Detailed information for compound 1185424

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 281.306 | Formula: C17H15NO3
  • H donors: 1 H acceptors: 3 LogP: 2.69 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)oc(=O)cc2CCc1cccc(n1)C
  • InChi: 1S/C17H15NO3/c1-11-3-2-4-13(18-11)6-5-12-9-17(20)21-16-10-14(19)7-8-15(12)16/h2-4,7-10,19H,5-6H2,1H3
  • InChiKey: LDCRVNBWINORDP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxysteroid (17-beta) dehydrogenase 3 310 aa 256 aa 32.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1326 0.1326
Echinococcus multilocularis peregrin 0.0034 0.0372 0.0372
Brugia malayi hypothetical protein 0.0028 0.0278 0.0388
Echinococcus granulosus diphosphomevalonate decarboxylase 0.0051 0.0652 0.0739
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0268 0.0374
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0028 0.0291 0.033
Schistosoma mansoni z-protein (S1r protein) 0.0016 0.0093 0.0106
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0268 0.0374
Loa Loa (eye worm) hypothetical protein 0.0035 0.0397 0.0555
Leishmania major phosphomevalonate kinase protein, putative 0.0121 0.175 0.3607
Echinococcus granulosus microtubule associated protein 2 0.0572 0.8821 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.005 0.0633 0.0718
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0024 0.0215 0.0381
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0415 0.0471
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0244
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0278 0.0694
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.0056 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0073 0.0126
Echinococcus multilocularis Mevalonate galactokinase 0.0121 0.175 0.175
Mycobacterium tuberculosis Possible D-alpha-D-heptose-7-phosphate kinase HddA 0.0121 0.175 0.3495
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0175 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Echinococcus multilocularis galactokinase 0.0315 0.4792 0.4792
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0024 0.0215 0.0426
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0073 0.0126
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0415 0.0471
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0175 0.0198
Leishmania major homoserine kinase, putative 0.0121 0.175 0.3607
Schistosoma mansoni axis inhibition protein axin 0.0016 0.0093 0.0106
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0024 0.0215 0.0215
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0173 0.2562 0.5232
Schistosoma mansoni ran 0.0023 0.0201 0.0228
Schistosoma mansoni kinase 0.0104 0.1483 0.1681
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0014 0.0016
Trypanosoma brucei mevalonate-diphosphate decarboxylase 0.0051 0.0652 0.2036
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0329 0.0972
Leishmania major GTP-binding protein, putative 0.0023 0.0201 0.035
Trypanosoma cruzi galactokinase, putative 0.0315 0.4792 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0175 0.0277
Brugia malayi nuclear hormone receptor 0.0021 0.0175 0.0244
Brugia malayi hypothetical protein 0.003 0.0312 0.0436
Schistosoma mansoni survival motor neuron protein 0.0039 0.0456 0.0517
Mycobacterium leprae PROBABLE HOMOSERINE KINASE THRB 0.0051 0.0652 0.0727
Echinococcus granulosus expressed protein 0.0309 0.47 0.5328
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0175 0.0244
Loa Loa (eye worm) hypothetical protein 0.0121 0.175 0.2446
Echinococcus granulosus zinc finger protein 0.0018 0.0134 0.0152
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0026
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0136 0.0154
Trypanosoma cruzi phosphomevalonate kinase protein, putative 0.0051 0.0652 0.1298
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0278 0.0512
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0175 0.0175
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0175 0.0198
Giardia lamblia Diphosphomevalonate decarboxylase 0.0051 0.0652 0.176
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0175 0.0175
Echinococcus multilocularis microtubule associated protein 2 0.0572 0.8821 0.8821
Mycobacterium ulcerans diphosphomevalonate decarboxylase 0.0051 0.0652 0.0953
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0215 0.0381
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0175 0.0465
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0175 0.0244
Echinococcus multilocularis regulator of G protein signaling 7 0.0016 0.0093 0.0093
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0156 0.2289 0.4648
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0016 0.0093 0.013
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0018 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0244
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0474 0.0474
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.1502 0.1502
Schistosoma mansoni galactokinase 0.0166 0.2449 0.2776
Loa Loa (eye worm) galactokinase 0.0166 0.2449 0.3422
Trypanosoma brucei galactokinase-like protein, putative 0.0201 0.2995 0.9756
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.0312 0.0312
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0175 0.057
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0122 0.1759 0.1994
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0014 0.0056 0.0056
Plasmodium vivax thioredoxin reductase, putative 0.0068 0.0916 0.2266
