Detailed information for compound 1187196

Basic information

Technical information
  • TDR Targets ID: 1187196
  • Name: [(2R,3S,4S,5R)-3,4,5-trihydroxyoxolan-2-yl]me thyl dihydrogen phosphate
  • MW: 230.11 | Formula: C5H11O8P
  • H donors: 5 H acceptors: 6 LogP: -3.62 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1[C@H](O)O[C@@H]([C@H]1O)COP(=O)(O)O
  • InChi: 1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4+,5-/m1/s1
  • InChiKey: KTVPXOYAKDPRHY-SQOUGZDYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [(2R,3S,4S,5R)-3,4,5-TRIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN PHOSPHATE
  • [(2R,3S,4S,5R)-3,4,5-trihydroxy-2-tetrahydrofuranyl]methyl dihydrogen phosphate
  • ABF
  • BETA-D-ARABINOFURANOSE-5'-PHOSPHATE

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi acetyltransferase, GNAT family protein 0.0309 0.0474 0.0473
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0082 0.0082
Brugia malayi Histone deacetylase 1 0.0062 0.0075 0.0075
Toxoplasma gondii histone lysine methyltransferase SET1 0.0187 0.0277 0.0324
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.5259 0.8439 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0067 0.0083 0.0098
Echinococcus multilocularis expressed conserved protein 0.0107 0.0149 0.0149
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0067 0.0083 0.0094
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0043 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0038
Brugia malayi F/Y-rich N-terminus family protein 0.0041 0.0041 0.0041
Brugia malayi thymidylate synthase 0.2263 0.3618 0.3618
Echinococcus granulosus snurportin 1 0.0969 0.1536 0.1536
Schistosoma mansoni histone deacetylase hda2 0.0018 0.0004 0.0003
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.2263 0.3618 0.3606
Plasmodium falciparum importin beta, putative 0.0091 0.0122 0.0144
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0082 0.0081
Echinococcus multilocularis Niemann Pick C1 protein 0.0163 0.0239 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0038
Brugia malayi hypothetical protein 0.1077 0.1709 0.1709
Echinococcus granulosus importin subunit beta 1 0.0091 0.0122 0.0122
Brugia malayi histone deacetylase 1 (HD1) 0.0062 0.0075 0.0075
Leishmania major histone deacetylase, putative 0.0018 0.0004 0.0001
Onchocerca volvulus 0.0093 0.0126 0.0338
Plasmodium vivax importin-beta 2, putative 0.0091 0.0122 0.0144
Schistosoma mansoni histone deacetylase hda2 0.0018 0.0004 0.0003
Schistosoma mansoni hypothetical protein 0.0051 0.0057 0.0056
Schistosoma mansoni hypothetical protein 0.0047 0.0052 0.0051
Echinococcus granulosus histone deacetylase 6 0.0018 0.0004 0.0004
Echinococcus multilocularis Smad4 0.0018 0.0005 0.0005
Schistosoma mansoni histone deacetylase 4 5 0.0018 0.0004 0.0003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0039 0.0039
Loa Loa (eye worm) beta-lactamase 0.0119 0.0167 0.0167
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0119 0.0167 0.016
Trichomonas vaginalis penicillin-binding protein, putative 0.0119 0.0167 0.0957
Loa Loa (eye worm) hypothetical protein 0.0114 0.016 0.016
Trichomonas vaginalis D-aminoacylase, putative 0.0119 0.0167 0.0957
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0024 0.0025
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0043 0.0043
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0969 0.1536 0.1535
Leishmania major hypothetical protein, conserved 0.0119 0.0167 0.0194
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0228 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0049 0.0055 0.0055
Mycobacterium tuberculosis Conserved protein 0.0119 0.0167 0.016
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.016 0.016
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0055 0.0055
Brugia malayi CHE-14 protein 0.0049 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.003 0.0024 0.0024
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0024 0.0025
Trichomonas vaginalis penicillin-binding protein, putative 0.0119 0.0167 0.0957
Onchocerca volvulus 0.0119 0.0167 0.045
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0075 0.0419
Brugia malayi histone deacetylase 11 0.0018 0.0004 0.0004
Leishmania major histone deacetylase, putative 0.0062 0.0075 0.0085
Onchocerca volvulus 0.0511 0.0799 0.2199
Brugia malayi beta-lactamase 0.0119 0.0167 0.0167
Schistosoma mansoni hypothetical protein 0.0715 0.1126 0.1125
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0074 0.0094 0.581
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.016 0.016
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.5259 0.8439 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.0286 0.0286
Leishmania major importin beta-1 subunit, putative 0.0074 0.0094 0.0108
Giardia lamblia Histone acetyltransferase GCN5 0.0083 0.011 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.002 0.0011
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0119 0.0167 0.0167
Plasmodium vivax histone deacetylase, putative 0.0018 0.0004 0.0004
