TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 366.43 | Formula: C21H18O4S
H donors: 0 H acceptors: 2 LogP: 4.68 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCS(=O)(=O)c1ccc(cc1)c1coc2c1cc(cc2)c1ccc(o1)C
InChi: 1S/C21H18O4S/c1-3-26(22,23)17-8-5-15(6-9-17)19-13-24-21-11-7-16(12-18(19)21)20-10-4-14(2)25-20/h4-13H,3H2,1-2H3
InChiKey: BQTJRYNLKIVLQR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycogen synthase kinase 3 beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei gambiense	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania braziliensis	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	Serine/threonine protein kinase required for induction of IME2 by Ime1p	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania infantum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus		Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium knowlesi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma cruzi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania mexicana	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania donovani	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Neospora caninum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium berghei	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium falciparum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	intracellular kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Theileria parva	glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium vivax	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K08822 glycogen synthase kinase 3 alpha, putative	Get druggable targets OG5_126888	All targets in OG5_126888

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	muscleblind protein 1	0.0174	0.5341	0.5341
Schistosoma mansoni	nuclear hormone receptor	0.0015	0.0307	0.0312
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0025	0.0622	0.0651
Brugia malayi	nuclear hormone receptor	0.0032	0.0849	0.0887
Trichomonas vaginalis	glutathione reductase, putative	0.0034	0.0911	0.1111
Toxoplasma gondii	exonuclease III APE	0.0022	0.0515	0.1414
Loa Loa (eye worm)	hypothetical protein	0.0308	0.9567	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0751	0.224
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0015	0.0307	0.0321
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0009	0.0112	0.0112
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0034	0.0911	0.9106
Schistosoma mansoni	ap endonuclease	0.0022	0.0515	0.0523
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0015	0.0307	0.0307
Schistosoma mansoni	nuclear hormone receptor	0.0032	0.0849	0.0862
Loa Loa (eye worm)	nuclear hormone receptor	0.0015	0.0307	0.0321
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0989	0.0989
Trypanosoma cruzi	trypanothione reductase, putative	0.0034	0.0911	0.2803
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0015	0.0307	0.0421
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0015	0.0307	0.0321
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0017	0.0365	0.0371
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.0849	0.0887
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0751	0.224
Brugia malayi	nuclear receptor NHR-67	0.0015	0.0307	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0174	0.5341	0.5582
Brugia malayi	Nuclear hormone receptor-like 1	0.0032	0.0849	0.0887
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0989	0.3079
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0034	0.0911	0.2803
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.0911	0.2803
Loa Loa (eye worm)	thioredoxin reductase	0.0099	0.2961	0.3095
Echinococcus multilocularis	apoptosis inducing factor 1 mitochondrial	0.0009	0.0112	0.0112
Trypanosoma brucei	protein kinase, putative	0.0058	0.166	0.5433
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0015	0.0307	0.0307
Giardia lamblia	Kinase, CMGC GSK	0.0058	0.166	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0911	0.2803
Brugia malayi	nuclear receptor RXR	0.0015	0.0307	0.0321
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.0849	0.0849
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0034	0.0911	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0515	0.0539
Schistosoma mansoni	retinoic acid receptor RXR	0.0032	0.0849	0.0862
Leishmania major	trypanothione reductase	0.0099	0.2961	1
Plasmodium falciparum	thioredoxin reductase	0.0034	0.0911	0.2803
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0032	0.0849	0.0887
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0032	0.0849	0.0862
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0022	0.0515	0.2603
Brugia malayi	Thioredoxin reductase	0.0099	0.2961	0.3095
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0015	0.0307	0.0307
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0515	0.4594
Onchocerca volvulus		0.003	0.0766	0.1049
Schistosoma mansoni	glutamate synthase	0.0009	0.0112	0.0114
Onchocerca volvulus	Bile acid receptor homolog	0.0032	0.0849	0.1163
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0849	0.0887
Plasmodium falciparum	glycogen synthase kinase 3	0.0058	0.166	0.5433
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0032	0.0849	0.0849
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0911	0.2803
