Detailed information for compound 1185332

Basic information

Technical information
  • TDR Targets ID: 1185332
  • Name: (2S)-2-amino-1-[(3S)-3-(1H-benzimidazol-2-yl) -3,4-dihydro-1H-isoquinolin-2-yl]-3-(4-hydrox y-2,6-dimethylphenyl)propan-1-one
  • MW: 440.537 | Formula: C27H28N4O2
  • H donors: 3 H acceptors: 3 LogP: 3.84 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cc(C)c(c(c1)C)C[C@@H](C(=O)N1Cc2ccccc2C[C@H]1c1nc2c([nH]1)cccc2)N
  • InChi: 1S/C27H28N4O2/c1-16-11-20(32)12-17(2)21(16)14-22(28)27(33)31-15-19-8-4-3-7-18(19)13-25(31)26-29-23-9-5-6-10-24(23)30-26/h3-12,22,25,32H,13-15,28H2,1-2H3,(H,29,30)/t22-,25-/m0/s1
  • InChiKey: CMBIVIIMBVYXLE-DHLKQENFSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-2-amino-1-[(3S)-3-(1H-benzimidazol-2-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-3-(4-hydroxy-2,6-dimethyl-phenyl)propan-1-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Delta opioid receptor Starlite/ChEMBL References
Rattus norvegicus Mu opioid receptor Starlite/ChEMBL References
Mus musculus opioid receptor, delta 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Delta opioid receptor   372 aa 344 aa 22.1 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Mu opioid receptor   398 aa 397 aa 22.7 %
Brugia malayi ORL1-like opioid receptor Delta opioid receptor   372 aa 300 aa 24.7 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Delta opioid receptor   372 aa 366 aa 22.7 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Mu opioid receptor   398 aa 334 aa 23.1 %
Brugia malayi GnHR receptor homolog Delta opioid receptor   372 aa 313 aa 18.5 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Delta opioid receptor   372 aa 320 aa 25.6 %
Echinococcus multilocularis allatostatin A receptor Delta opioid receptor   372 aa 302 aa 28.5 %
Schistosoma mansoni neuropeptide F-like receptor Mu opioid receptor   398 aa 335 aa 20.6 %
Schistosoma japonicum Rhodopsin, putative Mu opioid receptor   398 aa 328 aa 23.2 %
Echinococcus granulosus allatostatin A receptor Delta opioid receptor   372 aa 302 aa 27.8 %
Onchocerca volvulus Delta opioid receptor   372 aa 316 aa 26.9 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Delta opioid receptor   372 aa 315 aa 28.6 %
Echinococcus granulosus thyrotropin releasing hormone receptor Delta opioid receptor   372 aa 330 aa 24.5 %
Onchocerca volvulus Delta opioid receptor   372 aa 349 aa 22.1 %
Onchocerca volvulus Programmed cell death protein 5 homolog Mu opioid receptor   398 aa 323 aa 24.1 %
Schistosoma mansoni peptide (allatostatin)-like receptor Delta opioid receptor   372 aa 353 aa 29.2 %
Loa Loa (eye worm) neuropeptide F receptor Delta opioid receptor   372 aa 317 aa 23.3 %
Onchocerca volvulus Delta opioid receptor   372 aa 386 aa 22.8 %
Onchocerca volvulus Delta opioid receptor   372 aa 353 aa 21.0 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Delta opioid receptor   372 aa 330 aa 24.2 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0042
Echinococcus multilocularis aminopeptidase N 0.0682 0.51 0.534
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0839 0.6293 0.6293
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0073 0.0077
Brugia malayi Carboxylesterase family protein 0.0133 0.0925 0.0925
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.006 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0818 0.6135 0.6135
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0018 0.0054 0.0054
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0022 0.0088 0.0092
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0018 0.0054 0.0066
Schistosoma mansoni biogenic amine receptor 0.0018 0.0054 0.0066
Echinococcus granulosus peptide allatostatin:somatostatin 0.0018 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.0096 0.0649 0.0649
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0054 0.0056
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0963 0.1008
Leishmania major DNA polymerase eta, putative 0.0019 0.0061 0.0026
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Brugia malayi G-protein coupled receptor 0.0018 0.0054 0.0054
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0178 0.0915
Schistosoma mansoni myosin xvIII 0.0018 0.0054 0.0066
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0054 0.0054
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0012 0.001 0.001
Brugia malayi Matrixin family protein 0.0144 0.1011 0.1011
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0054 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.062 0.0762
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0018 0.0054 0.0056
Schistosoma mansoni neuropeptide f receptor 76f 0.0018 0.0054 0.0066
Brugia malayi steroid hormone receptor 0.002 0.0073 0.0073
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0073 0.0077
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0018 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.004 0.022 0.0271
Trichomonas vaginalis spcc417.12 protein, putative 0.0022 0.0088 0.0427
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0018 0.0054 0.0054
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0056 0.0056
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0012 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0133 0.0925 0.0925
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0061 0.0006
Loa Loa (eye worm) hypothetical protein 0.0022 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0035 0.0185 0.0227
Schistosoma mansoni hypothetical protein 0.0282 0.2063 0.2535
