TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 283.241 | Formula: C10H13N5O5
H donors: 5 H acceptors: 5 LogP: -2.85 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1OC([C@@H]([C@@H]1O)O)n1ncc2c1nc(N)[nH]c2=O
InChi: 1S/C10H13N5O5/c11-10-13-7-3(8(19)14-10)1-12-15(7)9-6(18)5(17)4(2-16)20-9/h1,4-6,9,16-18H,2H2,(H3,11,13,14,19)/t4-,5-,6-,9?/m1/s1
InChiKey: MJJUWOIBPREHRU-IAHXAJBFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0038	0.0086	0.0185
Loa Loa (eye worm)	jmjC domain-containing protein	0.0038	0.0086	0.0098
Onchocerca volvulus		0.0191	0.1182	0.1174
Echinococcus granulosus	chromobox protein 1	0.007	0.0318	0.0664
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0258	0.4434
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0268	0.0306
Brugia malayi	jmjC domain containing protein	0.0038	0.0086	0.0088
Schistosoma mansoni	jumonji domain containing protein	0.0304	0.1994	0.4273
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0086	0.0098
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0097	0.0089
Plasmodium vivax	hypothetical protein, conserved	0.0117	0.0653	0.5593
Brugia malayi	Bromodomain containing protein	0.045	0.3041	0.3463
Schistosoma mansoni	hypothetical protein	0.0092	0.0474	0.1016
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0135	0.0785	0.1683
Brugia malayi	latrophilin 2 splice variant baaae	0.0136	0.0792	0.0895
Echinococcus multilocularis	jumonji domain containing 1A	0.0038	0.0086	0.0166
Loa Loa (eye worm)	hypothetical protein	0.023	0.1466	0.1672
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0216	0.1361	0.2904
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0117	0.0653	0.1383
Echinococcus granulosus	JmjC domain containing protein 4	0.0038	0.0086	0.0166
Schistosoma mansoni	hypothetical protein	0.0063	0.0268	0.0574
Schistosoma mansoni	bromodomain containing protein	0.038	0.2537	0.5437
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.02	0.1244	0.142
Echinococcus granulosus	peregrin	0.0131	0.0755	0.1602
Schistosoma mansoni	hypothetical protein	0.0063	0.0268	0.0574
Echinococcus multilocularis	chromobox protein 1	0.007	0.0318	0.0664
Loa Loa (eye worm)	jmjC domain-containing protein	0.0038	0.0086	0.0098
Onchocerca volvulus		0.0031	0.0037	0.0028
Schistosoma mansoni	protein phosphatase 2C	0.0038	0.0086	0.0185
Toxoplasma gondii	PHD-finger domain-containing protein	0.0117	0.0653	0.5593
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.009	0.0034
Echinococcus multilocularis	microtubule associated protein 2	0.0678	0.4665	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0056	0.0219	0.024
Brugia malayi	PHD-finger family protein	0.0117	0.0653	0.0736
Echinococcus multilocularis	jumonji domain containing protein	0.0163	0.0981	0.2087
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0009	0.0019
Brugia malayi	jmjC domain containing protein	0.0038	0.0086	0.0088
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0009	0.001
Brugia malayi	jmjC domain containing protein	0.0038	0.0086	0.0088
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0282	0.1833	0.3917
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0258	0.4434
Schistosoma mansoni	hypothetical protein	0.0124	0.0703	0.1507
Trypanosoma brucei	ISWI complex protein	0.0092	0.0474	1
Schistosoma mansoni	zinc finger protein	0.0092	0.0474	0.1016
Echinococcus granulosus	zinc finger protein	0.0118	0.0658	0.1394
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.02	0.1244	0.1411
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0258	0.4434
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0038	0.009	0.0088
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0258	0.4434
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0056	0.022	0.3445
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0191	0.1182	0.2533
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0359	0.2383	0.5098
Echinococcus multilocularis	lysine specific demethylase 6a	0.0038	0.0086	0.0166
Loa Loa (eye worm)	jmjC domain-containing protein	0.0153	0.0911	0.104
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0258	0.4434
Brugia malayi	Pre-SET motif family protein	0.0179	0.1099	0.1246
Loa Loa (eye worm)	hypothetical protein	0.0282	0.1833	0.2091
Echinococcus granulosus	microtubule associated protein 2	0.0678	0.4665	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0063	0.0268	0.0557