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0251	0.7779	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0307	0.0321
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0989	0.5667
Brugia malayi	hypothetical protein	0.0015	0.0307	0.0321
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0032	0.0849	0.0849
Onchocerca volvulus		0.0032	0.0849	0.1163
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0032	0.0849	0.0862
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0032	0.0849	0.0887
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0015	0.0307	0.0421
Brugia malayi	glutathione reductase	0.0099	0.2961	0.3095
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0013	0.0239	0.0239
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.0911	0.9106
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0034	0.0911	0.2803
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0017	0.0365	0.0365
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0911	0.2803
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.1506	0.1529
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.1506	0.1574
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.166	0.2154
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0365	0.0382
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0015	0.0307	0.0307
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.1506	0.1574
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0009	0.0112	0.0117
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0365	0.0382
Plasmodium falciparum	thioredoxin reductase	0.0099	0.2961	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.0911	0.2803
Toxoplasma gondii	thioredoxin reductase	0.0099	0.2961	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0751	0.224
Treponema pallidum	NADH oxidase	0.0034	0.0911	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0032	0.0849	0.0849
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0515	0.0561
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0867	0.0985
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0032	0.0849	0.0849
Loa Loa (eye worm)	DR-78	0.0015	0.0307	0.0321
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.0989	1
Trichomonas vaginalis	mercuric reductase, putative	0.0034	0.0911	0.1111
Brugia malayi	Inositol-1	0.0037	0.0989	0.1034
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0307	0.0321
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.0849	0.0887
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0034	0.0911	0.2803
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.166	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0251	0.7779	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0766	0.0766
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0849	0.0887
Brugia malayi	RNA recognition motif domain containing protein	0.0074	0.2163	0.2261
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0307	0.0321
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0226	0.698	0.8958
Schistosoma mansoni	nuclear receptor nhr-48	0.0015	0.0307	0.0312
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0032	0.0849	0.0887
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.1506	0.1529
Brugia malayi	steroid hormone receptor	0.0032	0.0849	0.0887
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0032	0.0849	0.0849
Mycobacterium tuberculosis	Probable reductase	0.0226	0.698	0.8958
Loa Loa (eye worm)	glutathione reductase	0.0099	0.2961	0.3095
Loa Loa (eye worm)	hypothetical protein	0.0174	0.5341	0.5582
Plasmodium vivax	SET domain protein, putative	0.003	0.0766	0.2294
Echinococcus multilocularis	FTZ F1 alpha	0.0032	0.0849	0.0849
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0515	0.1414
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0032	0.0849	0.0862
Brugia malayi	ecdysteroid receptor	0.0032	0.0849	0.0887
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.0989	1
Entamoeba histolytica	hypothetical protein	0.0038	0.1012	0.5812
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0015	0.0307	0.0307
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0989	0.1005
Brugia malayi	ecdysone receptor	0.0015	0.0307	0.0321
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0766	0.0766
Plasmodium vivax	glutathione reductase, putative	0.0099	0.2961	1
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0515	0.0561
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.2163	0.2197
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0034	0.0911	0.1042
Brugia malayi	glutamate synthase	0.0009	0.0112	0.0117
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.166	0.2154
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0015	0.0307	0.0312
Echinococcus granulosus	FTZ F1 alpha	0.0032	0.0849	0.0849
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0032	0.0849	0.0849
Brugia malayi	hypothetical protein	0.0017	0.0365	0.0382
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0515	0.0515
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0034	0.0911	0.9106
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.1506	0.1506
Brugia malayi	Steroid receptor seven-up type 2	0.0032	0.0849	0.0887
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0515	0.5045
Brugia malayi	orphan nuclear receptor NR2E1	0.0015	0.0307	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0307	0.0321
