Detailed information for compound 1187814

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 385.415 | Formula: C23H19N3O3
  • H donors: 0 H acceptors: 3 LogP: 3.04 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1cc(oc2c1cccc2c1cccc(c1)c1cncnc1)N1CCOCC1
  • InChi: 1S/C23H19N3O3/c27-21-12-22(26-7-9-28-10-8-26)29-23-19(5-2-6-20(21)23)17-4-1-3-16(11-17)18-13-24-15-25-14-18/h1-6,11-15H,7-10H2
  • InChiKey: IQJAFXZUJLSTMN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase, DNA-activated, catalytic polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit Get druggable targets OG5_132688 All targets in OG5_132688
Echinococcus granulosus DNA dependent protein kinase catalytic subunit Get druggable targets OG5_132688 All targets in OG5_132688
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.2623 0.2581
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.2623 0.4944
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0016 0.0067 0.0018
Plasmodium falciparum glutathione reductase 0.0059 0.1519 0.2816
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1034 0.1141
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0172 0.0327
Giardia lamblia NADH oxidase lateral transfer candidate 0.0059 0.1519 0.5681
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0059 0.1519 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0016 0.0067 0.001
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0059 0.1519 0.2816
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0022 0.0271 0.0411
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1034 0.1141
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0059 0.1519 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0022 0.0271 0.0411
Plasmodium falciparum ferrodoxin reductase-like protein 0.0016 0.0067 0.0018
Loa Loa (eye worm) hypothetical protein 0.0044 0.1002 0.1911
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0016 0.0067 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Echinococcus granulosus glutamate synthase 0.0016 0.0067 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0016 0.0067 0.0127
Leishmania major ferric reductase, putative 0.0035 0.0717 0.1272
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0016 0.0067 0.0255
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0364 0.0591
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0364 0.0591
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0171 0.5246 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0057 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.1519 0.2816
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0016 0.0067 0.0255
Trypanosoma cruzi target of rapamycin kinase 3 0.0022 0.0271 0.0411
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0016 0.0067 0.0127
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0016 0.0067 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2623 1
Loa Loa (eye worm) thioredoxin reductase 0.0171 0.5246 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.0327
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1608 0.3065
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2623 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0059 0.1519 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0059 0.1519 0.2816
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.0327
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0172 0.022
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0067 0.0255
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1608 0.1811
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.32 0.6056
Schistosoma mansoni disulfide oxidoreductase 0.0016 0.0067 0.0012
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0016 0.0067 0.0018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.1519 0.2816
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0016 0.0067 0.0127
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1067 0.4069
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.016 0.4895 1
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.1002 0.1822
Loa Loa (eye worm) glutathione reductase 0.0171 0.5246 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0022 0.0271 0.0411
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0016 0.0067 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.0327
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0016 0.0067 0.001
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0016 0.0067 0.0127
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0364 0.0591
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0016 0.0067 0.001
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0022 0.0271 0.0516
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0057 0.0109
Brugia malayi hypothetical protein 0.0148 0.447 0.8505
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.0327
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0057 0.0001
Echinococcus multilocularis geminin 0.0166 0.5068 0.504
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0172 0.0327
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0059 0.1519 0.2816
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0057 0.0001
Schistosoma mansoni glutamate synthase 0.0016 0.0067 0.0012
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0035 0.0717 0.1272
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0022 0.0271 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1608 0.1811
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.2623 0.4945
Onchocerca volvulus Dual oxidase homolog 0.0075 0.2046 0.4495
Plasmodium vivax thioredoxin reductase, putative 0.0171 0.5246 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.0327
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0271 0.0411
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.1519 0.2816
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0016 0.0067 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1034 0.1141
Leishmania major hypothetical protein, conserved 0.0114 0.334 0.6327
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0057 0.0109
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0172 0.0654
Schistosoma mansoni kinase 0.0047 0.1108 0.1227
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0172 0.0327
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.2623 0.4944
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0059 0.1519 0.2816
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0016 0.0067 0.0255
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0016 0.0067 0.0018
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0016 0.0067 0.0018
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.2623 0.4944
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0364 0.0694
Trypanosoma cruzi NADH dehydrogenase, putative 0.0016 0.0067 0.0018
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0172 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.0327
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0044 0.0994 0.1807
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0044 0.0994 0.1807
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1608 0.1811
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0022 0.0271 0.0516
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.0327
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0016 0.0067 0.0018
Schistosoma mansoni hypothetical protein 0.0033 0.0654 0.0697
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1168 0.2142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0057 0.0001
Trichomonas vaginalis apoptosis inducing factor, putative 0.0016 0.0067 0.0255
Schistosoma mansoni hypothetical protein 0.0016 0.0067 0.0012
