Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.00526959 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.00526959 | 1 | 1 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0048409 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.00526959 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.00526959 | 1 | 1 |
Onchocerca volvulus | 0.0048409 | 0 | 0.5 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.00526959 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.00526959 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.00526959 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0048409 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.00526959 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.00526959 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.00526959 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.00526959 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.00526959 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.00526959 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0048409 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.00526959 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00526959 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.00526959 | 1 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.00526959 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.00526959 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.00526959 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.00526959 | 1 | 1 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0048409 | 0 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0048409 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.00526959 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 34 ng/ml | Antimalarial activity against chloroquine-resistant Plasmodium falciparum 3D7 infected erythrocytes after 72 hrs by MSF assay | ChEMBL. | 19058973 |
MIC (functional) | = 1 ug ml-1 | Antimalarial effect as schizonticidal activity against chloroquine-resistant Plasmodium falciparum 3D7 after 40 hrs | ChEMBL. | 19058973 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 19058973 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.