Loa Loa (eye worm) matrixin family protein 0.0132 0.0921 0.0921
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0018 0.0054 0.0054
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0054 0.0056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0073 0.0077
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0054 0.0056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0073 0.0077
Toxoplasma gondii aminopeptidase n, putative 0.0116 0.0797 0.0916
Brugia malayi hypothetical protein 0.0018 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0022 0.0088 0.0088
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.1082 0.8137 0.8137
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0649 0.0649
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0061 0.0075
Echinococcus granulosus alpha 1A adrenergic receptor 0.0018 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.0116 0.0797 0.0797
Brugia malayi AKH receptor 0.0018 0.0054 0.0054
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0546 0.4065 0.4996
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0061 0.0064
Brugia malayi Carboxylesterase family protein 0.0133 0.0925 0.0925
Brugia malayi Tachykinin-like peptides receptor 99D 0.0018 0.0054 0.0054
Brugia malayi putative neuropeptide receptor 0.0018 0.0054 0.0054
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0264 0.192 0.2359
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.066 0.0812
Brugia malayi hypothetical protein 0.0035 0.0185 0.0185
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0054 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Trypanosoma cruzi aminopeptidase, putative 0.0254 0.1849 1
Brugia malayi ecdysteroid receptor 0.002 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0818 0.6135 0.6135
Schistosoma mansoni patched 1 0.0041 0.0232 0.0285
Brugia malayi CHE-14 protein 0.0041 0.0232 0.0232
Echinococcus granulosus carboxylesterase 5A 0.0133 0.0925 0.0969
Brugia malayi G protein-coupled receptor F59B2.13 0.0018 0.0054 0.0054
Brugia malayi Matrixin family protein 0.006 0.037 0.037
Echinococcus granulosus GPCR family 2 0.0015 0.0034 0.0036
Echinococcus multilocularis protein dispatched 1 0.0047 0.0276 0.0289
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0243
Trypanosoma brucei unspecified product 0.0019 0.0061 0.0243
Brugia malayi neuropeptide F receptor 0.0018 0.0054 0.0054
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0073 0.0073
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.004 0.0225 0.0276
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0073 0.0073
Echinococcus multilocularis BC026374 protein (S09 family) 0.0022 0.0088 0.0092
Echinococcus granulosus expressed conserved protein 0.009 0.0605 0.0633
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Brugia malayi Peptidase family M1 containing protein 0.0116 0.0797 0.0797
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.062 0.0762
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0088 0.0039
Echinococcus multilocularis neuropeptide receptor A26 0.0018 0.0054 0.0056
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0546 0.4065 0.4996
Echinococcus multilocularis g-protein coupled receptor 0.0018 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Onchocerca volvulus 0.0022 0.0088 0.0068
Schistosoma mansoni coup transcription factor 0.002 0.0073 0.009
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0061 0.0006
Echinococcus granulosus muscleblind protein 0.0147 0.1033 0.1081
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0054 0.0056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.062 0.0649
Mycobacterium ulcerans zinc metalloprotease 0.1082 0.8137 1
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0054 0.0056
Loa Loa (eye worm) peptidase family M13 containing protein 0.0799 0.5992 0.5992
Entamoeba histolytica hypothetical protein 0.0035 0.0185 0.0718
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0018 0.0054 0.0066
Echinococcus multilocularis serotonin receptor 0.0018 0.0054 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0054 0.0066
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0061 0.0061
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0061 0.0006
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0054 0.0056
Echinococcus granulosus FTZ F1 alpha 0.002 0.0073 0.0077
Brugia malayi G protein-coupled receptor 0.0018 0.0054 0.0054
Schistosoma mansoni ap endonuclease 0.0018 0.0056 0.0069
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0073 0.0039
Echinococcus granulosus g protein coupled receptor 0.0018 0.0054 0.0056
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0073 0.0077
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Echinococcus granulosus neuroligin 0.0022 0.0088 0.0092
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0073 0.0077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0054 0.0066
Schistosoma mansoni thyroid hormone receptor 0.002 0.0073 0.009
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0018 0.0054 0.0056
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0254 0.1849 0.2272
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.062 0.062
Onchocerca volvulus Matrilysin homolog 0.0132 0.0921 0.1718
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0216 0.1562 0.1635
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0042
Echinococcus granulosus hyperpolarization activated cyclic 0.0012 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0034 0.0036
Schistosoma mansoni cpg binding protein 0.0029 0.0142 0.0174
Loa Loa (eye worm) hypothetical protein 0.1082 0.8137 0.8137