Loa Loa (eye worm) histone deacetylase 11 0.0018 0.0004 0.0004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.001 0.0038
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0074 0.0094 0.0533
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0038
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0043 0.0043
Trypanosoma brucei importin beta-1 subunit, putative 0.0091 0.0122 0.014
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0067 0.0083 0.0083
Leishmania major GTP-binding protein, putative 0.0067 0.0083 0.0095
Loa Loa (eye worm) kap beta 3 protein 0.0017 0.0003 0.0003
Echinococcus granulosus geminin 0.0715 0.1126 0.1126
Trichomonas vaginalis importin beta-1, putative 0.0074 0.0094 0.0533
Brugia malayi beta-lactamase family protein 0.0119 0.0167 0.0167
Plasmodium falciparum transportin 0.0017 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0969 0.1536 0.1535
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0038
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0057 0.0057
Schistosoma mansoni ran 0.0067 0.0083 0.0082
Toxoplasma gondii histone deacetylase HDAC1 0.0018 0.0004 0.0001
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0067 0.0083 0.0083
Trypanosoma brucei histone deacetylase 1 0.0062 0.0075 0.0085
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0057 0.0064
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0044 0.0238
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.0286 0.0286
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.0044 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.002 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.0286 0.0286
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.0152 0.0152
Plasmodium falciparum histone acetyltransferase GCN5 0.0083 0.011 0.0129
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0044 0.0047
Loa Loa (eye worm) histone deacetylase 7A 0.0018 0.0004 0.0004
Schistosoma mansoni Smad4 0.0018 0.0005 0.0004
Schistosoma mansoni smad1 5 8 and 0.0018 0.0005 0.0004
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0057 0.0063
Plasmodium vivax hypothetical protein, conserved 0.0119 0.0167 0.0197
Schistosoma mansoni hypothetical protein 0.0047 0.0051 0.005
Brugia malayi PHD-finger family protein 0.003 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0062 0.0075 0.0075
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0062 0.0075 0.0419
Echinococcus multilocularis dnaJ subfamily B 0.1332 0.2119 0.2119
Trichomonas vaginalis ran, putative 0.0067 0.0083 0.0469
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Schistosoma mansoni smad1 5 8 and 0.0018 0.0005 0.0004
Plasmodium vivax transportin, putative 0.0017 0.0003 0.0003
Brugia malayi MH2 domain containing protein 0.0018 0.0005 0.0005
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0044 0.2599
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.016 0.016
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0758 0.1195 0.1189
Echinococcus granulosus histone deacetylase 8 0.0018 0.0004 0.0004
Echinococcus granulosus importin 5 0.0017 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0119 0.0167 0.0193
Loa Loa (eye worm) hypothetical protein 0.0119 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0057 0.0068 0.0068
Entamoeba histolytica hypothetical protein 0.0039 0.0039 0.2263
Echinococcus granulosus microtubule associated protein 2 0.2121 0.3389 0.3389
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0005 0.0005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.006 0.0073 0.0072
Brugia malayi Bromodomain containing protein 0.0038 0.0036 0.0036
Leishmania major dihydrofolate reductase-thymidylate synthase 0.5259 0.8439 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0082 0.0094
Loa Loa (eye worm) hypothetical protein 0.0119 0.0167 0.0167
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0057 0.0064
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0044 0.0048
Schistosoma mansoni histone deacetylase 1 2 3 0.0018 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0052 0.0059 0.0059
Echinococcus granulosus expressed conserved protein 0.0107 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0109 0.0152 0.0152
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0044 0.0238
Toxoplasma gondii histone deacetylase HDAC5 0.0018 0.0004 0.0001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0119 0.0167 0.0167
Schistosoma mansoni ran 0.0067 0.0083 0.0082
Toxoplasma gondii HEAT repeat-containing protein 0.0091 0.0122 0.014
Schistosoma mansoni hypothetical protein 0.0047 0.0052 0.0051
Loa Loa (eye worm) acetyltransferase 0.0309 0.0474 0.0473
Brugia malayi CXXC zinc finger family protein 0.0093 0.0126 0.0126
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0075 0.0419
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0038
Echinococcus granulosus dnaJ subfamily B 0.1332 0.2119 0.2119
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2665 0.4265 0.4265
Echinococcus granulosus histone deacetylase 0.0018 0.0004 0.0004
Loa Loa (eye worm) transcription factor SMAD2 0.0265 0.0402 0.0402
