Detailed information for compound 1186924

Basic information

Technical information
  • TDR Targets ID: 1186924
  • Name: 5,6-dichloro-1-[(2R,4S,5R)-4-hydroxy-5-(hydro xymethyl)oxolan-2-yl]-2-methoxyindole-3-carbo nitrile
  • MW: 357.189 | Formula: C15H14Cl2N2O4
  • H donors: 2 H acceptors: 3 LogP: 2.64 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1c2cc(Cl)c(cc2c(c1OC)C#N)Cl
  • InChi: 1S/C15H14Cl2N2O4/c1-22-15-8(5-18)7-2-9(16)10(17)3-11(7)19(15)14-4-12(21)13(6-20)23-14/h2-3,12-14,20-21H,4,6H2,1H3/t12-,13+,14+/m0/s1
  • InChiKey: NYWIOWPXTRAKDN-BFHYXJOUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5,6-dichloro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-methoxy-indole-3-carbonitrile
  • 5,6-dichloro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-2-methoxy-3-indolecarbonitrile
  • 5,6-dichloro-1-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]-2-methoxy-indole-3-carbonitrile
  • 5,6-dichloro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-methoxy-indole-3-carbonitrile
  • 1H-Indole-3-carbonitrile, 2-methoxy-5,6-dichloro-1-(2-deoxy-b-D-erythro-pentofuranosyl)-
  • AIDS-225808
  • AIDS225808

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0087 0.2776 0.2908
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.1694 0.1756
Schistosoma mansoni biogenic amine receptor 0.0057 0.1694 0.1793
Echinococcus multilocularis peptidase Clp (S14 family) 0.0057 0.1678 0.174
Leishmania major hypothetical protein, conserved 0.0028 0.06 0.0269
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.1694 0.1793
Echinococcus granulosus g protein coupled receptor 0.0057 0.1694 0.1756
Echinococcus granulosus muscleblind protein 0.0152 0.5152 0.5434
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.1181 1
Treponema pallidum adenosine deaminase 0.0269 0.9447 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0057 0.1694 0.1488
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0057 0.1678 0.1455
Schistosoma mansoni amine GPCR 0.0057 0.1694 0.1793
Brugia malayi G-protein coupled receptor 0.0057 0.1694 0.1488
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.1694 0.1756
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.1694 0.1756
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0057 0.1694 0.1793
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Echinococcus granulosus adenosine deaminase 0.0269 0.9447 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0057 0.1694 0.1488
Schistosoma mansoni biogenic amine receptor 0.0057 0.1694 0.1793
Echinococcus granulosus alpha 1A adrenergic receptor 0.0057 0.1694 0.1756
Schistosoma mansoni amine GPCR 0.0057 0.1694 0.1793
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0057 0.1694 0.1756
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.1326 0.1404
Entamoeba histolytica AMP deaminase, putative 0.0088 0.28 0.2964
Echinococcus granulosus biogenic amine 5HT receptor 0.0057 0.1694 0.1756
Brugia malayi hypothetical protein 0.0057 0.1694 0.1488
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.1694 0.1793
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0057 0.1694 0.1793
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0087 0.2776 0.2908
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.1694 0.1756
Schistosoma mansoni biogenic amine (5HT) receptor 0.0057 0.1694 0.1793
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Schistosoma mansoni AMP deaminase 0.0088 0.28 0.2964
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0355 0.0355
Schistosoma mansoni opsin-like receptor 0.0057 0.1694 0.1793
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0057 0.1694 0.1756
Echinococcus multilocularis dro:myosuppressin receptor 0.0057 0.1694 0.1756
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Schistosoma mansoni hypothetical protein 0.0057 0.1694 0.1793
Echinococcus multilocularis geminin 0.0188 0.6497 0.6863
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.1694 0.1793
Loa Loa (eye worm) TYRA-2 protein 0.0057 0.1694 0.1694
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.1694 0.1756
Echinococcus granulosus AMP deaminase 2 0.0088 0.28 0.2932
Toxoplasma gondii hypothetical protein 0.003 0.0687 0.0727
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.1694 0.1793
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.1694 0.1756
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0168 0.5749 0.5749
Echinococcus granulosus neuropeptide s receptor 0.0057 0.1694 0.1756
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0057 0.1694 0.1488
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.1694 0.1756
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Echinococcus multilocularis fmrfamide receptor 0.0057 0.1694 0.1756
Echinococcus multilocularis muscleblind protein 1 0.0152 0.5152 0.5434
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0148 0.5017 0.5017
Trypanosoma cruzi AMP deaminase, putative 0.0088 0.28 1
Trypanosoma brucei cytochrome P450, putative 0.0029 0.0656 0.1231
Loa Loa (eye worm) acetyltransferase 0.0161 0.5497 0.5497
Trypanosoma brucei AMP deaminase, putative 0.0088 0.28 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0087 0.2776 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0668 0.0668
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.1694 0.1756