Echinococcus multilocularis acetylcholinesterase 0.0133 0.0925 0.0969
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0018 0.0054 0.0056
Brugia malayi hypothetical protein 0.0018 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Toxoplasma gondii aminopeptidase N protein 0.0116 0.0797 0.0916
Onchocerca volvulus 0.0022 0.0088 0.0068
Schistosoma mansoni histamine h1 receptor 0.0018 0.0054 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0073 0.0073
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0116 0.0797 0.413
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0285 0.0285
Loa Loa (eye worm) carboxylesterase 0.0133 0.0925 0.0925
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0054 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0088 0.0108
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0054 0.0056
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0073 0.009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Echinococcus granulosus BC026374 protein S09 family 0.0022 0.0088 0.0092
Echinococcus multilocularis neuroligin 0.0022 0.0088 0.0092
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0018 0.0054 0.0066
Echinococcus granulosus fmrfamide receptor 0.0018 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0073
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0054 0.0056
Loa Loa (eye worm) matrixin family protein 0.0144 0.1011 0.1011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1268 0.9552 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0264 0.192 0.2359
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0054 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0054 0.0066
Entamoeba histolytica hypothetical protein 0.0035 0.0185 0.0718
Onchocerca volvulus 0.0084 0.0559 0.1001
Echinococcus granulosus hyperpolarization activated cyclic 0.0012 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0022 0.0088 0.0088
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0054 0.0066
Loa Loa (eye worm) hypothetical protein 0.0022 0.0088 0.0088
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0116 0.0797 0.413
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0054 0.0056
Brugia malayi follicle stimulating hormone receptor 0.0018 0.0054 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0243
Giardia lamblia DINP protein human, muc B family 0.0019 0.0061 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0056 0.5
Brugia malayi Melatonin receptor type 1A 0.0018 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Mycobacterium ulcerans aminopeptidase N PepN 0.0254 0.1849 0.2218
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Echinococcus granulosus 7TM GPCR rhodopsin 0.0018 0.0054 0.0056
Brugia malayi Carboxylesterase family protein 0.0022 0.0088 0.0088
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0073 0.0073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0054 0.0056
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0072 0.0469 0.051
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0054 0.0056
Entamoeba histolytica hypothetical protein 0.0035 0.0185 0.0718
Loa Loa (eye worm) hypothetical protein 0.006 0.037 0.037
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0061 0.0061
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0233 0.0244
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0258 0.0318
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0254 0.1849 0.1936
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0054 0.0054
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0116 0.0797 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0061 0.0243
Brugia malayi nuclear receptor NHR-88 0.002 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.1082 0.8137 0.8137
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0054 0.0066
Toxoplasma gondii peptidase family M13 protein 0.1082 0.8137 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0073
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0254 0.1849 1
Echinococcus granulosus g protein coupled receptor 0.0018 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.0818 0.6135 0.6135
Schistosoma mansoni BC026374 protein (S09 family) 0.0022 0.0088 0.0108
Echinococcus granulosus neuropeptide receptor 0.0018 0.0054 0.0056
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0116 0.0797 0.413
Loa Loa (eye worm) hypothetical protein 0.0072 0.0469 0.0469
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0073 0.009
Schistosoma mansoni amine GPCR 0.0018 0.0054 0.0066
Echinococcus multilocularis allatostatin A receptor 0.0018 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.0232
Echinococcus multilocularis neuropeptide s receptor 0.0018 0.0054 0.0056
Leishmania major DNA polymerase kappa, putative 0.0019 0.0061 0.0026
Schistosoma mansoni adenoreceptor 0.0018 0.0054 0.0066
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0073 0.0077
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0015 0.0035 0.0037
Brugia malayi Hemopexin family protein 0.0084 0.0559 0.0559
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0073 0.0073
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0012 0.001 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.062 0.0649
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0185 0.0194
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0054 0.0066
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0034
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0054 0.0066
Schistosoma mansoni amine GPCR 0.0018 0.0054 0.0066