Schistosoma mansoni importin-beta 2 0.0017 0.0003 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0055 0.0301
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0119 0.0167 0.016
Trypanosoma brucei histone deacetylase 2 0.0018 0.0004 0.0001
Echinococcus multilocularis protein patched 0.0049 0.0055 0.0055
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Echinococcus granulosus histone deacetylase 3 0.0062 0.0075 0.0075
Echinococcus granulosus histone acetyltransferase KAT2B 0.0091 0.0122 0.0122
Echinococcus multilocularis neuropeptide receptor 0.0108 0.015 0.015
Loa Loa (eye worm) thymidylate synthase 0.2263 0.3618 0.3618
Echinococcus granulosus histone deacetylase 7 0.0018 0.0004 0.0004
Echinococcus granulosus GTP binding nuclear protein Ran 0.0067 0.0083 0.0083
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0119 0.0167 0.0166
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0076 0.0075
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0017 0.0017
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0026 0.0017 0.0017
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0134 0.0134
Entamoeba histolytica histone deacetylase, putative 0.0062 0.0075 0.4575
Echinococcus multilocularis histone deacetylase 8 0.0018 0.0004 0.0004
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0024 0.0024
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0338 0.052 0.0519
Echinococcus multilocularis beta LACTamase domain containing family member 0.0119 0.0167 0.0167
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.002 0.002
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0075 0.0419
Echinococcus granulosus histone acetyltransferase KAT2B 0.0301 0.046 0.046
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.1077 0.1709 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.002 0.0011
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0091 0.0122 0.0696
Onchocerca volvulus Alhambra homolog 0.003 0.0024 0.0056
Echinococcus granulosus Niemann Pick C1 protein 0.0163 0.0239 0.0239
Mycobacterium ulcerans thymidylate synthase 0.2263 0.3618 0.3613
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0067 0.0083 0.0083
Giardia lamblia Histone deacetylase 0.0062 0.0075 0.5921
Trypanosoma brucei histone deacetylase 4 0.0018 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0229 0.0344 0.0344
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0038
Brugia malayi Importin beta-1 subunit 0.0091 0.0122 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0038
Schistosoma mansoni hypothetical protein 0.003 0.0024 0.0023
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0057 0.0057
Echinococcus granulosus beta LACTamase domain containing family member 0.0119 0.0167 0.0167
Toxoplasma gondii histone deacetylase HDAC2 0.0062 0.0075 0.0085
Schistosoma mansoni hypothetical protein 0.0023 0.0012 0.0011
Mycobacterium ulcerans hypothetical protein 0.0119 0.0167 0.0158
Schistosoma mansoni ap endonuclease 0.0042 0.0044 0.0043
Plasmodium falciparum histone deacetylase 1 0.0062 0.0075 0.0088
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.5259 0.8439 1
Plasmodium falciparum histone deacetylase 2 0.0018 0.0004 0.0004
Leishmania major histone deacetylase, putative 0.0018 0.0004 0.0001
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0012 0.0012
Brugia malayi Pre-SET motif family protein 0.045 0.0699 0.0699
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.0286 0.0285
Loa Loa (eye worm) hypothetical protein 0.0119 0.0167 0.0167
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0051 0.0057 0.0056
Mycobacterium ulcerans esterase/lipase LipP 0.0119 0.0167 0.0158
Echinococcus multilocularis histone deacetylase 6 0.0018 0.0004 0.0004
Echinococcus granulosus GPCR family 2 0.0051 0.0057 0.0057
Echinococcus granulosus histone deacetylase 6 0.0018 0.0004 0.0004
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0309 0.0474 0.0472
Schistosoma mansoni hypothetical protein 0.0039 0.0039 0.0038
Brugia malayi Histone deacetylase family protein 0.0018 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0047 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Mycobacterium leprae Probable lipase LipE 0.0119 0.0167 0.0147
Echinococcus multilocularis snurportin 1 0.0969 0.1536 0.1536
Brugia malayi AMP-binding enzyme family protein 0.0028 0.002 0.002
Echinococcus granulosus peregrin 0.0038 0.0036 0.0036
Echinococcus granulosus translational activator gcn1 0.0017 0.0003 0.0003
Echinococcus multilocularis histone deacetylase 6 0.0018 0.0004 0.0004
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0102 0.01
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0039 0.0038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0201 0.0299 0.0298
Leishmania major hypothetical protein, conserved 0.0051 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.0091 0.0122 0.0122
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0051 0.0051
Loa Loa (eye worm) importin-beta domain-containing protein 0.0017 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.016 0.0233 0.0233
