Detailed information for compound 1187374

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 234.316 | Formula: C9H18N2O3S
  • H donors: 0 H acceptors: 3 LogP: 0.13 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCS(=O)(=O)N1CCCN(C1)C(=O)C
  • InChi: 1S/C9H18N2O3S/c1-3-7-15(13,14)11-6-4-5-10(8-11)9(2)12/h3-8H2,1-2H3
  • InChiKey: IHHYYKCEKWGEIR-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax P-type ATPase4, putative 0.0009 0.0028 0.0096
Echinococcus multilocularis pyruvate kinase 0.0034 0.0944 0.1584
Plasmodium vivax JmjC domain containing protein 0.0016 0.0287 0.098
Schistosoma mansoni hypothetical protein 0.0084 0.2783 0.2783
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0028 0.0047
Schistosoma mansoni hypothetical protein 0.0084 0.2783 0.2783
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0814 0.0814
Giardia lamblia Phospholipid-transporting ATPase IA, putative 0.0009 0.0028 0.0088
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.082 0.255
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0009 0.0028 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0079 0.008
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.596 0.6039
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0287 0.0892
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.082 0.2803
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0028 0.0029
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0426 0.1455
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.3217 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.1092 0.1106
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0573 0.1959
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0009 0.0028 0.0096
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0944 0.0957
Brugia malayi jmjC domain containing protein 0.006 0.1891 0.1916
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0009 0.0028 0.0029
Mycobacterium tuberculosis Probable reductase 0.0201 0.7055 0.8958
Trypanosoma brucei cation-transporting ATPase, putative 0.0009 0.0028 0.0088
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0221 0.0686
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.1962 0.3291
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0079 0.0079
Brugia malayi steroid hormone receptor 0.001 0.0079 0.008
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0426 0.0714
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.082 0.0831
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0079 0.0133
Onchocerca volvulus 0.0241 0.8513 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0426 0.0431
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.082 0.255
Loa Loa (eye worm) hypothetical protein 0.0018 0.0362 0.0367
Schistosoma mansoni eyes absent homolog 0.0092 0.3088 0.3088
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0944 0.1109
Trichomonas vaginalis mercuric reductase, putative 0.003 0.082 0.0831
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0028 0.0088
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0585 0.0593
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0079 0.0133
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1962 0.1988
Echinococcus multilocularis pyruvate kinase 0.0017 0.034 0.0571
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0028 0.0029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.082 0.255
Loa Loa (eye worm) apoptosis regulator protein 0.0084 0.2783 0.282
Plasmodium falciparum pyruvate kinase 0.0034 0.0944 0.3227
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0084 0.2783 0.467
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.008
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0028 0.0029
Echinococcus multilocularis copper transporting ATPase 1 0.0009 0.0028 0.0047
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.031 0.0965
Plasmodium vivax thioredoxin reductase, putative 0.0088 0.2926 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0426 0.0431
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.031 0.0965
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0079 0.0133
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.1092 0.1832
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0221 0.0259
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.031 0.0314
Schistosoma mansoni nuclear hormone receptor 0.001 0.0079 0.0079
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0524 0.0531
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0029
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0009 0.0028 0.0088
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0221 0.0686
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.3217 0.3259
Plasmodium falciparum glutathione reductase 0.0088 0.2926 1
Brugia malayi jmjC domain containing protein 0.006 0.1891 0.1916
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0426 0.0714
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0524 0.0531
Schistosoma mansoni apoptosis regulator bax 0.0084 0.2783 0.2783
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0573 0.1959
Brugia malayi Isocitrate dehydrogenase 0.0017 0.031 0.0314
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.1962 0.6099
Echinococcus multilocularis pyruvate kinase 0.0027 0.0683 0.1146
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0079 0.008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0079 0.008
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0079 0.0133
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0362 0.3838
Onchocerca volvulus 0.003 0.0814 0.0956
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0009 0.0028 0.0047
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0009 0.0028 0.0088
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0287 0.098
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.082 0.082
Loa Loa (eye worm) glutaminase 2 0.0278 0.987 1
Mycobacterium tuberculosis Cation transporter P-type ATPase a CtpA 0.0009 0.0028 0.0036
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase CtpV 0.0009 0.0028 0.0036
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.082 0.1376
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.1962 0.3291
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0079 0.0133
Loa Loa (eye worm) hypothetical protein 0.0024 0.0585 0.0593
Brugia malayi ecdysteroid receptor 0.001 0.0079 0.008
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0009 0.0028 0.0096
Loa Loa (eye worm) hypothetical protein 0.0084 0.2783 0.282
