Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1523 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.9282 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1523 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.1523 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0.003 % | Hair growth stimulatory activity in C3H/HeN mouse treated 5 days a week topically to shaved lower back twice daily for 4 weeks | ChEMBL. | 19900809 |
Activity (functional) | = 0.58 % | Effect on transepidermal penetration in human cadaver skin assessed as drug distributed to dermis after 40 hrs using Franz diffusion chamber | ChEMBL. | 19900809 |
Activity (functional) | = 6.17 % | Effect on transepidermal penetration in human cadaver skin assessed as total penetration after 40 hrs using Franz diffusion chamber | ChEMBL. | 19900809 |
Activity (functional) | = 9.88 % | Effect on transepidermal penetration in human cadaver skin assessed as drug distributed to epidermis after 40 hrs using Franz diffusion chamber | ChEMBL. | 19900809 |
Activity (functional) | = 0.14 microg/cm2/h | Effect on transepidermal penetration in human cadaver skin assessed as maximal penetration rate after 28 hrs using Franz diffusion chamber | ChEMBL. | 19900809 |
CL (ADMET) | = 15 ml/min.kg | Clearance in human blood | ChEMBL. | 19900809 |
CL (ADMET) | = 29 ml/min.kg | Intrinsic clearance in human | ChEMBL. | 19900809 |
EC50 (binding) | = 0.5 nM | Binding affinity to thyroid hormone receptor in human HepG2 cells | ChEMBL. | 19900809 |
Ki (binding) | = 0.4 nM | Binding affinity to thyroid receptor beta | ChEMBL. | 19900809 |
Ki (binding) | = 3 nM | Binding affinity to thyroid receptor alpha | ChEMBL. | 19900809 |
T1/2 (ADMET) | = 119 min | Half life in human hepatocytes | ChEMBL. | 19900809 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.