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0059 0.1519 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1608 0.3065
Schistosoma mansoni glutamate synthase 0.0016 0.0067 0.0012
Brugia malayi hypothetical protein 0.0016 0.0073 0.0031
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0016 0.0067 0.0127
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0172 0.022
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0059 0.1519 0.2816
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.2623 0.4999
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0059 0.1519 0.2816
Brugia malayi TAR-binding protein 0.0062 0.1608 0.299
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0172 0.022
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0016 0.0067 0.002
Leishmania major hypothetical protein, conserved 0.0025 0.0364 0.0591
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2623 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0016 0.0067 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Schistosoma mansoni hypothetical protein 0.0166 0.5068 0.5851
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0016 0.0067 0.0127
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0016 0.0067 0.0018
Brugia malayi Blistered cuticle protein 3 0.0075 0.2046 0.3834
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0654 0.115
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1034 0.1971
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0022 0.0271 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Plasmodium falciparum glutathione reductase 0.0171 0.5246 1
Giardia lamblia Kinase, PLK 0.0092 0.2623 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0364 0.0694
Echinococcus granulosus geminin 0.0166 0.5068 0.504
Brugia malayi Thioredoxin reductase 0.0171 0.5246 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0022 0.0271 0.025
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0057 0.0108
Schistosoma mansoni sulfide quinone reductase 0.0016 0.0067 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.3443 0.6524
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0172 0.022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0108
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0016 0.0067 0.0018
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0016 0.0067 0.0018
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0022 0.0271 0.0215
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0016 0.0067 0.001
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0568 0.0985
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0057 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2623 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0022 0.0271 0.0411
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0059 0.1519 0.2818
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0172 0.0116
Loa Loa (eye worm) hypothetical protein 0.0148 0.447 0.8521
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Brugia malayi isocitrate dehydrogenase 0.0015 0.0057 0.0002
Leishmania major hypothetical protein, conserved 0.0016 0.0067 0.0018
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0172 0.0116
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0059 0.1519 0.147
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0059 0.1519 0.2895
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0059 0.1519 0.147
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0016 0.0067 0.0255
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0364 0.0591
Giardia lamblia DINP protein human, muc B family 0.0019 0.0172 0.041
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0022 0.0271 0.0215
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0172 0.041
Trypanosoma brucei ferric reductase transmembrane protein, putative 0.0035 0.0717 0.1367
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.2623 0.2996
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0172 0.0721
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.3443 0.6993
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0059 0.1519 0.2895
Toxoplasma gondii selenide, water dikinase 0.0016 0.0067 0.0127
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0172 0.022
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0271 0.0516
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0016 0.0067 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Brugia malayi RNA binding protein 0.0062 0.1608 0.299
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0067 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Toxoplasma gondii NADPH-glutathione reductase 0.0059 0.1519 0.2895
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0035 0.0717 0.1272
Leishmania major NADH dehydrogenase, putative 0.0016 0.0067 0.0018
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.3436 0.6549
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1034 0.0983
Leishmania major hypothetical protein, conserved 0.0016 0.0067 0.0018
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0016 0.0067 0.0018
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.2623 0.5804
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0016 0.0067 0.0018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.1519 0.2816
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0016 0.0067 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0172 0.022
Echinococcus multilocularis thioredoxin glutathione reductase 0.0171 0.5246 0.5219
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0022 0.0271 0.0516
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0059 0.1519 1
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0016 0.0067 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1608 0.1811
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.2623 0.2581
Echinococcus multilocularis glutamate synthase 0.0016 0.0067 0.001
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0059 0.1519 0.2895
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0271 0.0411
Loa Loa (eye worm) blistered cuticle protein 3 0.0075 0.2046 0.39
Echinococcus granulosus thioredoxin glutathione reductase 0.0171 0.5246 0.5219
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0059 0.1519 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Trypanosoma brucei unspecified product 0.0019 0.0172 0.0327
Brugia malayi glutamate synthase 0.0016 0.0067 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.1519 0.2816
Loa Loa (eye worm) hypothetical protein 0.0025 0.0364 0.0694
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0022 0.0271 0.0411
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2623 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0271 0.0413
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1168 0.2226
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2623 1
Leishmania major hypothetical protein, conserved 0.0016 0.0067 0.0018
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0057 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0057 0.0002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0057 0.0001
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0067 0.0255
Onchocerca volvulus 0.0148 0.447 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0022 0.0271 0.0516
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0022 0.0271 0.0798
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0016 0.0067 0.0127
Trypanosoma cruzi trypanothione reductase, putative 0.0059 0.1519 0.2816
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0172 0.022
Loa Loa (eye worm) hypothetical protein 0.0033 0.0654 0.1246
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.1002 0.1821