Loa Loa (eye worm) hypothetical protein 0.0133 0.0925 0.0925
Loa Loa (eye worm) TYRA-2 protein 0.0018 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0033 0.0169 0.0169
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0054 0.0066
Loa Loa (eye worm) hypothetical protein 0.0428 0.3169 0.3169
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0056 0.5
Brugia malayi Cyclic-nucleotide gated cation channel 0.0012 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0282 0.2063 0.2535
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0839 0.6293 0.7734
Schistosoma mansoni hypothetical protein 0.0084 0.0559 0.0687
Schistosoma mansoni cpg binding protein 0.0028 0.0129 0.0159
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0018 0.0054 0.0056
Brugia malayi CXXC zinc finger family protein 0.0028 0.0129 0.0129
Brugia malayi Carboxylesterase family protein 0.0022 0.0088 0.0088
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0264 0.192 0.2359
Brugia malayi Peptidase family M13 containing protein 0.1082 0.8137 0.8137
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.062 0.0649
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0073 0.0073
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0254 0.1849 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0012 0.001 0.0012
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.001 0.0012
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0116 0.0797 0.0834
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0054 0.0056
Brugia malayi nuclear hormone receptor 0.002 0.0073 0.0073
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0012 0.001 0.0012
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0088 0.0108
Onchocerca volvulus 0.0116 0.0797 0.1472
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0018 0.0054 0.0054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0054 0.0056
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0073 0.009
Echinococcus multilocularis acetylcholinesterase 0.0133 0.0925 0.0969
Trypanosoma brucei Aminopeptidase M1, putative 0.0254 0.1849 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0061 0.0026
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0054 0.0056
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0285 0.0285
Echinococcus granulosus tachykinin peptides receptor 99D 0.0018 0.0054 0.0056
Schistosoma mansoni opsin-like receptor 0.0018 0.0054 0.0066
Echinococcus granulosus dro:myosuppressin receptor 0.0018 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0073 0.0077
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0018 0.0054 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0243
Echinococcus granulosus neuropeptide s receptor 0.0018 0.0054 0.0056
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0018 0.0054 0.0056
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0054 0.0056
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0073 0.009
Echinococcus multilocularis expressed conserved protein 0.009 0.0605 0.0633
Brugia malayi putative neuropeptide receptor NPR1 0.0018 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0818 0.6135 0.6135
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0012 0.001 0.001
Echinococcus multilocularis orexin receptor type 2 0.0018 0.0054 0.0056
Echinococcus granulosus g protein coupled receptor 0.0018 0.0054 0.0056
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0185 0.0194
Brugia malayi Matrixin family protein 0.006 0.037 0.037
Schistosoma mansoni hypothetical protein 0.004 0.022 0.0271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0073 0.0073
Brugia malayi Peptidase family M1 containing protein 0.0682 0.51 0.51
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0116 0.0797 0.413
Echinococcus granulosus neuropeptide receptor 0.0018 0.0054 0.0056
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0073 0.0077
Echinococcus multilocularis endothelin converting enzyme 1 0.1082 0.8137 0.8519
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0319 0.0325
Brugia malayi hypothetical protein 0.0018 0.0054 0.0054
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0233 0.0233
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.1082 0.8137 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0073 0.009
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0258 0.0318
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0072 0.0469 0.0469
Echinococcus multilocularis hyperpolarization activated cyclic 0.0012 0.001 0.001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0034 0.0036
Brugia malayi Muscleblind-like protein 0.0147 0.1033 0.1033
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0116 0.0797 0.0834
Brugia malayi hypothetical protein 0.0018 0.0054 0.0054
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0054 0.0056
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.006 0.037 0.0455
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0035 0.0043
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0018 0.0054 0.0054
Brugia malayi hypothetical protein 0.0018 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0147 0.1033 0.1033
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0018 0.0054 0.0066
Loa Loa (eye worm) hypothetical protein 0.0799 0.5992 0.5992
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.1082 0.8137 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0022 0.0088 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.122 0.658
Brugia malayi hypothetical protein 0.0018 0.0054 0.0054