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0102	0.0549	0.1177
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.0163	0.1994
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0045	0.0137	0.0293
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0049	0.0168	0.0343
Echinococcus granulosus	PHD finger protein rhinoceros	0.0117	0.0653	0.1383
Onchocerca volvulus	Alhambra homolog	0.0117	0.0653	0.0645
Echinococcus multilocularis	zinc finger protein	0.0118	0.0658	0.1394
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0063	0.0268	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0086	0.0098
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0038	0.009	0.0034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0258	0.4434
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0258	0.4434
Toxoplasma gondii	PHD-finger domain-containing protein	0.0038	0.009	0.0034
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0179	0.1099	0.2357
Echinococcus granulosus	chromobox protein 1	0.007	0.0318	0.0664
Plasmodium falciparum	phd finger protein, putative	0.0117	0.0653	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0009	0.001
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0063	0.0268	0.0557
Loa Loa (eye worm)	hypothetical protein	0.02	0.1251	0.1427
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0258	0.4434
Leishmania major	cathepsin L-like protease	0.0062	0.0258	0.4434
Brugia malayi	Pre-SET motif family protein	0.125	0.8764	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0282	0.1833	0.3928
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0179	0.1099	1
Schistosoma mansoni	hypothetical protein	0.0063	0.0268	0.0574
Echinococcus multilocularis	lysine specific demethylase 5A	0.0142	0.0829	0.1762
Brugia malayi	PHD-finger family protein	0.005	0.0172	0.0186
Leishmania major	cathepsin L-like protease	0.0062	0.0258	0.4434
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0119	0.0104
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0258	0.4434
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0063	0.0268	0.0306
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0258	0.4434
Schistosoma mansoni	lamin	0.0027	0.0009	0.0019
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0173	0.1052	0.2241
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0038	0.009	0.0088
Loa Loa (eye worm)	hypothetical protein	0.02	0.1244	0.142
Loa Loa (eye worm)	hypothetical protein	0.005	0.0172	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0256	0.165	0.1882
Echinococcus granulosus	histone lysine methyltransferase setb	0.0282	0.1833	0.3917
Loa Loa (eye worm)	jmjC domain-containing protein	0.0038	0.0086	0.0098
Schistosoma mansoni	chromobox protein	0.007	0.0318	0.0681
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0102	0.0549	0.1161
Echinococcus multilocularis	phd:f box containing protein	0.0038	0.0086	0.0166
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0117	0.0653	0.14
Brugia malayi	PHD-finger family protein	0.015	0.0887	0.1003
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0097	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0009	0.001
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0282	0.1833	0.3928
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0063	0.0268	0.0557
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0119	0.0104
Loa Loa (eye worm)	PHD-finger family protein	0.0124	0.0703	0.0802
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.125	0.8764	1
Schistosoma mansoni	hypothetical protein	0.0038	0.009	0.0192
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0318	0.0303
Schistosoma mansoni	hypothetical protein	0.0136	0.0792	0.1698
Schistosoma mansoni	jumonji domain containing protein	0.0038	0.0086	0.0185
Brugia malayi	Bromodomain containing protein	0.0131	0.0755	0.0852
Loa Loa (eye worm)	hypothetical protein	0.0425	0.2857	0.326
Loa Loa (eye worm)	hypothetical protein	0.0245	0.1567	0.1789
Schistosoma mansoni	zinc finger protein	0.0118	0.0658	0.141
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0179	0.1099	0.2342
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0653	0.0745
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0005	0.0006
Brugia malayi	jmjC domain containing protein	0.0383	0.2557	0.2911
Loa Loa (eye worm)	PHD-finger family protein	0.0117	0.0653	0.0745
