Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0115 | 0.0115 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.4555 | 0.6187 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.0201 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.0201 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0115 | 0.0115 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0201 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0115 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0115 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0122 | 0.4555 | 0.6187 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0201 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0115 | 0.0115 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0115 | 1 |
Brugia malayi | Inositol-1 | 0.0037 | 0.0201 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.7292 | 1 |
Onchocerca volvulus | 0.0036 | 0.0115 | 0.5 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0143 | 0.5596 | 0.7638 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.0201 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.7292 | 1 |
Echinococcus granulosus | geminin | 0.0176 | 0.7292 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.4555 | 0.6187 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0201 | 0.0121 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0201 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.0201 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0115 | 0.0115 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0201 | 1 |
Echinococcus multilocularis | geminin | 0.0176 | 0.7292 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0115 | 0.0115 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0143 | 0.5596 | 0.7638 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0115 | 0.0115 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0115 | 0.0115 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0201 | 0.0121 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.0201 | 0.5 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0115 | 0.0115 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.0201 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.0201 | 0.0121 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0201 | 1 |
Onchocerca volvulus | 0.0036 | 0.0115 | 0.5 | |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0115 | 0.0115 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0201 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0143 | 0.5596 | 0.7638 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0115 | 0.0115 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.0201 | 0.0121 |
Onchocerca volvulus | 0.0036 | 0.0115 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug uptake (ADMET) | = 0.3 ug ml-1 | Drug level in C57Bl6 mouse plasma at 100 mg/kg, po after 2 hrs by UV-reverse phase HPLC analysis | ChEMBL. | 20583844 |
Drug uptake (ADMET) | = 0.5 ug ml-1 | Drug level in C57Bl6 mouse plasma at 10 mg/kg, iv after 30 mins by UV-reverse phase HPLC analysis | ChEMBL. | 20583844 |
Drug uptake (ADMET) | = 1.7 ug ml-1 | Drug level in C57Bl6 mouse plasma at 100 mg/kg, po after 1 hr by UV-reverse phase HPLC analysis | ChEMBL. | 20583844 |
Drug uptake (ADMET) | = 6.2 ug ml-1 | Drug level in C57Bl6 mouse plasma at 10 mg/kg, iv after 5 mins by UV-reverse phase HPLC analysis | ChEMBL. | 20583844 |
Drug uptake (ADMET) | = 34 ug ml-1 | Drug level in C57Bl6 mouse plasma at 10 mg/kg, po after 2 hrs by UV-reverse phase HPLC analysis | ChEMBL. | 20583844 |
Drug uptake (ADMET) | = 42 ug ml-1 | Drug level in C57Bl6 mouse plasma at 10 mg/kg, po after 1 hr by UV-reverse phase HPLC analysis | ChEMBL. | 20583844 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.