Onchocerca volvulus 0.0028 0.0129 0.015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0073 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0073 0.0073
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0073 0.0039
Loa Loa (eye worm) hypothetical protein 0.1082 0.8137 0.8137
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0034 0.0034
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0232 0.0242
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0054 0.0066
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Mycobacterium leprae probable zinc metalloprotease 0.1082 0.8137 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0116 0.0797 0.428
Schistosoma mansoni opsin-like receptor 0.0018 0.0054 0.0066
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0042
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0054 0.0066
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0073 0.0073
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0116 0.0797 0.413
Brugia malayi Dopamine receptor protein 2 0.0018 0.0054 0.0054
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0138 0.097 0.1016
Loa Loa (eye worm) peptidase family M1 containing protein 0.0544 0.4048 0.4048
Schistosoma mansoni ap endonuclease 0.0018 0.0056 0.0069
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0073 0.0077
Echinococcus granulosus dna polymerase eta 0.0019 0.0061 0.0064
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0061 0.0006
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0034 0.0036
Loa Loa (eye worm) hypothetical protein 0.0799 0.5992 0.5992
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0061 0.0026
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0061 0.0026
Echinococcus multilocularis G-protein coupled receptor, putative 0.0018 0.0054 0.0056
Onchocerca volvulus 0.0254 0.1849 0.3557
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0254 0.1849 0.1936
Schistosoma mansoni hypothetical protein 0.0015 0.0034 0.0042
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0061 0.0243
Echinococcus multilocularis dna polymerase eta 0.0019 0.0061 0.0064
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0116 0.0797 0.413
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0254 0.1849 0.1936
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0061 0.0026
Loa Loa (eye worm) melatonin receptor type 1A 0.0018 0.0054 0.0054
Schistosoma mansoni amine GPCR 0.0018 0.0054 0.0066
Schistosoma mansoni biogenic amine receptor 0.0018 0.0054 0.0066
Loa Loa (eye worm) hypothetical protein 0.0536 0.399 0.399
Schistosoma mansoni neuropeptide receptor 0.0018 0.0054 0.0066
Loa Loa (eye worm) hypothetical protein 0.0138 0.097 0.097
Schistosoma mansoni DNA polymerase eta 0.0019 0.0061 0.0075
Echinococcus granulosus sex peptide receptor 0.0018 0.0054 0.0056
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0012 0.001 0.001
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0073 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0243
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0022 0.0088 0.0092
Echinococcus granulosus orexin receptor type 2 0.0018 0.0054 0.0056
Brugia malayi Carboxylesterase family protein 0.0022 0.0088 0.0088
Echinococcus multilocularis sex peptide receptor 0.0018 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0073 0.0077
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0034 0.0036
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0018 0.0054 0.0056
Schistosoma mansoni nuclear hormone receptor 0.002 0.0073 0.009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0264 0.192 0.2359
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0054 0.0056
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0185 0.0227
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0138 0.097 0.1192
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0799 0.5992 0.5992
Brugia malayi Dopamine receptor 0.0018 0.0054 0.0054
Echinococcus granulosus 7tm_1 domain containing protein 0.0018 0.0054 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0243
Trypanosoma brucei Aminopeptidase M1, putative 0.0254 0.1849 1
Brugia malayi Serotonin receptor 0.0018 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0054 0.0066
Schistosoma mansoni endothelin-converting enzyme-related 0.0264 0.192 0.2359
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0116 0.0797 0.0979
Trypanosoma brucei aminopeptidase, putative 0.0116 0.0797 0.4257
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0546 0.4065 0.4996
Schistosoma mansoni neprilysin-2 (M13 family) 0.0546 0.4065 0.4996
Loa Loa (eye worm) zinc metallopeptidase 4 0.0264 0.192 0.192
Brugia malayi hypothetical protein 0.0022 0.0088 0.0088
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0367 0.0451
Loa Loa (eye worm) hypothetical protein 0.0116 0.0797 0.0797
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0233 0.0244
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0018 0.0054 0.0054
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0116 0.0797 1
Brugia malayi neuropeptide F receptor 0.0018 0.0054 0.0054
Brugia malayi Dopamine receptor protein 1 0.0018 0.0054 0.0054
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0129 0.0129
Schistosoma mansoni hypothetical protein 0.0018 0.0054 0.0066
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0054 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0073 0.0073
Echinococcus granulosus endothelin converting enzyme 1 0.1082 0.8137 0.8519
Loa Loa (eye worm) acetylcholinesterase 1 0.0133 0.0925 0.0925
Trypanosoma cruzi aminopeptidase, putative 0.0116 0.0797 0.413