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.2163	0.2197
Schistosoma mansoni	sulfide quinone reductase	0.0009	0.0112	0.0114
Brugia malayi	hypothetical protein	0.0015	0.0307	0.0321
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0099	0.2961	0.3716
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0034	0.0911	0.2803
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0251	0.7779	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0032	0.0849	0.0887
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0307	0.0321
Entamoeba histolytica	hypothetical protein	0.0038	0.1012	0.5812
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0751	0.0785
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0515	0.1414
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0989	0.3079
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0058	0.166	0.5433
Brugia malayi	TAR-binding protein	0.0074	0.2163	0.2261
Entamoeba histolytica	hypothetical protein	0.0038	0.1012	0.5812
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0515	0.1414
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0032	0.0849	0.0887
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0226	0.698	0.8958
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.1506	0.1506
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0058	0.166	0.5433
Brugia malayi	nuclear receptor NHR-88	0.0032	0.0849	0.0887
Schistosoma mansoni	coup transcription factor	0.0032	0.0849	0.0862
Entamoeba histolytica	hypothetical protein	0.0038	0.1012	0.5812
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0515	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0307	0.0321
Toxoplasma gondii	NADPH-glutathione reductase	0.0034	0.0911	0.2803
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0074	0.2163	0.2261
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0515	0.1414
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0009	0.0112	0.0112
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0032	0.0849	0.0887
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0032	0.0849	0.0862
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0058	0.166	0.166
Schistosoma mansoni	hypothetical protein	0.0009	0.0112	0.0114
Loa Loa (eye worm)	programmed cell death 8	0.0009	0.0112	0.0117
Trypanosoma cruzi	trypanothione reductase, putative	0.0099	0.2961	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0365	0.0382
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0013	0.0239	0.0239
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0032	0.0849	0.1163
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0365	0.0382
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.1012	0.1012
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0032	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0849	0.0887
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0032	0.0849	0.0887
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0226	0.698	0.8958
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0989	0.122
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0034	0.0911	0.0911
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0034	0.0911	0.2803
Echinococcus multilocularis	sulfide:quinone oxidoreductase	0.0009	0.0112	0.0112
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0751	0.224
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0034	0.0911	0.2803
Echinococcus granulosus	tar DNA binding protein	0.0074	0.2163	0.2163
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0015	0.0307	0.0321
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0032	0.0849	0.0849
Echinococcus granulosus	thyroid hormone receptor alpha	0.0015	0.0307	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0849	0.0887
Onchocerca volvulus		0.0236	0.7299	1
Brugia malayi	Muscleblind-like protein	0.0174	0.5341	0.5582
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0365	0.0382
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0058	0.166	0.1735
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0009	0.0112	0.0117
Echinococcus multilocularis	glutamate synthase	0.0009	0.0112	0.0112
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0766	0.0778
Trypanosoma brucei	trypanothione reductase	0.0099	0.2961	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0034	0.0911	0.2803
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0015	0.0307	0.0307
Schistosoma mansoni	nuclear receptor	0.0015	0.0307	0.0312
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0034	0.0911	0.0925
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0766	0.0766
Loa Loa (eye worm)	RNA binding protein	0.0074	0.2163	0.2261
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0034	0.0911	0.2803
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0017	0.0365	0.0365
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0015	0.0307	0.0312
Schistosoma mansoni	nuclear receptor	0.0015	0.0307	0.0312
Brugia malayi	Pre-SET motif family protein	0.003	0.0766	0.08
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.0849	0.0887
Echinococcus multilocularis	tar DNA binding protein	0.0074	0.2163	0.2163
Schistosoma mansoni	thyroid hormone receptor	0.0032	0.0849	0.0862
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0032	0.0849	0.0862
