Detailed information for compound 1185424

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 281.306 | Formula: C17H15NO3
  • H donors: 1 H acceptors: 3 LogP: 2.69 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)oc(=O)cc2CCc1cccc(n1)C
  • InChi: 1S/C17H15NO3/c1-11-3-2-4-13(18-11)6-5-12-9-17(20)21-16-10-14(19)7-8-15(12)16/h2-4,7-10,19H,5-6H2,1H3
  • InChiKey: LDCRVNBWINORDP-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxysteroid (17-beta) dehydrogenase 3 310 aa 256 aa 32.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium ulcerans 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0364 0.5552 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0175 0.0175
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0116 0.0131
Echinococcus multilocularis regulator of G protein signaling 3 0.0016 0.0093 0.0093
Loa Loa (eye worm) PXA domain-containing protein 0.0016 0.0093 0.013
Plasmodium falciparum 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative 0.0242 0.3646 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0019 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0268 0.0374
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.013
Entamoeba histolytica hypothetical protein 0.003 0.0312 0.0465
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0237 0.0484
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0104 0.0118
Plasmodium falciparum histone acetyltransferase GCN5 0.0032 0.0352 0.0669
Echinococcus multilocularis geminin 0.0546 0.842 0.842
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0268 0.0491
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0296 0.0512
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0017 0.0104 0.0145
Onchocerca volvulus Serine\/threonine kinase homolog 0.0205 0.3069 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0175 0.0244
Onchocerca volvulus Alhambra homolog 0.0029 0.0296 0.0966
Trypanosoma cruzi polo-like protein kinase, putative 0.0205 0.3069 0.6379
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0175 0.0244
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0104 0.0118
Loa Loa (eye worm) hypothetical protein 0.0037 0.0421 0.0588
Trypanosoma cruzi trypanothione reductase, putative 0.0024 0.0215 0.0381
Giardia lamblia Mevalonate kinase 0.0121 0.175 0.5504
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0116 0.0116
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0116 0.0269
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0043 0.0521 0.0521
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0218 0.0247
Trichomonas vaginalis mercuric reductase, putative 0.0024 0.0215 0.041
Brugia malayi hypothetical protein 0.0011 0.0019 0.0026
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0175 0.0175
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0016 0.0093 0.0106
Brugia malayi nuclear hormone receptor 0.0021 0.0175 0.0244
Mycobacterium tuberculosis Probable reductase 0.0156 0.2289 0.4648
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0626 0.0626
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.033 0.5025 0.7022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0244
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0201 0.0365
Loa Loa (eye worm) hypothetical protein 0.0027 0.0268 0.0374
Wolbachia endosymbiont of Brugia malayi 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0364 0.5552 1
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0093 0.0106
Echinococcus multilocularis peregrin 0.0034 0.0372 0.0372
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0122 0.1759 0.1994
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0024 0.0215 0.0381
Echinococcus multilocularis zinc finger protein 0.0018 0.0134 0.0134
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0201 0.0241
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0166 0.245 0.3424
Brugia malayi Regulator of G protein signaling domain containing protein 0.0016 0.0093 0.013
Plasmodium vivax thioredoxin reductase, putative 0.0068 0.0916 0.2266
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0268 0.0243
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0175 0.0198
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0038 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0073 0.0126
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.1502 0.1703
Mycobacterium leprae Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) 0.0364 0.5552 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0026
Trichomonas vaginalis galactokinase, putative 0.0166 0.2449 0.7917
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.0312 0.0312
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0136 0.0143
Echinococcus multilocularis regulator of G protein signaling 0.0016 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0224
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0778 0.1088
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0175 0.0277
Trypanosoma cruzi galactokinase, putative 0.0315 0.4792 1
Leishmania major hypothetical protein, conserved 0.0028 0.0278 0.0512
Toxoplasma gondii NADPH-glutathione reductase 0.0024 0.0215 0.0426
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0024 0.0215 0.0244
Schistosoma mansoni hypothetical protein 0.0546 0.842 0.9545
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0215 0.0381
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0017 0.0104 0.0145
Giardia lamblia Kinase, PLK 0.0205 0.3069 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0016 0.0093 0.0093
