Detailed information for compound 1184947

Basic information

Technical information
  • TDR Targets ID: 1184947
  • Name: N-[2-(cyclohexylamino)-2-oxo-1-pyridin-4-ylet hyl]-N-(2,5-dimethylphenyl)thiadiazole-4-carb oxamide
  • MW: 449.568 | Formula: C24H27N5O2S
  • H donors: 1 H acceptors: 5 LogP: 4.3 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(N(c1cc(C)ccc1C)C(=O)c1csnn1)c1ccncc1)NC1CCCCC1
  • InChi: 1S/C24H27N5O2S/c1-16-8-9-17(2)21(14-16)29(24(31)20-15-32-28-27-20)22(18-10-12-25-13-11-18)23(30)26-19-6-4-3-5-7-19/h8-15,19,22H,3-7H2,1-2H3,(H,26,30)
  • InChiKey: PRCYJHLIYGBZRU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(cyclohexylamino)-2-oxo-1-(4-pyridyl)ethyl]-N-(2,5-dimethylphenyl)thiadiazole-4-carboxamide
  • N-[2-(cyclohexylamino)-2-oxo-1-(4-pyridyl)ethyl]-N-(2,5-dimethylphenyl)-4-thiadiazolecarboxamide
  • N-[2-(cyclohexylamino)-2-keto-1-(4-pyridyl)ethyl]-N-(2,5-dimethylphenyl)thiadiazole-4-carboxamide
  • N-[2-(cyclohexylamino)-2-oxo-1-pyridin-4-yl-ethyl]-N-(2,5-dimethylphenyl)-1,2,3-thiadiazole-4-carboxamide
  • ASN 06291194

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.3387 0.5
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.3387 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.3387 0.3387
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.3387 0.5
Echinococcus granulosus dna polymerase eta 0.0023 0.3387 0.5
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.3387 0.5
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.3387 0.5
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.3387 0.5
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.3387 0.5
Echinococcus multilocularis dna polymerase eta 0.0023 0.3387 0.5
Echinococcus granulosus dna polymerase kappa 0.0023 0.3387 0.5
Schistosoma mansoni DNA polymerase eta 0.0023 0.3387 0.5
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.3387 0.5
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.3387 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.3387 0.5
Giardia lamblia DINP protein human, muc B family 0.0023 0.3387 0.5
Echinococcus multilocularis dna polymerase kappa 0.0023 0.3387 0.5
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.3387 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.3387 0.3387

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5973 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.1689 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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