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0175 0.0297
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0029 0.0041
Echinococcus multilocularis N acetylgalactosamine kinase 0.0166 0.2449 0.2449
Leishmania major trypanothione reductase 0.0068 0.0916 0.1853
Loa Loa (eye worm) hypothetical protein 0.0466 0.7156 1
Schistosoma mansoni coup transcription factor 0.0021 0.0175 0.0198
Plasmodium falciparum thioredoxin reductase 0.0068 0.0916 0.2266
Schistosoma mansoni hypothetical protein 0.033 0.5025 0.5696
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0175 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0175 0.0244
Echinococcus granulosus GPCR family 2 0.005 0.0626 0.071
Mycobacterium tuberculosis Probable oxidoreductase 0.0173 0.2562 0.5232
Schistosoma mansoni hypothetical protein 0.0546 0.842 0.9545
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.3069 1
Echinococcus multilocularis neuropeptide s receptor 0.0374 0.571 0.571
Trypanosoma cruzi mevalonate-diphosphate decarboxylase, putative 0.0051 0.0652 0.1298
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0278 0.0459
Mycobacterium tuberculosis Probable reductase 0.0156 0.2289 0.4648
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0175 0.0198
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0175 0.0465
Onchocerca volvulus 0.0039 0.0456 0.1485
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0016 0.0093 0.0093
Echinococcus multilocularis GPCR, family 2 0.005 0.0626 0.0626
Echinococcus granulosus thioredoxin glutathione reductase 0.0069 0.0922 0.1046
Brugia malayi galactokinase family protein 0.0166 0.2449 0.3422
Echinococcus granulosus fetal alzheimer antigen falz 0.0018 0.0124 0.0141
Trichomonas vaginalis ran, putative 0.0023 0.0201 0.0362
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0166 0.245 0.3424
Loa Loa (eye worm) hypothetical protein 0.0191 0.2844 0.3974
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0237 0.0484
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0175 0.0175
Onchocerca volvulus Alhambra homolog 0.0029 0.0296 0.0966
Trypanosoma brucei unspecified product 0.0021 0.0175 0.0465
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0268 0.0243
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.0025 0.0237 0.0307
Brugia malayi Regulator of G protein signaling domain containing protein 0.0016 0.0093 0.013
Brugia malayi regulator of G-protein signaling egl-10 0.0016 0.0093 0.013
Schistosoma mansoni hypothetical protein 0.0108 0.1534 0.1739
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.016 0.0095
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0329 0.0329
Echinococcus granulosus axis inhibition protein axin 0.0016 0.0093 0.0106
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0175 0.0297
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.003 0.0312 0.0354
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0156 0.2289 0.3825
Echinococcus multilocularis survival motor neuron protein 1 0.0191 0.2844 0.2844
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0024 0.0215 0.0301
Trypanosoma cruzi polo-like protein kinase, putative 0.0205 0.3069 0.6379
Toxoplasma gondii GHMP kinase, N-terminal domain-containing protein 0.0166 0.2449 1
Plasmodium vivax importin-beta 2, putative 0.0031 0.0329 0.0604
Toxoplasma gondii aldehyde dehydrogenase 0.0043 0.0521 0.1736
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.2316 0.3237
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0268 0.0491
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0093 0.0106
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0037 0.0428 0.1337
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0175 0.057
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0175 0.0175
Loa Loa (eye worm) glutathione reductase 0.0068 0.0916 0.128
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0116 0.0269
Echinococcus multilocularis regulator of G protein signaling 3 0.0016 0.0093 0.0093
Trichomonas vaginalis galactokinase, putative 0.0166 0.2449 0.7917
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0024 0.0215 0.0381
Leishmania major fucose kinase, putative 0.0051 0.0652 0.1298
Echinococcus multilocularis zinc finger protein 0.0018 0.0134 0.0134
Trichomonas vaginalis galactokinase, putative 0.0166 0.2449 0.7917
Schistosoma mansoni ap endonuclease 0.0019 0.0136 0.0154
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.013
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0201 0.0281
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0043 0.0521 0.0591
Leishmania major galactokinase-like protein 0.0315 0.4792 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0019 0.0021
Treponema pallidum NADH oxidase 0.0024 0.0215 0.0147
Giardia lamblia Mevalonate kinase 0.0121 0.175 0.5504
Trypanosoma brucei polo-like protein kinase 0.0205 0.3069 1
Plasmodium falciparum importin beta, putative 0.0031 0.0329 0.0604
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0175 0.0245
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0626 0.0626
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.0521 0.0591
Echinococcus granulosus beta-adrenergic receptor kinase 0.0017 0.0104 0.0118
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0175 0.0244
Echinococcus multilocularis neuropeptide receptor A26 0.0374 0.571 0.571
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0122 0.1759 0.1759
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1326 0.1504