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.3069 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0039 0.0456 0.0637
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.2316 0.3237
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0156 0.2289 0.4648
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0136 0.0213
Echinococcus granulosus histone acetyltransferase KAT2B 0.0117 0.1677 0.1901
Echinococcus granulosus Regulator of G protein signaling 20 0.0016 0.0093 0.0106
Schistosoma mansoni hypothetical protein 0.0108 0.1534 0.1739
Brugia malayi Thioredoxin reductase 0.0068 0.0916 0.128
Echinococcus multilocularis microtubule associated protein 2 0.0572 0.8821 0.8821
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.3069 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0175 0.0277
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0296 0.0414
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0626 0.0875
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0652 0.1878
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0136 0.0043
Mycobacterium leprae PROBABLE HOMOSERINE KINASE THRB 0.0051 0.0652 0.0727
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0017 0.0104 0.0145
Echinococcus multilocularis expressed protein 0.0309 0.47 0.47
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0296 0.0336
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0136 0.0213
Onchocerca volvulus 0.0051 0.0652 0.2125
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0024 0.0215 0.0282
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0024 0.0215 0.0381
Brugia malayi nuclear receptor RXR 0.0011 0.0019 0.0026
Mycobacterium ulcerans hypothetical protein 0.0176 0.2609 0.4565
Toxoplasma gondii aldehyde dehydrogenase 0.0043 0.0521 0.1736
Entamoeba histolytica hypothetical protein 0.003 0.0312 0.0465
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0268 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0175 0.0175
Toxoplasma gondii thioredoxin reductase 0.0068 0.0916 0.3429
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0175 0.0175
Trypanosoma brucei mevalonate-diphosphate decarboxylase 0.0051 0.0652 0.2036
Onchocerca volvulus 0.0013 0.0041 0.0135
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0019 0.0021
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0106 0.1502 0.2099
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0122 0.1759 0.1759
Brugia malayi hypothetical protein 0.0011 0.0019 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0019 0.0021
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0175 0.0465
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0201 0.0201
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0175 0.0199
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0175 0.0198
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0278 0.0694
Schistosoma mansoni axis inhibition protein axin 0.0016 0.0093 0.0106
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0268 0.0243
Echinococcus multilocularis GPCR, family 2 0.005 0.0626 0.0626
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0175 0.0175
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0043 0.0521 0.1023
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0016 0.0093 0.0106
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0278 0.0803
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0201 0.0281
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0215 0.0381
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0024 0.0215 0.0128
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0278 0.0512
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0415 0.0471
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0087 0.1206 0.1686
Schistosoma mansoni mevalonate kinase 0.0121 0.175 0.1984
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0136 0.0057
Trypanosoma cruzi trypanothione reductase, putative 0.0068 0.0916 0.1853
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0268 0.0371
Schistosoma mansoni hypothetical protein 0.0012 0.0034 0.0039
Echinococcus granulosus jumonji domain containing protein 0.004 0.0474 0.0537
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0268 0.0243
Echinococcus granulosus dna polymerase kappa 0.0021 0.0175 0.0199
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0156 0.2289 0.4648
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0024 0.0215 0.0381
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0136 0.0136
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0218 0.0247
Schistosoma mansoni galactokinase 0.0166 0.2449 0.2776
Leishmania major phosphomevalonate kinase protein, putative 0.0121 0.175 0.3607
Schistosoma mansoni survival motor neuron protein 0.0039 0.0456 0.0517
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.0521 0.0591
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0093 0.0106
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0018 0.0124 0.0141
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0136 0.0335
Giardia lamblia DINP protein human, muc B family 0.0021 0.0175 0.0135
Echinococcus granulosus methyl CpG binding domain protein 2 0.0014 0.0056 0.0064
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0019 0.0026
Echinococcus granulosus geminin 0.0546 0.842 0.9545
Schistosoma mansoni coup transcription factor 0.0021 0.0175 0.0198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0175 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0268 0.0491