Onchocerca volvulus		0.0058	0.166	0.2274
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0911	0.2803
Brugia malayi	hypothetical protein	0.0029	0.0751	0.0785
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0034	0.0911	0.0952
Echinococcus multilocularis	ecdysone induced protein 78C	0.0032	0.0849	0.0849
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0034	0.0911	0.2803
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0034	0.0911	0.0911
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0307	0.0321
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0731	0.0731
Echinococcus granulosus	sulfide:quinone oxidoreductase	0.0009	0.0112	0.0112
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0307	0.0307
Echinococcus granulosus	glutamate synthase	0.0009	0.0112	0.0112
Schistosoma mansoni	nuclear hormone receptor	0.0015	0.0307	0.0312
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0751	0.224
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0989	0.1005
Onchocerca volvulus		0.0015	0.0307	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0307	0.0321
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.1012	0.1012
Schistosoma mansoni	zinc finger protein	0.0015	0.0307	0.0312
Giardia lamblia	Kinase, CMGC GSK	0.0058	0.166	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0015	0.0307	0.0321
Leishmania major	hypothetical protein, conserved	0.0029	0.0751	0.224
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0032	0.0849	0.0862
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.166	1
Echinococcus multilocularis	pyridine nucleotide disulfide oxidoreductase	0.0009	0.0112	0.0112
Brugia malayi	intracellular kinase	0.0058	0.166	0.1735
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0989	0.0989
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0017	0.0365	0.0371
Echinococcus granulosus	ecdysone induced protein 78C	0.0032	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0365	0.0382
Brugia malayi	Pre-SET motif family protein	0.0208	0.6391	0.6681
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.2163	0.2197
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0911	0.2803
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0034	0.0911	0.2803
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0515	0.1414
Entamoeba histolytica	protein kinase, putative	0.0058	0.166	1
Echinococcus granulosus	apoptosis inducing factor 1 mitochondrial	0.0009	0.0112	0.0112
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0015	0.0307	0.0321
Schistosoma mansoni	RAR-like nuclear receptor	0.0032	0.0849	0.0862
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.0849	0.0887
Loa Loa (eye worm)	TAR-binding protein	0.0074	0.2163	0.2261
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0032	0.0849	0.0862
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0226	0.698	0.8958
Echinococcus multilocularis	muscleblind protein	0.0174	0.5341	0.5341
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0251	0.7779	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0032	0.0849	0.0887
Plasmodium falciparum	glutathione reductase	0.0099	0.2961	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0032	0.0849	0.0887
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0112	0.0117
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0032	0.0849	0.0887
Onchocerca volvulus	Protein ultraspiracle homolog	0.0032	0.0849	0.1163
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.0515	0.2603
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0515	0.1414
Schistosoma mansoni	ap endonuclease	0.0022	0.0515	0.0523
Schistosoma mansoni	hypothetical protein	0.0013	0.0239	0.0243
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.1012	0.1027
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0515	0.4594
Echinococcus granulosus	NADPH:adrenodoxin oxidoreductase	0.0009	0.0112	0.0112
Echinococcus multilocularis	protein kinase shaggy	0.0058	0.166	0.166
Loa Loa (eye worm)	steroid hormone receptor	0.0032	0.0849	0.0887
Echinococcus granulosus	pyridine nucleotide disulfide oxidoreductase	0.0009	0.0112	0.0112
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.0867	0.0985
Onchocerca volvulus		0.0015	0.0307	0.0421
Echinococcus granulosus	nuclear receptor nhr 48	0.0015	0.0307	0.0307
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0751	0.224
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0989	0.3079
Echinococcus multilocularis	NADPH:adrenodoxin oxidoreductase	0.0009	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0849	0.0887
Echinococcus granulosus	thioredoxin glutathione reductase	0.01	0.298	0.298
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0058	0.166	0.1735
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.0849	0.0849
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0058	0.166	0.1686
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0034	0.0911	0.2803
Brugia malayi	tailless protein	0.0015	0.0307	0.0321
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.1506	0.1506
Brugia malayi	hypothetical protein	0.0017	0.0365	0.0382
Schistosoma mansoni	glutamate synthase	0.0009	0.0112	0.0114
Brugia malayi	hypothetical protein	0.0038	0.1012	0.1058
Plasmodium falciparum	glutathione reductase	0.0034	0.0911	0.2803
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0515	0.0539