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0093 0.0106
Echinococcus granulosus methyl CpG binding domain protein 2 0.0014 0.0056 0.0064
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0024 0.0215 0.0147
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0175 0.0465
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0175 0.0198
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0296 0.0296
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0156 0.2289 0.4648
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0175 0.0175
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0521 0.0711
Echinococcus granulosus geminin 0.0546 0.842 0.9545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0175 0.0244
Schistosoma mansoni transcription factor LCR-F1 0.003 0.0312 0.0354
Schistosoma mansoni hypothetical protein 0.0016 0.0101 0.0114
Brugia malayi hypothetical protein 0.0016 0.0093 0.013
Trypanosoma cruzi fucose kinase, putative 0.007 0.0942 0.1908
Giardia lamblia Kinase, PLK 0.0205 0.3069 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0028 0.0291 0.0291
Plasmodium falciparum glutathione reductase 0.0068 0.0916 0.2266
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0038 0.0038
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0626 0.071
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0024 0.0215 0.0597
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0201 0.0281
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0017 0.0104 0.0145
Trypanosoma cruzi mevalonate kinase, putative 0.0121 0.175 0.3607
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Trichomonas vaginalis mercuric reductase, putative 0.0024 0.0215 0.041
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0215 0.0381
Trypanosoma cruzi galactokinase-like protein, putative 0.0264 0.3983 0.8301
Loa Loa (eye worm) hypothetical protein 0.0027 0.0268 0.0374
Loa Loa (eye worm) RGS-3 protein 0.0016 0.0093 0.013
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0037 0.0428 0.1125
Leishmania major mevalonate-diphosphate decarboxylase, putative 0.0051 0.0652 0.1298
Treponema pallidum galactokinase 0.0264 0.3983 0.7103
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0175 0.0198
Schistosoma mansoni axis inhibition protein axin 0.0016 0.0093 0.0106
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0175 0.0198
Mycobacterium ulcerans hypothetical protein 0.0027 0.0268 0.0243
Schistosoma mansoni hypothetical protein 0.005 0.0626 0.071
Trypanosoma cruzi fucose kinase, putative 0.007 0.0942 0.1908
Trypanosoma cruzi homoserine kinase 0.0121 0.175 0.3607
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.016 0.0126
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0019 0.0026
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0017 0.0104 0.0145
Loa Loa (eye worm) hypothetical protein 0.0049 0.062 0.0866
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0205 0.3069 0.4288
Brugia malayi hypothetical protein 0.0018 0.0124 0.0173
Entamoeba histolytica Ran family GTPase 0.0023 0.0201 0.0229
Brugia malayi jmjC domain containing protein 0.0036 0.0415 0.0581
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0175 0.0199
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0175 0.0198
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0215 0.0381
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.2316 0.3237
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0173 0.2562 0.4342
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0224
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0268 0.0325
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.0218 0.0436
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0175 0.0245
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.0056 0.0064
Schistosoma mansoni bromodomain containing protein 0.0053 0.0678 0.0768
Echinococcus granulosus neuropeptide s receptor 0.0374 0.571 0.6473
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0104 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Plasmodium vivax 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative 0.0242 0.3646 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0392 0.0392
Brugia malayi Cytochrome P450 family protein 0.0016 0.0099 0.0138
Trypanosoma cruzi trypanothione reductase, putative 0.0068 0.0916 0.1853
Mycobacterium ulcerans hypothetical protein 0.0176 0.2609 0.4565
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0019 0.0026
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0175 0.0198
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0175 0.0244
Loa Loa (eye worm) PXA domain-containing protein 0.0016 0.0093 0.013
Leishmania major mevalonate kinase, putative 0.0121 0.175 0.3607
Plasmodium vivax SET domain protein, putative 0.0024 0.0218 0.0288
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0175 0.0297
Echinococcus granulosus muscleblind protein 0.0466 0.7156 0.8112
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0136 0.0057
Mycobacterium ulcerans 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0364 0.5552 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0626 0.0875
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0175 0.0198
Echinococcus multilocularis transcription factor eb 0.0087 0.1213 0.1213
Schistosoma mansoni zinc finger protein 0.0012 0.0034 0.0039
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0017 0.0117 0.0163
Loa Loa (eye worm) hypothetical protein 0.003 0.0322 0.0449