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0043 0.0521 0.0591
Brugia malayi isocitrate dehydrogenase 0.0017 0.0116 0.0162
Brugia malayi PHD-finger family protein 0.0011 0.0016 0.0022
Trichomonas vaginalis mevalonate kinase, putative 0.0051 0.0652 0.1878
Echinococcus multilocularis neuropeptide s receptor 0.0374 0.571 0.571
Echinococcus multilocularis transcription factor eb 0.0087 0.1213 0.1213
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.005 0.0633 0.0718
Echinococcus granulosus beta-adrenergic receptor kinase 0.0017 0.0104 0.0118
Brugia malayi hypothetical protein 0.0016 0.0093 0.013
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0175 0.0244
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0175 0.0198
Entamoeba histolytica acetyltransferase, GNAT family 0.0032 0.0352 0.0551
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0175 0.0198
Entamoeba histolytica serine/threonine protein kinase, putative 0.0205 0.3069 0.6333
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0175 0.0175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0175 0.0244
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0244
Schistosoma mansoni ran 0.0023 0.0201 0.0228
Echinococcus multilocularis beta adrenergic receptor kinase 0.0017 0.0104 0.0104
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.3069 1
Mycobacterium ulcerans galactokinase 0.0315 0.4792 0.8595
Schistosoma mansoni ap endonuclease 0.0019 0.0136 0.0154
Schistosoma mansoni kinase 0.0104 0.1483 0.1681
Echinococcus granulosus survival motor neuron protein 1 0.0191 0.2844 0.3223
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0143 0.0058
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0175 0.0073
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0175 0.0175
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.2316 0.3237
Plasmodium falciparum acyl-CoA synthetase 0.002 0.016 0.0126
Trypanosoma brucei homoserine kinase 0.0121 0.175 0.5655
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0175 0.0244
Loa Loa (eye worm) hypothetical protein 0.0035 0.0397 0.0555
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0019 0.0026
Trypanosoma brucei mevalonate kinase, putative 0.0121 0.175 0.5655
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.0056 0.0064
Schistosoma mansoni microtubule-associated protein tau 0.0572 0.8821 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0173 0.2562 0.5232
Loa Loa (eye worm) hypothetical protein 0.0191 0.2844 0.3974
Treponema pallidum NADH oxidase 0.0024 0.0215 0.0147
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0037 0.0428 0.1337
Trypanosoma cruzi mevalonate-diphosphate decarboxylase, putative 0.0051 0.0652 0.1298
Trypanosoma brucei phosphomevalonate kinase protein, putative 0.0121 0.175 0.5655
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0175 0.057
Brugia malayi glutathione reductase 0.0068 0.0916 0.128
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0175 0.0245
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0175 0.0198
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0521 0.0711
Loa Loa (eye worm) hypothetical protein 0.0029 0.0296 0.0414
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0329 0.0972
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0116 0.0162
Leishmania major DNA polymerase kappa, putative 0.0021 0.0175 0.0297
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0024 0.0215 0.0597
Mycobacterium tuberculosis Probable homoserine kinase ThrB 0.0051 0.0652 0.1147
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0024 0.0215 0.0381
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1326 0.1504
Loa Loa (eye worm) hypothetical protein 0.0037 0.043 0.0601
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1326 0.1326
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0017 0.0117 0.0163
Schistosoma mansoni diphosphomevalonate decarboxylase 0.0051 0.0652 0.0739
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0043 0.0521 0.0866
Echinococcus granulosus transcription factor eb 0.0087 0.1213 0.1375
Brugia malayi Latrophilin receptor protein 2 0.005 0.0626 0.0875
Brugia malayi hypothetical protein 0.003 0.0312 0.0436
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0201 0.035
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0626 0.071
Entamoeba histolytica hypothetical protein 0.0025 0.0237 0.0307
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0244
Schistosoma mansoni hypothetical protein 0.003 0.0312 0.0354
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0201 0.0222
Echinococcus granulosus neuropeptide receptor A26 0.0374 0.571 0.6473
Leishmania major importin beta-1 subunit, putative 0.0025 0.0237 0.0427
Leishmania major GTP-binding protein, putative 0.0023 0.0201 0.035
Schistosoma mansoni hypothetical protein 0.0039 0.0456 0.0517
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0143 0.0058
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.1534 0.2144
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0173 0.2562 0.5232
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0175 0.0244
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0136 0.019
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0024 0.0215 0.0426
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0016 0.0093 0.0106
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0224
Loa Loa (eye worm) glutathione reductase 0.0068 0.0916 0.128