Brugia malayi hypothetical protein 0.0057 0.1694 0.1488
Schistosoma mansoni amine GPCR 0.0057 0.1694 0.1793
Brugia malayi neuropeptide F receptor 0.0057 0.1694 0.1488
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.1694 0.1756
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Echinococcus multilocularis somatostatin receptor 0.0057 0.1694 0.1756
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0269 0.9447 1
Plasmodium falciparum AMP deaminase, putative 0.0088 0.28 0.2689
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0396 0.0377
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.1326 0.1404
Loa Loa (eye worm) hypothetical protein 0.0018 0.0259 0.0259
Trypanosoma cruzi AMP deaminase, putative 0.0088 0.28 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0057 0.1694 0.1793
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.0088 0.28 0.2689
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0656 0.0656
Toxoplasma gondii AMP deaminase 0.0088 0.28 0.2964
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0161 0.5497 0.5801
Brugia malayi ORL1-like opioid receptor 0.0057 0.1694 0.1488
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.1694 0.1756
Leishmania major hypothetical protein, conserved 0.0088 0.28 0.2689
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.06 0.0269
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.1694 0.1756
Brugia malayi hypothetical protein 0.0057 0.1694 0.1488
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0396 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.1694 0.1793
Brugia malayi Cytochrome P450 family protein 0.0029 0.0656 0.0425
Brugia malayi G-protein coupled receptor 0.0057 0.1694 0.1488
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.1694 0.1756
Loa Loa (eye worm) RecQ helicase 0.0022 0.0396 0.0396
Schistosoma mansoni neuropeptide receptor 0.0057 0.1694 0.1793
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.1694 0.1793
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0396 0.0499
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.1326 0.1365
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.1694 0.1793
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.1694 0.1756
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.06 0.0269
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.1694 0.1756
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0057 0.1694 0.1793
Loa Loa (eye worm) CYP4Cod1 0.0029 0.0656 0.0656
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.1326 0.1404
Echinococcus multilocularis AMP deaminase 2 0.0088 0.28 0.2932
Mycobacterium ulcerans adenosine deaminase 0.0269 0.9447 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.2776 0.2939
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0057 0.1694 0.1694
Toxoplasma gondii exonuclease III APE 0.0021 0.0355 0.0376
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0148 0.5017 0.4894
Schistosoma mansoni hypothetical protein 0.0057 0.1694 0.1793
Echinococcus multilocularis sex peptide receptor 0.0057 0.1694 0.1756
Echinococcus granulosus serotonin receptor 0.0057 0.1694 0.1756
Echinococcus granulosus neuropeptide receptor A26 0.0057 0.1694 0.1756
Brugia malayi Muscleblind-like protein 0.0152 0.5152 0.5032
Brugia malayi hypothetical protein 0.0057 0.1694 0.1488
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.1181 0.125
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0057 0.1694 0.1756
Brugia malayi Dopamine receptor protein 1 0.0057 0.1694 0.1488
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0057 0.1678 0.1132
Plasmodium vivax adenosine deaminase, putative 0.0269 0.9447 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0687 0.0365
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.1694 0.1756
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.1694 0.1793
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0057 0.1694 0.1488
Brugia malayi Dopamine receptor protein 2 0.0057 0.1694 0.1488
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0057 0.1694 0.1793
Leishmania major adenine aminohydrolase 0.0269 0.9447 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.2776 0.2663
Schistosoma mansoni hypothetical protein 0.0057 0.1694 0.1793
Brugia malayi G protein-coupled receptor F59B2.13 0.0057 0.1694 0.1488
Brugia malayi hypothetical protein 0.0168 0.5749 0.5644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0396 0.0419
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Trypanosoma cruzi AMP deaminase, putative 0.0088 0.28 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0396 0.0377
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.1694 0.1756
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.2776 0.2939
Echinococcus granulosus 7tm_1 domain containing protein 0.0057 0.1694 0.1756
Brugia malayi Serotonin receptor 0.0057 0.1694 0.1488
Echinococcus granulosus biogenic amine 5HT receptor 0.0057 0.1694 0.1756
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0057 0.1694 0.1793
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.1694 0.1756
Brugia malayi Cytochrome P450 family protein 0.0029 0.0656 0.0425
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0057 0.1694 0.1793
Loa Loa (eye worm) AMP deaminase 0.0088 0.28 0.28
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.1694 0.1793