Schistosoma mansoni ap endonuclease 0.002 0.0426 0.0426
Trypanosoma brucei trypanothione reductase 0.0088 0.2926 0.9097
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0084 0.2783 0.467
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.1092 0.3395
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0079 0.008
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.1891 0.3172
Brugia malayi nuclear hormone receptor 0.001 0.0079 0.008
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.082 0.2803
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0079 0.0079
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0223 0.7875 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0944 0.1109
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0084 0.2783 0.467
Leishmania major proton motive ATPase, putative 0.0009 0.0028 0.0088
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.596 1
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.0009 0.0028 0.0088
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0944 0.0957
Brugia malayi hypothetical protein 0.0092 0.3088 0.3128
Loa Loa (eye worm) glutaminase 0.0278 0.987 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0084 0.2783 0.467
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.082 0.255
Loa Loa (eye worm) hypothetical protein 0.003 0.0814 0.0824
Brugia malayi Pre-SET motif family protein 0.0211 0.7444 0.7542
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.034 0.1163
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0585 0.0593
Leishmania major pyruvate kinase 0.0034 0.0944 0.2935
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0362 0.1238
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.031 0.0521
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0814 0.0814
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0326 0.0414
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0573 0.1959
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0009 0.0028 0.0029
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0079 0.0133
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0287 0.098
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0585 0.182
Loa Loa (eye worm) E1-E2 ATPase 0.0009 0.0028 0.0029
Trichomonas vaginalis glutaminase, putative 0.0278 0.987 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.1092 0.1106
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.082 0.255
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.031 0.106
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.3217 0.3778
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0079 0.0133
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0009 0.0028 0.0047
Schistosoma mansoni alpha glucosidase 0.0038 0.1092 0.1092
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.1443 0.1462
Leishmania major hypothetical protein, conserved 0.0016 0.0287 0.0892
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0585 0.182
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0079 0.008
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0028 0.0028
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.1092 0.1106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0079 0.008
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0084 0.2783 0.282
Loa Loa (eye worm) hypothetical protein 0.0014 0.0221 0.0224
Giardia lamblia Pyruvate kinase 0.0034 0.0944 0.2935
Leishmania major P-type H -ATPase, putative 0.0009 0.0028 0.0088
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0009 0.0028 0.0088
Onchocerca volvulus 0.0024 0.0585 0.0688
Schistosoma mansoni alpha-glucosidase 0.0147 0.5089 0.5089
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0079 0.0093
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.082 0.255
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0573 0.0728
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0426 0.0541
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0009 0.0028 0.0047
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.3217 0.5397
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0814 0.0814
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.1092 0.3732
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0028 0.0029
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.082 0.255
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0028 0.0088
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.596 0.6039
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.1092 0.1106
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0079 0.0079
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.031 0.106
Loa Loa (eye worm) hypothetical protein 0.0084 0.2796 0.2832
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0079 0.0133
Plasmodium vivax copper-transporting ATPase, putative 0.0009 0.0028 0.0096
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0029
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0287 0.0481
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0028 0.0028
Echinococcus multilocularis pyruvate kinase 0.0017 0.034 0.0571
Mycobacterium ulcerans cation transporter p-type ATPase D CtpD 0.0009 0.0028 0.0029
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0009 0.0028 0.0029
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0079 0.0093
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.008
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0585 0.182
Toxoplasma gondii P-type ATPase4, putative 0.0009 0.0028 0.0096
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.3217 0.3259
Loa Loa (eye worm) thioredoxin reductase 0.0088 0.2926 0.2965
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0221 0.0686
Echinococcus granulosus phd:f box containing protein 0.0016 0.0287 0.0481
Schistosoma mansoni hypothetical protein 0.0084 0.2783 0.2783
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0221 0.0224
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0201 0.7055 0.8958
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0079 0.008
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0079 0.0079
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0079 0.0133
Treponema pallidum cation-transporting ATPase, P-type 0.0009 0.0028 0.0343
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0009 0.0028 0.0029
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0221 0.0224
Echinococcus granulosus copper transporting ATPase 1 0.0009 0.0028 0.0047
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.1962 0.6704