Entamoeba histolytica hypothetical protein 0.003 0.0312 0.0465
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0024 0.0215 0.0282
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0175 0.057
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.3069 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0024 0.0215 0.0597
Echinococcus granulosus zinc finger protein 0.0018 0.0134 0.0152
Echinococcus granulosus regulator of G protein signaling 7 0.0016 0.0093 0.0106
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0175 0.0465
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.013
Leishmania major trypanothione reductase 0.0068 0.0916 0.1853
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0175 0.0198
Trypanosoma cruzi phosphomevalonate kinase protein, putative 0.0051 0.0652 0.1298
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0024 0.0215 0.0147
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0268 0.0491
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0175 0.0198
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0224
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0329 0.0329
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0175 0.0198
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0173 0.2562 0.4342
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0296 0.0774
Brugia malayi Muscleblind-like protein 0.0466 0.7156 1
Mycobacterium ulcerans homoserine kinase 0.0121 0.175 0.298
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0026
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0201 0.0241
Brugia malayi hypothetical protein 0.0018 0.0124 0.0173
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0037 0.0428 0.1337
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0175 0.0244
Brugia malayi regulator of G-protein signaling rgs-7 0.0016 0.0093 0.013
Leishmania major DNA polymerase eta, putative 0.0021 0.0175 0.0297
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0215 0.0381
Loa Loa (eye worm) hypothetical protein 0.005 0.0626 0.0875
Echinococcus granulosus snurportin 1 0.033 0.5025 0.5696
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0175 0.0198
Brugia malayi A-kinase anchor protein 10, precursor 0.0016 0.0093 0.013
Plasmodium falciparum importin beta, putative 0.0031 0.0329 0.0604
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0175 0.0244
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0329 0.0914
Trichomonas vaginalis galactokinase, putative 0.0051 0.0652 0.1878
Plasmodium falciparum thioredoxin reductase 0.0068 0.0916 0.2266
Schistosoma mansoni z-protein (S1r protein) 0.0016 0.0093 0.0106
Mycobacterium tuberculosis Probable galactokinase GalK (galactose kinase) 0.0315 0.4792 1
Trichomonas vaginalis galactokinase, putative 0.0166 0.2449 0.7917
Trypanosoma cruzi polo-like protein kinase, putative 0.0205 0.3069 0.6379
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0024 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.013
Leishmania major galactokinase-like protein 0.0315 0.4792 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0175 0.0244
Echinococcus multilocularis snurportin 1 0.033 0.5025 0.5025
Onchocerca volvulus 0.0039 0.0456 0.1485
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0136 0.0091
Schistosoma mansoni ran 0.0023 0.0201 0.0228
Trypanosoma cruzi mevalonate kinase, putative 0.0121 0.175 0.3607
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0116 0.0171
Echinococcus multilocularis Mevalonate galactokinase 0.0121 0.175 0.175
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0016 0.0093 0.013
Mycobacterium ulcerans hypothetical protein 0.0027 0.0268 0.0243
Schistosoma mansoni hypothetical protein 0.005 0.0626 0.071
Brugia malayi Pre-SET motif family protein 0.0024 0.0218 0.0304
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.1502 0.1703
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0278 0.0512
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.043 0.0487
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0037 0.0428 0.1125
Echinococcus multilocularis diphosphomevalonate decarboxylase 0.0051 0.0652 0.0652
Brugia malayi hypothetical protein 0.0016 0.0093 0.013
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0201 0.035
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0244
Loa Loa (eye worm) PHD-finger family protein 0.0016 0.0101 0.0141
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0175 0.0244
Echinococcus multilocularis Regulator of G protein signaling 20 0.0016 0.0093 0.0093
Treponema pallidum galactokinase 0.0264 0.3983 0.7103
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0024 0.0215 0.0147
Echinococcus granulosus peregrin 0.0034 0.0372 0.0422
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0116 0.0171
Echinococcus multilocularis muscleblind protein 0.0466 0.7156 0.7156
Mycobacterium tuberculosis Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) 0.0242 0.3646 0.755
Entamoeba histolytica hypothetical protein 0.003 0.0312 0.0465
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0175 0.0199
Loa Loa (eye worm) hypothetical protein 0.0121 0.175 0.2446
Onchocerca volvulus 0.0027 0.0268 0.0872
Trichomonas vaginalis galactokinase, putative 0.007 0.0942 0.2853
Echinococcus granulosus regulator of G protein signaling 3 0.0016 0.0093 0.0106
Echinococcus granulosus Mevalonate galactokinase 0.0121 0.175 0.1984
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0175 0.0465