Brugia malayi Importin beta-1 subunit 0.0031 0.0329 0.046
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0024 0.0215 0.0381
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0116 0.0116
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0136 0.0057
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0237 0.0484
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0037 0.0428 0.1337
Trypanosoma brucei unspecified product 0.0015 0.0073 0.0126
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0038 0.0044
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0175 0.0175
Giardia lamblia Histone acetyltransferase GCN5 0.0032 0.0352 0.0738
Loa Loa (eye worm) hypothetical protein 0.0157 0.2316 0.3237
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0024 0.0215 0.0282
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0268 0.0371
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0224
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.1502 0.1703
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0175 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Trichomonas vaginalis galactokinase, putative 0.0166 0.2449 0.7917
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0278 0.0459
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.3069 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0019 0.0019
Brugia malayi diphosphomevalonate decarboxylase family protein 0.0051 0.0652 0.0911
Echinococcus multilocularis regulator of G protein signaling 0.0016 0.0093 0.0093
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0521 0.0711
Brugia malayi hypothetical protein 0.0016 0.0093 0.013
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.1534 0.2144
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0104 0.0118
Trypanosoma brucei homoserine kinase 0.0121 0.175 0.5655
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0043 0.0521 0.0521
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0175 0.0175
Brugia malayi PHD-finger family protein 0.0029 0.0296 0.0414
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.2316 0.3237
Trypanosoma cruzi homoserine kinase 0.0121 0.175 0.3607
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0626 0.0875
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0175 0.0297
Schistosoma mansoni hypothetical protein 0.0012 0.0034 0.0039
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0296 0.0414
Trichomonas vaginalis diphosphomevalonate decarboxylase, putative 0.0051 0.0652 0.1878
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0175 0.0199
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0019 0.0021
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0278 0.0803
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0201 0.0222
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0017 0.0104 0.0145
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0024 0.0215 0.0597
Trichomonas vaginalis set domain proteins, putative 0.0189 0.2811 0.9132
Echinococcus multilocularis muscleblind protein 0.0466 0.7156 0.7156
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0018 0.0124 0.0141
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.005 0.0626 0.071
Toxoplasma gondii GHMP kinase, putative 0.0121 0.175 0.7005
Echinococcus granulosus snurportin 1 0.033 0.5025 0.5696
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0136 0.019
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0268 0.0374
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0175 0.0245
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0173 0.2562 0.5232
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0024 0.0215 0.0282
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0224
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0175 0.0175
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0116 0.0171
Echinococcus multilocularis beta adrenergic receptor kinase 0.0017 0.0104 0.0104
Echinococcus multilocularis axis inhibition protein axin 0.0016 0.0093 0.0093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0268 0.0325
Loa Loa (eye worm) hypothetical protein 0.0037 0.0421 0.0588
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0175 0.0244
Onchocerca volvulus 0.0021 0.0175 0.057
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0136 0.019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0026
Brugia malayi isocitrate dehydrogenase 0.0017 0.0116 0.0162
Brugia malayi hypothetical protein 0.0191 0.2844 0.3974
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0201 0.0228
Trypanosoma cruzi polo-like protein kinase, putative 0.0205 0.3069 0.6379
Echinococcus granulosus N acetylgalactosamine kinase 0.0166 0.2449 0.2776
Plasmodium falciparum glutathione reductase 0.0024 0.0215 0.0282
Brugia malayi hypothetical protein 0.0011 0.0019 0.0026
Echinococcus granulosus neuropeptide receptor A26 0.0374 0.571 0.6473
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0024 0.0215 0.0147
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0244
Toxoplasma gondii exonuclease III APE 0.0019 0.0136 0.0086
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0024 0.0215 0.0597
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0175 0.0198
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.013
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0136 0.0143
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0175 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0175 0.0244