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0022 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0018 0.0054 0.0066
Echinococcus multilocularis muscleblind protein 0.0147 0.1033 0.1081
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0073
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0061 0.0064
Schistosoma mansoni biogenic amine receptor 0.0018 0.0054 0.0066
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0018 0.0054 0.0066
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.001 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0054 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0054 0.0056
Brugia malayi hypothetical protein 0.0351 0.2587 0.2587
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0254 0.1849 0.1936
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0012 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0073 0.0073
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0546 0.4065 0.4996
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0061 0.0281
Schistosoma mansoni neuropeptide receptor 0.0018 0.0054 0.0066
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0216 0.1562 0.1635
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0179 0.1275 0.1275
Brugia malayi hypothetical protein 0.0018 0.0054 0.0054
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0254 0.1849 0.1936
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0054 0.0056
Schistosoma mansoni alpha-1 adrenergic receptor 0.0018 0.0054 0.0066
Brugia malayi hypothetical protein 0.0018 0.0054 0.0054
Brugia malayi sulfakinin receptor protein 0.0018 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0282 0.2063 0.2535
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0054 0.0066
Loa Loa (eye worm) TATA binding protein associated factor 0.0116 0.0797 0.0797
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0061 0.0061
Mycobacterium ulcerans aminopeptidase N PepN 0.0116 0.0797 0.0916
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0022 0.0088 0.0427
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0061 0.0026
Echinococcus granulosus neuropeptide FF receptor 2 0.0018 0.0054 0.0056
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0254 0.1849 0.2272
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Brugia malayi RE15519p 0.0018 0.0054 0.0054
Echinococcus multilocularis hyperpolarization activated cyclic 0.0012 0.001 0.001
Entamoeba histolytica hypothetical protein 0.0035 0.0185 0.0718
Brugia malayi hypothetical protein 0.0018 0.0054 0.0054
Onchocerca volvulus Matrilysin homolog 0.006 0.037 0.0626
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0088 0.0108
Schistosoma mansoni amine GPCR 0.0018 0.0054 0.0066
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0232 0.0232
Brugia malayi Peptidase family M1 containing protein 0.0254 0.1849 0.1849
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0054 0.0066
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Schistosoma mansoni neprilysin 0.0282 0.2063 0.2535
Schistosoma mansoni hypothetical protein 0.0282 0.2063 0.2535
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0254 0.1849 0.1936
Brugia malayi Matrixin family protein 0.006 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0116 0.0797 0.0797
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0061
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0061 0.0026
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0116 0.0797 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0963 0.1008
Schistosoma mansoni hypothetical protein 0.0033 0.0169 0.0208
Echinococcus granulosus cpg binding protein 0.0029 0.0142 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0073 0.0073
Brugia malayi GnHR receptor homolog 0.0018 0.0054 0.0054
Echinococcus multilocularis G protein coupled receptor 139 0.0018 0.0054 0.0056
Brugia malayi larval opioid receptor 0.0018 0.0054 0.0054
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0254 0.1849 1
Echinococcus granulosus para nitrobenzyl esterase 0.0022 0.0088 0.0092
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0056 0.0056
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0178 0.0915
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0232 0.0242
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0018 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0054 0.0054
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0061 0.0243
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0264 0.192 0.2359
Brugia malayi ORL1-like opioid receptor 0.0018 0.0054 0.0054
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0073 0.009
Echinococcus granulosus G protein coupled receptor 139 0.0018 0.0054 0.0056
Schistosoma mansoni hypothetical protein 0.0282 0.2063 0.2535
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0073 0.0039
Loa Loa (eye worm) hypothetical protein 0.0022 0.0088 0.0088
Echinococcus multilocularis muscleblind protein 1 0.0147 0.1033 0.1081
Schistosoma mansoni neuropeptide receptor 0.0018 0.0054 0.0066
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Echinococcus multilocularis somatostatin receptor 0.0018 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0397 0.2933 0.3604
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0282 0.2063 0.2535
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0649 0.068
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0056 0.0255
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0012 0.001 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0054 0.0056
Schistosoma mansoni opsin-like receptor 0.0018 0.0054 0.0066