Echinococcus multilocularis cpg binding protein 0.0099 0.0135 0.0135
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0009 0.001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0074 0.0094 0.0533
Brugia malayi MH1 domain containing protein 0.0018 0.0005 0.0005
Brugia malayi Pre-SET motif family protein 0.0066 0.0082 0.0082
Echinococcus multilocularis GPCR, family 2 0.0051 0.0057 0.0057
Brugia malayi hypothetical protein 0.0033 0.0028 0.0028
Mycobacterium tuberculosis Probable lipase LipE 0.0119 0.0167 0.016
Mycobacterium ulcerans lipase LipD 0.0119 0.0167 0.0158
Loa Loa (eye worm) CXXC zinc finger family protein 0.0093 0.0126 0.0126
Echinococcus multilocularis histone deacetylase 0.0018 0.0004 0.0004
Echinococcus multilocularis geminin 0.0715 0.1126 0.1126
Echinococcus granulosus histone deacetylase 1 0.0062 0.0075 0.0075
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0005 0.0005
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0044 0.0044
Mycobacterium tuberculosis Probable esterase LipL 0.0119 0.0167 0.016
Echinococcus granulosus mixed lineage leukemia protein mll 0.0026 0.0017 0.0017
Schistosoma mansoni cpg binding protein 0.0099 0.0135 0.0134
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.0721 0.0721
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0057 0.0067
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0075 0.0075
Brugia malayi MH2 domain containing protein 0.0265 0.0402 0.0402
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0057 0.0057
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0119 0.0167 0.0158
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.002 0.0011
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0043 0.0043
Schistosoma mansoni cpg binding protein 0.0093 0.0126 0.0125
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.002 0.0011
Mycobacterium ulcerans hypothetical protein 0.0028 0.002 0.0011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0119 0.0167 0.0166
Echinococcus multilocularis histone deacetylase 3 0.0062 0.0075 0.0075
Echinococcus multilocularis peregrin 0.0038 0.0036 0.0036
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.1077 0.1709 0.2021
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0082 0.0082
Loa Loa (eye worm) histone deacetylase 0.0018 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0715 0.1126 0.1125
Entamoeba histolytica Ran family GTPase 0.0067 0.0083 0.511
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0067 0.0083 0.0094
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.002 0.1066
Loa Loa (eye worm) hypothetical protein 0.0051 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0051 0.0057 0.0056
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0091 0.0122 0.0141
Echinococcus multilocularis smad 0.0018 0.0005 0.0005
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0024 0.0024
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0057 0.0063
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.016 1
Brugia malayi jmjC domain containing protein 0.0098 0.0134 0.0134
Schistosoma mansoni smad1 5 8 and 0.0018 0.0005 0.0004
Schistosoma mansoni hypothetical protein 0.0051 0.0057 0.0056
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.0344 0.0344
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0038
Loa Loa (eye worm) histone deacetylase 3 0.0062 0.0075 0.0075
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0005 0.0005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0044 0.0047
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0066 0.0082 0.0082
Echinococcus multilocularis microtubule associated protein 2 0.2121 0.3389 0.3389
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.5259 0.8439 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.045 0.0699 0.0699
Echinococcus granulosus thymidylate synthase 0.2263 0.3618 0.3618
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0082 0.0081
Echinococcus multilocularis importin subunit beta 1 0.0091 0.0122 0.0122
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0193 0.0286 0.0286
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0091 0.0122 0.0141
Toxoplasma gondii exonuclease III APE 0.0042 0.0044 0.0048
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0068 0.0067
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0119 0.0167 0.016
Brugia malayi RNA, U transporter 1 0.0258 0.0391 0.0391
Plasmodium falciparum histone deacetylase, putative 0.0018 0.0004 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0028 0.002 0.002
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.2263 0.3618 0.3618
Entamoeba histolytica acetyltransferase, GNAT family 0.0083 0.011 0.6814
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0047 0.0052 0.0051
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.0721 0.0721
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Plasmodium vivax hypothetical protein, conserved 0.003 0.0024 0.0028
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.002 0.0011