Onchocerca volvulus Adenosine deaminase homolog 0.0269 0.9447 1
Brugia malayi acetyltransferase, GNAT family protein 0.0161 0.5497 0.5386
Schistosoma mansoni hypothetical protein 0.0057 0.1694 0.1793
Loa Loa (eye worm) hypothetical protein 0.0088 0.28 0.28
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0355 0.1268
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0057 0.1694 0.1756
Schistosoma mansoni ap endonuclease 0.0021 0.0355 0.0376
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0057 0.1694 0.1756
Echinococcus granulosus orexin receptor type 2 0.0057 0.1694 0.1756
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.06 0.0635
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0057 0.1694 0.1488
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.1694 0.1793
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0355 0.1268
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.5017 0.529
Echinococcus granulosus sex peptide receptor 0.0057 0.1694 0.1756
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.06 0.1002
Schistosoma mansoni adenosine deaminase-related 0.0269 0.9447 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Echinococcus multilocularis serotonin receptor 0.0057 0.1694 0.1756
Trypanosoma cruzi AMP deaminase, putative 0.0088 0.28 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0057 0.1694 0.1756
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0161 0.5497 0.5819
Brugia malayi adenosine monophosphate deaminase 0.0088 0.28 0.2622
Echinococcus granulosus geminin 0.0188 0.6497 0.6863
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.1181 0.0909
Brugia malayi RE15519p 0.0057 0.1694 0.1488
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Brugia malayi Cytochrome P450 family protein 0.0029 0.0668 0.0437
Trypanosoma brucei AMP deaminase, putative 0.0088 0.28 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.1694 0.1756
Schistosoma mansoni neuropeptide f receptor 76f 0.0057 0.1694 0.1793
Echinococcus granulosus somatostatin receptor 0.0057 0.1694 0.1756
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.5017 0.5311
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Brugia malayi hypothetical protein 0.0057 0.1694 0.1488
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0396 0.0045
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Plasmodium falciparum adenosine deaminase 0.0269 0.9447 1
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0656 0.2343
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.2776 0.5
Echinococcus granulosus fmrfamide receptor 0.0057 0.1694 0.1756
Brugia malayi Serotonin receptor 0.0057 0.1694 0.1488
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.1694 0.1756
Trypanosoma cruzi AMP deaminase 2, putative 0.0088 0.28 1
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.0088 0.28 0.2689
Loa Loa (eye worm) hypothetical protein 0.0181 0.6235 0.6235
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.06 0.2142
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0656 0.2343
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0057 0.1694 0.1793
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Echinococcus multilocularis neuropeptide FF receptor 2 0.0057 0.1694 0.1756
Echinococcus multilocularis neuropeptide receptor 0.0057 0.1694 0.1756
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0355 0.0376
Leishmania major AMP deaminase, putative 0.0088 0.28 0.2689
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0355 0.0333
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Brugia malayi AKH receptor 0.0057 0.1694 0.1488
Schistosoma mansoni neuropeptide receptor 0.0057 0.1694 0.1793
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Onchocerca volvulus AMP deaminase 2 homolog 0.0088 0.28 0.1426
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.1694 0.1793
Echinococcus granulosus neuropeptide receptor 0.0057 0.1694 0.1756
Schistosoma mansoni biogenic amine (5HT) receptor 0.0057 0.1694 0.1793
Brugia malayi putative neuropeptide receptor NPR1 0.0057 0.1694 0.1488
Loa Loa (eye worm) hypothetical protein 0.0269 0.9447 0.9447
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0396 0.0419
Schistosoma mansoni adenosine deaminase 0.0269 0.9447 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0087 0.2776 0.2939
Echinococcus granulosus g protein coupled receptor 0.0057 0.1694 0.1756
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Entamoeba histolytica AMP deaminase, putative 0.0088 0.28 0.2964
Echinococcus granulosus dro:myosuppressin receptor 0.0057 0.1694 0.1756
Echinococcus multilocularis g protein coupled receptor 0.0057 0.1694 0.1756
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0396 0.0045
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.2776 0.2663
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Brugia malayi Probable ClpP-like protease 0.0087 0.2776 0.2598
Trichomonas vaginalis adenosine deaminase, putative 0.0269 0.9447 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.1694 0.1756
Loa Loa (eye worm) hypothetical protein 0.0022 0.0396 0.0396
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.1694 0.1756
Echinococcus multilocularis neuropeptide s receptor 0.0057 0.1694 0.1756
Schistosoma mansoni amine GPCR 0.0057 0.1694 0.1793
Schistosoma mansoni hypothetical protein 0.0188 0.6497 0.6877