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Leishmania major trypanothione reductase 0.0171 0.5246 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0059 0.1519 0.2816
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0022 0.0271 0.0411
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0067 0.0255
Plasmodium vivax ferrodoxin reductase, putative 0.0016 0.0067 0.0018
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0022 0.0271 0.0798
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0568 0.1083
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.2623 1
Trypanosoma brucei polo-like protein kinase 0.0092 0.2623 0.4999
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0016 0.0067 0.0018
Trypanosoma cruzi trypanothione reductase, putative 0.0171 0.5246 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.016 0.4895 0.9323
Loa Loa (eye worm) hypothetical protein 0.0049 0.1168 0.2226
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0022 0.0271 0.0411
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0172 0.0134
Trypanosoma brucei trypanothione reductase 0.0171 0.5246 1
Trichomonas vaginalis glutamate synthase, putative 0.0016 0.0067 0.0255
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0172 0.0654
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0172 0.0134
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0016 0.0067 0.0018
Schistosoma mansoni hypothetical protein 0.0166 0.5068 0.5851
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0067 0.0255
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.1002 0.1911
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Treponema pallidum NADH oxidase 0.0059 0.1519 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0016 0.0067 0.002
Echinococcus granulosus dna polymerase kappa 0.0019 0.0172 0.0116
Trichomonas vaginalis glutamate synthase, putative 0.0016 0.0067 0.0255
Echinococcus multilocularis dna polymerase eta 0.0044 0.1002 0.0951
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0022 0.0271 0.025
Leishmania major DNA polymerase kappa, putative 0.0019 0.0172 0.022
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0057 0.0109
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0067 0.0127
Leishmania major DNA polymerase eta, putative 0.0044 0.1002 0.1821
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.3443 0.6524
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.1519 0.2816
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1067 0.4069
Mycobacterium tuberculosis Probable oxidoreductase 0.016 0.4895 0.9323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0016 0.0067 0.0127
Schistosoma mansoni DNA polymerase eta 0.0044 0.1002 0.1104
Loa Loa (eye worm) RNA binding protein 0.0062 0.1608 0.3065
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1608 0.1811
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0067 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.0327
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0059 0.1519 0.2816
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0016 0.0067 0.001
Giardia lamblia GTOR 0.0022 0.0271 0.0798
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1168 0.2142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Mycobacterium tuberculosis Probable reductase 0.0117 0.3443 0.6524
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0016 0.0067 0.001
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0172 0.0721
Schistosoma mansoni sulfide quinone reductase 0.0016 0.0067 0.0012
Brugia malayi MH2 domain containing protein 0.0117 0.3436 0.6511
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0016 0.0067 0.0018
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0022 0.0271 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0059 0.1519 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Echinococcus granulosus dna polymerase eta 0.0044 0.1002 0.0951
Toxoplasma gondii thioredoxin reductase 0.0171 0.5246 1
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0016 0.0067 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Echinococcus granulosus tar DNA binding protein 0.0062 0.1608 0.156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0022 0.0271 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0016 0.0067 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Trichomonas vaginalis mercuric reductase, putative 0.0059 0.1519 0.5791
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0016 0.0067 0.0018
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1608 0.156
Trichomonas vaginalis glutathione reductase, putative 0.0059 0.1519 0.5791
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1034 0.1883
Loa Loa (eye worm) hypothetical protein 0.0016 0.0067 0.0127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1034 0.0983
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1034 0.0983
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.3443 0.6524
Schistosoma mansoni glutamate synthase 0.0016 0.0067 0.0012
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0057 0.0001
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0172 0.0116
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0059 0.1519 0.2816
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0172 0.0327
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1034 0.0983
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.3443 0.6524
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.3443 0.6524
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0057 0.0109
Loa Loa (eye worm) programmed cell death 8 0.0016 0.0067 0.0127
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0016 0.0067 0.0018
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0059 0.1519 0.2895
Trypanosoma brucei NADH dehydrogenase 0.0016 0.0067 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Leishmania major DNA polymerase eta, putative 0.0031 0.0568 0.0985
Trypanosoma cruzi NADH dehydrogenase, putative 0.0016 0.0067 0.0018
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0059 0.1519 0.2816
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0059 0.1519 0.2816
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0059 0.1519 0.1707
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0016 0.0067 0.001
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0016 0.0067 0.0255
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0271 0.0516
Plasmodium falciparum thioredoxin reductase 0.0171 0.5246 1
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0067 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0271 0.0413
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2623 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0871 0.166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Brugia malayi glutathione reductase 0.0171 0.5246 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.0327
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1608 0.299
Brugia malayi hypothetical protein 0.0025 0.0364 0.0593
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.0327
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.016 0.4895 0.9323
Plasmodium vivax glutathione reductase, putative 0.0171 0.5246 1
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.3436 0.6549
Plasmodium falciparum thioredoxin reductase 0.0059 0.1519 0.2816
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0271 0.1032
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0364 0.0591

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.57 uM Inhibition of DNA-dependent protein kinase ChEMBL. 18678488

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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