.0009 0.0014 0.0002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0166 0.0847
Brugia malayi hypothetical protein 0.0009 0.0014 0.0002
Loa Loa (eye worm) RNA binding protein 0.0212 0.3266 0.4093
Schistosoma mansoni importin beta-1 0.0032 0.0386 0.0556
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0052 0.0703 0.9866
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0014 0.0021
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0052 0.0703 0.1014
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0014 0.0014
Echinococcus granulosus CTD small phosphatase protein like 0.0014 0.0096 0.0096
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0251 0.03
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0251 0.2527
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Echinococcus multilocularis cpg binding protein 0.0033 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.0164 0.2489 0.3115
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.1781 0.8837
Brugia malayi RNA recognition motif domain containing protein 0.0212 0.3266 0.4093
Echinococcus granulosus allatostatin A receptor 0.0009 0.0014 0.0014
Brugia malayi Serotonin receptor 0.0009 0.0014 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0711 1
Trypanosoma brucei trypanothione reductase 0.0052 0.0711 1
Echinococcus multilocularis smad 0.0009 0.0013 0.0013
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.1993 1
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0015 0.011 0.0237
Plasmodium vivax glutathione reductase, putative 0.0052 0.0711 1
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0015 0.011 0.0176
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0166 0.114
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0014 0.0014
Echinococcus granulosus neuropeptide FF receptor 2 0.0009 0.0014 0.0014
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0251 0.03
Schistosoma mansoni hypothetical protein 0.0442 0.6938 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0251 0.2527
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0166 0.114
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0703 0.7325
Plasmodium vivax hypothetical protein, conserved 0.0015 0.011 0.0237
Brugia malayi hypothetical protein 0.0009 0.0014 0.0002
Brugia malayi MH2 domain containing protein 0.0125 0.1871 0.2338
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0009 0.0014 0.0021
Brugia malayi hypothetical protein 0.0028 0.0328 0.0397
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0014 0.0014
Brugia malayi Pip kinase protein 1 0.0015 0.011 0.0123
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0052 0.0703 0.294
Onchocerca volvulus 0.0182 0.2787 0.3489
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0166 0.0847
Schistosoma mansoni amine GPCR 0.0009 0.0014 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0021
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0052 0.0703 0.0703
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0703 0.0869
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.034 0.531 0.6664
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0015 0.011 0.0159
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0166 0.114
Schistosoma mansoni opsin-like receptor 0.0009 0.0014 0.0021
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0212 0.3266 0.4093
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0009 0.0014 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0328 0.3774
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0166 0.5
Trichomonas vaginalis glutaminase, putative 0.0306 0.4772 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.0013 0.0018
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0009 0.0014 0.0014
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0166 0.0847
Schistosoma mansoni neuropeptide receptor 0.0009 0.0014 0.0021
Schistosoma mansoni hypothetical protein 0.0052 0.0703 0.1014
Echinococcus multilocularis GPCR, family 2 0.0052 0.0703 0.0703
Brugia malayi GnHR receptor homolog 0.0009 0.0014 0.0002
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0089 0.0096
Plasmodium vivax importin-beta 2, putative 0.0032 0.0386 0.471
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0386 0.471
Plasmodium falciparum thioredoxin reductase 0.0052 0.0711 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0052 0.0703 0.9866
Schistosoma mansoni histamine h1 receptor 0.0009 0.0014 0.0021
Brugia malayi hypothetical protein 0.0009 0.0014 0.0002
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0711 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0014 0.0014
Brugia malayi glutaminase DH11.1 0.0306 0.4772 0.5986
Echinococcus multilocularis snurportin 1 0.034 0.531 0.531
Schistosoma mansoni opsin-like receptor 0.0009 0.0014 0.0021
Echinococcus multilocularis orexin receptor type 2 0.0009 0.0014 0.0014
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0925 0.0925
Echinococcus granulosus cpg binding protein 0.0033 0.0401 0.0401
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0014 0.0014
Brugia malayi RNA, U transporter 1 0.0091 0.1324 0.165
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0014 0.0014
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0711 0.2985
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0014 0.0014
Giardia lamblia Hypothetical protein 0.0015 0.011 0.0937
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0703 0.9866
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0703 0.0703
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0014 0.0096 0.0096
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0925 1
Schistosoma mansoni tar DNA-binding protein 0.0212 0.3266 0.4708
Loa Loa (eye worm) isocitrate dehydrogenase 0.0052 0.0703 0.0869
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0014 0.0096 0.0105
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0166 0.0166
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0703 0.9866
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0251 0.0251
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0014 0.0014
Echinococcus granulosus neuropeptide receptor 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0093 0.0101
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0373 0.0453
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0015 0.011 0.0176
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0014 0.0021
Brugia malayi G protein-coupled receptor 0.0009 0.0014 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0014 0.0014
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0328 0.3774
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Echinococcus multilocularis isocitrate dehydrogenase 0.0052 0.0703 0.0703
Brugia malayi Pip kinase protein 2 0.0182 0.2787 0.349
Brugia malayi glutathione reductase 0.0052 0.0711 0.0879
Brugia malayi RNA binding protein 0.0212 0.3266 0.4093
