Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0334 | 0.0335 |
Schistosoma mansoni | survival motor neuron protein | 0.0054 | 0.1753 | 0.6208 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.4864 | 0.4872 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0681 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.1217 | 0.1219 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0419 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0419 | 0.042 |
Brugia malayi | Carboxylesterase family protein | 0.0014 | 0.0182 | 0.0182 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0014 | 0.0182 | 0.0182 |
Onchocerca volvulus | 0.0034 | 0.0949 | 0.0782 | |
Loa Loa (eye worm) | carboxylesterase | 0.0014 | 0.0182 | 0.0182 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0377 | 0.3905 |
Schistosoma mansoni | gliotactin | 0.0014 | 0.0182 | 0.0643 |
Schistosoma mansoni | acetylcholinesterase | 0.0014 | 0.0182 | 0.0643 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0334 | 0.1183 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0014 | 0.0182 | 0.0643 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.1217 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0377 | 0.3905 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.1217 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.1753 | 0.6208 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0681 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0266 | 0.9982 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.2824 | 0.2829 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0182 | 0.0182 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.1217 | 1 |
Echinococcus granulosus | neuroligin | 0.0014 | 0.0182 | 0.0182 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0681 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.1134 | 0.1136 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0182 | 0.0182 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0054 | 0.1753 | 0.1756 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0419 | 0.4752 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0681 | 0.0682 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0334 | 0.1183 |
Brugia malayi | Carboxylesterase family protein | 0.0014 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0419 | 0.042 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.2824 | 0.2829 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0681 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0419 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0334 | 0.1183 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0681 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0901 | 0.0903 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0681 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0014 | 0.0182 | 0.0643 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0182 | 0.0182 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0334 | 0.0335 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0681 | 0.0682 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0014 | 0.0182 | 0.0643 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1134 | 0.1136 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0334 | 0.0335 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.2824 | 0.2829 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0334 | 0.0335 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.1217 | 0.4311 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0334 | 0.0335 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0681 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.0949 | 0.3363 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0681 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0014 | 0.0182 | 0.0182 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.4864 | 0.4872 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0334 | 0.0335 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0681 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0681 | 0.0682 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0681 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0949 | 0.3363 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0681 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0014 | 0.0182 | 0.0643 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2824 | 0.2829 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.2824 | 1 |
Onchocerca volvulus | 0.0054 | 0.1753 | 0.16 | |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0419 | 0.042 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0014 | 0.0182 | 0.0182 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0266 | 0.9982 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.1217 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.1824 | 0.1827 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0681 | 0.0682 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0949 | 0.3363 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0334 | 0.0335 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.0949 | 0.0951 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.2824 | 0.2829 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0949 | 0.0951 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0014 | 0.0182 | 0.0182 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0377 | 0.3905 |
Brugia malayi | Carboxylesterase family protein | 0.0014 | 0.0182 | 0.0182 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0681 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0234 | 0.8743 | 0.8758 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.1217 | 0.1219 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1217 | 0.4311 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0334 | 0.1183 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0681 | 0.0682 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.0949 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.2824 | 0.2829 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0014 | 0.0182 | 0.0643 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.002 | 0.0419 | 0.4752 |
Onchocerca volvulus | 0.0027 | 0.0681 | 0.0509 | |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.0949 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0014 | 0.0182 | 0.0182 |
Brugia malayi | hypothetical protein | 0.004 | 0.1217 | 0.1219 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.2824 | 0.2829 |
Brugia malayi | hypothetical protein | 0.0266 | 0.9982 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0014 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0234 | 0.8743 | 0.8758 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0949 | 0.3363 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0334 | 0.0335 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.2824 | 0.2829 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0681 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.4864 | 0.4872 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0681 | 0.0682 |
Echinococcus multilocularis | neuroligin | 0.0014 | 0.0182 | 0.0182 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0681 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0419 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0334 | 0.0335 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.1824 | 0.1827 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.2824 | 0.2829 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0419 | 0.042 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0334 | 0.0335 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0182 | 0.0182 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0014 | 0.0182 | 0.0182 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.2824 | 0.2829 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0949 | 0.0951 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1134 | 0.4017 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0377 | 0.3905 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.0949 | 0.0951 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0014 | 0.0182 | 0.0182 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0681 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0949 | 0.0951 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1824 | 0.1827 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.9982 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.1824 | 0.1827 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.2824 | 0.2829 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2824 | 0.2829 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of horse serum BuChE upto 500 uM by Ellman's method | ChEMBL. | 17574306 | |
IC50 (binding) | = 34.96 uM | Inhibition of Electrophorus electricus AChE by Ellman's method | ChEMBL. | 17574306 |
Inhibition (binding) | Inhibition of mushroom tyrosinase at 200 uM | ChEMBL. | 19800229 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.