Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0375 | 0.0375 |
Echinococcus multilocularis | lamin | 0.0028 | 0.3537 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.3537 | 0.3537 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.3537 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.3537 | 0.6116 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.5545 | 0.5545 |
Schistosoma mansoni | lamin | 0.0028 | 0.3537 | 0.6116 |
Echinococcus granulosus | lamin | 0.0028 | 0.3537 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.5545 | 0.5545 |
Echinococcus multilocularis | musashi | 0.0028 | 0.3537 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.3537 | 0.3537 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0375 | 0.0375 |
Schistosoma mansoni | lamin | 0.0028 | 0.3537 | 0.6116 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.3537 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0375 | 0.0375 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.3537 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0375 | 0.0375 |
Onchocerca volvulus | 0.0028 | 0.3537 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.3397 | 0.3397 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.3537 | 0.3537 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.5545 | 1 |
Onchocerca volvulus | 0.0028 | 0.3537 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.3537 | 0.3537 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.3537 | 0.3537 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 22.9 uM | Inhibition of human recombinant SHP2 | ChEMBL. | 18680359 |
IC50 (binding) | = 25.7 uM | Inhibition of human recombinant PTP1B | ChEMBL. | 18680359 |
IC50 (binding) | = 32.4 uM | Inhibition of human recombinant SHP1 | ChEMBL. | 18680359 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.