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.082 0.2803
Leishmania major P-type H -ATPase, putative 0.0009 0.0028 0.0088
Mycobacterium ulcerans glutaminase 0.0278 0.987 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0362 0.0367
Trypanosoma cruzi cation-transporting ATPase, putative 0.0009 0.0028 0.0088
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.2796 0.2832
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0079 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.1092 0.3395
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0028 0.0088
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.082 0.255
Echinococcus multilocularis thioredoxin glutathione reductase 0.0089 0.2945 0.4941
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0573 0.0581
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0009 0.0028 0.0047
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.082 0.255
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.1891 0.3172
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0009 0.0028 0.0096
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.1092 0.1106
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1962 0.1988
Brugia malayi nuclear receptor NHR-88 0.001 0.0079 0.008
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0426 0.1455
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.1092 0.1106
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0009 0.0028 0.0029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.082 0.255
Plasmodium falciparum thioredoxin reductase 0.003 0.082 0.2803
Loa Loa (eye worm) hypothetical protein 0.0018 0.0362 0.0367
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0362 0.1238
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0079 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0079 0.008
Leishmania major trypanothione reductase 0.0088 0.2926 0.9097
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0221 0.0224
Schistosoma mansoni atpase class VI type 11c 0.0009 0.0028 0.0028
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0223 0.7875 1
Plasmodium falciparum copper-transporting ATPase 0.0009 0.0028 0.0096
Schistosoma mansoni thyroid hormone receptor 0.001 0.0079 0.0079
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0201 0.7055 0.8958
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0814 0.1365
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.3217 0.3259
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.008
Toxoplasma gondii P-type ATPase PMA1 0.0009 0.0028 0.0096
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0084 0.2783 0.2783
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0944 0.2935
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0585 0.0593
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.1891 0.1891
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0079 0.008
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0009 0.0028 0.0088
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0079 0.0079
Brugia malayi jmjC domain containing protein 0.0016 0.0287 0.0291
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.082 0.8688
Mycobacterium tuberculosis Probable dehydrogenase 0.0201 0.7055 0.8958
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0028 0.0029
Mycobacterium tuberculosis Probable oxidoreductase 0.0223 0.7875 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0944 0.0957
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0079 0.008
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0426 0.1324
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0028 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0585 0.0593
Echinococcus granulosus cation transporting ATPase 13A3 0.0009 0.0028 0.0047
Mycobacterium ulcerans cation transporter p-type ATPase a CtpA 0.0009 0.0028 0.0029
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0287 0.0481
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0585 0.182
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0326 0.0414
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0079 0.0093
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1962 0.1988
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0585 0.0593
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.031 0.0521
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0287 0.0481
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0079 0.008
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0287 0.0481
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.1092 0.1106
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0009 0.0028 0.0047
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.3217 0.3259
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0287 0.0287
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0221 0.0224
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0028 0.0047
Giardia lamblia Pyruvate kinase 0.0017 0.034 0.1058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0814 0.0814
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.3217 0.3259
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0573 0.6988
Echinococcus granulosus cation transporting ATPase 13A1 0.0009 0.0028 0.0047
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0009 0.0028 0.0088
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0028 0.0047
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.031 0.0965
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.1092 0.1106
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0944 0.1109
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.082 1
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0028 0.0088
Toxoplasma gondii thioredoxin reductase 0.0088 0.2926 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0028 0.0029
Mycobacterium ulcerans metal cation transporter p-type ATPase, CtpV 0.0009 0.0028 0.0029
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.082 0.2803
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0028 0.0047
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0569 0.1768
Onchocerca volvulus 0.001 0.0079 0.0093
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0009 0.0028 0.0088
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0028 0.0088
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.2796 0.469
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.1962 0.2491
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0287 0.098
Brugia malayi jmjC domain containing protein 0.0016 0.0287 0.0291
