Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0636 | 0.0636 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.2321 | 0.5 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.2321 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.4081 | 0.4081 |
Leishmania major | cytochrome p450-like protein | 0.0016 | 0.0636 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.2578 | 0.2657 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2805 | 0.2805 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0044 | 0.2578 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0016 | 0.0636 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2805 | 0.2805 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.2805 | 0.2805 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.2805 | 0.2805 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.2805 | 0.289 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.2578 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.2805 | 0.2805 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0146 | 0.9705 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0636 | 0.0636 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.2805 | 0.2805 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0016 | 0.0636 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0044 | 0.2578 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.0636 | 0.0636 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.2805 | 0.289 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.2321 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4081 | 0.4081 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0044 | 0.2578 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.4081 | 0.4081 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.4081 | 0.4081 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0044 | 0.2578 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4081 | 0.4081 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0122 | 0.0122 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.4081 | 0.4081 |
Trypanosoma brucei | cytochrome P450, putative | 0.0016 | 0.0636 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.4081 | 0.4081 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2805 | 0.2805 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0016 | 0.0636 | 0.0636 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.0636 | 0.0636 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4081 | 0.4081 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4081 | 0.4081 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4081 | 0.4081 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0016 | 0.0636 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.4081 | 0.4205 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.4081 | 0.4081 |
Brugia malayi | RNA binding protein | 0.0066 | 0.4081 | 0.4081 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 50 % | Anticonvulsant activity in CF1 albino mouse assessed as protection against electrically-induced seizure at 100 mg/kg, ip after 4 hrs by 6Hz psychomotor seizure test | ChEMBL. | 20638856 |
Activity (functional) | = 100 mg kg-1 | Anticonvulsant activity in ip dosed CF1 albino mouse assessed as dose required to protect against maximal electroshock-induced seizures after 4 hrs | ChEMBL. | 20638856 |
Activity (ADMET) | = 300 mg kg-1 | Neurotoxicity in ip dosed CF1 albino mouse assessed as dose required to cause toxicity after 0.5 hrs by rotarod test | ChEMBL. | 20638856 |
Activity (functional) | = 300 mg kg-1 | Anticonvulsant activity in ip dosed CF1 albino mouse assessed as dose required to protect against maximal electroshock-induced seizures after 0.5 hrs | ChEMBL. | 20638856 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.