Mycobacterium ulcerans diphosphomevalonate decarboxylase 0.0051 0.0652 0.0953
Schistosoma mansoni bromodomain containing protein 0.0053 0.0678 0.0768
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0215 0.0381
Loa Loa (eye worm) hypothetical protein 0.0031 0.0329 0.046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.1502 0.1703
Trypanosoma cruzi mevalonate-diphosphate decarboxylase, putative 0.0051 0.0652 0.1298
Loa Loa (eye worm) hypothetical protein 0.0056 0.0724 0.1012
Echinococcus granulosus fetal alzheimer antigen falz 0.0018 0.0124 0.0141
Echinococcus granulosus N acetylgalactosamine kinase 0.0166 0.2449 0.2776
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.043 0.0487
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0175 0.0297
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.144 0.4527
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0244
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0237 0.0427
Schistosoma mansoni ap endonuclease 0.0019 0.0136 0.0154
Entamoeba histolytica galactokinase, putative 0.0315 0.4792 1
Brugia malayi hypothetical protein 0.0191 0.2844 0.3974
Entamoeba histolytica Ran family GTPase 0.0023 0.0201 0.0229
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.016 0.0126
Schistosoma mansoni hypothetical protein 0.005 0.0626 0.071
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0296 0.0774
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0175 0.0198
Echinococcus granulosus muscleblind protein 0.0466 0.7156 0.8112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.1502 0.1703
Echinococcus granulosus GPCR family 2 0.005 0.0626 0.071
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0156 0.2289 0.4648
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0093 0.0106
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0024 0.0215 0.0213
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0237 0.0484
Mycobacterium tuberculosis Probable dehydrogenase 0.0156 0.2289 0.4648
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.3069 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0014 0.0016
Mycobacterium ulcerans phosphomevalonate kinase 0.0121 0.175 0.298
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0104 0.0118
Echinococcus granulosus thioredoxin glutathione reductase 0.0069 0.0922 0.1046
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0014 0.0056 0.0056
Echinococcus granulosus expressed protein 0.0309 0.47 0.5328
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0521 0.0711
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0016 0.0093 0.0106
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.1502 0.1703
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0175 0.0244
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0175 0.0175
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.043 0.0487
Brugia malayi Bromodomain containing protein 0.0033 0.0367 0.0513
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0024 0.0215 0.0147
Loa Loa (eye worm) hypothetical protein 0.0087 0.1206 0.1686
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0392 0.0392
Echinococcus granulosus axis inhibition protein axin 0.0016 0.0093 0.0106
Treponema pallidum hypothetical protein 0.0364 0.5552 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0173 0.2562 0.5232
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0024 0.0215 0.0381
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0037 0.0428 0.0884
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0474 0.0474
Trypanosoma cruzi homoserine kinase 0.0121 0.175 0.3607
Brugia malayi steroid hormone receptor 0.0021 0.0175 0.0244
Leishmania major fucose kinase, putative 0.0051 0.0652 0.1298
Schistosoma mansoni hypothetical protein 0.033 0.5025 0.5696
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0268 0.0243
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0175 0.0297
Trypanosoma brucei mevalonate diphosphate decarboxylase 0.0051 0.0652 0.2036
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0175 0.0128
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0268 0.0243
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0245
Plasmodium vivax glutathione reductase, putative 0.0068 0.0916 0.2266
Brugia malayi ecdysteroid receptor 0.0021 0.0175 0.0244
Plasmodium falciparum phd finger protein, putative 0.0029 0.0296 0.0512
Trypanosoma brucei unspecified product 0.0015 0.0073 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0175 0.0244
Onchocerca volvulus 0.0021 0.0175 0.057
Trichomonas vaginalis galactokinase, putative 0.0166 0.2449 0.7917
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Giardia lamblia PHD finger protein 15 0.0029 0.0296 0.0548
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0175 0.0244
Echinococcus granulosus histone acetyltransferase KAT2B 0.0037 0.0428 0.0485
Brugia malayi RNA, U transporter 1 0.0088 0.1224 0.171
Leishmania major homoserine kinase, putative 0.0121 0.175 0.3607
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0244
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0028 0.0291 0.0291
Echinococcus granulosus regulator of G protein signaling 7 0.0016 0.0093 0.0106
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0029 0.0041
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0019 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0175 0.0244
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0136 0.0213
Loa Loa (eye worm) hypothetical protein 0.0027 0.0268 0.0374