Trypanosoma cruzi	ISWI complex protein	0.0092	0.0474	1
Leishmania major	cathepsin L-like protease	0.0062	0.0258	0.4434
Loa Loa (eye worm)	jmjC domain-containing protein	0.0241	0.1544	0.1762
Brugia malayi	Latrophilin receptor protein 2	0.0063	0.0268	0.0296
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0049	0.0168	0.0343
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0359	0.2383	0.5098
Schistosoma mansoni	phd/f-box containing protein	0.0038	0.0086	0.0185
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0135	0.0785	0.1668
Echinococcus granulosus	jumonji domain containing 1A	0.0038	0.0086	0.0166
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.0258	0.4434
Echinococcus granulosus	lysine specific demethylase 5A	0.0153	0.0911	0.1938
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0038	0.009	0.006
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0216	0.1361	0.2904
Brugia malayi	Bromodomain containing protein	0.023	0.1463	0.1661
Schistosoma mansoni	lamin	0.0027	0.0009	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0097	0.0082
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0383	0.2557	0.5472
Echinococcus multilocularis	chromobox protein 1	0.007	0.0318	0.0664
Brugia malayi	Calcitonin receptor-like protein seb-1	0.02	0.1244	0.1411
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0258	0.4434
Echinococcus granulosus	phd:f box containing protein	0.0038	0.0086	0.0166
Schistosoma mansoni	phosphatidylserine receptor	0.0038	0.0086	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0792	0.0904
Schistosoma mansoni	microtubule-associated protein tau	0.0678	0.4665	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0153	0.0911	0.1953
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0383	0.2557	0.5472
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0318	0.0303
Loa Loa (eye worm)	bromodomain containing protein	0.0106	0.0576	0.0657
Trypanosoma cruzi	ISWI complex protein	0.0092	0.0474	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0063	0.0268	0.0557
Toxoplasma gondii	PHD-finger domain-containing protein	0.0117	0.0653	0.5593
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0153	0.0911	0.1953
Brugia malayi	Heterochromatin protein 1	0.007	0.0318	0.0353
Schistosoma mansoni	hypothetical protein	0.0117	0.0653	0.14
Brugia malayi	jmjC domain containing protein	0.0153	0.0911	0.1031
Echinococcus granulosus	lysine specific demethylase 6a	0.0038	0.0086	0.0166
Leishmania major	hypothetical protein, conserved	0.0092	0.0474	1
Echinococcus granulosus	GPCR family 2	0.0063	0.0268	0.0557
Echinococcus granulosus	fetal alzheimer antigen falz	0.0135	0.0785	0.1668
Echinococcus multilocularis	JmjC domain containing protein 4	0.0038	0.0086	0.0166
Echinococcus multilocularis	peregrin	0.0131	0.0755	0.1602
Brugia malayi	chromobox protein homolog 3	0.0039	0.0097	0.0101
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0258	0.4434
Echinococcus granulosus	jumonji domain containing protein	0.0163	0.0981	0.2087
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0102	0.0549	0.1177
Schistosoma mansoni	chromobox protein	0.007	0.0318	0.0681
Plasmodium vivax	SET domain protein, putative	0.0179	0.1099	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0258	0.4434
Brugia malayi	AF-10 protein	0.0038	0.009	0.0092
Giardia lamblia	PHD finger protein 15	0.0117	0.0653	0.5
Brugia malayi	jmjC domain containing protein	0.0038	0.0086	0.0088
Loa Loa (eye worm)	heterochromatin protein 1	0.007	0.0318	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0037	0.0042
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0258	0.4434
Schistosoma mansoni	hypothetical protein	0.0063	0.0268	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0097	0.0111
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0119	0.011
Echinococcus multilocularis	GPCR, family 2	0.0063	0.0268	0.0557
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0102	0.0549	0.1161

Activities

Activity type	Activity value	Assay description	Source	Reference
Cytotoxicity (functional)	= 26.9 %	In vivo effect of Guanosines on murine NK cell activity at E:T ratio of 50:1	ChEMBL.	2165164
Cytotoxicity (functional)	= 41.1 %	In vivo effect of Guanosines on murine NK cell activity at E:T ratio of 100:1	ChEMBL.	2165164

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL603504

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1186014