Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0036 | 0.1559 | 0.5811 |
Schistosoma mansoni | tar DNA-binding protein | 0.0046 | 0.2683 | 0.2683 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0033 | 0.123 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0033 | 0.123 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0213 | 0.0213 |
Brugia malayi | RNA binding protein | 0.0046 | 0.2683 | 1 |
Brugia malayi | hypothetical protein | 0.0033 | 0.123 | 0.4585 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0046 | 0.2683 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0046 | 0.2683 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0025 | 0.0213 | 0.0794 |
Echinococcus multilocularis | tar DNA binding protein | 0.0046 | 0.2683 | 0.2683 |
Leishmania major | hypothetical protein, conserved | 0.0033 | 0.123 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0033 | 0.123 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0046 | 0.2683 | 0.2683 |
Schistosoma mansoni | tar DNA-binding protein | 0.0046 | 0.2683 | 0.2683 |
Schistosoma mansoni | tar DNA-binding protein | 0.0046 | 0.2683 | 0.2683 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0033 | 0.123 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0036 | 0.1559 | 0.545 |
Loa Loa (eye worm) | RNA binding protein | 0.0046 | 0.2683 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1559 | 0.545 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0033 | 0.123 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.123 | 0.4118 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0033 | 0.123 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0046 | 0.2683 | 0.2683 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0046 | 0.2683 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0036 | 0.1559 | 0.5811 |
Schistosoma mansoni | tar DNA-binding protein | 0.0046 | 0.2683 | 0.2683 |
Brugia malayi | TAR-binding protein | 0.0046 | 0.2683 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0033 | 0.123 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 200 ug ml-1 | Inhibition of Candida albicans ICL assessed as formation of glyoxylate phenylhydrazone by spectrophotometry | ChEMBL. | 21377877 |
Inhibition (functional) | Antifungal activity against Candida albicans ATCC 10231 at 100 ug/ml after 2 weeks | ChEMBL. | 21377877 | |
Inhibition (binding) | = 80 % | Inhibition of butylcholine esterase at 100 ug/mL | ChEMBL. | 15921416 |
MIC (functional) | > 100 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by broth dilution method | ChEMBL. | 21377877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.