Leishmania major cytochrome p450-like protein 0.0029 0.0656 0.0331
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.2776 0.2663
Entamoeba histolytica adenosine deaminase, putative 0.0269 0.9447 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Brugia malayi hypothetical protein 0.0057 0.1694 0.1488
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0057 0.1694 0.1694
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.1694 0.1694
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0057 0.1694 0.1694
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.06 0.0635
Echinococcus multilocularis G protein coupled receptor 139 0.0057 0.1694 0.1756
Loa Loa (eye worm) hypothetical protein 0.0181 0.6235 0.6235
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Entamoeba histolytica adenosine deaminase, putative 0.0269 0.9447 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.06 0.2142
Echinococcus multilocularis serotonin receptor 0.0057 0.1694 0.1756
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0057 0.1694 0.1756
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.1694 0.1694
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0396 0.0377
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0057 0.1694 0.1756
Trypanosoma brucei AMP deaminase, putative 0.0088 0.28 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0269 0.9447 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.1326 0.1068
Loa Loa (eye worm) hypothetical protein 0.0028 0.06 0.06
Brugia malayi putative neuropeptide receptor 0.0057 0.1694 0.1488
Echinococcus multilocularis adenosine deaminase 0.0269 0.9447 1
Schistosoma mansoni neuropeptide receptor 0.0057 0.1694 0.1793
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.1694 0.1793
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0396 0.0159
Echinococcus granulosus 7TM GPCR rhodopsin 0.0057 0.1694 0.1756
Echinococcus granulosus bloom syndrome protein 0.0022 0.0396 0.0377
Schistosoma mansoni neuropeptide receptor 0.0057 0.1694 0.1793
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0396 0.0159
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.1694 0.1756
Plasmodium vivax adenosine/AMP deaminase, putative 0.0088 0.28 0.2964
Echinococcus granulosus allatostatin A receptor 0.0057 0.1694 0.1756
Brugia malayi neuropeptide F receptor 0.0057 0.1694 0.1488
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.1694 0.1756
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0355 0.0333
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0656 0.0656
Loa Loa (eye worm) melatonin receptor type 1A 0.0057 0.1694 0.1694
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0396 0.0159
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.1694 0.1793
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.0687 0.0727
Echinococcus granulosus g-protein coupled receptor 0.0057 0.1694 0.1756
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0057 0.1694 0.1756
Schistosoma mansoni growth hormone secretagogue receptor 0.0057 0.1694 0.1793
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0057 0.1694 0.1756
Schistosoma mansoni hypothetical protein 0.0012 0.0042 0.0044
Brugia malayi hypothetical protein 0.0057 0.1694 0.1488
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0396 0.0045
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Schistosoma mansoni myosin xvIII 0.0057 0.1694 0.1793
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0355 0.0116
Onchocerca volvulus 0.0168 0.5749 0.523
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.2776 0.2939
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.1694 0.1756
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0057 0.1694 0.1756
Echinococcus multilocularis neuropeptide receptor A26 0.0057 0.1694 0.1756
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0057 0.1694 0.1756
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0269 0.9447 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.5017 0.529
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0057 0.1694 0.1793
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.1694 0.1756
Echinococcus granulosus neuropeptide receptor 0.0057 0.1694 0.1756
Brugia malayi larval opioid receptor 0.0057 0.1694 0.1488
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0087 0.2776 0.2386
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.1694 0.1756
Schistosoma mansoni biogenic amine receptor 0.0057 0.1694 0.1793
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0396 0.0377
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Brugia malayi hypothetical protein 0.0057 0.1694 0.1488
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Loa Loa (eye worm) hypothetical protein 0.0087 0.2776 0.2776
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0057 0.1694 0.1694
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.5017 0.529
Echinococcus multilocularis G-protein coupled receptor, putative 0.0057 0.1694 0.1756
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.1694 0.1793
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0057 0.1694 0.1488
Schistosoma mansoni adenoreceptor 0.0057 0.1694 0.1793
Schistosoma mansoni amine GPCR 0.0057 0.1694 0.1793
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0396 0.0419
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.2776 0.5