Brugia malayi Latrophilin receptor protein 2 0.005 0.0626 0.0875
Mycobacterium tuberculosis Probable dehydrogenase 0.0156 0.2289 0.4648
Schistosoma mansoni microtubule-associated protein tau 0.0572 0.8821 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Leishmania major DNA polymerase eta, putative 0.0021 0.0175 0.0297
Trypanosoma brucei phosphomevalonate kinase protein, putative 0.0121 0.175 0.5655
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0175 0.0198
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0106 0.1502 0.2099
Mycobacterium leprae Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) 0.0364 0.5552 1
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0093 0.0106
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0116 0.0116
Entamoeba histolytica acetyltransferase, GNAT family 0.0032 0.0352 0.0551
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0024 0.0215 0.0244
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0175 0.0198
Brugia malayi ecdysteroid receptor 0.0021 0.0175 0.0244
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0201 0.0549
Echinococcus granulosus Regulator of G protein signaling 20 0.0016 0.0093 0.0106
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0175 0.0073
Loa Loa (eye worm) hypothetical protein 0.005 0.0626 0.0875
Treponema pallidum hypothetical protein 0.0364 0.5552 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0136 0.0213
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.1502 0.1703
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0116 0.0116
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0296 0.0774
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0043 0.0521 0.1023
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0175 0.0198
Onchocerca volvulus 0.0027 0.0268 0.0872
Plasmodium falciparum acyl-CoA synthetase 0.002 0.016 0.0126
Leishmania major fucose kinase, putative 0.0051 0.0652 0.1298
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0175 0.0244
Schistosoma mansoni importin beta-1 0.0031 0.0329 0.0373
Echinococcus granulosus survival motor neuron protein 1 0.0191 0.2844 0.3223
Loa Loa (eye worm) hypothetical protein 0.0028 0.0278 0.0388
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0136 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0175 0.0198
Trypanosoma cruzi mevalonate-diphosphate decarboxylase, putative 0.0051 0.0652 0.1298
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0175 0.0198
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0268 0.0243
Loa Loa (eye worm) thioredoxin reductase 0.0068 0.0916 0.128
Trypanosoma cruzi phosphomevalonate kinase protein, putative 0.0051 0.0652 0.1298
Onchocerca volvulus 0.0051 0.0652 0.2125
Onchocerca volvulus 0.0024 0.0218 0.0709
Trichomonas vaginalis galactokinase, putative 0.0051 0.0652 0.1878
Onchocerca volvulus 0.0189 0.2811 0.9159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.1502 0.1703
Brugia malayi steroid hormone receptor 0.0021 0.0175 0.0244
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0175 0.0198
Brugia malayi Pre-SET motif family protein 0.0166 0.245 0.3424
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0218 0.0247
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0024 0.0215 0.0147
Schistosoma mansoni hypothetical protein 0.0029 0.0296 0.0336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.1502 0.1703
Echinococcus granulosus galactokinase 0.0315 0.4792 0.5432
Chlamydia trachomatis 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0294 0.4454 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.043 0.043
Schistosoma mansoni mevalonate kinase 0.0121 0.175 0.1984
Mycobacterium ulcerans galactokinase 0.0315 0.4792 0.8595
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0268 0.0371
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0024 0.0215 0.0597
Brugia malayi nuclear receptor RXR 0.0011 0.0019 0.0026
Echinococcus granulosus histone acetyltransferase KAT2B 0.0117 0.1677 0.1901
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0116 0.0162
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.1502 0.1703
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0296 0.0336
Brugia malayi PXA domain containing protein 0.0016 0.0093 0.013
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0175 0.0297
Giardia lamblia PHD finger protein 15 0.0029 0.0296 0.0548
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0244
Echinococcus granulosus Mevalonate galactokinase 0.0121 0.175 0.1984
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0156 0.2289 0.4648
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0237 0.0427
Loa Loa (eye worm) hypothetical protein 0.0031 0.0329 0.046
Trichomonas vaginalis galactokinase, putative 0.007 0.0942 0.2853
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.005 0.0633 0.0633
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.013
Brugia malayi regulator of G-protein signaling rgs-7 0.0016 0.0093 0.013
Trypanosoma cruzi galactokinase, putative 0.0315 0.4792 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0175 0.0244
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.043 0.0487
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0175 0.0277
Brugia malayi RNA, U transporter 1 0.0088 0.1224 0.171
Schistosoma mansoni hypothetical protein 0.0039 0.0456 0.0517
Schistosoma mansoni hypothetical protein 0.005 0.0626 0.071
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0268 0.0243