Brugia malayi kap beta 3 protein 0.0017 0.0003 0.0003
Brugia malayi jmjC domain containing protein 0.0042 0.0043 0.0043
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0044 0.0044
Onchocerca volvulus 0.0119 0.0167 0.045
Brugia malayi histone deacetylase 3 (HD3) 0.0062 0.0075 0.0075
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0044 0.2321
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.0286 0.0286
Mycobacterium ulcerans beta-lactamase 0.0119 0.0167 0.0158
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0024 0.0023
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0228 0.0344 0.0344
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0075 0.0419
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0004
Echinococcus multilocularis G protein coupled receptor 139 0.0108 0.015 0.015
Schistosoma mansoni hypothetical protein 0.0109 0.0152 0.0151
Plasmodium vivax histone deacetylase 2, putative 0.0018 0.0004 0.0004
Onchocerca volvulus 0.0057 0.0068 0.0177
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0009 0.0002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0119 0.0167 0.0167
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0134 0.0134
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0082 0.0081
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.002 0.002
Schistosoma mansoni histone deacetylase 0.0062 0.0075 0.0074
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0038
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0039 0.0039
Echinococcus multilocularis transportin 1 0.0017 0.0003 0.0003
Brugia malayi hypothetical protein 0.0039 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0051 0.0057 0.0057
Schistosoma mansoni importin beta-1 0.0091 0.0122 0.0121
Echinococcus granulosus neuropeptide s receptor 0.0463 0.0721 0.0721
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0067 0.0083 0.0098
Trypanosoma cruzi histone deacetylase 1, putative 0.0062 0.0075 0.0084
Entamoeba histolytica hypothetical protein 0.0039 0.0039 0.2263
Trichomonas vaginalis set domain proteins, putative 0.0511 0.0799 0.4664
Toxoplasma gondii histone deacetylase HDAC3 0.0062 0.0075 0.0085
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.002 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0028 0.002 0.002
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0044 0.0051
Mycobacterium tuberculosis Probable lipase LipD 0.0119 0.0167 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0119 0.0167 0.0193
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0005 0.0005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0026 0.0026
Trichomonas vaginalis D-aminoacylase, putative 0.0119 0.0167 0.0957
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0309 0.0474 0.0474
Loa Loa (eye worm) histone deacetylase 1 0.0062 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0119 0.0167 0.0167
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0082 0.0081
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0075 0.0419
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.5259 0.8439 1
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.0344 0.0344
Trypanosoma brucei histone deacetylase, putative 0.0018 0.0004 0.0001
Echinococcus granulosus smad 0.0018 0.0005 0.0005
Onchocerca volvulus 0.0028 0.002 0.0044
Trichomonas vaginalis helicase, putative 0.0021 0.001 0.0038
Echinococcus multilocularis histone deacetylase 7 0.0018 0.0004 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.002 0.0013
Echinococcus multilocularis translational activator gcn1 0.0017 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Trichomonas vaginalis esterase, putative 0.0119 0.0167 0.0957
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0044 0.0048
Schistosoma mansoni microtubule-associated protein tau 0.2121 0.3389 0.3388
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.002 0.0013
Plasmodium vivax histone deacetylase 1, putative 0.0062 0.0075 0.0088
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0067 0.0083 0.0095
Schistosoma mansoni cpg binding protein 0.0099 0.0135 0.0134
Plasmodium vivax SET domain protein, putative 0.0066 0.0082 0.0097
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0338 0.052 0.0519
Echinococcus granulosus histone deacetylase 6 0.0018 0.0004 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.0286 0.0285
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0012 0.0012
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0044 0.0044
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0062 0.0075 0.0419
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0038
Trichomonas vaginalis bromodomain-containing protein, putative 0.0091 0.0122 0.0696
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0055 0.0055
Brugia malayi MH1 domain containing protein 0.0018 0.0005 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0057 0.0067
Leishmania major histone deacetylase, putative 0.0062 0.0075 0.0085
Loa Loa (eye worm) histone methyltransferase 0.0031 0.0026 0.0026
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.001 0.0038