Loa Loa (eye worm) hypothetical protein 0.0152 0.5152 0.5152
Echinococcus granulosus neuropeptide FF receptor 2 0.0057 0.1694 0.1756
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.5017 0.5311
Loa Loa (eye worm) hypothetical protein 0.0181 0.6235 0.6235
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.0088 0.28 0.2689
Echinococcus multilocularis g protein coupled receptor 0.0057 0.1694 0.1756
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0057 0.1694 0.1756
Loa Loa (eye worm) hypothetical protein 0.0181 0.6235 0.6235
Schistosoma mansoni opsin-like receptor 0.0057 0.1694 0.1793
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.1694 0.1793
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.1694 0.1756
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0088 0.28 1
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0269 0.9447 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Echinococcus multilocularis neuropeptide receptor 0.0057 0.1694 0.1756
Brugia malayi hypothetical protein 0.0028 0.06 0.0367
Brugia malayi G protein-coupled receptor 0.0057 0.1694 0.1488
Echinococcus granulosus G protein coupled receptor 139 0.0057 0.1694 0.1756
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.1694 0.1756
Schistosoma mansoni DNA helicase recq5 0.0022 0.0396 0.0419
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.1694 0.1756
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0355 0.0376
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.1694 0.1756
Brugia malayi hypothetical protein 0.0057 0.1694 0.1488
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0687 0.0727
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0088 0.28 1
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.1694 0.1756
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0057 0.1678 0.1455
Brugia malayi Adenosine/AMP deaminase family protein 0.0269 0.9447 0.9433
Echinococcus multilocularis g protein coupled receptor 0.0057 0.1694 0.1756
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.5332 0.5624
Echinococcus multilocularis g-protein coupled receptor 0.0057 0.1694 0.1756
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0088 0.28 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.1694 0.1793
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.1694 0.1756
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.5017 0.529
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0396 0.0377
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.1694 0.1694
Echinococcus multilocularis allatostatin A receptor 0.0057 0.1694 0.1756
Echinococcus multilocularis orexin receptor type 2 0.0057 0.1694 0.1756
Brugia malayi hypothetical protein 0.0057 0.1694 0.1488
Trichomonas vaginalis adenosine deaminase, putative 0.0269 0.9447 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0396 0.0169
Echinococcus multilocularis fmrfamide receptor 0.0057 0.1694 0.1756
Trypanosoma cruzi AMP deaminase, putative 0.0088 0.28 1
Echinococcus granulosus peptidase Clp S14 family 0.0057 0.1678 0.174
Echinococcus granulosus tachykinin peptides receptor 99D 0.0057 0.1694 0.1756
Echinococcus multilocularis muscleblind protein 0.0152 0.5152 0.5434
Echinococcus granulosus peptide allatostatin:somatostatin 0.0057 0.1694 0.1756
Schistosoma mansoni DNA helicase recq1 0.0022 0.0396 0.0419
Brugia malayi GnHR receptor homolog 0.0057 0.1694 0.1488
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0396 0.0045
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.1694 0.1694
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0029 0.0656 0.0331
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0396 0.1415
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.1694 0.1756
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.1326 0.1068
Brugia malayi sulfakinin receptor protein 0.0057 0.1694 0.1488
Brugia malayi Dopamine receptor 0.0057 0.1694 0.1488
Schistosoma mansoni ap endonuclease 0.0021 0.0355 0.0376
Brugia malayi Melatonin receptor type 1A 0.0057 0.1694 0.1488
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0396 0.0045
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0355 0.0376
Loa Loa (eye worm) hypothetical protein 0.0011 0.00000000033317 0.00000000033317
Echinococcus granulosus g protein coupled receptor 0.0057 0.1694 0.1756
Loa Loa (eye worm) hypothetical protein 0.0057 0.1694 0.1694
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.2776 0.2939
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.5017 0.5311
Loa Loa (eye worm) hypothetical protein 0.0152 0.5152 0.5152
Echinococcus granulosus hypothetical protein 0.0057 0.1694 0.1756
Schistosoma mansoni opsin-like receptor 0.0057 0.1694 0.1793
Onchocerca volvulus 0.0088 0.28 0.1426
Schistosoma mansoni histamine h1 receptor 0.0057 0.1694 0.1793
Schistosoma mansoni hypothetical protein 0.0188 0.6497 0.6877

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 68 uM Inhibitory concentration required against human cytomegalovirus (HCMV) expressed in HFF cells was determined by plaque reduction assay ChEMBL. 15509176
IC50 (functional) > 100 uM Cytotoxicity produced in stationary HFF cells was determined by microscopic inspection of uninfected cells ChEMBL. 15509176

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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