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0093 0.0106
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0245
Loa Loa (eye worm) hypothetical protein 0.0027 0.0268 0.0374
Echinococcus multilocularis expressed protein 0.0309 0.47 0.47
Mycobacterium tuberculosis Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) 0.0242 0.3646 0.755
Echinococcus granulosus transcription factor eb 0.0087 0.1213 0.1375
Brugia malayi Bromodomain containing protein 0.0033 0.0367 0.0513
Brugia malayi Pre-SET motif family protein 0.0024 0.0218 0.0304
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0329 0.0972
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0244
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0175 0.0128
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0175 0.057
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0005 0.0006
Mycobacterium ulcerans mevalonate kinase, Erg12 0.0121 0.175 0.298
Giardia lamblia DINP protein human, muc B family 0.0021 0.0175 0.0135
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0024 0.0215 0.0381
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0087 0.1213 0.1695
Echinococcus granulosus dna polymerase kappa 0.0021 0.0175 0.0199
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0019 0.0026
Trichomonas vaginalis mevalonate kinase, putative 0.0051 0.0652 0.1878
Schistosoma mansoni diphosphomevalonate decarboxylase 0.0051 0.0652 0.0739
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0175 0.0244
Leishmania major DNA polymerase kappa, putative 0.0021 0.0175 0.0297
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0026
Schistosoma mansoni DNA polymerase eta 0.0021 0.0175 0.0199
Schistosoma mansoni ran 0.0023 0.0201 0.0228
Brugia malayi Thioredoxin reductase 0.0068 0.0916 0.128
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0329 0.0914
Loa Loa (eye worm) hypothetical protein 0.0029 0.0296 0.0414
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0205 0.3069 0.3479
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0175 0.0244
Entamoeba histolytica galactokinase, putative 0.0315 0.4792 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0201 0.0365
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0143 0.0058
Echinococcus multilocularis regulator of G protein signaling 3 0.0016 0.0093 0.0093
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0175 0.0199
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.013
Echinococcus multilocularis geminin 0.0546 0.842 0.842
Brugia malayi PHD-finger family protein 0.0023 0.02 0.028
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0136 0.0143
Loa Loa (eye worm) PHD-finger family protein 0.0016 0.0101 0.0141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0175 0.0244
Echinococcus granulosus dna polymerase eta 0.0021 0.0175 0.0199
Brugia malayi Bromodomain containing protein 0.0034 0.0372 0.052
Echinococcus multilocularis muscleblind protein 1 0.0466 0.7156 0.7156
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.3069 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0175 0.0244
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0024 0.0215 0.0282
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0296 0.0512
Brugia malayi Bromodomain containing protein 0.0062 0.0824 0.1151
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0136 0.0213
Schistosoma mansoni ap endonuclease 0.0019 0.0136 0.0154
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0099 0.0138
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0024 0.0215 0.0244
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.3069 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0218 0.0247
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.013
Echinococcus granulosus regulator of G protein signaling 7 0.0016 0.0093 0.0106
Trypanosoma brucei mevalonate diphosphate decarboxylase 0.0051 0.0652 0.2036
Echinococcus multilocularis axis inhibition protein axin 0.0016 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0026
Schistosoma mansoni jumonji domain containing protein 0.0075 0.1022 0.1158
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0024 0.0215 0.0128
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0415 0.0471
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0224
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0136 0.0136
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0116 0.0162
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0778 0.1088
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0023 0.0204 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0175 0.0244
Wolbachia endosymbiont of Brugia malayi 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0364 0.5552 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0136 0.0091
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0201 0.0201
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0175 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0175 0.0244
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0175 0.0198
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0116 0.0116
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.3069 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0024 0.0215 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0175 0.0244
Mycobacterium ulcerans phosphomevalonate kinase 0.0121 0.175 0.298
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.043 0.0487
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0205 0.3069 0.6379