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0028 0.0047
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.031 0.0965
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0028 0.0088
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0079 0.0133
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0585 0.0593
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0223 0.7875 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0079 0.0133
Loa Loa (eye worm) glutathione reductase 0.0088 0.2926 0.2965
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0426 0.5191
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0287 0.0892
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0009 0.0028 0.0088
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0028 0.0088
Treponema pallidum NADH oxidase 0.003 0.082 1
Schistosoma mansoni phosphoserine phosphatase 0.0009 0.0028 0.0028
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0287 0.0481
Schistosoma mansoni ATPase 0.0009 0.0028 0.0028
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0287 0.0481
Loa Loa (eye worm) hypothetical protein 0.0092 0.3088 0.3128
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.082 0.0831
Loa Loa (eye worm) hypothetical protein 0.0024 0.0569 0.0576
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0221 0.0224
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0944 0.0957
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0009 0.0028 0.0029
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0028 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.008
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.082 0.2803
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0009 0.0028 0.0096
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0079 0.0133
Giardia lamblia Copper-transporting P-type ATPase 0.0009 0.0028 0.0088
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0201 0.7055 0.8958
Leishmania major calcium-translocating P-type ATPase 0.0009 0.0028 0.0088
Plasmodium vivax calcium-transporting ATPase, putative 0.0009 0.0028 0.0096
Brugia malayi Thioredoxin reductase 0.0088 0.2926 0.2965
Mycobacterium tuberculosis Probable metal cation transporter ATPase P-type CtpE 0.0009 0.0028 0.0036
Trypanosoma cruzi copper-transporting ATPase, putative 0.0009 0.0028 0.0088
Echinococcus multilocularis cation transporting atpase worm 0.0009 0.0028 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0287 0.0291
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.3217 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0221 0.0686
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.3217 0.3259
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0944 0.1199
Mycobacterium ulcerans hypothetical protein 0.0024 0.0585 0.0593
Mycobacterium tuberculosis Probable cation transporter P-type ATPase D CtpD 0.0009 0.0028 0.0036
Schistosoma mansoni coup transcription factor 0.001 0.0079 0.0079
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0573 0.1782
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0287 0.0291
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.1891 0.1891
Trypanosoma brucei P-type H+-ATPase, putative 0.0009 0.0028 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0079 0.008
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0028 0.0047
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0944 0.2935
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.082 0.255
Echinococcus multilocularis cation transporting ATPase 13A3 0.0009 0.0028 0.0047
Brugia malayi Na,K-ATPase alpha subunit 0.0009 0.0028 0.0029
Trichomonas vaginalis glutathione reductase, putative 0.003 0.082 0.0831
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0573 0.1959
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.082 0.2803
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0009 0.0028 0.0088
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0079 0.0133
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0009 0.0028 0.0029
Loa Loa (eye worm) hypothetical protein 0.0092 0.3088 0.3128
Loa Loa (eye worm) hypothetical protein 0.0018 0.0362 0.0367
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0079 0.008
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.3217 1
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0009 0.0028 0.0088
Schistosoma mansoni cation-transporting ATPase 0.0009 0.0028 0.0028
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0028 0.0088
Echinococcus granulosus cation transporting atpase worm 0.0009 0.0028 0.0047
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0221 0.0224
Schistosoma mansoni glutaminase 0.0278 0.987 0.987
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0814 0.1365
Plasmodium vivax SET domain protein, putative 0.003 0.0814 0.2781
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0814 0.1365
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0944 0.3227
Onchocerca volvulus 0.0084 0.2796 0.3284
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.082 0.255
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0221 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0079 0.008
Mycobacterium leprae PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB 0.0009 0.0028 0.0036
Toxoplasma gondii exonuclease III APE 0.002 0.0426 0.1455
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0287 0.0892
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.2796 0.2796
Brugia malayi jmjC domain containing protein 0.0016 0.0287 0.0291
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.1092 0.1832
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0585 0.0743
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.3217 0.3217
Trypanosoma brucei glucosidase, putative 0.0038 0.1092 0.3395
Trypanosoma brucei polo-like protein kinase 0.0096 0.3217 1
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.1092 0.3395
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0009 0.0028 0.0096
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.1092 0.1106
Loa Loa (eye worm) hypothetical protein 0.0016 0.0287 0.0291
Plasmodium falciparum pyruvate kinase 2 0.0017 0.034 0.1163
Onchocerca volvulus 0.0099 0.3322 0.3903
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0426 0.0431
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0362 0.046
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0079 0.008
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0028 0.0047