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0034	0.0911	0.2803
Schistosoma mansoni	thyroid hormone receptor	0.0032	0.0849	0.0862
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0989	0.122
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0307	0.0321
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0034	0.0911	0.2803
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0989	0.122
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0032	0.0849	0.0887
Brugia malayi	nuclear receptor RXR	0.0017	0.0365	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0849	0.0887
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0034	0.0911	0.9106
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0032	0.0849	0.0849
Brugia malayi	Nuclear hormone receptor E75	0.0015	0.0307	0.0321
Brugia malayi	Nuclear hormone receptor E75	0.0015	0.0307	0.0321
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.0849	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0307	0.0321
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0009	0.0112	0.0112
Trichomonas vaginalis	set domain proteins, putative	0.0236	0.7299	1
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0989	0.3079
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0307	0.0321
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.0849	0.0887
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0032	0.0849	0.0887
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.2163	0.2197
Mycobacterium tuberculosis	Probable dehydrogenase	0.0226	0.698	0.8958
Brugia malayi	hypothetical protein	0.0019	0.0422	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0365	0.0382
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0025	0.0622	0.0651
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0766	0.2294
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.1506	0.1506
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0989	0.3079
Schistosoma mansoni	sulfide quinone reductase	0.0009	0.0112	0.0114
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.0009	0.0112	0.0117
Brugia malayi	RNA binding protein	0.0074	0.2163	0.2261
Echinococcus granulosus	protein kinase shaggy	0.0058	0.166	0.166
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0766	0.0778
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0015	0.0307	0.0307
Brugia malayi	conserved hypotetical protein	0.0015	0.0307	0.0321
Plasmodium vivax	thioredoxin reductase, putative	0.0099	0.2961	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0307	0.0321
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0058	0.166	0.5433
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0034	0.0911	0.9106
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0226	0.698	0.8958
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0849	0.0887
Brugia malayi	nuclear hormone receptor	0.0015	0.0307	0.0321
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0034	0.0911	0.516
Echinococcus granulosus	muscleblind protein	0.0174	0.5341	0.5341
Loa Loa (eye worm)	inositol-1	0.0037	0.0989	0.1034
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0032	0.0849	0.0887
Echinococcus multilocularis	nuclear receptor nhr 48	0.0015	0.0307	0.0307
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0766	0.0778
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0307	0.0321
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0515	0.0526
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0017	0.0365	0.0382
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0032	0.0849	0.0849
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0766	0.0778
Onchocerca volvulus		0.0009	0.0112	0.0154
Echinococcus multilocularis	thioredoxin glutathione reductase	0.01	0.298	0.298
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0307	0.0307
Brugia malayi	nuclear receptor NHR-88	0.0015	0.0307	0.0321
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.1506	0.1529
Schistosoma mansoni	disulfide oxidoreductase	0.0009	0.0112	0.0114
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0751	0.224
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0208	0.6391	0.6681
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0009	0.0112	0.0112
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0058	0.166	0.166
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.2163	0.2197
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0032	0.0849	0.0887
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0034	0.0911	0.2803
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.0849	0.0849
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.0849	0.0887
Schistosoma mansoni	hypothetical protein	0.0038	0.1012	0.1027
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0058	0.166	0.5433
Loa Loa (eye worm)	hypothetical protein	0.003	0.0766	0.08
Brugia malayi	photoreceptor-specific nuclear receptor	0.0308	0.9567	1
Brugia malayi	NADPH:adrenodoxin oxidoreductase, mitochondrial precursor	0.0009	0.0112	0.0117
Schistosoma mansoni	glutamate synthase	0.0009	0.0112	0.0114

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 38 nM	Inhibition of human recombinant GSK3-beta	ChEMBL.	19775160

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL578628

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1184183