Echinococcus granulosus regulator of G protein signaling 3 0.0016 0.0093 0.0106
Echinococcus granulosus histone acetyltransferase KAT2B 0.0037 0.0428 0.0485
Loa Loa (eye worm) hypothetical protein 0.0108 0.1534 0.2144
Echinococcus multilocularis regulator of G protein signaling 7 0.0016 0.0093 0.0093
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0016 0.0093 0.0106
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0268 0.0243
Plasmodium vivax glutathione reductase, putative 0.0068 0.0916 0.2266
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0016 0.0093 0.0106
Entamoeba histolytica hypothetical protein 0.003 0.0312 0.0465
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0143 0.0058
Brugia malayi hypothetical protein 0.0011 0.0019 0.0026
Echinococcus granulosus regulator of G protein signaling 3 0.0016 0.0093 0.0106
Loa Loa (eye worm) hypothetical protein 0.0027 0.0268 0.0374
Loa Loa (eye worm) hypothetical protein 0.0037 0.043 0.0601
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0201 0.0241
Toxoplasma gondii NADPH-glutathione reductase 0.0024 0.0215 0.0426
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.1502 0.1502
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0175 0.0297
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.144 0.4527
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0016 0.0093 0.0106
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0037 0.0428 0.0884
Loa Loa (eye worm) acetyltransferase 0.0122 0.1759 0.2458
Onchocerca volvulus 0.0013 0.0041 0.0135
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0278 0.0512
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0268 0.0243
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0024 0.0215 0.0147
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0136 0.0213
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0296 0.0774
Echinococcus multilocularis Regulator of G protein signaling 20 0.0016 0.0093 0.0093
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0296 0.0336
Brugia malayi PXA domain containing protein 0.0016 0.0093 0.013
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0116 0.0269
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.011 0.0154
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0278 0.0459
Schistosoma mansoni hypothetical protein 0.0012 0.0038 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.3069 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0024 0.0215 0.0381
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0017 0.0117 0.0163
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0268 0.0371
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0043 0.0521 0.0866
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0201 0.0241
Brugia malayi Regulator of G protein signaling domain containing protein 0.0016 0.0093 0.013
Brugia malayi glutathione reductase 0.0068 0.0916 0.128
Plasmodium falciparum 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative 0.0242 0.3646 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0626 0.071
Schistosoma mansoni hypothetical protein 0.0546 0.842 0.9545
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Brugia malayi A-kinase anchor protein 10, precursor 0.0016 0.0093 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0106 0.1502 0.2099
Schistosoma mansoni hypothetical protein 0.003 0.0312 0.0354
Schistosoma mansoni serine/threonine protein kinase 0.0205 0.3069 0.3479
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0175 0.0244
Loa Loa (eye worm) hypothetical protein 0.0056 0.0724 0.1012
Entamoeba histolytica hypothetical protein 0.003 0.0312 0.0465
Plasmodium falciparum thioredoxin reductase 0.0024 0.0215 0.0282
Echinococcus granulosus regulator of G protein signaling 7 0.0016 0.0093 0.0106
Mycobacterium tuberculosis Probable galactokinase GalK (galactose kinase) 0.0315 0.4792 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0652 0.1878
Trypanosoma brucei unspecified product 0.0015 0.0073 0.0126
Echinococcus multilocularis diphosphomevalonate decarboxylase 0.0051 0.0652 0.0652
Trypanosoma brucei mevalonate kinase, putative 0.0121 0.175 0.5655
Schistosoma mansoni zinc finger protein 0.0018 0.0134 0.0152
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0215 0.0381
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0175 0.0073
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0626 0.0626
Echinococcus multilocularis snurportin 1 0.033 0.5025 0.5025
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0024 0.0215 0.0282
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.3069 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0116 0.0171
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0521 0.0711
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0143 0.0058
Echinococcus multilocularis thioredoxin glutathione reductase 0.0069 0.0922 0.0922
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0244
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0244
Entamoeba histolytica serine/threonine protein kinase, putative 0.0205 0.3069 0.6333
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0136 0.0335
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0175 0.0244
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0073 0.0126
Brugia malayi jmjC domain containing protein 0.0094 0.1326 0.1853
Brugia malayi mevalonate kinase family protein 0.0121 0.175 0.2446
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0237 0.0484
