Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Leukotriene A-4 hydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma japonicum | ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Echinococcus granulosus | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania donovani | aminopeptidase-like protein | Leukotriene A-4 hydrolase | 611 aa | 508 aa | 21.5 % |
Onchocerca volvulus | Leukotriene A-4 hydrolase | 611 aa | 597 aa | 44.2 % | |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Leukotriene A-4 hydrolase | 611 aa | 519 aa | 22.7 % |
Leishmania infantum | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | Leukotriene A-4 hydrolase | 611 aa | 508 aa | 21.5 % |
Brugia malayi | Peptidase family M1 containing protein | Leukotriene A-4 hydrolase | 611 aa | 508 aa | 22.4 % |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | Leukotriene A-4 hydrolase | 611 aa | 510 aa | 23.3 % |
Dictyostelium discoideum | puromycin-sensitive aminopeptidase-like protein | Leukotriene A-4 hydrolase | 611 aa | 492 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0279 | 0.8225 | 0.8225 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0076 | 0.0353 | 0.1484 |
Brugia malayi | hypothetical protein | 0.0128 | 0.2378 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.021 | 0.5569 | 0.6771 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.021 | 0.5569 | 0.6771 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0279 | 0.8225 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1718 | 0.2089 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.0155 | 0.0188 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0279 | 0.8225 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0155 | 0.0155 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0256 | 0.7323 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0155 | 0.0155 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.0155 | 0.0188 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.0155 | 0.0188 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.0155 | 0.0188 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0155 | 0.0155 |
Brugia malayi | RNA binding protein | 0.0071 | 0.0155 | 0.0651 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0111 | 0.1718 | 0.2089 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0279 | 0.8225 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.0155 | 0.0188 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0111 | 0.1718 | 0.7226 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.0155 | 0.0651 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.0155 | 0.0651 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0111 | 0.1718 | 0.7226 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0155 | 0.0155 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0353 | 0.0353 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.0155 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0353 | 0.0429 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10000 nM | Inhibition of LTA4 hydrolase in guinea pig lung assessed as inhibition of LTB4 production | ChEMBL. | 19042128 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.