Echinococcus granulosus pyruvate kinase 0.0017 0.034 0.0571
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1962 0.1962
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.1092 0.3395
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0944 0.0957
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0426 0.0431
Schistosoma mansoni alpha-glucosidase 0.0147 0.5089 0.5089
Loa Loa (eye worm) calcium ATPase 0.0009 0.0028 0.0029
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.082 0.255
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0585 0.0593
Echinococcus granulosus FTZ F1 alpha 0.001 0.0079 0.0133
Plasmodium falciparum glutathione reductase 0.003 0.082 0.2803
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0573 0.6071
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0944 0.3227
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.031 0.0521
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0079 0.008
Schistosoma mansoni pyruvate kinase 0.0017 0.034 0.034
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0009 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0029
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0009 0.0028 0.0036
Schistosoma mansoni pyruvate kinase 0.0034 0.0944 0.0944
Mycobacterium leprae Probable metal cation-transporting P-type ATPase C CtpC 0.0009 0.0028 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.1443 0.1462
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0201 0.7055 0.8958
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0221 0.0686
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0585 0.182
Mycobacterium ulcerans metal cation-transporting p-type ATPase CtpC 0.0009 0.0028 0.0029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.082 0.255
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0201 0.7055 0.8958
Plasmodium vivax cation transporting ATPase, putative 0.0009 0.0028 0.0096
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0079 0.0133
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0009 0.0028 0.0028
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0079 0.008
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.008
Echinococcus granulosus pyruvate kinase 0.0034 0.0944 0.1584
Mycobacterium ulcerans metal cation transporter ATPase p-type CtpE 0.0009 0.0028 0.0029
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0028 0.0029
Trypanosoma cruzi proton motive ATPase 1, putative 0.0009 0.0028 0.0088
Loa Loa (eye worm) hypothetical protein 0.0018 0.0362 0.0367
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0773 0.1297
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.082 0.0831
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0028 0.0088
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.031 0.106
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0079 0.0133
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0585 0.0593
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0079 0.0079
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.031 0.0521
Plasmodium falciparum thioredoxin reductase 0.0088 0.2926 1
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0009 0.0028 0.0088
Treponema pallidum hypothetical protein 0.0009 0.0028 0.0343
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.082 0.255
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0009 0.0028 0.0036
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0028 0.0088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.031 0.0521
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.7444 0.7542
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0944 0.2935
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0079 0.008
Schistosoma mansoni kinase 0.0049 0.1489 0.1489
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0079 0.008
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0009 0.0028 0.0088
Toxoplasma gondii cation-transporting atpase family protein 0.0009 0.0028 0.0096
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.031 0.0965
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0029
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.031 0.106
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.031 0.031
Brugia malayi hypothetical protein 0.0009 0.0028 0.0029
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.3217 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.596 1
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0009 0.0028 0.0047
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0573 0.0581
Brugia malayi jmjC domain containing protein 0.0016 0.0287 0.0291
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0079 0.008
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.082 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0585 0.0593
Echinococcus multilocularis pyruvate kinase 0.0034 0.0944 0.1584
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0426 0.1324
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0287 0.0287
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.082 0.255
Echinococcus granulosus phospholipid transporting ATPase VA 0.0009 0.0028 0.0047
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.082 0.1376
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0009 0.0028 0.0088
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0944 0.0957
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0079 0.0079
Brugia malayi isocitrate dehydrogenase 0.0017 0.031 0.0314
Entamoeba histolytica hypothetical protein 0.0024 0.0573 0.1782
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0221 0.0224
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0009 0.0028 0.0047
Mycobacterium ulcerans cation-transporter p-type ATPase B CtpB 0.0009 0.0028 0.0029
Brugia malayi glutathione reductase 0.0088 0.2926 0.2965
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0573 0.1782
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0079 0.0079
Plasmodium vivax glutathione reductase, putative 0.0088 0.2926 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0079 0.0079
Leishmania major copper-transporting ATPase-like protein, putative 0.0009 0.0028 0.0088
Onchocerca volvulus 0.0009 0.0028 0.0033
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0009 0.0028 0.0088
Echinococcus granulosus pyruvate kinase 0.0017 0.034 0.0571
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.1891 0.1916
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0944 0.1199
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0009 0.0028 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.008