Onchocerca volvulus 0.0189 0.2811 0.9159
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0175 0.0198
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0175 0.0198
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0116 0.0116
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0268 0.0243
Brugia malayi Bromodomain containing protein 0.0062 0.0824 0.1151
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0268 0.0374
Echinococcus multilocularis regulator of G protein signaling 7 0.0016 0.0093 0.0093
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0175 0.0297
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0237 0.0484
Trypanosoma brucei galactokinase-like protein, putative 0.0201 0.2995 0.9756
Echinococcus granulosus microtubule associated protein 2 0.0572 0.8821 1
Brugia malayi mevalonate kinase family protein 0.0121 0.175 0.2446
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.043 0.043
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0175 0.0297
Echinococcus multilocularis N acetylgalactosamine kinase 0.0166 0.2449 0.2449
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0175 0.0198
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0024 0.0215 0.0597
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0626 0.0626
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0415 0.0471
Loa Loa (eye worm) acetyltransferase 0.0122 0.1759 0.2458
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0014 0.0014
Echinococcus granulosus neuropeptide s receptor 0.0374 0.571 0.6473
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0175 0.0297
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Schistosoma mansoni transcription factor LCR-F1 0.003 0.0312 0.0354
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.144 0.4527
Trichomonas vaginalis set domain proteins, putative 0.0189 0.2811 0.9132
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0175 0.0244
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0019 0.0019
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0016 0.0093 0.0093
Trichomonas vaginalis ran, putative 0.0023 0.0201 0.0362
Brugia malayi Cytochrome P450 family protein 0.0016 0.0099 0.0138
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0018 0.0124 0.0124
Leishmania major mevalonate kinase, putative 0.0121 0.175 0.3607
Loa Loa (eye worm) hypothetical protein 0.0021 0.0175 0.0244
Giardia lamblia Histone acetyltransferase GCN5 0.0032 0.0352 0.0738
Brugia malayi Pre-SET motif family protein 0.0166 0.245 0.3424
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0205 0.3069 0.4288
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0175 0.0244
Plasmodium falciparum thioredoxin reductase 0.0024 0.0215 0.0282
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0136 0.0143
Trichomonas vaginalis glutathione reductase, putative 0.0024 0.0215 0.041
Echinococcus granulosus axis inhibition protein axin 0.0016 0.0093 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0175 0.0175
Trypanosoma brucei unspecified product 0.0015 0.0073 0.0126
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0175 0.0198
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.1502 0.1502
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0038 0.0038
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0136 0.019
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.2316 0.3237
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0026
Mycobacterium ulcerans mevalonate kinase, Erg12 0.0121 0.175 0.298
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.1502 0.1502
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0024 0.0215 0.0147
Brugia malayi Importin beta-1 subunit 0.0031 0.0329 0.046
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.013
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0023 0.0204 0.0231
Brugia malayi acetyltransferase, GNAT family protein 0.0122 0.1759 0.2458
Echinococcus granulosus diphosphomevalonate decarboxylase 0.0051 0.0652 0.0739
Echinococcus multilocularis axis inhibition protein axin 0.0016 0.0093 0.0093
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0268 0.0325
Onchocerca volvulus 0.0024 0.0218 0.0709
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0175 0.0244
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0175 0.0175
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0116 0.0171
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0224
Leishmania major fucose kinase, putative 0.0051 0.0652 0.1298
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0175 0.0073
Schistosoma mansoni DNA polymerase eta 0.0021 0.0175 0.0199
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0175 0.0198
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0005 0.0006
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0175 0.0245
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0024 0.0215 0.0381
Loa Loa (eye worm) hypothetical protein 0.0028 0.0278 0.0388
Echinococcus multilocularis survival motor neuron protein 1 0.0191 0.2844 0.2844
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.016 0.0046
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0024 0.0215 0.0244
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0175 0.0465
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0415 0.0471
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0026
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0024 0.0215 0.0597
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0024 0.0215 0.0282