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0201 0.035
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0104 0.0118
Giardia lamblia NADH oxidase lateral transfer candidate 0.0024 0.0215 0.0271
Echinococcus granulosus axis inhibition protein axin 0.0016 0.0093 0.0106
Echinococcus multilocularis dna polymerase eta 0.0021 0.0175 0.0175
Plasmodium falciparum histone acetyltransferase GCN5 0.0032 0.0352 0.0669
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.016 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0175 0.0244
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0268 0.0243
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0143 0.0058
Brugia malayi Muscleblind-like protein 0.0466 0.7156 1
Trichomonas vaginalis glutathione reductase, putative 0.0024 0.0215 0.041
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0156 0.2289 0.4648
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0026
Trypanosoma cruzi trypanothione reductase, putative 0.0024 0.0215 0.0381
Toxoplasma gondii thioredoxin reductase 0.0068 0.0916 0.3429
Trypanosoma brucei trypanothione reductase 0.0068 0.0916 0.2905
Loa Loa (eye worm) hypothetical protein 0.0087 0.1206 0.1686
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0175 0.0128
Mycobacterium tuberculosis Probable homoserine kinase ThrB 0.0051 0.0652 0.1147
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0268 0.0243
Echinococcus granulosus peregrin 0.0034 0.0372 0.0422
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.043 0.0487
Trichomonas vaginalis galactokinase, putative 0.0166 0.2449 0.7917
Brugia malayi acetyltransferase, GNAT family protein 0.0122 0.1759 0.2458
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0024 0.0215 0.0213
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0205 0.3069 0.3069
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0039 0.0456 0.0637
Brugia malayi serine/threonine-protein kinase plk-2 0.0205 0.3069 0.4288
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0019 0.0021
Entamoeba histolytica hypothetical protein 0.003 0.0312 0.0465
Plasmodium falciparum phd finger protein, putative 0.0029 0.0296 0.0512
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0244
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.144 0.4527
Loa Loa (eye worm) hypothetical protein 0.0466 0.7156 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0014 0.0014
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0093 0.0106
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0116 0.0131
Leishmania major hypothetical protein, conserved 0.0028 0.0278 0.0512
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0175 0.0198
Brugia malayi nuclear receptor NHR-88 0.0021 0.0175 0.0244
Mycobacterium ulcerans homoserine kinase 0.0121 0.175 0.298
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0268 0.0491
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0016 0.0093 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0175 0.0244
Trypanosoma cruzi galactokinase, putative 0.0264 0.3983 0.8301
Leishmania major importin beta-1 subunit, putative 0.0025 0.0237 0.0427
Brugia malayi PHD-finger family protein 0.0011 0.0016 0.0022
Trichomonas vaginalis bromodomain-containing protein, putative 0.0037 0.0428 0.1125
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0175 0.0198
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.033 0.5025 0.7022
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0201 0.035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0215 0.0381
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.0521 0.0591
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0215 0.0381
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0068 0.0916 0.1711
Entamoeba histolytica hypothetical protein 0.003 0.0312 0.0465
Echinococcus granulosus importin subunit beta 1 0.0031 0.0329 0.0373
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0175 0.0175
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0175 0.0465
Schistosoma mansoni hypothetical protein 0.005 0.0626 0.071
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0087 0.1206 0.1686
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0116 0.0171
Loa Loa (eye worm) hypothetical protein 0.0051 0.0652 0.0911
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0268 0.0491
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0415 0.0581
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0175 0.0244
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0024 0.0215 0.0381
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0116 0.0131
Echinococcus granulosus jumonji domain containing protein 0.004 0.0474 0.0537
Onchocerca volvulus Serine\/threonine kinase homolog 0.0205 0.3069 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) Antagonist activity at ER by reporter gene assay ChEMBL. 19954971
IC50 (functional) Agonist activity at GR by reporter gene assay ChEMBL. 19954971
IC50 (functional) Antagonist activity at GR by reporter gene assay ChEMBL. 19954971
IC50 (binding) Inhibition of 17beta-HSD1 by human cell based assay ChEMBL. 19954971
IC50 (functional) Agonist activity at ER by reporter gene assay ChEMBL. 19954971
IC50 (binding) Inhibition of 17beta-HSD2 by human cell based assay ChEMBL. 19954971
IC50 (binding) = 0.008 uM Inhibition of human 17beta-HSD3 expressed in HeLa cells ChEMBL. 19954971

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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