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0009 0.0028 0.0096
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0287 0.0291
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0585 0.0593
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0079 0.008
Echinococcus granulosus pyruvate kinase 0.0017 0.034 0.0571
Echinococcus multilocularis cation transporting ATPase 13A1 0.0009 0.0028 0.0047
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0028 0.0047
Chlamydia trachomatis pyruvate kinase 0.0034 0.0944 1
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0944 0.0957
Loa Loa (eye worm) hypothetical protein 0.0016 0.0287 0.0291
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1962 0.1962
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0009 0.0028 0.0029
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0287 0.0287
Trichomonas vaginalis set domain proteins, putative 0.0241 0.8513 0.8625
Schistosoma mansoni pyruvate kinase 0.0034 0.0944 0.0944
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.031 0.0394
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.082 0.255
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0079 0.0133
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0569 0.0576
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0585 0.0743
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.3217 0.3259
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0585 0.0743
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0221 0.0224
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.1891 0.3172
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.2796 0.469
Giardia lamblia Kinase, PLK 0.0096 0.3217 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0426 0.1324
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0426 0.1324
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0009 0.0028 0.0029
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0426 0.1324
Loa Loa (eye worm) hypothetical protein 0.0009 0.0028 0.0029
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0028 0.0029
Schistosoma mansoni ap endonuclease 0.002 0.0426 0.0426
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0009 0.0028 0.0029
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.034 0.1163
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0088 0.2926 0.3716
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0287 0.0481
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0585 0.0593
Echinococcus multilocularis pyruvate kinase 0.0017 0.034 0.0571
Chlamydia trachomatis metal transport ATPase 0.0009 0.0028 0.0298
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0028 0.0088
Brugia malayi glutaminase DH11.1 0.0278 0.987 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.082 0.255
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.3217 0.3259
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0944 0.2935
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.1092 0.1106
Trypanosoma brucei P-type H+-ATPase, putative 0.0009 0.0028 0.0088
Schistosoma mansoni copper ABC transporter ATPase 0.0009 0.0028 0.0028
Trypanosoma cruzi trypanothione reductase, putative 0.0088 0.2926 0.9097
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0426 0.5191
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0426 0.0431
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0814 0.2781
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0009 0.0028 0.0029
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0287 0.0481
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.3217 0.5397
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.082 0.0831
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.082 0.1042
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0287 0.0287
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0028 0.0029
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.1891 0.3172
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.596 1
Brugia malayi Pre-SET motif family protein 0.003 0.0814 0.0824
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0079 0.0079
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0009 0.0028 0.0088
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0585 0.182
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0009 0.0028 0.0029
Echinococcus granulosus thioredoxin glutathione reductase 0.0089 0.2945 0.4941
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0287 0.0481
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0944 0.0957
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.1092 0.3395
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0079 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.3217 0.3259
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0573 0.0728
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0585 0.0743
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.1092 0.1106
Schistosoma mansoni type V p-type atpase isoform 0.0009 0.0028 0.0028
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0009 0.0028 0.0096
Leishmania major pyruvate kinase 0.0034 0.0944 0.2935
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0326 0.0414
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0426 0.1324
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0028 0.0029
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0287 0.0291
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0585 0.0593
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0079 0.008
Schistosoma mansoni ATPase 0.0009 0.0028 0.0028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0326 0.0414
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0944 0.0957
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0079 0.0133
Echinococcus granulosus pyruvate kinase 0.0034 0.0944 0.1584
Loa Loa (eye worm) hypothetical protein 0.0018 0.0362 0.0367
Schistosoma mansoni jumonji domain containing protein 0.006 0.1891 0.1891
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0573 0.6988
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.031 0.0521
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0287 0.0287

Activities

Activity type Activity value Assay description Source Reference
MED (functional) = 1 mg kg-1 Antiamnesic activity against scopolamine-induced amnesia in ip dosed mouse by passive-avoidance test ChEMBL. 19786353

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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