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0415 0.0581
Echinococcus multilocularis axis inhibition protein axin 0.0016 0.0093 0.0093
Brugia malayi PHD-finger family protein 0.0023 0.02 0.028
Trypanosoma brucei trypanothione reductase 0.0068 0.0916 0.2905
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0175 0.0244
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0215 0.0381
Toxoplasma gondii exonuclease III APE 0.0019 0.0136 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.3069 1
Echinococcus multilocularis neuropeptide receptor A26 0.0374 0.571 0.571
Plasmodium falciparum glutathione reductase 0.0024 0.0215 0.0282
Loa Loa (eye worm) hypothetical protein 0.0051 0.0652 0.0911
Loa Loa (eye worm) RGS-3 protein 0.0016 0.0093 0.013
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0068 0.0916 0.1711
Schistosoma mansoni hypothetical protein 0.005 0.0626 0.071
Chlamydia trachomatis 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0294 0.4454 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0268 0.0374
Trichomonas vaginalis CAMK family protein kinase 0.0205 0.3069 1
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0175 0.057
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.011 0.0154
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0175 0.0198
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0175 0.0198
Brugia malayi regulator of G-protein signaling egl-10 0.0016 0.0093 0.013
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0175 0.0244
Schistosoma mansoni zinc finger protein 0.0018 0.0134 0.0152
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.003 0.0312 0.0354
Plasmodium falciparum glutathione reductase 0.0068 0.0916 0.2266
Plasmodium vivax importin-beta 2, putative 0.0031 0.0329 0.0604
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0136 0.0154
Trypanosoma brucei unspecified product 0.0021 0.0175 0.0465
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0116 0.0131
Trypanosoma cruzi galactokinase-like protein, putative 0.0264 0.3983 0.8301
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0093 0.0106
Giardia lamblia Diphosphomevalonate decarboxylase 0.0051 0.0652 0.176
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0143 0.0058
Brugia malayi serine/threonine-protein kinase plk-2 0.0205 0.3069 0.4288
Echinococcus granulosus dna polymerase eta 0.0021 0.0175 0.0199
Brugia malayi galactokinase family protein 0.0166 0.2449 0.3422
Echinococcus multilocularis muscleblind protein 1 0.0466 0.7156 0.7156
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0156 0.2289 0.4648
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.013
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0626 0.0875
Loa Loa (eye worm) galactokinase 0.0166 0.2449 0.3422
Toxoplasma gondii GHMP kinase, N-terminal domain-containing protein 0.0166 0.2449 1
Brugia malayi Bromodomain containing protein 0.0034 0.0372 0.052
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0201 0.0549
Brugia malayi jmjC domain containing protein 0.0094 0.1326 0.1853
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0175 0.0244
Schistosoma mansoni importin beta-1 0.0031 0.0329 0.0373
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0201 0.0228
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0268 0.0371
Schistosoma mansoni jumonji domain containing protein 0.0075 0.1022 0.1158
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0024 0.0215 0.0147
Trypanosoma cruzi homoserine kinase 0.0121 0.175 0.3607
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0224
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0278 0.0459
Toxoplasma gondii GHMP kinase, putative 0.0121 0.175 0.7005
Trypanosoma cruzi phosphomevalonate kinase protein, putative 0.0051 0.0652 0.1298
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0175 0.0198
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0296 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0073 0.0126
Trypanosoma brucei polo-like protein kinase 0.0205 0.3069 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0201 0.0281
Trypanosoma cruzi fucose kinase, putative 0.007 0.0942 0.1908
Brugia malayi PXA domain containing protein 0.0016 0.0093 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0073 0.0126
Loa Loa (eye worm) hypothetical protein 0.0108 0.1534 0.2144
Trichomonas vaginalis galactokinase, putative 0.0166 0.2449 0.7917
Loa Loa (eye worm) thioredoxin reductase 0.0068 0.0916 0.128
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0175 0.0244
Schistosoma mansoni hypothetical protein 0.0012 0.0038 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0215 0.0381
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.0218 0.0218
Brugia malayi PXA domain containing protein 0.0016 0.0093 0.013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0268 0.0325
Schistosoma mansoni hypothetical protein 0.0016 0.0101 0.0114
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0093 0.0106
Brugia malayi PHD-finger family protein 0.0029 0.0296 0.0414
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0296 0.0296
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0028 0.0291 0.033
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0175 0.0198
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0022
Mycobacterium tuberculosis Possible D-alpha-D-heptose-7-phosphate kinase HddA 0.0121 0.175 0.3495
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0278 0.0459
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0626 0.071