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0116 0.0797 1
Onchocerca volvulus 0.0022 0.0088 0.0068
Schistosoma mansoni aminopeptidase A (M01 family) 0.0116 0.0797 0.0979
Mycobacterium tuberculosis Carboxylesterase LipT 0.0022 0.0088 0.0039
Echinococcus granulosus neuropeptide receptor A26 0.0018 0.0054 0.0056
Onchocerca volvulus 0.006 0.037 0.0626
Loa Loa (eye worm) hypothetical protein 0.0037 0.0196 0.0196
Loa Loa (eye worm) carboxylesterase 0.0022 0.0088 0.0088
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0061 0.0281
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0054 0.0054
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0073 0.009
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0015 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0073 0.0073
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0056 0.0059
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0056 0.0059
Brugia malayi TATA binding protein associated factor 0.0116 0.0797 0.0797
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0054 0.0056
Schistosoma mansoni thyroid hormone receptor 0.002 0.0073 0.009
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0073 0.0077
Brugia malayi hypothetical protein 0.0116 0.0797 0.0797
Brugia malayi Serotonin receptor 0.0018 0.0054 0.0054
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0254 0.1849 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0054 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0073 0.0073
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0254 0.1849 1
Schistosoma mansoni hypothetical protein 0.004 0.022 0.0271
Echinococcus multilocularis GPCR, family 2 0.0015 0.0034 0.0036
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0138 0.097 0.5097
Echinococcus granulosus serotonin receptor 0.0018 0.0054 0.0056
Brugia malayi hypothetical protein 0.0254 0.1849 0.1849
Loa Loa (eye worm) hypothetical protein 0.0147 0.1033 0.1033
Echinococcus granulosus acetylcholinesterase 0.0133 0.0925 0.0969
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0034 0.0034
Schistosoma mansoni amine GPCR 0.0018 0.0054 0.0066
Schistosoma mansoni hypothetical protein 0.0018 0.0054 0.0066
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0018 0.0054 0.0056
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0073 0.009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0073 0.009
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0254 0.1849 0.1936
Loa Loa (eye worm) hypothetical protein 0.0138 0.097 0.097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0054 0.0066
Schistosoma mansoni acetylcholinesterase 0.0022 0.0088 0.0108
Loa Loa (eye worm) peptidase family M13 containing protein 0.0799 0.5992 0.5992
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0061 0.0075
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.0302
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0649 0.068
Loa Loa (eye worm) hypothetical protein 0.0048 0.0285 0.0285
Brugia malayi peptidase family M13 containing protein 0.0264 0.192 0.192
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.062 0.0649
Loa Loa (eye worm) hypothetical protein 0.0566 0.4222 0.4222
Echinococcus granulosus leukotriene A 4 hydrolase 0.0839 0.6293 0.6589
Onchocerca volvulus 0.0022 0.0088 0.0068
Echinococcus multilocularis para nitrobenzyl esterase 0.0022 0.0088 0.0092
Onchocerca volvulus 0.0682 0.51 1
Brugia malayi Matrixin family protein 0.006 0.037 0.037
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.062 0.062
Echinococcus granulosus dnaJ subfamily B 0.0397 0.2933 0.307
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0232 0.1207
Schistosoma mansoni hypothetical protein 0.0282 0.2063 0.2535
Schistosoma mansoni growth hormone secretagogue receptor 0.0018 0.0054 0.0066
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0056 0.0255
Loa Loa (eye worm) aminopeptidase N 0.0254 0.1849 0.1849
Loa Loa (eye worm) hypothetical protein 0.0818 0.6135 0.6135
Mycobacterium ulcerans hydrolase 0.0072 0.0469 0.051
Echinococcus multilocularis carboxylesterase 5A 0.0133 0.0925 0.0969
Loa Loa (eye worm) hypothetical protein 0.006 0.037 0.037
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0054 0.0056
Echinococcus multilocularis protein patched 0.0041 0.0232 0.0242
Loa Loa (eye worm) hypothetical protein 0.0799 0.5992 0.5992
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0018 0.0054 0.0066
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0169 0.0169
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0054 0.0056
Echinococcus multilocularis serotonin receptor 0.0018 0.0054 0.0056
Onchocerca volvulus 0.0022 0.0088 0.0068
Trypanosoma cruzi Aminopeptidase M1, putative 0.0254 0.1849 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0061 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0243
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0061 0.0243
Echinococcus granulosus allatostatin A receptor 0.0018 0.0054 0.0056
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0054 0.0056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0054 0.0056
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0649 0.3306
Mycobacterium tuberculosis Possible exported protein 0.0531 0.3951 0.482
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0073 0.0077
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0088 0.0039
Echinococcus granulosus acetylcholinesterase 0.0133 0.0925 0.0969
Echinococcus multilocularis neuropeptide FF receptor 2 0.0018 0.0054 0.0056
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0133 0.0925 0.1137