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0251 0.0251
Brugia malayi hypothetical protein 0.0009 0.0014 0.0002
Echinococcus granulosus G protein coupled receptor 139 0.0009 0.0014 0.0014
Brugia malayi latrophilin 2 splice variant baaae 0.0112 0.1663 0.2075
Loa Loa (eye worm) pip kinase 1 0.0015 0.011 0.0123
Echinococcus granulosus g-protein coupled receptor 0.0009 0.0014 0.0014
Echinococcus multilocularis somatostatin receptor 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Echinococcus granulosus fmrfamide receptor 0.0009 0.0014 0.0014
Brugia malayi Thioredoxin reductase 0.0052 0.0711 0.0879
Schistosoma mansoni ran 0.0023 0.0251 0.0362
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.1781 0.8837
Brugia malayi G protein-coupled receptor F59B2.13 0.0009 0.0014 0.0002
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0009 0.0014 0.0014
Schistosoma mansoni smad 0.0009 0.0013 0.0018
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0166 0.114
Schistosoma mansoni hypothetical protein 0.034 0.531 0.7654
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0703 0.0869
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Echinococcus multilocularis 0.0014 0.0096 0.0096
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0015 0.011 0.0176
Schistosoma mansoni hypothetical protein 0.0014 0.0093 0.0134
Echinococcus multilocularis allatostatin A receptor 0.0009 0.0014 0.0014
Echinococcus granulosus neuropeptide receptor 0.0009 0.0014 0.0014
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0052 0.0703 0.9866
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0386 0.471
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0164 0.2489 0.3115
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0015 0.011 0.0237
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0009 0.0014 0.0002
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0015 0.011 0.0123
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0014 0.0014
Echinococcus granulosus neuropeptide receptor A26 0.0009 0.0014 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0014 0.0014
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.1781 0.8837
Brugia malayi putative neuropeptide receptor 0.0009 0.0014 0.0002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0703 0.0703
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.011 0.0237
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0925 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.2787 0.349
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0251 0.1876
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0711 0.0711
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0014 0.0014
Brugia malayi Importin beta-1 subunit 0.0032 0.0386 0.0469
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Echinococcus granulosus tachykinin peptides receptor 99D 0.0009 0.0014 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0014 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0021
Echinococcus granulosus tar DNA binding protein 0.0212 0.3266 0.3266
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0703 0.7325
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0009 0.0014 0.0002
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0166 0.0193
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0703 0.0869
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0014 0.0014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0925 0.1648
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0009 0.0014 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0021
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0015 0.011 0.0237
Schistosoma mansoni hypothetical protein 0.0112 0.1663 0.2396
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0014 0.0014
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0015 0.011 0.011
Echinococcus multilocularis serotonin receptor 0.0009 0.0014 0.0014
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0009 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.1993 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0014 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0212 0.3266 0.4708
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0015 0.011 0.0159
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0014 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0928 0.1338
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0009 0.0014 0.0021
Echinococcus granulosus peptide allatostatin:somatostatin 0.0009 0.0014 0.0014
Schistosoma mansoni smad1 5 8 and 0.0009 0.0013 0.0018
Schistosoma mansoni neuropeptide receptor 0.0009 0.0014 0.0021
Plasmodium falciparum glutathione reductase 0.0052 0.0711 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0014 0.0014
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0015 0.011 0.0237
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0014 0.0014
Brugia malayi Dopamine receptor protein 2 0.0009 0.0014 0.0002
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0251 0.2527
Echinococcus granulosus Smad4 0.0009 0.0013 0.0013
Echinococcus granulosus alpha 1A adrenergic receptor 0.0009 0.0014 0.0014
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.011 0.0237
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0015 0.011 0.0237
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0009 0.0014 0.0021
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0009 0.0014 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0014 0.0014
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0089 0.0096
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0386 0.0386
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0112 0.1663 0.2075
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0002
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0013 0.0013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0164 0.2489 0.3115
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.011 0.0753
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0015 0.011 0.0159
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0009 0.0014 0.0021
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0166 0.0847
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0021
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0009 0.0014 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0014 0.0021
Brugia malayi hypothetical protein 0.0009 0.0014 0.0002

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > 1000 nM Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in CHO cells ChEMBL. 19211245
Ki (binding) > 1000 nM Displacement of [3H]diprenorphine from mouse delta opioid receptor expressed in CHO cells ChEMBL. 19211245
Ki (binding) > 1000 nM Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cells ChEMBL. 19211245

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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