Echinococcus granulosus importin subunit beta 1 0.0031 0.0329 0.0373
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0017 0.0117 0.0163
Loa Loa (eye worm) hypothetical protein 0.0049 0.062 0.0866
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0106 0.1502 0.2099
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0116 0.0116
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.003 0.0322 0.0449
Echinococcus multilocularis thioredoxin glutathione reductase 0.0069 0.0922 0.0922
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0268 0.0374
Brugia malayi Regulator of G protein signaling domain containing protein 0.0016 0.0093 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0175 0.0465
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0175 0.0128
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0116 0.0269
Brugia malayi diphosphomevalonate decarboxylase family protein 0.0051 0.0652 0.0911
Echinococcus granulosus galactokinase 0.0315 0.4792 0.5432
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0175 0.0245
Trichomonas vaginalis bromodomain-containing protein, putative 0.0037 0.0428 0.1125
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.0218 0.0436
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0268 0.0371
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0116 0.0162
Giardia lamblia NADH oxidase lateral transfer candidate 0.0024 0.0215 0.0271
Schistosoma mansoni hypothetical protein 0.0546 0.842 0.9545
Brugia malayi nuclear receptor NHR-88 0.0021 0.0175 0.0244
Schistosoma mansoni hypothetical protein 0.0029 0.0296 0.0336
Brugia malayi jmjC domain containing protein 0.0036 0.0415 0.0581
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0156 0.2289 0.3825
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0175 0.0244
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0116 0.0116
Leishmania major mevalonate-diphosphate decarboxylase, putative 0.0051 0.0652 0.1298
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0205 0.3069 0.6379
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.0056 0.0064
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0205 0.3069 0.3069
Echinococcus granulosus regulator of G protein signaling 3 0.0016 0.0093 0.0106
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0175 0.0198
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0024 0.0215 0.0301
Loa Loa (eye worm) hypothetical protein 0.0157 0.2316 0.3237
Echinococcus multilocularis regulator of G protein signaling 7 0.0016 0.0093 0.0093
Trypanosoma cruzi galactokinase, putative 0.0264 0.3983 0.8301
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0175 0.0175
Echinococcus multilocularis dna polymerase eta 0.0021 0.0175 0.0175
Plasmodium vivax SET domain protein, putative 0.0024 0.0218 0.0288
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0521 0.0711
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.016 0.0095
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0136 0.0057
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0175 0.0297
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.013
Schistosoma mansoni axis inhibition protein axin 0.0016 0.0093 0.0106
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0024 0.0215 0.0282
Schistosoma mansoni hypothetical protein 0.005 0.0626 0.071
Echinococcus multilocularis galactokinase 0.0315 0.4792 0.4792
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0175 0.0175
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0143 0.0058
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0329 0.0972
Loa Loa (eye worm) hypothetical protein 0.0466 0.7156 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0175 0.0244
Trypanosoma cruzi fucose kinase, putative 0.007 0.0942 0.1908
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.0521 0.0591
Brugia malayi hypothetical protein 0.0028 0.0278 0.0388
Loa Loa (eye worm) hypothetical protein 0.0466 0.7156 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0205 0.3069 0.3479
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0175 0.0199
Plasmodium vivax 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative 0.0242 0.3646 1
Trypanosoma cruzi galactokinase, putative 0.0315 0.4792 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0278 0.0459
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0099 0.0138
Trichomonas vaginalis diphosphomevalonate decarboxylase, putative 0.0051 0.0652 0.1878
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0087 0.1213 0.1695
Schistosoma mansoni serine/threonine protein kinase 0.0205 0.3069 0.3479
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.005 0.0633 0.0633
Schistosoma mansoni zinc finger protein 0.0012 0.0034 0.0039
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0175 0.0198

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) Antagonist activity at ER by reporter gene assay ChEMBL. 19954971
IC50 (functional) Agonist activity at GR by reporter gene assay ChEMBL. 19954971
IC50 (functional) Antagonist activity at GR by reporter gene assay ChEMBL. 19954971
IC50 (binding) Inhibition of 17beta-HSD1 by human cell based assay ChEMBL. 19954971
IC50 (functional) Agonist activity at ER by reporter gene assay ChEMBL. 19954971
IC50 (binding) Inhibition of 17beta-HSD2 by human cell based assay ChEMBL. 19954971
IC50 (binding) = 0.008 uM Inhibition of human 17beta-HSD3 expressed in HeLa cells ChEMBL. 19954971

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.