Brugia malayi Carboxylesterase family protein 0.0022 0.0088 0.0088
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0254 0.1849 1
Schistosoma mansoni cpg binding protein 0.0029 0.0142 0.0174
Loa Loa (eye worm) hypothetical protein 0.0022 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0018 0.0054 0.0066
Brugia malayi hypothetical protein 0.0018 0.0054 0.0054
Echinococcus granulosus hypothetical protein 0.0018 0.0054 0.0056
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0073 0.0077
Schistosoma mansoni gliotactin 0.0022 0.0088 0.0108
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0056 0.0217
Loa Loa (eye worm) hypothetical protein 0.0818 0.6135 0.6135
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0054 0.0056
Echinococcus granulosus voltage gated potassium channel 0.0015 0.0035 0.0037
Loa Loa (eye worm) matrix metalloproteinase 0.006 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Schistosoma mansoni neuropeptide receptor 0.0018 0.0054 0.0066
Onchocerca volvulus Matrix metalloproteinase homolog 0.0132 0.0921 0.1718
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0018 0.0054 0.0066
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.001 0.0012
Echinococcus granulosus aminopeptidase N 0.0682 0.51 0.534
Mycobacterium ulcerans carboxylesterase, LipT 0.0022 0.0088 0.0039
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0054 0.0056
Echinococcus multilocularis voltage gated potassium channel 0.0015 0.0035 0.0037
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0035 0.0043
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0179 0.1275 0.1275
Brugia malayi G-protein coupled receptor 0.0018 0.0054 0.0054
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0054 0.0056
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0233 0.0233
Echinococcus multilocularis cpg binding protein 0.0029 0.0142 0.0148
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0054 0.0056
Echinococcus multilocularis dro:myosuppressin receptor 0.0018 0.0054 0.0056
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0012 0.001 0.001
Onchocerca volvulus 0.0536 0.399 0.78
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0054 0.0066
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0018 0.0054 0.0054
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0073 0.0073
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0232 0.0242
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0018 0.0054 0.0054
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0018 0.0054 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0243
Echinococcus granulosus tm gpcr rhodopsin 0.1268 0.9552 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0061 0.0064
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0073 0.0077
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0054 0.0056
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0034 0.0034
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0018 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0018 0.0054 0.0056
Toxoplasma gondii aminopeptidase N, putative 0.0116 0.0797 0.0916
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0254 0.1849 0.1936
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0073 0.0077
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0018 0.0054 0.0054
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0839 0.6293 0.6589
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0015 0.0035 0.0037
Echinococcus granulosus g-protein coupled receptor 0.0018 0.0054 0.0056
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0073 0.0077
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0073
Entamoeba histolytica aminopeptidase, putative 0.0254 0.1849 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0054 0.0056
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0054 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0243
Loa Loa (eye worm) carboxylesterase 0.0022 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.004 0.022 0.0271
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0254 0.1849 0.1936
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0054 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0243
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0054 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.062 0.0762
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.2933 0.307
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Echinococcus granulosus somatostatin receptor 0.0018 0.0054 0.0056
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0012 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0073 0.0073
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0061 0.0064
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0254 0.1849 0.1936
Onchocerca volvulus 0.002 0.0073 0.0039

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = -7.28 Negative logarithm of the molar concentration required to produce 50% of the maximum effect in mu receptor from mouse vas deferens (MVD) ChEMBL. 11806723
Kd (functional) = 7.9 Negative logarithm of the molar concentration required to double the agonist concentration to achieve the original response in mouse vas deferens (MVD) ChEMBL. 11806723
Ki (binding) = 0.13 nM Binding affinity of the compound at Opioid receptor delta 1 using rat brain receptor (P2 synaptosome) assay ChEMBL. 11806723
Ki (binding) = 7.22 nM Binding affinity for rat brain P2 synaptosome Opioid receptor mu 1 ChEMBL. 11806723

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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