Mycobacterium tuberculosis Hypothetical protein 0.1077 0.1709 0.1703
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.002 0.0011
Trypanosoma cruzi histone deacetylase 1, putative 0.0062 0.0075 0.0084
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0038
Schistosoma mansoni ap endonuclease 0.0042 0.0044 0.0043
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0044 0.5
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0005 0.0005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0193 0.0286 0.0286
Entamoeba histolytica hypothetical protein 0.0039 0.0039 0.2263
Echinococcus multilocularis histone deacetylase 6 0.0018 0.0004 0.0004
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.0721 0.0721
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0082 0.0082
Echinococcus multilocularis thymidylate synthase 0.2263 0.3618 0.3618
Schistosoma mansoni neuropeptide receptor 0.0108 0.015 0.0149
Schistosoma mansoni histone deacetylase 4 5 0.0018 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0119 0.0167 0.0167
Schistosoma mansoni smad 0.0018 0.0005 0.0004
Schistosoma mansoni hypothetical protein 0.1332 0.2119 0.2118
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0043 0.0043
Brugia malayi beta-lactamase family protein 0.0119 0.0167 0.0167
Onchocerca volvulus 0.2263 0.3618 1
Echinococcus multilocularis tumor protein p63 0.0392 0.0607 0.0607
Schistosoma mansoni patched 1 0.0049 0.0055 0.0054
Echinococcus granulosus Smad4 0.0018 0.0005 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0057 0.0067
Echinococcus multilocularis histone deacetylase 1 0.0062 0.0075 0.0075
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0038
Echinococcus multilocularis protein dispatched 1 0.0056 0.0066 0.0066
Echinococcus granulosus tumor protein p63 0.0392 0.0607 0.0607
Schistosoma mansoni histone deacetylase 0.0062 0.0075 0.0074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.0286 0.0285
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.002 0.1066
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Mycobacterium tuberculosis Conserved protein 0.0119 0.0167 0.016
Brugia malayi Calcitonin receptor-like protein seb-1 0.016 0.0233 0.0233
Echinococcus granulosus cpg binding protein 0.0099 0.0135 0.0135
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0067 0.0083 0.6896
Onchocerca volvulus 0.0047 0.0051 0.013
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0044 0.0035
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0067 0.0083 0.0095
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0044 0.0051
Toxoplasma gondii histone deacetylase HDAC4 0.0018 0.0004 0.0001
Brugia malayi MH2 domain containing protein 0.0018 0.0005 0.0005
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.0044 0.0037
Echinococcus granulosus transportin 1 0.0017 0.0003 0.0003
Loa Loa (eye worm) Smad1 0.0018 0.0005 0.0005
Onchocerca volvulus 0.0066 0.0082 0.0217
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0091 0.0122 0.0144
Trypanosoma brucei importin beta-1 subunit, putative 0.0091 0.0122 0.014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0035 0.0033 0.0032
Trypanosoma brucei hypothetical protein, conserved 0.0119 0.0167 0.0194
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.2263 0.3618 0.3614
Plasmodium falciparum phd finger protein, putative 0.003 0.0024 0.0028
Mycobacterium tuberculosis Probable hydrolase 0.0119 0.0167 0.016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.002 0.1066
Brugia malayi Smad1 0.0018 0.0005 0.0005
Schistosoma mansoni survival motor neuron protein 0.0047 0.0051 0.005
Brugia malayi hypothetical protein 0.0051 0.0057 0.0057
Brugia malayi Histone deacetylase family protein 0.0018 0.0004 0.0004
Mycobacterium leprae conserved hypothetical protein 0.0119 0.0167 0.0147
Entamoeba histolytica hypothetical protein 0.0039 0.0039 0.2263
Onchocerca volvulus 0.0119 0.0167 0.045
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0062 0.0075 0.0419
Echinococcus granulosus neuropeptide receptor 0.0108 0.015 0.015
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0075 0.0419
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0009 0.001
Mycobacterium tuberculosis Conserved protein 0.0119 0.0167 0.016
Trichomonas vaginalis D-aminoacylase, putative 0.0119 0.0167 0.0957
Brugia malayi hypothetical protein 0.0229 0.0344 0.0344
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0005 0.0005
Trypanosoma cruzi importin beta-1 subunit, putative 0.0074 0.0094 0.0107
Loa Loa (eye worm) MH2 domain-containing protein 0.0265 0.0402 0.0402
Echinococcus multilocularis importin 5 0.0017 0.0003 0.0003
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0044 0.0044
Toxoplasma gondii ABC1 family protein 0.0119 0.0167 0.0194
Plasmodium vivax histone deacetylase, putative 0.0018 0.0004 0.0004
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0116 0.0163 0.0161
Trypanosoma brucei histone deacetylase 3 0.0018 0.0004 0.0001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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